| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:MRPS35_STK38L |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MRPS35_STK38L | KinaseFusionDB ID: KFG3956 | FusionGDB2.0 ID: KFG3956 | Hgene | Tgene | Gene symbol | MRPS35 | STK38L | Gene ID | 60488 | 23012 | |
| Gene name | mitochondrial ribosomal protein S35 | serine/threonine kinase 38 like | ||||||||||
| Synonyms | HDCMD11P|MDS023|MRP-S28|MRPS28|mS35 | NDR2 | ||||||||||
| Cytomap | 12p11.22 | 12p11.23 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | small ribosomal subunit protein mS3528S ribosomal protein S28, mitochondrial28S ribosomal protein S35, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35 | serine/threonine-protein kinase 38-likeNDR2 protein kinasenuclear Dbf2-related 2nuclear Dbf2-related kinase 2 | ||||||||||
| Modification date | 20240403 | 20240305 | ||||||||||
| UniProtAcc | Q9Y2Q9 | Q9Y2H1 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000081029, ENST00000538315, | ENST00000389032, ENST00000539577, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MRPS35 [Title/Abstract] AND STK38L [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK38L(27455121)-MRPS35(27908114), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | STK38L | GO:0006468 | protein phosphorylation | 15037617 |
| Tgene | STK38L | GO:0006468 | protein phosphorylation | 15067004 |
| Tgene | STK38L | GO:0010507 | negative regulation of autophagy | 35670107 |
| Tgene | STK38L | GO:0035556 | intracellular signal transduction | 15067004 |
| Kinase Fusion gene breakpoints across MRPS35 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across STK38L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | SK-MEL-28 | MRPS35 | chr12 | 27872801 | STK38L | chr12 | 27450643 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27455121/:27908114) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPS35 | STK38L |
| FUNCTION: Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of MRPS35_STK38L |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| STK38L | Q9Y2H1 | human | IRF3 | Q14653 | S396 | NtVDLHIsNsHPLsL | |
| STK38L | Q9Y2H1 | human | NUAK1 | O60285 | T211 | QKDKFLQtFCGSPLY | Pkinase |
| STK38L | Q9Y2H1 | human | RAB3IP | Q96QF0 | S288 | KGHTRNKstSSAMSG | |
| STK38L | Q9Y2H1 | human | YAP1 | P46937 | S127 | PQHVRAHssPAsLQL | |
| STK38L | Q9Y2H1 | human | ULK1 | O75385 | S495 | GVLARKMsLGGGRPY | |
| STK38L | Q9Y2H1 | human | STK38L | Q9Y2H1 | S282 | NRRQLAYstVGtPDy | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| STK38L | ID | Description | 0.00e+00 |
| STK38L | GO:0031345 | negative regulation of cell projection organization | 6.69e-03 |
| STK38L | GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 1.02e-02 |
| STK38L | GO:0001959 | regulation of cytokine-mediated signaling pathway | 4.20e-02 |
| STK38L | GO:0060759 | regulation of response to cytokine stimulus | 4.20e-02 |
| STK38L | GO:0031099 | regeneration | 4.20e-02 |
| STK38L | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 4.20e-02 |
| STK38L | GO:0060491 | regulation of cell projection assembly | 4.20e-02 |
| STK38L | GO:0042594 | response to starvation | 4.20e-02 |
| STK38L | GO:1902115 | regulation of organelle assembly | 4.20e-02 |
| STK38L | GO:0060560 | developmental growth involved in morphogenesis | 4.20e-02 |
| STK38L | GO:0031669 | cellular response to nutrient levels | 4.20e-02 |
| STK38L | GO:0034727 | piecemeal microautophagy of the nucleus | 4.20e-02 |
| STK38L | GO:0060245 | detection of cell density | 4.20e-02 |
| STK38L | GO:0031668 | cellular response to extracellular stimulus | 4.20e-02 |
| STK38L | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0039530 | MDA-5 signaling pathway | 4.20e-02 |
| STK38L | GO:0048671 | negative regulation of collateral sprouting | 4.20e-02 |
| STK38L | GO:0050847 | progesterone receptor signaling pathway | 4.20e-02 |
| STK38L | GO:1903059 | regulation of protein lipidation | 4.20e-02 |
| STK38L | GO:0018105 | peptidyl-serine phosphorylation | 4.20e-02 |
| STK38L | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0072182 | regulation of nephron tubule epithelial cell differentiation | 4.20e-02 |
| STK38L | GO:0018209 | peptidyl-serine modification | 4.20e-02 |
| STK38L | GO:0016237 | lysosomal microautophagy | 4.20e-02 |
| STK38L | GO:0048638 | regulation of developmental growth | 4.20e-02 |
| STK38L | GO:0071888 | macrophage apoptotic process | 4.20e-02 |
| STK38L | GO:0072160 | nephron tubule epithelial cell differentiation | 4.20e-02 |
| STK38L | GO:0048368 | lateral mesoderm development | 4.20e-02 |
| STK38L | GO:0071496 | cellular response to external stimulus | 4.20e-02 |
| STK38L | GO:0030522 | intracellular receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0010506 | regulation of autophagy | 4.20e-02 |
| STK38L | GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 4.20e-02 |
| STK38L | GO:2000696 | regulation of epithelial cell differentiation involved in kidney development | 4.20e-02 |
| STK38L | GO:0050746 | regulation of lipoprotein metabolic process | 4.20e-02 |
| STK38L | GO:0071360 | cellular response to exogenous dsRNA | 4.20e-02 |
| STK38L | GO:0060271 | cilium assembly | 4.20e-02 |
| STK38L | GO:0048339 | paraxial mesoderm development | 4.20e-02 |
| STK38L | GO:0060576 | intestinal epithelial cell development | 4.20e-02 |
| STK38L | GO:0061709 | reticulophagy | 4.20e-02 |
| STK38L | GO:0001829 | trophectodermal cell differentiation | 4.20e-02 |
| STK38L | GO:0030903 | notochord development | 4.20e-02 |
| STK38L | GO:0044804 | nucleophagy | 4.20e-02 |
| STK38L | GO:0060602 | branch elongation of an epithelium | 4.20e-02 |
| STK38L | GO:2000786 | positive regulation of autophagosome assembly | 4.20e-02 |
| STK38L | GO:0050767 | regulation of neurogenesis | 4.20e-02 |
| STK38L | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway | 4.20e-02 |
| STK38L | GO:1902018 | negative regulation of cilium assembly | 4.20e-02 |
| STK38L | GO:0044782 | cilium organization | 4.20e-02 |
Top |
Related Drugs to MRPS35_STK38L |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MRPS35-STK38L and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to MRPS35_STK38L |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |