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Kinase Fusion Gene:MSL2_GSK3B |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: MSL2_GSK3B | KinaseFusionDB ID: KFG3960 | FusionGDB2.0 ID: KFG3960 | Hgene | Tgene | Gene symbol | MSL2 | GSK3B | Gene ID | 55167 | 2932 | |
Gene name | MSL complex subunit 2 | glycogen synthase kinase 3 beta | ||||||||||
Synonyms | MSL-2|MSL2L1|RNF184 | - | ||||||||||
Cytomap | 3q22.3 | 3q13.33 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | E3 ubiquitin-protein ligase MSL2E3 ubiquitin-protein transferase MSL2MSL2-like 1male-specific lethal 2 homologmale-specific lethal 2-like 1male-specific lethal-2 homolog 1ring finger protein 184 | glycogen synthase kinase-3 betaGSK-3 betaserine/threonine-protein kinase GSK3B | ||||||||||
Modification date | 20240413 | 20240411 | ||||||||||
UniProtAcc | Q9HCI7 | P49841 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000309993, ENST00000434835, | ENST00000264235, ENST00000316626, ENST00000473886, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MSL2 [Title/Abstract] AND GSK3B [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MSL2 | GO:0006513 | protein monoubiquitination | 21726816|23874665|30930284 |
Hgene | MSL2 | GO:0006974 | DNA damage response | 19033443|23874665 |
Tgene | GSK3B | GO:0005977 | glycogen metabolic process | 8638126 |
Tgene | GSK3B | GO:0006468 | protein phosphorylation | 11035810|16315267|20937854 |
Tgene | GSK3B | GO:0006983 | ER overload response | 14744935 |
Tgene | GSK3B | GO:0018105 | peptidyl-serine phosphorylation | 11104755|14744935 |
Tgene | GSK3B | GO:0018105 | peptidyl-serine phosphorylation | 8638126|11955436|17139249 |
Tgene | GSK3B | GO:0018107 | peptidyl-threonine phosphorylation | 11955436|17139249|25897075 |
Tgene | GSK3B | GO:0031175 | neuron projection development | 19830702 |
Tgene | GSK3B | GO:0031334 | positive regulation of protein-containing complex assembly | 8638126 |
Tgene | GSK3B | GO:0031398 | positive regulation of protein ubiquitination | 29142209 |
Tgene | GSK3B | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 19364825|22660580 |
Tgene | GSK3B | GO:0035556 | intracellular signal transduction | 14749367 |
Tgene | GSK3B | GO:0043066 | negative regulation of apoptotic process | 14744935 |
Tgene | GSK3B | GO:0046777 | protein autophosphorylation | 23184662 |
Tgene | GSK3B | GO:0046825 | regulation of protein export from nucleus | 12223487 |
Tgene | GSK3B | GO:0046827 | positive regulation of protein export from nucleus | 14744935 |
Tgene | GSK3B | GO:0060070 | canonical Wnt signaling pathway | 16890161 |
Tgene | GSK3B | GO:0099171 | presynaptic modulation of chemical synaptic transmission | 17989287 |
Tgene | GSK3B | GO:1904886 | beta-catenin destruction complex disassembly | 10428961 |
Kinase Fusion gene breakpoints across MSL2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across GSK3B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
CCLE | TGBC1TKB | MSL2 | chr3 | 135870447 | GSK3B | chr3 | 119666198 |
CCLE | TGBC1TKB | MSL2 | chr3 | 135913814 | GSK3B | chr3 | 119666198 |
CCLE | TGBC1TKB | MSL2 | chr3 | 135914992 | GSK3B | chr3 | 119666198 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:/chr3:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MSL2 | GSK3B |
FUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. {ECO:0000269|PubMed:21726816}. | FUNCTION: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1 (PubMed:1846781, PubMed:9072970, PubMed:14690523, PubMed:20937854, PubMed:12554650, PubMed:11430833, PubMed:16484495). Requires primed phosphorylation of the majority of its substrates (PubMed:11430833, PubMed:16484495). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507). May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (PubMed:8397507). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:12554650). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA (PubMed:1846781). Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin (PubMed:9072970). Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules (PubMed:14690523). MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease (PubMed:14690523). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair (By similarity). Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (By similarity). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin (PubMed:9819408). Is necessary for the establishment of neuronal polarity and axon outgrowth (PubMed:20067585). Phosphorylates MARK2, leading to inhibition of its activity (By similarity). