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Kinase Fusion Gene:MKNK2_RNF126 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MKNK2_RNF126 | KinaseFusionDB ID: KFG3887 | FusionGDB2.0 ID: KFG3887 | Hgene | Tgene | Gene symbol | MKNK2 | RNF126 | Gene ID | 2872 | 55658 | |
| Gene name | MAPK interacting serine/threonine kinase 2 | ring finger protein 126 | ||||||||||
| Synonyms | GPRK7|MNK2 | - | ||||||||||
| Cytomap | 19p13.3 | 19p13.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | MAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase interacting serine/threonine kinase 2MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2 | E3 ubiquitin-protein ligase RNF126 | ||||||||||
| Modification date | 20240305 | 20240411 | ||||||||||
| UniProtAcc | Q9HBH9 | Q9BV68 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000250896, ENST00000309340, ENST00000541165, ENST00000588014, ENST00000591142, ENST00000591588, ENST00000591601, | ENST00000292363, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MKNK2 [Title/Abstract] AND RNF126 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MKNK2(2041839)-RNF126(652884), # samples:3 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MKNK2 | GO:0006468 | protein phosphorylation | 11463832 |
| Hgene | MKNK2 | GO:0030097 | hemopoiesis | 21149447 |
| Hgene | MKNK2 | GO:0035556 | intracellular signal transduction | 11463832 |
| Hgene | MKNK2 | GO:0071243 | cellular response to arsenic-containing substance | 18299328 |
| Tgene | RNF126 | GO:0006511 | ubiquitin-dependent protein catabolic process | 24981174 |
| Tgene | RNF126 | GO:0006513 | protein monoubiquitination | 23277564 |
| Tgene | RNF126 | GO:0035519 | protein K29-linked ubiquitination | 36563124 |
| Tgene | RNF126 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 24981174 |
| Tgene | RNF126 | GO:0044314 | protein K27-linked ubiquitination | 36563124 |
| Tgene | RNF126 | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 36563124 |
| Kinase Fusion gene breakpoints across MKNK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across RNF126 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-AB-2897-03A | MKNK2 | chr19 | 2041839 | RNF126 | chr19 | 652884 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:2041839/chr19:652884) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MKNK2 | RNF126 |
| FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141, ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020, ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}. | FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564). {ECO:0000250|UniProtKB:Q91YL2, ECO:0000269|PubMed:23277564, ECO:0000269|PubMed:23418353, ECO:0000269|PubMed:24275455, ECO:0000269|PubMed:24981174, ECO:0000269|PubMed:29042515, ECO:0000305|PubMed:23026136}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MKNK2_RNF126 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MKNK2 | Q9HBH9 | human | SFPQ | P23246 | S283 | EGFkANLsLLRRPGE | |
| MKNK2 | Q9HBH9 | human | SFPQ | P23246 | S8 | MSRDRFrsrGGGGGG | |
| MKNK2 | Q9HBH9 | human | SPRY2 | O43597 | S112 | APLSRSIsTVssGsR | |
| MKNK2 | Q9HBH9 | human | EIF4E | P06730 | S209 | DtATksGsttKNRFV | |
| MKNK2 | Q9HBH9 | human | PLEC | Q15149 | S4642 | RAGsRrGsFDAtGsG | |
| MKNK2 | Q9HBH9 | human | SPRY2 | O43597 | S121 | VssGsRSsTRtSTSs |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
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Related Drugs to MKNK2_RNF126 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MKNK2-RNF126 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MKNK2_RNF126 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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