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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ABL1_BCR

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: ABL1_BCR
	KinaseFusionDB ID: KFG39
	FusionGDB2.0 ID: KFG39
		Hgene	Tgene
	Gene symbol	ABL1	BCR
	Gene ID	25	613
	Gene name	ABL proto-oncogene 1, non-receptor tyrosine kinase	BCR activator of RhoGEF and GTPase
	Synonyms	ABL\|BCR-ABL\|CHDSKM\|JTK7\|bcr/abl\|c-ABL\|c-ABL1\|p150\|v-abl	ALL\|BCR1\|CML\|D22S11\|D22S662\|PHL
	Cytomap	9q34.12	22q11.23
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1BCR-ABL1 p190BCR/ABL e8a2 fusionBCR/ABL1 e1a2 fusion proteinbcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncog	breakpoint cluster region proteinBCR, RhoGEF and GTPase activating proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26
	Modification date	20240416	20240416
	UniProtAcc	P00519	P11274
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000318560,	ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: ABL1 [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract] Expression of the ABL-BCR Fusion Gene in Philadelphia-Positive Acute Lymphoblastic Leukemia (pmid: 8490164) A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9 (pmid: 9809034)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BCR(23632600)-ABL1(133729451), # samples:12 ABL1(133589842)-BCR(23634728), # samples:6

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABL1	GO:0006974	DNA damage response	15657060
Hgene	ABL1	GO:0018108	peptidyl-tyrosine phosphorylation	7590236\|9144171\|10713049\|11121037
Hgene	ABL1	GO:0042770	signal transduction in response to DNA damage	9037071\|15657060\|18280240
Hgene	ABL1	GO:0043065	positive regulation of apoptotic process	9037071
Hgene	ABL1	GO:0046777	protein autophosphorylation	10713049
Hgene	ABL1	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	15657060
Hgene	ABL1	GO:0051353	positive regulation of oxidoreductase activity	12893824
Hgene	ABL1	GO:0051444	negative regulation of ubiquitin-protein transferase activity	20823226
Hgene	ABL1	GO:0070301	cellular response to hydrogen peroxide	10713049
Hgene	ABL1	GO:0071103	DNA conformation change	9558345
Hgene	ABL1	GO:0071901	negative regulation of protein serine/threonine kinase activity	11121037
Hgene	ABL1	GO:1990051	activation of protein kinase C activity	10713049
Hgene	ABL1	GO:2000042	negative regulation of double-strand break repair via homologous recombination	9461559
Tgene	BCR	GO:0090630	activation of GTPase activity	7479768

Kinase Fusion gene breakpoints across ABL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across BCR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-AB-2817-03A	ABL1	chr9	133589842	BCR	chr22	23595986
ChimerDB4	TCGA-AB-2901_700FEAAXX_2	ABL1	chr9	133589842	BCR	chr22	23634728
ChimerDB4	TCGA-AB-2941	ABL1	chr9	133589842	BCR	chr22	23634727
ChiTaRS5.0	FN869160	ABL1	chr9	133640782	BCR	chr22	23634788
ChiTaRS5.0	FN869173	ABL1	chr9	133649377	BCR	chr22	23631757
ChiTaRS5.0	JQ425245	ABL1	chr9	133614221	BCR	chr22	23632569
ChiTaRS5.0	FN869132	ABL1	chr9	133661281	BCR	chr22	23329601
ChiTaRS5.0	FN869133	ABL1	chr9	133665065	BCR	chr22	23632278
ChiTaRS5.0	FN869135	ABL1	chr9	133662856	BCR	chr22	23634037
ChiTaRS5.0	FN869136	ABL1	chr9	133601712	BCR	chr22	23634625
ChiTaRS5.0	FN869138	ABL1	chr9	133640438	BCR	chr22	23632376
ChiTaRS5.0	FN869140	ABL1	chr9	133608655	BCR	chr22	23632746
ChiTaRS5.0	FN869141	ABL1	chr9	133728433	BCR	chr22	23633949
ChiTaRS5.0	FN869142	ABL1	chr9	133707481	BCR	chr22	23633310
ChiTaRS5.0	FN869143	ABL1	chr9	133720322	BCR	chr22	23634652
ChiTaRS5.0	FN869144	ABL1	chr9	133718268	BCR	chr22	23632030
ChiTaRS5.0	FN869145	ABL1	chr9	133688104	BCR	chr22	23631893
ChiTaRS5.0	FN869146	ABL1	chr9	133710292	BCR	chr22	23632310
ChiTaRS5.0	FN869147	ABL1	chr9	133659980	BCR	chr22	23632150
ChiTaRS5.0	FN869148	ABL1	chr9	133637880	BCR	chr22	23632063
ChiTaRS5.0	FN869149	ABL1	chr9	133648542	BCR	chr22	23631641
ChiTaRS5.0	FN869151	ABL1	chr9	133656687	BCR	chr22	23632085
ChiTaRS5.0	FN869152	ABL1	chr9	133717558	BCR	chr22	23632009
ChiTaRS5.0	FN869153	ABL1	chr9	133605484	BCR	chr22	23594824
ChiTaRS5.0	FN869156	ABL1	chr9	133619871	BCR	chr22	23371217
ChiTaRS5.0	FN869157	ABL1	chr9	133657429	BCR	chr22	23632936
ChiTaRS5.0	FN869159	ABL1	chr9	133677898	BCR	chr22	23631846
ChiTaRS5.0	FN869161	ABL1	chr9	133721863	BCR	chr22	23632679
ChiTaRS5.0	FN869162	ABL1	chr9	133708503	BCR	chr22	23632334
ChiTaRS5.0	FN869163	ABL1	chr9	133631737	BCR	chr22	23631966
ChiTaRS5.0	FN869164	ABL1	chr9	133632336	BCR	chr22	23632430
ChiTaRS5.0	FN869165	ABL1	chr9	133714309	BCR	chr22	23634313
ChiTaRS5.0	FN869166	ABL1	chr9	133723232	BCR	chr22	23633596
ChiTaRS5.0	FN869168	ABL1	chr9	133605256	BCR	chr22	23383190
ChiTaRS5.0	FN869169	ABL1	chr9	133593182	BCR	chr22	23355254
ChiTaRS5.0	FN869171	ABL1	chr9	133597121	BCR	chr22	23632824
ChiTaRS5.0	FN869172	ABL1	chr9	133610029	BCR	chr22	23631563
ChiTaRS5.0	FN869174	ABL1	chr9	133656666	BCR	chr22	23632342
ChiTaRS5.0	FN869175	ABL1	chr9	133680063	BCR	chr22	23634651
ChiTaRS5.0	FN869176	ABL1	chr9	133591406	BCR	chr22	23632030
ChiTaRS5.0	JQ425240	ABL1	chr9	133686164	BCR	chr22	23632728
ChiTaRS5.0	JQ425243	ABL1	chr9	133609600	BCR	chr22	23633410
ChiTaRS5.0	JQ425248	ABL1	chr9	133715193	BCR	chr22	23632419
ChiTaRS5.0	JQ425250	ABL1	chr9	133651594	BCR	chr22	23633431
ChiTaRS5.0	JQ425252	ABL1	chr9	133611321	BCR	chr22	23632429
CCLE	HAP1	ABL1	chr9	133589842	BCR	chr22	23632526
CCLE	KCL-22	ABL1	chr9	133589842	BCR	chr22	23632526
CCLE	BV-173	ABL1	chr9	133589842	BCR	chr22	23632526
CCLE	KYO-1	ABL1	chr9	133589842	BCR	chr22	23632526
CCLE	JK-1	ABL1	chr9	133589842	BCR	chr22	23632526
CCLE	MEG-01	ABL1	chr9	133589842	BCR	chr22	23632526
CCLE	MOLM-6	ABL1	chr9	133589842	BCR	chr22	23632526
CCLE	HAP1	ABL1	chr9	133589842	BCR	chr22	23632415
CCLE	HAP1	ABL1	chr9	133589842	BCR	chr22	23651611
CCLE	HNT-34	ABL1	chr9	133710912	BCR	chr22	23634728
CCLE	MOLM-1	ABL1	chr9	133589842	BCR	chr22	23631704
CCLE	EM-2	ABL1	chr9	133589842	BCR	chr22	23637211
CCLE	KU812	ABL1	chr9	133589842	BCR	chr22	23637211
CCLE	HNT-34	ABL1	chr9	133589842	BCR	chr22	23637211
CCLE	SUP-B15	ABL1	chr9	133710912	BCR	chr22	23595986