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity (PubMed:18348280). Phosphorylates ZC3HAV1 which enhances its antiviral activity (PubMed:22514281). Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation (PubMed:15448698, PubMed:15647282). Phosphorylates SFPQ at 'Thr-687' upon T-cell activation (PubMed:20932480). Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2 (PubMed:19946213, PubMed:28903391). Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation (By similarity). Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation (PubMed:19946213). Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation (PubMed:28903391). Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899). Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (PubMed:18846110). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (PubMed:17050006, PubMed:28992046). Phosphorylates mTORC2 complex component RICTOR at 'Thr-1695' which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P18266, ECO:0000250|UniProtKB:Q9WV60, ECO:0000269|PubMed:11430833, ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:14690523, ECO:0000269|PubMed:15448698, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:17050006, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19946213, ECO:0000269|PubMed:20067585, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:22514281, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25897075, ECO:0000269|PubMed:28903391, ECO:0000269|PubMed:28992046, ECO:0000269|PubMed:30704899, ECO:0000269|PubMed:8397507, ECO:0000269|PubMed:9072970, ECO:0000269|PubMed:9819408}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MSL2_GSK3B |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
GSK3B | P49841 | human | SRC | P12931 | S51 | AdGHRGPsAAFAPAA | |
GSK3B | P49841 | human | SREBF1 | P36956 | S434 | PPPsDAGsPFQSsPL | |
GSK3B | P49841 | human | MAPT | P10636-8 | T231 | KKVAVVRtPPKsPss | |
GSK3B | P49841 | human | OGT | O15294 | S3 | _____MAssVGNVAD | |
GSK3B | P49841 | human | GRB14 | Q14449 | S362 | QGRsGCSsQSIsPMR | |
GSK3B | P49841 | human | PSEN1 | P49768 | S353 | sHLGPHRstPEsRAA | Presenilin |
GSK3B | P49841 | human | AHR | P35869 | S723 | ELDYPMGsFEPsPYP | |
GSK3B | P49841 | human | CLASP2 | O75122 | S507 | QGCsREAsPsRLsVA | |
GSK3B | P49841 | human | BORA | Q6PGQ7 | S278 | PISsPTFsPIEFQIG | |
GSK3B | P49841 | human | RXRA | P19793 | S49 | GSPGQLHsPISTLSS | Nuc_recep-AF1 |
GSK3B | P49841 | human | MAPT | P10636-8 | S199 | GDRsGyssPGsPGtP | |
GSK3B | P49841 | human | AHR | P35869 | S440 | NGTsGkDsATTsTLS | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7314 | KSAsRPGsRAGsRAG | |
GSK3B | P49841 | human | JUN | P05412 | S243 | PGEtPPLsPIDMEsQ | |
GSK3B | P49841 | human | SUFU | Q9UMX1 | S342 | LAHDRAPsRkDsLEs | SUFU_C |
GSK3B | P49841 | human | APBB1 | O00213 | T579 | SSSREQWtPSHVSVA | PID |
GSK3B | P49841 | human | IRF3 | Q14653 | T180 | sPsLDNPtPFPNLGP | |
GSK3B | P49841 | human | AHR | P35869 | T697 | EMDsMPYtQNFISCN | |
GSK3B | P49841 | human | TNKS | O95271 | T982 | SLIsPAStPSCLsAA | |
GSK3B | P49841 | human | ERG | P11308 | T180 | KDDFQRLtPSyNADI | SAM_PNT |
GSK3B | P49841 | human | PIAS1 | O75925 | S17 | MVMsLRVsELQVLLG | |
GSK3B | P49841 | human | MUC1 | P15941 | S1227 | PPsstDRsPyEKVsA | |
GSK3B | P49841 | human | CD274 | Q9NZQ7 | S184 | GkTtTTNsKREEKLF | C2-set_2 |
GSK3B | P49841 | human | MAFA | Q8NHW3 | S61 | PLStPCSsVPSsPSF | |
GSK3B | P49841 | human | GFI1 | Q99684 | S94 | EDFWRPPsPSAsPAS | |
GSK3B | P49841 | human | HSPA1B | P0DMV8 | T636 | GGsGsGPtIEEVD__ | |
GSK3B | P49841 | human | NBR1 | Q14596 | T586 | HNtPVDVtPCMsPLP | |
GSK3B | P49841 | human | NEFH | P12036 | S503 | GGEEEtKsPPAEEAA | |
GSK3B | P49841 | human | DNM1L | O00429 | S40 | TQSSGKSsVLEsLVG | Dynamin_N |
GSK3B | P49841 | human | STK38 | Q15208 | T7 | _MAMtGstPCssMsN | |
GSK3B | P49841 | human | GATA6 | Q92908 | S37 | REPStPPsPIsSSSS | |
GSK3B | P49841 | human | CDC25A | P30304 | S76 | SNLQRMGssEstDsG | |
GSK3B | P49841 | human | DROSHA | Q9NRR4 | S302 | RDNRRsPsLERSYKK | |
GSK3B | P49841 | human | PIAS1 | O75925 | S13 | ELkQMVMsLRVsELQ | |
GSK3B | P49841 | human | BAX | Q07812 | S163 | GGWDGLLsYFGtPTW | |
GSK3B | P49841 | human | FBXL20 | Q96IG2 | T417 | HAYFAPVtPPPsVGG | |
GSK3B | P49841 | human | SFPQ | P23246 | T687 | PrGMGPGtPAGyGrG | |
GSK3B | P49841 | human | EIF6 | P56537 | S235 | QPstIAtsMRDsLID | |
