Ensembl transtripts involved in fusion gene | ENST ids | ENST00000346798, ENST00000348990, ENST00000354192, ENST00000357903, ENST00000358918, ENST00000359726, ENST00000439274, ENST00000440126, ENST00000448388, ENST00000474136,
| ENST00000508708, ENST00000345990, ENST00000395411, ENST00000395412, ENST00000360683, ENST00000361991, ENST00000510842, ENST00000511130, ENST00000512718, ENST00000521364,
|
Hgene | Tgene |
APP
Q8NEU8 | CSNK1G3
Q9Y6M4 |
FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}. | FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}. |
Kinase | GOID | GO term | P.adjust |
CSNK1G3 | ID | Description | 0.00e+00 |
CSNK1G3 | GO:0006469 | negative regulation of protein kinase activity | 3.26e-04 |
CSNK1G3 | GO:0033673 | negative regulation of kinase activity | 3.26e-04 |
CSNK1G3 | GO:0051348 | negative regulation of transferase activity | 3.45e-04 |
CSNK1G3 | GO:0071900 | regulation of protein serine/threonine kinase activity | 5.13e-04 |
CSNK1G3 | GO:0001933 | negative regulation of protein phosphorylation | 5.13e-04 |
CSNK1G3 | GO:0042326 | negative regulation of phosphorylation | 5.32e-04 |
CSNK1G3 | GO:0045936 | negative regulation of phosphate metabolic process | 6.12e-04 |
CSNK1G3 | GO:0010563 | negative regulation of phosphorus metabolic process | 6.12e-04 |
CSNK1G3 | GO:0031400 | negative regulation of protein modification process | 8.49e-04 |
CSNK1G3 | GO:0043086 | negative regulation of catalytic activity | 1.01e-03 |
CSNK1G3 | GO:0140029 | exocytic process | 2.95e-03 |
CSNK1G3 | GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 2.95e-03 |
CSNK1G3 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 3.96e-03 |
CSNK1G3 | GO:0051209 | release of sequestered calcium ion into cytosol | 6.20e-03 |
CSNK1G3 | GO:0051283 | negative regulation of sequestering of calcium ion | 6.20e-03 |
CSNK1G3 | GO:0051282 | regulation of sequestering of calcium ion | 6.20e-03 |
CSNK1G3 | GO:0051208 | sequestering of calcium ion | 6.20e-03 |
CSNK1G3 | GO:0010950 | positive regulation of endopeptidase activity | 6.97e-03 |
CSNK1G3 | GO:0010952 | positive regulation of peptidase activity | 7.80e-03 |
CSNK1G3 | GO:1903169 | regulation of calcium ion transmembrane transport | 7.80e-03 |
CSNK1G3 | GO:0017157 | regulation of exocytosis | 8.86e-03 |
CSNK1G3 | GO:0097553 | calcium ion transmembrane import into cytosol | 9.84e-03 |
CSNK1G3 | GO:0045055 | regulated exocytosis | 1.15e-02 |
CSNK1G3 | GO:0051651 | maintenance of location in cell | 1.20e-02 |
CSNK1G3 | GO:0002274 | myeloid leukocyte activation | 1.20e-02 |
CSNK1G3 | GO:0051924 | regulation of calcium ion transport | 1.25e-02 |
CSNK1G3 | GO:0006898 | receptor-mediated endocytosis | 1.27e-02 |
CSNK1G3 | GO:0052548 | regulation of endopeptidase activity | 1.52e-02 |
CSNK1G3 | GO:0006874 | intracellular calcium ion homeostasis | 1.59e-02 |
CSNK1G3 | GO:0015850 | organic hydroxy compound transport | 1.59e-02 |
CSNK1G3 | GO:0052547 | regulation of peptidase activity | 1.59e-02 |
CSNK1G3 | GO:1904062 | regulation of monoatomic cation transmembrane transport | 1.59e-02 |
CSNK1G3 | GO:0055074 | calcium ion homeostasis | 1.64e-02 |
CSNK1G3 | GO:0032496 | response to lipopolysaccharide | 1.64e-02 |
CSNK1G3 | GO:0006887 | exocytosis | 1.64e-02 |
CSNK1G3 | GO:0045862 | positive regulation of proteolysis | 1.64e-02 |
CSNK1G3 | GO:0051235 | maintenance of location | 1.64e-02 |
CSNK1G3 | GO:0070588 | calcium ion transmembrane transport | 1.64e-02 |
CSNK1G3 | GO:1990778 | protein localization to cell periphery | 1.64e-02 |
CSNK1G3 | GO:0002237 | response to molecule of bacterial origin | 1.75e-02 |
CSNK1G3 | GO:0010959 | regulation of metal ion transport | 1.81e-02 |
CSNK1G3 | GO:0050727 | regulation of inflammatory response | 1.81e-02 |
CSNK1G3 | GO:0043434 | response to peptide hormone | 1.81e-02 |
CSNK1G3 | GO:0009410 | response to xenobiotic stimulus | 1.81e-02 |
CSNK1G3 | GO:0060368 | regulation of Fc receptor mediated stimulatory signaling pathway | 1.81e-02 |
CSNK1G3 | GO:0060397 | growth hormone receptor signaling pathway via JAK-STAT | 1.81e-02 |
CSNK1G3 | GO:1901856 | negative regulation of cellular respiration | 1.81e-02 |
CSNK1G3 | GO:1905245 | regulation of aspartic-type peptidase activity | 1.81e-02 |
CSNK1G3 | GO:0006816 | calcium ion transport | 1.81e-02 |