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000318560	ENST00000305877	ABL1	chr9	133710912	BCR	chr22	23634728	4009	407
ENST00000318560	ENST00000305877	ABL1	chr9	133710912	BCR	chr22	23595986	5512	908

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000318560_ENST00000305877_ABL1_chr9_133710912_BCR_chr22_23634728_length(amino acids)=407
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEDLYCTLEVDSFGYFVNKAKTRVYRDTA
EPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMP
SRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRE
LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPAN

--------------------------------------------------------------

>ENST00000318560_ENST00000305877_ABL1_chr9_133710912_BCR_chr22_23595986_length(amino acids)=908
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEDGSFGTPPGYGCAADRAEEQRRHQDGL
PYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQI
ETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDP
TTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGAR
KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATER
LKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKED
DESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGES
TDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGM
EEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPE
ANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQ

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:23632600/chr22:133729451)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABL1 P00519	BCR P11274
FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250\|UniProtKB:P00520, ECO:0000269\|PubMed:10391250, ECO:0000269\|PubMed:11971963, ECO:0000269\|PubMed:12379650, ECO:0000269\|PubMed:12531427, ECO:0000269\|PubMed:12672821, ECO:0000269\|PubMed:15031292, ECO:0000269\|PubMed:15556646, ECO:0000269\|PubMed:15657060, ECO:0000269\|PubMed:15886098, ECO:0000269\|PubMed:16424036, ECO:0000269\|PubMed:16678104, ECO:0000269\|PubMed:16943190, ECO:0000269\|PubMed:17306540, ECO:0000269\|PubMed:17623672, ECO:0000269\|PubMed:18328268, ECO:0000269\|PubMed:18945674, ECO:0000269\|PubMed:19891780, ECO:0000269\|PubMed:20357770, ECO:0000269\|PubMed:20417104, ECO:0000269\|PubMed:22810897, ECO:0000269\|PubMed:28428613, ECO:0000269\|PubMed:9037071, ECO:0000269\|PubMed:9144171, ECO:0000269\|PubMed:9461559}.	FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250\|UniProtKB:Q6PAJ1, ECO:0000269\|PubMed:1657398, ECO:0000269\|PubMed:17116687, ECO:0000269\|PubMed:1903516, ECO:0000269\|PubMed:23940119, ECO:0000269\|PubMed:7479768}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	22	893_1020	426	1228	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00041
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	23	893_1020	426	1272	Domain	Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00041
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	22	498_691	426	1228	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	23	498_691	426	1272	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	22	708_866	426	1228	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00145
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	23	708_866	426	1272	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00145
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	22	1054_1248	426	1228	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00172
Tgene	ABL1	133710912	BCR	23595986	ENST00000318560	0	23	1054_1248	426	1272	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00172
Tgene	ABL1	133710912	BCR	23634728	ENST00000318560	13	22	1054_1248	927	1228	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00172
Tgene	ABL1	133710912	BCR	23634728	ENST00000318560	13	23	1054_1248	927	1272	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00172

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>2_ABL1_BCR	ENST00000318560	ENST00000305877	ABL1	chr9	133710912	BCR	chr22	23595986	MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEDGSFGTPPGYGCAADRAEEQRRHQDGL PYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQI ETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDP TTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGAR KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATER LKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKED DESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGES TDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGM EEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPE ANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQ	908
3D view using mol* of 2_ABL1_BCR

PDB file >>>TKFP_4_ABL1_BCR	ENST00000318560	ENST00000305877	ABL1	chr9	133710912	BCR	chr22	23634728	MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEDLYCTLEVDSFGYFVNKAKTRVYRDTA EPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMP SRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRE LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPAN	407_ABL1_BCR
PDB file >>>TKFP_5_ABL1_BCR	ENST00000318560	ENST00000305877	ABL1	chr9	133710912	BCR	chr22	23595986	MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEDGSFGTPPGYGCAADRAEEQRRHQDGL PYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQI ETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDP TTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGAR KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATER LKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKED DESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGES TDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGM EEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPE ANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQ	908_ABL1_BCR
3D view using mol* of TKFP_5_ABL1_BCR

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_44_BCR_ABL1_vs_HKFP_45_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_44_BCR_ABL1_vs_HKFP_46_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_44_BCR_ABL1_vs_HKFP_47_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_44_BCR_ABL1_vs_HKFP_48_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_44_BCR_ABL1_vs_HKFP_50_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_45_BCR_ABL1_vs_HKFP_46_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_45_BCR_ABL1_vs_HKFP_47_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_45_BCR_ABL1_vs_HKFP_48_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_45_BCR_ABL1_vs_HKFP_50_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_46_BCR_ABL1_vs_HKFP_47_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_46_BCR_ABL1_vs_HKFP_48_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_46_BCR_ABL1_vs_HKFP_50_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_47_BCR_ABL1_vs_HKFP_48_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_47_BCR_ABL1_vs_HKFP_50_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_48_BCR_ABL1_vs_HKFP_50_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_100_BCR_ABL1_vs_TKFP_101_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_100_BCR_ABL1_vs_TKFP_84_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_101_BCR_ABL1_vs_TKFP_84_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_4_ABL1_BCR_vs_TKFP_5_ABL1_BCR_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_83_BCR_ABL1_vs_TKFP_100_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_83_BCR_ABL1_vs_TKFP_101_BCR_ABL1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_83_BCR_ABL1_vs_TKFP_84_BCR_ABL1_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/TKFP_5_ABL1_BCR_vs_TKFP_4_ABL1_BCR.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ABL1_BCR does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/2_ABL1_BCR.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_5_ABL1_BCR_updated_violin_plot.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

2_ABL1_BCR.png

TKFP_5_ABL1_BCR.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
TKFP_5_ABL1_BCR	1.049	222	1.032	779.639	0.5	0.771	1.007	0.338	1.137	0.297	0.621	Chain A: 51,348,349,350,351,352,353,432,435,436,43 9,452,455,463,466,467,484,485,486,490,493,494,529, 533,534,535,536,537,538,539,540,541,543,544,545,54 7,573,575,576,577,578,605,607,608,610,639,641,643, 644

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

2_ABL1_BCR_ramachandran.png

TKFP_5_ABL1_BCR_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
2_ABL1_BCR-DOCK_HTVS_1-001	Sunitinib	-7.77544	-7.77964	-51.3031
2_ABL1_BCR-DOCK_HTVS_1-001	Osimertinib	-7.23233	-7.24003	-54.6319
2_ABL1_BCR-DOCK_HTVS_1-001	Nilotinib	-7.23061	-7.37021	-54.8641
2_ABL1_BCR-DOCK_HTVS_1-001	Nilotinib	-7.23061	-7.37021	-54.8641
2_ABL1_BCR-DOCK_HTVS_1-001	Selumetinib	-7.12018	-7.1288800000000005	-49.7011
2_ABL1_BCR-DOCK_HTVS_1-001	Selumetinib	-7.12018	-7.1288800000000005	-49.7011
2_ABL1_BCR-DOCK_HTVS_1-001	Binimetinib	-7.05271	-7.06141	-49.5684
2_ABL1_BCR-DOCK_HTVS_1-001	Binimetinib	-7.05271	-7.06141	-49.5684
2_ABL1_BCR-DOCK_HTVS_1-001	Upadacitinib	-6.8738600000000005	-6.874860000000001	-39.1638
2_ABL1_BCR-DOCK_HTVS_1-001	Cobimetinib	-6.77335	-6.77615	-52.6207
2_ABL1_BCR-DOCK_HTVS_1-001	Lapatinib	-6.665780000000001	-6.754580000000001	-47.5169
2_ABL1_BCR-DOCK_HTVS_1-001	Pralsetinib	-6.562069999999999	-6.653569999999999	-58.4519
2_ABL1_BCR-DOCK_HTVS_1-001	Zanubrutinib	-6.513	-6.513	-46.7127
2_ABL1_BCR-DOCK_HTVS_1-001	Upadacitinib	-6.47369	-6.47469	-34.7772
2_ABL1_BCR-DOCK_HTVS_1-001	Larotrectinib	-6.35081	-6.35081	-51.8107
2_ABL1_BCR-DOCK_HTVS_1-001	Dacomitinib	-6.3486400000000005	-6.45694	-44.4006
2_ABL1_BCR-DOCK_HTVS_1-001	Dacomitinib	-6.3486400000000005	-6.45694	-44.4006
2_ABL1_BCR-DOCK_HTVS_1-001	Erdafitinib	-6.303730000000001	-6.30393	-42.0892
2_ABL1_BCR-DOCK_HTVS_1-001	Selpercatinib	-6.25716	-6.28766	-48.7924
2_ABL1_BCR-DOCK_HTVS_1-001	Selpercatinib	-6.25716	-6.28766	-48.7924

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Kinase-Substrate Information of ABL1_BCR