GSK3B | P49841 | human | ESR1 | P03372 | S104 | FPPLNsVsPsPLMLL | Oest_recep |
GSK3B | P49841 | human | AKAP11 | Q9UKA4 | T1136 | AKEFAPAtPPStPHN | |
GSK3B | P49841 | human | HDAC4 | P56524 | S302 | APGsGPSsPNNSSGS | |
GSK3B | P49841 | human | KAT5 | Q92993 | S86 | TKNGLPGsRPGsPER | |
GSK3B | P49841 | human | USF1 | P22415 | S186 | APRTHPYsPKsEAPR | |
GSK3B | P49841 | human | PTTG1 | O95997 | S184 | NLLQSPssILSTLDV | Securin |
GSK3B | P49841 | human | PTEN | P60484 | S362 | SNPEASSsTSVtPDV | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7222 | FRsRGRRsKPSsRAA | |
GSK3B | P49841 | human | STAT2 | P52630 | S393 | LtPEKGQsQGLIWDF | STAT_bind |
GSK3B | P49841 | human | SQLE | Q14534 | S87 | WAKsPPEsENkEQLE | |
GSK3B | P49841 | human | SPAG5 | Q96R06 | T978 | AEMsIMTtELQSLCS | |
GSK3B | P49841 | human | ZNF281 | Q9Y2X9 | S638 | PRVDLHtsGEHsELV | |
GSK3B | P49841 | human | CDKN1A | P38936 | S114 | EEDHVDLsLSCTLVP | |
GSK3B | P49841 | human | FOXP3 | Q9BZS1 | S270 | kMALTkAsSVAssDK | |
GSK3B | P49841 | human | RFX1 | P22670 | T124 | sEAsPGStAsQTGVP | |
GSK3B | P49841 | human | HSP90AB1 | P08238 | S718 | LEGDEDAsRMEEVD_ | |
GSK3B | P49841 | human | MCL1 | Q07820 | S159 | NNtStDGsLPstPPP | |
GSK3B | P49841 | human | CCNE1 | P24864 | S73 | AVCADPCsLIPtPDK | |
GSK3B | P49841 | human | GYS1 | P13807 | S641 | yRyPRPAsVPPsPsL | Glycogen_syn |
GSK3B | P49841 | human | CLASP2 | O75122 | S499 | KRsKIPRsQGCsREA | |
GSK3B | P49841 | human | RASSF1 | Q9NS23-2 | S178 | VRPVsVPssKKPPsL | |
GSK3B | P49841 | human | DES | P17661 | S32 | PLGsPLssPVFPrAG | Filament_head |
GSK3B | P49841 | human | CTNNB1 | P35222 | S37 | yLDsGIHsGATtTAP | |
GSK3B | P49841 | human | RASSF1 | Q9NS23-2 | S175 | LKLVRPVsVPssKKP | |
GSK3B | P49841 | human | VDAC1 | P21796 | T107 | DssFsPNtGkkNAKI | Porin_3 |
GSK3B | P49841 | human | PRKAA1 | Q13131 | T482 | RSIDDEItEAksGtA | AdenylateSensor |
GSK3B | P49841 | human | PHLPP1 | O60346 | S1379 | GSKGLWDsLsVEEAV | PP2C |
GSK3B | P49841 | human | GLE1 | Q53GS7 | S99 | ssAFsPAsPAtPNGT | |
GSK3B | P49841 | human | FBXL20 | Q96IG2 | S251 | RGCHKLQsLCAsGCS | |
GSK3B | P49841 | human | TNKS | O95271 | S991 | SCLsAASsIDNLTGP | |
GSK3B | P49841 | human | SNAI2 | O43623 | S96 | PPPsDTSsKDHsGSE | |
GSK3B | P49841 | human | SPAG5 | Q96R06 | S974 | EESLAEMsIMTtELQ | |
GSK3B | P49841 | human | PRKAA1 | Q13131 | S486 | DEItEAksGtAtPQR | AdenylateSensor |
GSK3B | P49841 | human | SOX2 | P48431 | S251 | VksEAsssPPVVtSS | |
GSK3B | P49841 | human | MAPT | P10636-8 | S396 | GAEIVyKsPVVsGDt | |
GSK3B | P49841 | human | TP53 | P04637 | S376 | LkskkGQstsRHkkL | |
GSK3B | P49841 | human | FBXL20 | Q96IG2 | S255 | KLQsLCAsGCSNITD | |
GSK3B | P49841 | human | MYBPC3 | Q14896 | S304 | SLLKKRDsFRtPRDs | |
GSK3B | P49841 | human | E2F1 | Q01094 | T433 | DCDFGDLtPLDF___ | |
GSK3B | P49841 | human | MAPT | P10636-8 | S404 | PVVsGDtsPRHLsNV | |
GSK3B | P49841 | human | DNM1L | O00429 | S44 | GKSsVLEsLVGRDLL | Dynamin_N |
GSK3B | P49841 | human | BCLAF1 | Q9NYF8 | S531 | KstFREEsPLRIkMI | THRAP3_BCLAF1 |
GSK3B | P49841 | human | MITF | O75030-9 | S298 | QARAHGLsLIPSTGL | DUF3371 |
GSK3B | P49841 | human | MAFA | Q8NHW3 | T57 | LSStPLStPCSsVPS | |
GSK3B | P49841 | human | RPTOR | Q8N122 | S792 | DKMRRAssYSsLNSL | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7318 | RPGsRAGsRAGsRAs | |
GSK3B | P49841 | human | SOX9 | P48436 | T236 | GQSQGPPtPPtTPKT | |
GSK3B | P49841 | human | PGR | P06401-2 | S390 | PDSEASQsPQYsFES | Prog_receptor |
GSK3B | P49841 | human | CTNNB1 | P35222 | S45 | GATtTAPsLsGkGNP | |
GSK3B | P49841 | human | MAPT | P10636-8 | S262 | NVKskIGstENLkHQ | Tubulin-binding |
GSK3B | P49841 | human | CABYR | O75952 | T151 | PATPKTTtPPSsPPP | |
GSK3B | P49841 | human | ENDOG | Q14249 | S288 | NILARAGsLkAITAG | |
GSK3B | P49841 | human | CAP1 | Q01518 | S310 | PKPQtsPsPkRAtKk | |
GSK3B | P49841 | human | CLASP2 | O75122 | S537 | REAsREssRDTsPVR | |
GSK3B | P49841 | human | RPTOR | Q8N122 | S877 | HIHQAGGsPPAssts | |
GSK3B | P49841 | human | GSK3B | P49841 | Y216 | RGEPNVsyICsRyyR | Pkinase |
GSK3B | P49841 | human | GCM1 | Q9NP62 | S322 | NYPFPLTsWPCsFSP | |
GSK3B | P49841 | human | DNMT1 | P26358 | S714 | DNIPEMPsPkKMHQG | |
GSK3B | P49841 | human | CEBPD | P49716 | T171 | PRSsPRQtPAPGPAR | |
GSK3B | P49841 | human | LRP6 | O75581 | S1490 | AILNPPPsPAtERsH | |
GSK3B | P49841 | human | KLC2 | Q9H0B6 | S608 | LsDSRtLssssMDLs | |
GSK3B | P49841 | human | MAFA | Q8NHW3 | S49 | CHRLPPGsLSStPLS | |
GSK3B | P49841 | human | RICTOR | Q6R327 | T1695 | EAEAVLAtPPKQPIV | |