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
ABL1	P00519	human	YAP1	P46937	Y407	sGLsMsSySVPRtPD
ABL1	P00519	human	DCBLD2	Q96PD2	Y750	PAPDELVyQVPQStQ
ABL1	P00519	human	SMAD4	Q13485	Y301	MPPHPGHyWPVHNEL
ABL1	P00519	human	DCBLD1	Q8N8Z6	S657	GDyQRPHsAQPADRG
ABL1	P00519	human	TBX21	Q9UL17	Y305	QFIAVTAyQNAEITQ	T-box
ABL1	P00519	human	CAT	P04040	Y231	NANGEAVyCkFHYkT	Catalase
ABL1	P00519	human	MYLK	Q15746	Y1449	EKEPEVDyRTVTINT
ABL1	P00519	human	ABL1	P00519	Y393	RLMtGDtytAHAGAk	PK_Tyr_Ser-Thr
ABL1	P00519	human	TP73	O15350	Y99	SVPTHSPyAQPSSTF
ABL1	P00519	human	DCBLD2	Q96PD2	Y715	PPPLVGtyNtLLsRt
ABL1	P00519	human	SORBS2	O94875-2	Y59	RPFSPSAySLPASLN
ABL1	P00519	human	DCBLD2	Q96PD2	Y565	KKkTEGtyDLPyWDR
ABL1	P00519	human	CDC73	Q6P1J9	Y315	KIDTMGTyHGMTLkS
ABL1	P00519	human	DCBLD1	Q8N8Z6	S695	THPGTsDsysAPRDC
ABL1	P00519	human	MET	P08581	Y1349	stFIGEHyVHVNAty
ABL1	P00519	human	HRAS	P01112	Y137	AQDLARSyGIPYIEt	Ras
ABL1	P00519	human	MYC	P01106	Y89	sGLCsPSyVAVtPFs	Myc_N
ABL1	P00519	human	MDM4	O15151	Y55	TVKEVMHyLGQYIMV	SWIB
ABL1	P00519	human	PIK3AP1	Q6ZUJ8	Y513	LGQEEDVyHTVDDDE
ABL1	P00519	human	PDGFRB	P09619	Y970	GEGYKKKyQQVDEEF
ABL1	P00519	human	KAT5	Q92993	Y294	HPPGNEIyRkGTISF	MOZ_SAS
ABL1	P00519	human	MYC	P01106	Y47	CDEEENFyQQQQQSE	Myc_N
ABL1	P00519	human	CRK	P46108	Y221	GGPEPGPyAQPsVNt
ABL1	P00519	human	CASP9	P55211	Y153	RGNADLAyILSMEPC
ABL1	P00519	human	PLSCR1	O15162	Y69	PVPNQPVyNQPVyNQ
ABL1	P00519	human	ANXA1	P04083	Y21	IENEEQEyVQtVkss
ABL1	P00519	human	PXN	P49023	Y118	VGEEEHVysFPNkQk	Paxillin
ABL1	P00519	human	SMAD4	Q13485	Y195	NRASTETyStPALLA
ABL1	P00519	human	ROBO1	Q9Y6N7	Y1038	MLPESTVyGDVDLSN
ABL1	P00519	human	CRKL	P46109	Y207	IPEPAHAyAQPQttt
ABL1	P00519	human	VAV1	P15498	Y174	EAEGDEIyEDLMRsE
ABL1	P00519	human	TP63	Q9H3D4	Y290	RQSVLVPyEPPQVGT	P53
ABL1	P00519	human	DCBLD2	Q96PD2	T756	VyQVPQStQEVsGAG
ABL1	P00519	human	RB1	P06400	Y805	rIPGGNIyIsPLksP	Rb_C
ABL1	P00519	human	NOX5	Q96PH1	Y476	FHYRPGDyLyLNIPT	FAD_binding_8
ABL1	P00519	human	FHL2	Q14192	Y176	ITTGGVtyREQPWHK	LIM
ABL1	P00519	human	MDM2	Q00987	Y394	QsQESEDysQPSTSS
ABL1	P00519	human	ESR1	P03372	Y219	sIQGHNDyMCPATNQ	zf-C4
ABL1	P00519	human	RAPGEF1	Q13905	Y504	APIPSVPyAPFAAIL
ABL1	P00519	human	PLK1	P53350	Y445	DSTRLILyNDGDsLQ	POLO_box
ABL1	P00519	human	CRK	P46108	Y239	NLQNGPIyARVIQKR	SH3_2
ABL1	P00519	human	ZAP70	P43403	Y319	tsVyEsPysDPEELk
ABL1	P00519	human	JUNB	P17275	Y182	GPEPPPVyTNLSSyS	Jun
ABL1	P00519	human	EGFR	P00533	Y1092	tFLPVPEyINQsVPk
ABL1	P00519	human	DCBLD2	Q96PD2	S600	tPVRysssEVNHLsP
ABL1	P00519	human	ABI1	Q8IZP0	Y213	PPtVPNDyMtsPARL
ABL1	P00519	human	MAVS	Q7Z434	Y30	DVVEILPyLPCLTAR	CARD_2
ABL1	P00519	human	PHF5A	Q7RTV0	Y36	kCVICDSyVRPCTLV	PHF5
ABL1	P00519	human	TP63	Q9H3D4	Y149	SVTAPSPyAQPSSTF
ABL1	P00519	human	ABL1	P00519-2	Y412	RLMTGDtyTAHAGAK	PK_Tyr_Ser-Thr
ABL1	P00519	human	DCBLD1	Q8N8Z6	S697	PGTsDsysAPRDCLT
ABL1	P00519	human	PXN	P49023	Y31	FLSEEtPysyPtGNH
ABL1	P00519	human	WASF3	Q9UPY6	Y151	KKDGLKFyTDPSyFF
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y665	AQPADRGyDRPKAVs
ABL1	P00519	human	PDGFRB	P09619	Y686	IITEyCRyGDLVDyL	PK_Tyr_Ser-Thr
ABL1	P00519	human	DCBLD2	Q96PD2	S598	EEtPVRysssEVNHL
ABL1	P00519	human	CDC73	Q6P1J9	Y293	IPAAyNRyDQERFkG	CDC73_N