GSK3B | P49841 | human | FBXL20 | Q96IG2 | S139 | DATCTSLskFCsKLR | |
GSK3B | P49841 | human | MAPRE1 | Q15691 | S156 | PkkPLtssSAAPQRP | |
GSK3B | P49841 | human | SNAI1 | O95863 | S119 | sFSsTSVsSLEAEAY | |
GSK3B | P49841 | human | IKBKG | Q9Y6K9 | S43 | PAMLHLPsEQGAPEt | |
GSK3B | P49841 | human | MYC | P01106 | T73 | kkFELLPtPPLsPsR | Myc_N |
GSK3B | P49841 | human | CDX2 | Q99626 | S283 | RsVPEPLsPVSSLQA | |
GSK3B | P49841 | human | CTPS1 | P17812 | S571 | RDtysDrsGsssPDs | |
GSK3B | P49841 | human | DPYSL3 | Q14195 | T514 | tttPkGGtPAGsArG | |
GSK3B | P49841 | human | ATP2A2 | P16615 | S663 | EFDELNPsAQRDACL | |
GSK3B | P49841 | human | PHLPP1 | O60346 | T1363 | HVQsVLLtPQDEFFI | PP2C |
GSK3B | P49841 | human | USF1 | P22415 | T153 | EALLGQAtPPGTGQF | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7322 | RAGsRAGsRAssRRG | |
GSK3B | P49841 | human | MAPT | P10636-8 | T153 | DGKtKIAtPRGAAPP | |
GSK3B | P49841 | human | MAPT | P10636-3 | S199 | KVTSKCGsLGNIHHK | Tubulin-binding |
GSK3B | P49841 | human | SRC | P12931 | S43 | QtPsKPAsAdGHRGP | |
GSK3B | P49841 | human | PRKCE | Q02156 | S346 | sEEDRsKsAPtsPCD | |
GSK3B | P49841 | human | PGR | P06401-2 | S164 | RQLLEDEsYDGGAGA | Prog_receptor |
GSK3B | P49841 | human | HRAS | P01112 | T144 | yGIPYIEtsAktRQG | Ras |
GSK3B | P49841 | human | FCAR | P24071 | S284 | LTFARTPsVCK____ | |
GSK3B | P49841 | human | NIFK | Q9BYG3 | S230 | tPEKtVDsQGPtPVC | hNIFK_binding |
GSK3B | P49841 | human | CREB1 | P16220 | S115 | QKRREILsRRPsyRk | pKID |
GSK3B | P49841 | human | MITF | O75030-9 | S405 | PGAsKTSsRRSsMSM | DUF3371 |
GSK3B | P49841 | human | STAT3 | P40763 | S727 | NtIDLPMsPrTLDSL | |
GSK3B | P49841 | human | RBM38 | Q9H0Z9 | S195 | DQYPYAAsPATAASF | |
GSK3B | P49841 | human | RELB | Q01201 | S573 | AFGGGLLsPGPEAt_ | RelB_transactiv |
GSK3B | P49841 | human | MCL1 | Q07820 | S121 | PAADAIMsPEEELDG | |
GSK3B | P49841 | human | RELA | Q04206 | S468 | AVFTDLAsVDNsEFQ | |
GSK3B | P49841 | human | FOXP3 | Q9BZS1 | S274 | TkAsSVAssDKGSCC | |
GSK3B | P49841 | human | DPYSL2 | Q16555 | T509 | PVCEVsVtPktVtPA | |
GSK3B | P49841 | human | DPYSL2 | Q16555 | T514 | sVtPktVtPAssAkt | |
GSK3B | P49841 | human | CEBPB | P17676 | S223 | VPsGSSGsLsTSSss | |
GSK3B | P49841 | human | SRF | P11831 | S224 | TCLNsPDsPPRsDPT | |
GSK3B | P49841 | human | DES | P17661 | S28 | APGFPLGsPLssPVF | Filament_head |
GSK3B | P49841 | human | CCND1 | P24385 | T286 | EEVDLACtPtDVRDV | |
GSK3B | P49841 | human | FBXL20 | Q96IG2 | S425 | PPPsVGGsRQRFCRC | |
GSK3B | P49841 | human | BCL2L1 | Q07817 | S62 | PSWHLADsPAVNGAT | |
GSK3B | P49841 | human | NFE2L2 | Q16236 | S347 | NDSDsGIsLNTsPSV | |
GSK3B | P49841 | human | MYCL | P12524 | S38 | KKFELVPsPPtsPPW | Myc_N |
GSK3B | P49841 | human | SNAI1 | O95863 | S100 | DEDsGkGsQPPsPPs | |
GSK3B | P49841 | human | OSBP2 | Q969R2 | S762 | ECSKVMHssPssPsS | Oxysterol_BP |
GSK3B | P49841 | human | H1-5 | P16401 | T11 | tAPAEtAtPAPVEks | |
GSK3B | P49841 | human | AKAP11 | Q9UKA4 | T1140 | APAtPPStPHNSSVG | |
GSK3B | P49841 | human | GYS1 | P13807 | S653 | PsLsRHssPHQsEDE | Glycogen_syn |
GSK3B | P49841 | human | MITF | O75030-9 | S401 | SSVsPGAsKTSsRRS | DUF3371 |
GSK3B | P49841 | human | UNG | P13051 | S64 | EPGtPPssPLsAEQL | |
GSK3B | P49841 | human | OGT | O15294 | S4 | ____MAssVGNVADS | |
GSK3B | P49841 | human | PICK1 | Q9NRD5 | S342 | QRLVsTMsKYYNDCy | Arfaptin |
GSK3B | P49841 | human | APC | P25054 | S1501 | ESTPDGFsCsssLsA | APC_r |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7226 | GRRsKPSsRAAsPTR | |
GSK3B | P49841 | human | BMAL1 | O00327 | T21 | DFMsPGPtDLLSSSL | |
GSK3B | P49841 | human | STMN3 | Q9NZ72 | S60 | sFEVILksPSDLsPE | Stathmin |
GSK3B | P49841 | human | E2F1 | Q01094 | S403 | PEEFISLsPPHEALD | |
GSK3B | P49841 | human | RFX1 | P22670 | S120 | SETVsEAsPGStAsQ | |
GSK3B | P49841 | human | SREBF1 | P36956 | T426 | TEVEDTLtPPPsDAG | |
GSK3B | P49841 | human | CLOCK | O15516 | S427 | ALERFDHsPtPsASs | |
GSK3B | P49841 | human | CCND3 | P30281 | T283 | QGPsQtstPtDVtAI | |
GSK3B | P49841 | human | RCAN1 | P53805 | S163 | PDKQFLIsPPAsPPV | Calcipressin |
GSK3B | P49841 | human | OSBP2 | Q969R2 | S766 | VMHssPssPsSDGKQ | Oxysterol_BP |
GSK3B | P49841 | human | UNG | P13051 | T60 | AGQEEPGtPPssPLs | |
GSK3B | P49841 | human | ADD2 | P35612 | S693 | SVTSGPMsPEGsPsK | |
GSK3B | P49841 | human | FBXL20 | Q96IG2 | S143 | TSLskFCsKLRHLDL | LRR_6 |