ABL1	P00519	human	CASP9	P55211	Y397	AVSVkGIyKQMPGCF	Peptidase_C14
ABL1	P00519	human	PYCARD	Q9ULZ3	Y146	kVLTDEQyQAVRAEP	CARD
ABL1	P00519	human	CD19	P15391	Y508	EDMRGILyAAPQLRs
ABL1	P00519	human	CDKN1B	P46527	Y88	kGsLPEFyyRPPRPP
ABL1	P00519	human	CTNNB1	P35222	Y86	VADIDGQyAMTRAQR
ABL1	P00519	human	FOXA1	P55317	Y429	QALQYsPyGSTLPAS	HNF_C
ABL1	P00519	human	MYLK	Q15746	Y792	QPWHAGQyEILLKNR	I-set
ABL1	P00519	human	MYLK	Q15746	Y464	QEGsIEVyEDAGsHy	I-set
ABL1	P00519	human	DCBLD2	Q96PD2	Y655	GyADLDPyNsPGQEV
ABL1	P00519	human	JUNB	P17275	Y173	PAGPGGVyAGPEPPP	Jun
ABL1	P00519	human	SNCA	P37840	Y125	VDPDNEAyEMPsEEG	Synuclein
ABL1	P00519	human	NOX5	Q96PH1	Y478	YRPGDyLyLNIPTIA	FAD_binding_8
ABL1	P00519	human	MYLK	Q15746	Y231	NQDDVGVyTCLVVNG	I-set
ABL1	P00519	human	MYLK	Q15746	Y846	DGGGSDRyGsLRPGW
ABL1	P00519	human	PIK3AP1	Q6ZUJ8	Y594	DRPQssIyDPFAGMk
ABL1	P00519	human	GPX1	P07203	Y98	EILNSLkyVRPGGGF	GSHPx
ABL1	P00519	human	SRCIN1	Q9C0H9	Y396	LVKGEGLyADPyGLL
ABL1	P00519	human	NOS3	P29474	Y81	WEVGSITyDTLSAQA
ABL1	P00519	human	DCBLD2	Q96PD2	S760	PQStQEVsGAGRDGE
ABL1	P00519	human	MDM4	O15151	Y99	VkDPsPLyDMLRKNL
ABL1	P00519	human	HIPK2	Q9H2X6	Y367	tyLQsRYyRAPEIIL	Pkinase
ABL1	P00519	human	TRIM33	Q9UPN9	Y1048	MMKVVQVyADtQEIN	Bromodomain
ABL1	P00519	human	TBX21	Q9UL17	Y220	SMPGNRLyVHPDSPN	T-box
ABL1	P00519	human	PSMA7	O14818	Y106	EDPVTVEyItRyIAS	Proteasome
ABL1	P00519	human	PPARG	P37231	Y78	SSISTPHyEDIPFTR	PPARgamma_N
ABL1	P00519	human	ATR	Q13535	Y291	DTDQLKLyEEPLSkL
ABL1	P00519	human	DCBLD2	Q96PD2	Y649	EEGKEAGyADLDPyN
ABL1	P00519	human	AHSA1	O95433	Y223	LtsPEELyRVFTTQE	AHSA1
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y589	QRAGRHEyALPLAPP
ABL1	P00519	human	DNM1L	O00429	Y266	TDSIRDEyAFLQkkY	Dynamin_M
ABL1	P00519	human	LGALS3	P17931	Y107	AYPATGPyGAPAGPL
ABL1	P00519	human	LGALS3	P17931	Y79	GAPAPGVyPGPPSGP
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y600	LAPPEPEyAtPIVER
ABL1	P00519	human	WASF3	Q9UPY6	Y486	SRRIAVEySDSDDDS
ABL1	P00519	human	DCBLD1	Q8N8Z6	S556	GTVTRKGsTFRPMDT
ABL1	P00519	human	ESR2	Q92731	Y36	SIYIPSSyVDSHHEY	ERbeta_N
ABL1	P00519	human	RAD51	Q06609	Y54	HTVEAVAyAPkkELI	HHH_5
ABL1	P00519	human	EGFR	P00533	Y1197	stAENAEyLRVAPQS
ABL1	P00519	human	GLO1	Q04760	Y136	GIAVPDVysACkRFE	Glyoxalase
ABL1	P00519	human	STX17	P56962	Y157	SQSLTQIyALPEIPQ
ABL1	P00519	human	PPARG	P37231	Y102	yDLKLQEyQSAIkVE	PPARgamma_N
ABL1	P00519	human	GMNN	O75496	Y150	EVAEHVQyMAELIER	Geminin
ABL1	P00519	human	SNCA	P37840	Y39	kTkEGVLyVGsKTkE	Synuclein
ABL1	P00519	human	NFKBIA	P25963	Y305	FtEDELPyDDCVFGG
ABL1	P00519	human	MUC1	P15941	Y1243	NGGSsLsytNPAVAA
ABL1	P00519	human	DCBLD1	Q8N8Z6	S693	PPTHPGTsDsysAPR
ABL1	P00519	human	SORBS2	O94875-2	Y573	NTKGAEDyPDPPIPH
ABL1	P00519	human	ERRFI1	Q9UJM3	Y394	KKVsstHyyLLPERP
ABL1	P00519	human	CAV1	Q03135	Y14	VDsEGHLytVPIREQ
ABL1	P00519	human	RAD51	Q06609	Y315	EtRICKIyDSPCLPE	Rad51
ABL1	P00519	human	FOXA1	P55317	Y464	PAYYQGVySRPVLNT
ABL1	P00519	human	RTCB	Q9Y3I0	Y316	GMAAAGNyAWVNRSS	RtcB
ABL1	P00519	human	ESR1	P03372	Y52	DssKPAVyNYPEGAA	Oest_recep
ABL1	P00519	human	ATR	Q13535	Y310	FPFEAEAyRNIEPVY
ABL1	P00519	human	BCR	P11274	Y177	ADAEKPFyVNVEFHH
ABL1	P00519	human	PLCG1	P19174	Y1003	KGKKFLQyNRLQLSR	PI-PLC-Y
ABL1	P00519	human	MET	P08581	Y1356	yVHVNAtyVNVKCVA
ABL1	P00519	human	BTK	Q06187	Y223	LKKVVALyDyMPMNA	SH3_1
ABL1	P00519	human	EGFR	P00533	Y1016	DVVDADEyLIPQQGF
ABL1	P00519	human	RACK1	P63244	Y52	LtrDEtNyGIPQRAL
ABL1	P00519	human	SORBS2	O94875-2	Y175	YTYNAGLyNPPYSAQ
ABL1	P00519	human	ABL2	P42684	Y261	GLVTTLHyPAPKCNK
ABL1	P00519	human	STK3	Q13188	Y81	MQQCDSPyVVKYYGS	Pkinase
ABL1	P00519	human	PLCG1	P19174	Y771	IGtAEPdyGALyEGR
ABL1	P00519	human	PLK1	P53350	Y217	tLCGtPNyIAPEVLs	Pkinase
ABL1	P00519	human	SNW1	Q13573	Y292	AKLAEALyIADRKAR	SKIP_SNW
ABL1	P00519	human	PIK3AP1	Q6ZUJ8	Y570	QERPGNFyVSSEsIR
ABL1	P00519	human	CEBPB	P17676	Y78	RAIDFsPyLEPLGAP
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y540	ITsDMADyQQPLMIG
ABL1	P00519	human	OTULIN	Q96BN8	Y56	AEHEEDMyRAADEIE
ABL1	P00519	human	JUN	P05412	Y170	LHSEPPVyANLSNFN	Jun
ABL1	P00519	human	IRF3	Q14653	Y292	rLGHCHTyWAVSEEL	IRF-3
ABL1	P00519	human	DCBLD2	Q96PD2	Y597	HEEtPVRysssEVNH
ABL1	P00519	human	DCBLD2	Q96PD2	Y621	LQADsAEyAQPLVGG
ABL1	P00519	human	CTTN	Q14247	Y486	yPAEDStyDEYENDL
ABL1	P00519	human	TP63	Q9H3D4	Y171	AIPSNTDyPGPHSFD	P53
ABL1	P00519	human	NCOA3	Q9Y6Q9	Y1357	HPQAASIyQSSEMKG
ABL1	P00519	human	RBM39	Q14498	Y95	DRRFRGRyrsPysGP
ABL1	P00519	human	SNW1	Q13573	Y433	EDEIyNVyDQAWrGG
ABL1	P00519	human	EMD	P50402	Y167	AyQsItHyRPVsAsR
ABL1	P00519	human	DCBLD2	Q96PD2	T679	ITGPEyAtPIIMDMS
ABL1	P00519	human	NCK1	P16333	Y105	VDPGERLyDLNMPAy
ABL1	P00519	human	PIK3AP1	Q6ZUJ8	Y694	AKVEFGVyEsGPRKs
ABL1	P00519	human	DCBLD2	Q96PD2	Y677	LPITGPEyAtPIIMD
ABL1	P00519	human	CAT	P04040	Y386	yRARVANyQRDGPMC	Catalase
ABL1	P00519	human	RAD52	P43351	Y104	DLNNGKFyVGVCAFV	Rad52_Rad22
ABL1	P00519	human	ROBO1	Q9Y6N7	Y1114	QEVAPVQyNIVEQNk
ABL1	P00519	human	YAP1	P46937-3	Y357	SGLSMSSySVPRtPD
ABL1	P00519	human	WASF3	Q9UPY6	Y337	LPAQIIEyYNPSGPP
ABL1	P00519	human	DDX5	P17844	Y593	NGMNQQAyAyPATAA
ABL1	P00519	human	DCBLD1	Q8N8Z6	S513	yPFARHQsAEFtISY
ABL1	P00519	human	PLK1	P53350	Y425	SDkYGLGyQLCDNSV	POLO_box
ABL1	P00519	human	DCBLD2	Q96PD2	S618	TTVLQADsAEyAQPL
ABL1	P00519	human	CDC73	Q6P1J9	Y290	kQPIPAAyNRyDQER	CDC73_N
ABL1	P00519	human	ARHGDIB	P52566	Y24	ELdskLNykPPPQks	Rho_GDI
ABL1	P00519	human	TBX21	Q9UL17	Y266	VLQsLHKyQPRLHIV	T-box
ABL1	P00519	human	MYLK	Q15746	Y1635	VAPEVINyEPIGYAT	Pkinase
ABL1	P00519	human	JUNB	P17275	Y188	VyTNLSSySPASASS	Jun
ABL1	P00519	human	DCBLD2	Q96PD2	Y666	GQEVyHAyAEPLPIT
ABL1	P00519	human	PIK3AP1	Q6ZUJ8	Y553	QLPDNEPyIFKVFAE
ABL1	P00519	human	GMFG	O60234	Y104	kPEQQMMyAGSkNRL	Cofilin_ADF
ABL1	P00519	human	SRCIN1	Q9C0H9	Y264	IYRKEPLyAAFPGSH	AIP3
ABL1	P00519	human	PSMA7	O14818	Y153	QTDPsGtyHAWkANA	Proteasome
ABL1	P00519	human	TRIM33	Q9UPN9	Y524	QHMQQQVyAQKHQQL
ABL1	P00519	human	CDKN1B	P46527	Y89	GsLPEFyyRPPRPPK
ABL1	P00519	human	NUMA1	Q14980	Y1774	VEsLEsLyFtPIPAR
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y578	STDAGGHyDCPQRAG
ABL1	P00519	human	CRK	P46108	Y251	QKRVPNAyDktALAL	SH3_2
ABL1	P00519	human	DNM1L	O00429	Y368	CGGARICyIFHETFG	Dynamin_M
ABL1	P00519	human	ZNF746	Q6NUN9	Y137	ETLVSLDyAISKPEV
ABL1	P00519	human	DCBLD2	Q96PD2	T593	kAVDHEEtPVRysss
ABL1	P00519	human	TUBG1	P23258	Y443	HAATRPDyISWGTQE
ABL1	P00519	human	PLEKHG2	Q9H7P9	Y489	sEPVKDPyVMFPQNA
ABL1	P00519	human	DDB1	Q16531	Y182	APTICFVyQDPQGRH	MMS1_N
ABL1	P00519	human	SORBS2	O94875-2	Y50	AVSPMSYyQRPFSPS