GSK3B | P49841 | human | MAPT | P10636-8 | S409 | DtsPRHLsNVsstGs | |
GSK3B | P49841 | human | SNAI1 | O95863 | S107 | sQPPsPPsPAPssFS | |
GSK3B | P49841 | human | IKBKG | Q9Y6K9 | S8 | MNRHLWKsQLCEMVQ | |
GSK3B | P49841 | human | WT1 | P19544-7 | S69 | RsRGAsGsEPQQMGs | |
GSK3B | P49841 | human | GLE1 | Q53GS7 | T102 | FsPAsPAtPNGTKGk | |
GSK3B | P49841 | human | PSEN1 | P49768 | S357 | PHRstPEsRAAVQEL | Presenilin |
GSK3B | P49841 | human | DROSHA | Q9NRR4 | S300 | RHRDNRRsPsLERSY | |
GSK3B | P49841 | human | BMAL1 | O00327 | S17 | STISDFMsPGPtDLL | |
GSK3B | P49841 | human | NR1D1 | P20393 | S59 | FPPsPTGsLTQDPAR | |
GSK3B | P49841 | human | STAT3 | P40763 | T714 | ktKFICVtPTtCsNt | |
GSK3B | P49841 | human | STAT2 | P52630 | T385 | ILTsNQktLtPEKGQ | STAT_bind |
GSK3B | P49841 | human | MYCL | P12524 | S42 | LVPsPPtsPPWGLGP | Myc_N |
GSK3B | P49841 | human | DPYSL2 | Q16555 | S518 | ktVtPAssAktsPAk | |
GSK3B | P49841 | human | SMAD4 | Q13485 | T265 | ATYHHNStTTWtGSR | |
GSK3B | P49841 | human | SPAG5 | Q96R06 | T111 | PIPQIsStPkTsEEA | |
GSK3B | P49841 | human | SNCA | P37840 | S129 | NEAyEMPsEEGyQDy | Synuclein |
GSK3B | P49841 | human | MYCN | P04198 | T58 | KkFELLPtPPLsPsr | Myc_N |
GSK3B | P49841 | human | IRF3 | Q14653 | S123 | DFSQPDTsPDTNGGG | |
GSK3B | P49841 | human | XIAP | P98170 | T180 | WPDYAHLtPRELASA | BIR |
GSK3B | P49841 | human | SP1 | P08047 | S728 | VGtLPLDsGAGsEGS | |
GSK3B | P49841 | human | BLM | P54132 | T171 | ETSksFVtPPQsHFV | BLM_N |
GSK3B | P49841 | human | MAPT | P10636-8 | S46 | tDAGLkEsPLQtPtE | |
GSK3B | P49841 | human | FRAT1 | Q92837 | S188 | RLQQRRGsQPETRTG | GSK-3_bind |
GSK3B | P49841 | human | MAFA | Q8NHW3 | T53 | PPGsLSStPLStPCS | |
GSK3B | P49841 | human | PRKAA1 | Q13131 | T490 | EAksGtAtPQRsGsV | AdenylateSensor |
GSK3B | P49841 | human | TOP2A | P11388 | S1361 | sPPKTKtsPKLsNkE | |
GSK3B | P49841 | human | RPTOR | Q8N122 | S859 | DtssLtQsAPAsPtN | |
GSK3B | P49841 | human | EIF4EBP1 | Q13541 | S65 | FLMECrNsPVtktPP | eIF_4EBP |
GSK3B | P49841 | human | FBXL21P | Q9UKT6 | T33 | FYSSLNQtHTHTVLL | |
GSK3B | P49841 | human | STK38 | Q15208 | S6 | __MAMtGstPCssMs | |
GSK3B | P49841 | human | AHR | P35869 | S727 | PMGsFEPsPYPtTSS | |
GSK3B | P49841 | human | BCAM | P50895 | S596 | PPGEPGLsHsGsEQP | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7330 | RAssRRGsDAsDFDL | |
GSK3B | P49841 | human | NFKB2 | Q00653 | S711 | PLPsPPTsDsDsDsE | |
GSK3B | P49841 | human | FOXL2 | P58012 | S33 | EPEGPPPsPGKGGGG | |
GSK3B | P49841 | human | MAPT | P10636-8 | S202 | sGyssPGsPGtPGsR | |
GSK3B | P49841 | human | TCAP | O15273 | S157 | GALRRsLsRSMsQEA | Telethonin |
GSK3B | P49841 | human | SNAI1 | O95863 | S104 | GkGsQPPsPPsPAPs | |
GSK3B | P49841 | human | STAT2 | P52630 | S381 | RkFNILTsNQktLtP | STAT_bind |
GSK3B | P49841 | human | ESR1 | P03372 | S102 | GGFPPLNsVsPsPLM | Oest_recep |
GSK3B | P49841 | human | SQLE | Q14534 | S83 | IGFFWAKsPPEsENk | |
GSK3B | P49841 | human | RASSF1 | Q9NS23-2 | S179 | RPVsVPssKKPPsLQ | |
GSK3B | P49841 | human | SREBF1 | P36956 | S430 | DTLtPPPsDAGsPFQ | |
GSK3B | P49841 | human | GRB14 | Q14449 | S358 | MHPYQGRsGCSsQSI | |
GSK3B | P49841 | human | CEACAM1 | P13688 | S508 | QQPTQPTsAsPsLTA | |
GSK3B | P49841 | human | ESR1 | P03372 | S118 | LHPPPQLsPFLQPHG | Oest_recep |
GSK3B | P49841 | human | MAPT | P10636-8 | S400 | VyKsPVVsGDtsPRH | |
GSK3B | P49841 | human | TNKS | O95271 | S978 | VVSASLIsPAStPSC | |
GSK3B | P49841 | human | JUNB | P17275 | T255 | EARsRDAtPPVsPIN | Jun |
GSK3B | P49841 | human | SPI1 | P17947 | S41 | EYYPYLSsDGESHSD | |
GSK3B | P49841 | human | DSP | P15924 | S2845 | RsGsRsGsRRGsFDA | |
GSK3B | P49841 | human | GRB14 | Q14449 | S370 | QSIsPMRsIsENsLV | BPS |
GSK3B | P49841 | human | PTEN | P60484 | T366 | ASSsTSVtPDVsDNE | |
GSK3B | P49841 | human | CIITA | P33076 | S373 | VQARLERsSSKSLER | |
GSK3B | P49841 | human | WT1 | P19544-7 | S67 | GRRsRGAsGsEPQQM | |
GSK3B | P49841 | human | ESR1 | P03372 | S106 | PLNsVsPsPLMLLHP | Oest_recep |
GSK3B | P49841 | human | HNRNPD | Q14103 | S83 | DEGHsNssPRHsEAA | |
GSK3B | P49841 | human | EGLN2 | Q96KS0 | S401 | KGVQVPVsQPPtPT_ | |
GSK3B | P49841 | human | GRB14 | Q14449 | S423 | THGsPtAsSQSSATN | |
GSK3B | P49841 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
GSK3B | P49841 | human | FANCL | Q9NW38 | T178 | VPFCASWtPQSSLIS | FANCL_d2 |
GSK3B | P49841 | human | PKM | P14618 | T328 | GkPVICAtQMLESMI | PK |
GSK3B | P49841 | human | MAPT | P10636-8 | T217 | sRtPsLPtPPtREPK | |