ABL1	P00519	human	LGALS3	P17931	Y118	AGPLIVPyNLPLPGG	Gal-bind_lectin
ABL1	P00519	human	PRAG1	Q86YV5	Y413	ATQPEPIyAEsTKRK
ABL1	P00519	human	MYLK	Q15746	Y611	KSSRkSEyLLPVAPS
ABL1	P00519	human	CTNNB1	P35222	Y489	QNAVRLHyGLPVVVk
ABL1	P00519	human	CTNNB1	P35222	Y654	RNEGVAtyAAAVLFR
ABL1	P00519	human	SORBS2	O94875-2	Y164	PDDDTDMyNTPYTYN
ABL1	P00519	human	DNM1L	O00429	Y449	IIQHCSNySTQELLR	Dynamin_M
ABL1	P00519	human	PLSCR1	O15162	Y74	PVyNQPVyNQPVGAA
ABL1	P00519	human	ERCC6	Q03468	Y932	GANRVVIyDPDWNPS	Helicase_C
ABL1	P00519	human	DCBLD2	Q96PD2	T714	QPPPLVGtyNtLLsR
ABL1	P00519	human	PRKN	O60260	Y143	sPAGRSIyNSFYVYC
ABL1	P00519	human	MYLK	Q15746	Y556	LNGQPIQyARSTCEA	I-set
ABL1	P00519	human	SNW1	Q13573	Y430	AGGEDEIyNVyDQAW
ABL1	P00519	human	FHL2	Q14192	Y97	TDCySNEySSkCQEC	LIM
ABL1	P00519	human	RAD9A	Q99638	Y28	SRIGDELyLEPLEDG	Rad9
ABL1	P00519	human	SPTLC1	O15269	Y164	KTEEAIIySYGFATI	Aminotran_1_2
ABL1	P00519	human	MAVS	Q7Z434	Y71	RRPGWVEyFIAALRG	CARD_2
ABL1	P00519	human	CHCHD2	Q9Y6H1	Y99	PARPDITyQEPQGTQ
ABL1	P00519	human	STK4	Q13043	Y433	kIPQDGDyEFLksWt	Mst1_SARAH
ABL1	P00519	human	PDGFRB	P09619	Y934	AHAsDEIyEIMQKCW	PK_Tyr_Ser-Thr
ABL1	P00519	human	RBM39	Q14498	Y99	RGRyrsPysGPkFNs
ABL1	P00519	human	NFAT5	O94916	Y143	PkRHtVLyIsPPPED
ABL1	P00519	human	DCBLD2	Q96PD2	Y663	NsPGQEVyHAyAEPL
ABL1	P00519	human	ERRFI1	Q9UJM3	Y395	KVsstHyyLLPERPP
ABL1	P00519	human	TRIM33	Q9UPN9	Y610	PrHSGPQySMMQPHL
ABL1	P00519	human	WASF3	Q9UPY6	Y248	HASDVtDySYPATPN
ABL1	P00519	human	HDAC2	Q92769	Y222	IGAGkGkyYAVNFPM	Hist_deacetyl
ABL1	P00519	human	FHL2	Q14192	Y236	SGLGGTkyIsFEERQ	LIM
ABL1	P00519	human	ROBO1	Q9Y6N7	Y1073	PSGQPTPyAtTQLIQ
ABL1	P00519	human	MYLK	Q15746	Y1575	QISEGVEyIHKQGIV	Pkinase
ABL1	P00519	human	PDHA1	P08559	Y301	MsDPGVsyRtREEIQ	E1_dh
ABL1	P00519	human	MDM2	Q00987	Y276	sDEDDEVyQVtVyQA
ABL1	P00519	human	RTCB	Q9Y3I0	Y306	AsPEGQDyLkGMAAA	RtcB
ABL1	P00519	human	PDK1	Q15118	Y243	ARRLCDLyyINSPEL
ABL1	P00519	human	FUS	P35637	Y526	QDrrErPy_______
ABL1	P00519	human	FHL2	Q14192	Y217	LNCFCDLyAKkCAGC	LIM
ABL1	P00519	human	DCBLD2	Q96PD2	S599	EtPVRysssEVNHLs
ABL1	P00519	human	MDM2	Q00987	Y405	STSSSIIyssQEDVK
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y621	tFsAQsGyRVPGPQP
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y696	HPGTsDsysAPRDCL
ABL1	P00519	human	LASP1	Q14847	Y171	IPtsAPVyQQPQQQP
ABL1	P00519	human	PRKD1	Q15139	Y463	NDTGsRYyKEIPLSE	PH
ABL1	P00519	human	YY1	P25490	Y254	sPPDySEyMTGkKLP
ABL1	P00519	human	ARHGDIB	P52566	Y130	LkYVQHtyRTGVkVD	Rho_GDI
ABL1	P00519	human	DDB1	Q16531	Y718	HIRtVPLyEsPRkIC
ABL1	P00519	human	WAS	P42768	Y291	AEtsKLIyDFIEDQG	PBD
ABL1	P00519	human	CKMT1B	P12532	Y153	AsKIRsGyFDErYVL
ABL1	P00519	human	DCBLD1	Q8N8Z6	S535	QkLDLITsDMADyQQ
ABL1	P00519	human	KAT5	Q92993	Y44	ISGRKLFyVHYIDFN	Tudor-knot
ABL1	P00519	human	MAVS	Q7Z434	Y9	PFAEDkTykyICRNF	CARD_2
ABL1	P00519	human	RTCB	Q9Y3I0	Y475	MEEAPESykNVTDVV	RtcB
ABL1	P00519	human	DCBLD1	Q8N8Z6	Y652	VGAQDGDyQRPHsAQ
ABL1	P00519	human	TOP1	P11387	Y268	AkMLDHEyTTkEIFR	Topoisom_I_N
ABL1	P00519	human	SMAD4	Q13485	Y322	SNHPAPEyWCSIAYF
ABL1	P00519	human	VAV1	P15498	Y267	TPGAANLyQVFIKYK	RhoGEF
BCR	P11274	human	YWHAQ	P27348	S232	LTLWtsDsAGEECDA
BCR	P11274	human	YWHAZ	P63104	T232	LTLWtsDtQGDEAEA
BCR	P11274	human	AFDN	P55196	T909	VVTVAENtADELARS

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
ABL1	ID	Description	0.00e+00
ABL1	GO:0097193	intrinsic apoptotic signaling pathway	2.05e-15
ABL1	GO:0062197	cellular response to chemical stress	1.46e-14
ABL1	GO:0034599	cellular response to oxidative stress	9.05e-12
ABL1	GO:2001233	regulation of apoptotic signaling pathway	1.04e-10
ABL1	GO:0006979	response to oxidative stress	1.04e-10
ABL1	GO:0030522	intracellular receptor signaling pathway	1.04e-10
ABL1	GO:0050673	epithelial cell proliferation	2.35e-10
ABL1	GO:0000302	response to reactive oxygen species	4.09e-10
ABL1	GO:0072331	signal transduction by p53 class mediator	6.46e-10
ABL1	GO:0032355	response to estradiol	8.39e-10
ABL1	GO:0042770	signal transduction in response to DNA damage	1.51e-09
ABL1	GO:0032970	regulation of actin filament-based process	1.94e-09
ABL1	GO:1902903	regulation of supramolecular fiber organization	2.61e-09
ABL1	GO:0032956	regulation of actin cytoskeleton organization	2.61e-09
ABL1	GO:0050678	regulation of epithelial cell proliferation	5.06e-09
ABL1	GO:0002757	immune response-activating signaling pathway	6.54e-09
ABL1	GO:0051098	regulation of binding	6.54e-09
ABL1	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	1.06e-08
ABL1	GO:0002764	immune response-regulating signaling pathway	1.42e-08
ABL1	GO:0034614	cellular response to reactive oxygen species	1.67e-08
ABL1	GO:0031334	positive regulation of protein-containing complex assembly	2.17e-08
ABL1	GO:0061614	miRNA transcription	4.65e-08
ABL1	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	5.89e-08
ABL1	GO:1902905	positive regulation of supramolecular fiber organization	6.15e-08
ABL1	GO:0010212	response to ionizing radiation	6.56e-08
ABL1	GO:0010586	miRNA metabolic process	6.96e-08
ABL1	GO:0031400	negative regulation of protein modification process	7.69e-08
ABL1	GO:0048144	fibroblast proliferation	7.79e-08
ABL1	GO:2001242	regulation of intrinsic apoptotic signaling pathway	1.31e-07
ABL1	GO:0051090	regulation of DNA-binding transcription factor activity	1.86e-07
ABL1	GO:2000628	regulation of miRNA metabolic process	1.86e-07
ABL1	GO:0010517	regulation of phospholipase activity	1.86e-07
ABL1	GO:0048145	regulation of fibroblast proliferation	2.43e-07
ABL1	GO:0001933	negative regulation of protein phosphorylation	2.59e-07
ABL1	GO:0043254	regulation of protein-containing complex assembly	2.59e-07
ABL1	GO:0051099	positive regulation of binding	3.27e-07
ABL1	GO:0009314	response to radiation	3.32e-07
ABL1	GO:0045936	negative regulation of phosphate metabolic process	4.34e-07
ABL1	GO:0010563	negative regulation of phosphorus metabolic process	4.38e-07
ABL1	GO:0048732	gland development	5.01e-07
ABL1	GO:0042326	negative regulation of phosphorylation	5.46e-07
ABL1	GO:0098781	ncRNA transcription	5.46e-07
ABL1	GO:1902893	regulation of miRNA transcription	5.58e-07
ABL1	GO:0030330	DNA damage respons	1.01e-08
ABL1	GO:2001235	positive regulation of apoptotic signaling pathway	9.26e-07
ABL1	GO:0033673	negative regulation of kinase activity	1.19e-06
ABL1	GO:0060191	regulation of lipase activity	1.19e-06
ABL1	GO:0010332	response to gamma radiation	1.20e-06
ABL1	GO:0051091	positive regulation of DNA-binding transcription factor activity	1.28e-06

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Related Drugs to ABL1_BCR

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning ABL1-BCR and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to ABL1_BCR

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ABL1	C0023473	Myeloid Leukemia, Chronic	3	CGI;CTD_human;ORPHANET
Hgene	ABL1	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Hgene	ABL1	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Hgene	ABL1	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CGI;CTD_human
Tgene	BCR	C0005586	Bipolar Disorder	4	PSYGENET
Tgene	BCR	C0023473	Myeloid Leukemia, Chronic	3	CTD_human;ORPHANET

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date