GSK3B | P49841 | human | KDM1A | O60341 | S683 | NLFGHVGsTTAsRGE | Amino_oxidase |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7230 | KPSsRAAsPTRsssS | |
GSK3B | P49841 | human | FBXL2 | Q9UKC9 | T404 | HAYFAPVtPPTAVAG | |
GSK3B | P49841 | human | DCX | O43602-2 | S327 | StPKSKQsPIStPTs | |
GSK3B | P49841 | human | EIF6 | P56537 | S243 | MRDsLIDsLt_____ | |
GSK3B | P49841 | human | JUN | P05412 | T239 | VPEMPGEtPPLsPID | Jun |
GSK3B | P49841 | human | MAPT | P10636-8 | S195 | PPKsGDRsGyssPGs | |
GSK3B | P49841 | human | MAPT | P10636-8 | S214 | GsRsRtPsLPtPPtR | |
GSK3B | P49841 | human | SMAD1 | Q15797 | T202 | sPGSSSStYPHsPTS | |
GSK3B | P49841 | human | USF2 | Q15853 | T230 | PkIDGtRtPRDERRR | |
GSK3B | P49841 | human | EIF6 | P56537 | T231 | LNEAQPstIAtsMRD | |
GSK3B | P49841 | human | IKBKG | Q9Y6K9 | S31 | QDVLGEEsPLGKPAM | |
GSK3B | P49841 | human | MAPT | P10636-8 | T50 | LkEsPLQtPtEDGsE | |
GSK3B | P49841 | human | DPYSL5 | Q9BPU6 | T516 | tPLADtPtRPVTRHG | |
GSK3B | P49841 | human | IL17RA | Q96F46 | T780 | MVLTDPHtPYEEEQR | |
GSK3B | P49841 | human | SMAD4 | Q13485 | T273 | TTWtGSRtAPYtPNL | |
GSK3B | P49841 | human | HRAS | P01112 | T148 | YIEtsAktRQGVEDA | Ras |
GSK3B | P49841 | human | EIF4EBP1 | Q13541 | T70 | rNsPVtktPPRDLPt | eIF_4EBP |
GSK3B | P49841 | human | JUNB | P17275 | S251 | QTVPEARsRDAtPPV | Jun |
GSK3B | P49841 | human | SNAI2 | O43623 | S104 | KDHsGSEsPISDEEE | |
GSK3B | P49841 | human | HSP90AA1 | P07900 | S726 | LEGDDDtsRMEEVD_ | |
GSK3B | P49841 | human | IKZF3 | Q9UKT9 | S378 | VPSERGLsPNNSGHD | |
GSK3B | P49841 | human | ETS1 | P14921 | S269 | DRLtQsWssQssFNs | Ets1_N_flank |
GSK3B | P49841 | human | RAB11FIP5 | Q9BXF6 | T276 | GPGAELLtRsPsRss | |
GSK3B | P49841 | human | SP1 | P08047 | S732 | PLDsGAGsEGSGtAt | |
GSK3B | P49841 | human | SMAD4 | Q13485 | T269 | HNStTTWtGSRtAPY | |
GSK3B | P49841 | human | WT1 | P19544-7 | S63 | ERLQGRRsRGAsGsE | |
GSK3B | P49841 | human | TNKS | O95271 | S987 | AStPSCLsAASsIDN | |
GSK3B | P49841 | human | HSP90AA1 | P07900 | T725 | PLEGDDDtsRMEEVD | |
GSK3B | P49841 | human | MYLK | Q15746 | S1776 | GRKsstGsPtsPLNA | |
GSK3B | P49841 | human | NR1D1 | P20393 | S55 | CPTYFPPsPTGsLTQ | |
GSK3B | P49841 | human | FBXO4 | Q9UKT5 | S12 | EPRsGtNsPPPPFSD | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7234 | RAAsPTRsssSAsQs | |
GSK3B | P49841 | human | AHR | P35869 | S444 | GkDsATTsTLSKDSL | |
GSK3B | P49841 | human | SNAI2 | O43623 | S100 | DTSsKDHsGSEsPIS | |
GSK3B | P49841 | human | MAP3K11 | Q16584 | S789 | VsAGPRPsPLPsPQP | |
GSK3B | P49841 | human | RPTOR | Q8N122 | S863 | LtQsAPAsPtNkGVH | |
GSK3B | P49841 | human | MAPT | P10636-8 | T181 | ktPPAPktPPssGEP | |
GSK3B | P49841 | human | DNM1L | O00429 | S616 | PIPIMPAsPQKGHAV | |
GSK3B | P49841 | human | PICK1 | Q9NRD5 | S415 | kGGsWCDs_______ | |
GSK3B | P49841 | human | CLASP2 | O75122 | S533 | QGCsREAsREssRDT | |
GSK3B | P49841 | human | TBK1 | Q9UHD2 | S172 | EDDEQFVsLyGTEEy | Pkinase |
GSK3B | P49841 | human | GRB14 | Q14449 | S419 | LRLGTHGsPtAsSQS | |
GSK3B | P49841 | human | RAB11FIP5 | Q9BXF6 | S188 | sMKDKPRsPFsKIRD | |
GSK3B | P49841 | human | CCNE1 | P24864 | T395 | PLPSGLLtPPQsGKK | |
GSK3B | P49841 | human | NR3C1 | P04150 | S404 | SMRPDVSsPPSSSST | |
GSK3B | P49841 | human | MCL1 | Q07820 | T163 | tDGsLPstPPPAEEE | |
GSK3B | P49841 | human | EIF4EBP1 | Q13541 | T37 | PPGDysttPGGtLFs | eIF_4EBP |
GSK3B | P49841 | human | HSF1 | Q00613 | S303 | RVkEEPPsPPQsPRV | Vert_HS_TF |
GSK3B | P49841 | human | MAPT | P10636-8 | T175 | AtRIPAktPPAPktP | |
GSK3B | P49841 | human | TRAF6 | Q9Y4K3 | T266 | ARHLQENtQSHMRML | |
GSK3B | P49841 | human | BCL2L12 | Q9HB09 | S156 | SESPRPCsLPIRPCY | |
GSK3B | P49841 | human | OSBP2 | Q969R2 | S768 | HssPssPsSDGKQKT | Oxysterol_BP |
GSK3B | P49841 | human | HRAS | P01112 | S183 | ESGPGCMsCKCVLS_ | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7326 | RAGsRAssRRGsDAs | |
GSK3B | P49841 | human | ZNF322 | Q6U7Q0 | S391 | SEKGLELsPPHAsEA | |
GSK3B | P49841 | human | SNAI1 | O95863 | S96 | TsLsDEDsGkGsQPP | |
GSK3B | P49841 | human | MYC | P01106 | S77 | LLPtPPLsPsRRsGL | Myc_N |
GSK3B | P49841 | human | ADD2 | P35612 | S613 | AKEAEtKsPLVsPsK | |
GSK3B | P49841 | human | ACBD5 | Q5T8D3-2 | S269 | DsEVYCDsMEQFGQE | |
GSK3B | P49841 | human | KAT5 | Q92993 | S90 | LPGsRPGsPEREVPA | |
GSK3B | P49841 | human | RXRA | P19793 | S66 | NGMGPPFsVISSPMG | Nuc_recep-AF1 |
GSK3B | P49841 | human | CTNNB1 | P35222 | S33 | QQQsyLDsGIHsGAT | |
GSK3B | P49841 | human | APC | P25054 | S1503 | TPDGFsCsssLsALs | APC_r |
GSK3B | P49841 | human | MITF | O75030-9 | S397 | DPLLSSVsPGAsKTS | DUF3371 |
GSK3B | P49841 | human | AHR | P35869 | S436 | LRTKNGTsGkDsATT | |
GSK3B | P49841 | human | SPI1 | P17947 | S140 | EEEGERQsPPLEVsD | |
GSK3B | P49841 | human | WEE1 | P30291 | S211 | SSVkLRGssLFMDtE | |
GSK3B | P49841 | human | PHLPP1 | O60346 | S1359 | VPRPHVQsVLLtPQD | PP2C |
GSK3B | P49841 | human | MAPT | P10636-8 | T212 | tPGsRsRtPsLPtPP | |
GSK3B | P49841 | human | MAPRE1 | Q15691 | S155 | kPkkPLtssSAAPQR | |
GSK3B | P49841 | human | ATXN3 | P54252 | S256 | LRRAIQLsMQGsSRN | UIM |
GSK3B | P49841 | human | CABYR | O75952 | S155 | KTTtPPSsPPPTAVS | |
GSK3B | P49841 | human | OSBP2 | Q969R2 | S763 | CSKVMHssPssPsSD | Oxysterol_BP |
GSK3B | P49841 | human | NFKB2 | Q00653 | S222 | QPIHDSKsPGASNLk | |
GSK3B | P49841 | human | GFI1 | Q99684 | S98 | RPPsPSAsPASEKSM | |
GSK3B | P49841 | human | EZH2 | Q15910 | S363 | GRLPNNssRPstPtI | |
GSK3B | P49841 | human | SNCAIP | Q9Y6H5 | S556 | AQKSEGKsLPssPss | SNCAIP_SNCA_bd |
GSK3B | P49841 | human | AHR | P35869 | S689 | SQEFPYKsEMDsMPY | |
GSK3B | P49841 | human | IRF1 | P10914 | S184 | QALtPALsPCAVSST | |
GSK3B | P49841 | human | NFKB2 | Q00653 | S707 | EPLCPLPsPPTsDsD | |
GSK3B | P49841 | human | SNAI1 | O95863 | S115 | PAPssFSsTSVsSLE | |
GSK3B | P49841 | human | CLASP2 | O75122 | S503 | IPRsQGCsREAsPsR | |
GSK3B | P49841 | human | CTNNB1 | P35222 | T41 | GIHsGATtTAPsLsG | |
GSK3B | P49841 | human | DNM1L | O00429 | S693 | LVGQLYKsSLLDDLL | GED |
GSK3B | P49841 | human | VHL | P40337 | S68 | PVLRSVNsREPsQVI | VHL |
GSK3B | P49841 | human | SRC | P12931 | S493 | CPPECPEsLHDLMCQ | PK_Tyr_Ser-Thr |
GSK3B | P49841 | human | CCND2 | P30279 | T280 | DELDQAstPtDVRDI | Cyclin_C |
GSK3B | P49841 | human | RICTOR | Q6R327 | S1235 | GIssMSssPSRETVG | |
GSK3B | P49841 | human | SNAI2 | O43623 | S92 | RVsPPPPsDTSsKDH | |
GSK3B | P49841 | human | VDAC1 | P21796 | S13 | TYADLGksARDVFtk | Porin_3 |
GSK3B | P49841 | human | DSP | P15924 | S2849 | RsGsRRGsFDAtGNs | |
GSK3B | P49841 | human | FOXM1 | Q08050-2 | S474 | PPLEEWPsPAPSFkE | |
GSK3B | P49841 | human | GLE1 | Q53GS7 | S93 | PKsPDAssAFsPAsP | |
GSK3B | P49841 | human | PPP1R2 | P41236 | T73 | MKIDEPstPyHSMMG | IPP-2 |
GSK3B | P49841 | human | PHLPP1 | O60346 | S1381 | KGLWDsLsVEEAVEA | PP2C |
GSK3B | P49841 | human | EIF4EBP1 | Q13541 | T46 | GGtLFsttPGGtRII | eIF_4EBP |
GSK3B | P49841 | human | AHR | P35869 | T731 | FEPsPYPtTSSLEDF | |
GSK3B | P49841 | human | SPAG5 | Q96R06 | T937 | ADEEPEStPVPLLGs | |
GSK3B | P49841 | human | EIF6 | P56537 | S239 | IAtsMRDsLIDsLt_ | |
GSK3B | P49841 | human | SRC | P12931 | Y419 | RLIEDNEytARQGAk | PK_Tyr_Ser-Thr |
GSK3B | P49841 | human | CEBPD | P49716 | S167 | SPEPPRSsPRQtPAP | |
GSK3B | P49841 | human | NIFK | Q9BYG3 | T234 | tVDsQGPtPVCtPtF | hNIFK_binding |
GSK3B | P49841 | human | CCNE1 | P24864 | T77 | DPCsLIPtPDKEDDD | |
GSK3B | P49841 | human | ETS1 | P14921 | T265 | yDsCDRLtQsWssQs | Ets1_N_flank |
GSK3B | P49841 | human | NFE2L2 | Q16236 | S344 | AEFNDSDsGIsLNTs | |
GSK3B | P49841 | human | GYS1 | P13807 | S645 | RPAsVPPsPsLsRHs | Glycogen_syn |
GSK3B | P49841 | human | NFE2L1 | Q14494 | S379 | SQDFLLFsPEVESLP | |
GSK3B | P49841 | human | GLE1 | Q53GS7 | S92 | VPKsPDAssAFsPAs | |
GSK3B | P49841 | human | EZH2 | Q15910 | T367 | NNssRPstPtINVLE | |
GSK3B | P49841 | human | MAPT | P10636-8 | T205 | ssPGsPGtPGsRsRt | |
GSK3B | P49841 | human | FBXL20 | Q96IG2 | S421 | APVtPPPsVGGsRQR | |
GSK3B | P49841 | human | MARK2 | Q7KZI7 | S212 | KLDtFCGsPPYAAPE | Pkinase |
GSK3B | P49841 | human | KLF5 | Q13887 | S303 | QATYFPPsPPSSEPG | |
GSK3B | P49841 | human | GRB14 | Q14449 | S366 | GCSsQSIsPMRsIsE | |
GSK3B | P49841 | human | DPYSL3 | Q14195 | T509 | PVFDLtttPkGGtPA | |
GSK3B | P49841 | human | SLC6A4 | P31645 | S48 | GQISNGysAVPSPGA | 5HT_transport_N |
GSK3B | P49841 | human | IRF1 | P10914 | T180 | LEVEQALtPALsPCA | |
GSK3B | P49841 | human | MAPT | P10636-8 | S422 | GsIDMVDsPQLAtLA | |
GSK3B | P49841 | human | RXRA | P19793 | S78 | PMGPHSMsVPTtPTL | Nuc_recep-AF1 |
GSK3B | P49841 | human | CD274 | Q9NZQ7 | T180 | QVLSGkTtTTNsKRE | C2-set_2 |
GSK3B | P49841 | human | USF2 | Q15853 | S155 | NPFSNGGsPAAEAVS | |
GSK3B | P49841 | human | MAPT | P10636-8 | S235 | VVRtPPKsPssAKsR | |
GSK3B | P49841 | human | GLE1 | Q53GS7 | S88 | QPSFVPKsPDAssAF | |
GSK3B | P49841 | human | ENDOG | Q14249 | T128 | VHAYHRAtNADYRGS | Endonuclease_NS |
GSK3B | P49841 | human | IRF3 | Q14653 | S173 | PCPQPLRsPsLDNPt | |
GSK3B | P49841 | human | CDKN1A | P38936 | T57 | NFDFVtEtPLEGDFA | CDI |
GSK3B | P49841 | human | DPYSL3 | Q14195 | S518 | kGGtPAGsArGsPtR | |
GSK3B | P49841 | human | AHR | P35869 | S693 | PYKsEMDsMPYtQNF | |
GSK3B | P49841 | human | KNSTRN | Q9Y448 | T294 | VRFLEQQtLCNNQVN | |
GSK3B | P49841 | human | RPTOR | Q8N122 | S722 | PrLrsVssyGNIRAV | |
GSK3B | P49841 | human | MAP3K11 | Q16584 | S793 | PRPsPLPsPQPAPRR | |
GSK3B | P49841 | human | IKBKG | Q9Y6K9 | S17 | LCEMVQPsGGPAADQ | |
GSK3B | P49841 | human | HDAC4 | P56524 | S298 | ACSSAPGsGPSsPNN | |
GSK3B | P49841 | human | MAPT | P10636-8 | S210 | PGtPGsRsRtPsLPt | |
GSK3B | P49841 | human | AREL1 | O15033-2 | T783 | IAAPTHStLPTAHT_ | HECT |
GSK3B | P49841 | human | CAP1 | Q01518 | S308 | sAPKPQtsPsPkRAt | |
GSK3B | P49841 | human | PTTG1 | O95997 | S183 | SNLLQSPssILSTLD | Securin |
GSK3B | P49841 | human | BORA | Q6PGQ7 | S274 | TSPsPISsPTFsPIE | |
GSK3B | P49841 | human | MYBPC3 | Q14896 | S133 | ELGESAPsPKGSSSA | |
GSK3B | P49841 | human | TRIM72 | Q6ZMU5 | S255 | LQKILAEsPPPARLD | |
GSK3B | P49841 | human | SIGIRR | Q6IA17 | T372 | EPSAPPHtSGVSLGE | |
GSK3B | P49841 | human | MACF1 | Q9UPN3 | S7310 | ADPKKSAsRPGsRAG | |
GSK3B | P49841 | human | PPIF | P30405 | S191 | IEsFGsksGRTSKKI | Pro_isomerase |
GSK3B | P49841 | human | EGLN2 | Q96KS0 | T405 | VPVsQPPtPT_____ | |
GSK3B | P49841 | human | NACA | E9PAV3 | T2022 | NIQENtQtPtVQEEs | |
GSK3B | P49841 | human | SNAI1 | O95863 | S111 | sPPsPAPssFSsTSV | |
GSK3B | P49841 | human | TCAP | O15273 | S161 | RsLsRSMsQEAQRG_ | Telethonin |
GSK3B | P49841-2 | human | GSK3B | P49841-2 | Y216 | RGEPNVSyICSRYYR | Pkinase |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
GSK3B | ID | Description | 0.00e+00 |
GSK3B | GO:2000628 | regulation of miRNA metabolic process | 4.88e-19 |
GSK3B | GO:1902893 | regulation of miRNA transcription | 4.22e-18 |
GSK3B | GO:0061614 | miRNA transcription | 4.22e-18 |
GSK3B | GO:0010586 | miRNA metabolic process | 9.03e-18 |
GSK3B | GO:0140747 | regulation of ncRNA transcription | 4.04e-16 |
GSK3B | GO:2000630 | positive regulation of miRNA metabolic process | 4.59e-16 |
GSK3B | GO:1902895 | positive regulation of miRNA transcription | 4.59e-16 |
GSK3B | GO:0048511 | rhythmic process | 3.17e-15 |
GSK3B | GO:0098781 | ncRNA transcription | 1.75e-14 |
GSK3B | GO:0007623 | circadian rhythm | 2.51e-12 |
GSK3B | GO:0044843 | cell cycle G1/S phase transition | 8.96e-11 |
GSK3B | GO:0030522 | intracellular receptor signaling pathway | 9.58e-10 |
GSK3B | GO:0010212 | response to ionizing radiation | 1.19e-09 |
GSK3B | GO:2001233 | regulation of apoptotic signaling pathway | 1.20e-09 |
GSK3B | GO:0071214 | cellular response to abiotic stimulus | 1.97e-09 |
GSK3B | GO:0104004 | cellular response to environmental stimulus | 1.97e-09 |
GSK3B | GO:0062012 | regulation of small molecule metabolic process | 2.19e-09 |
GSK3B | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 2.43e-09 |
GSK3B | GO:0097193 | intrinsic apoptotic signaling pathway | 5.65e-09 |
GSK3B | GO:0000082 | G1/S transition of mitotic cell cycle | 6.56e-09 |
GSK3B | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 6.97e-09 |
GSK3B | GO:0071479 | cellular response to ionizing radiation | 9.69e-09 |
GSK3B | GO:0042752 | regulation of circadian rhythm | 1.04e-08 |
GSK3B | GO:0048732 | gland development | 3.92e-08 |
GSK3B | GO:0071900 | regulation of protein serine/threonine kinase activity | 3.95e-08 |
GSK3B | GO:0031669 | cellular response to nutrient levels | 4.18e-08 |
GSK3B | GO:0031667 | response to nutrient levels | 4.88e-08 |
GSK3B | GO:0051347 | positive regulation of transferase activity | 6.04e-08 |
GSK3B | GO:1903706 | regulation of hemopoiesis | 6.65e-08 |
GSK3B | GO:0009314 | response to radiation | 1.03e-07 |
GSK3B | GO:0071496 | cellular response to external stimulus | 1.05e-07 |
GSK3B | GO:0009410 | response to xenobiotic stimulus | 1.24e-07 |
GSK3B | GO:0010332 | response to gamma radiation | 1.30e-07 |
GSK3B | GO:0031668 | cellular response to extracellular stimulus | 1.81e-07 |
GSK3B | GO:0048863 | stem cell differentiation | 1.92e-07 |
GSK3B | GO:0071478 | cellular response to radiation | 2.17e-07 |
GSK3B | GO:0022411 | cellular component disassembly | 2.19e-07 |
GSK3B | GO:0043620 | regulation of DNA-templated transcription in response to stress | 2.75e-07 |
GSK3B | GO:0044772 | mitotic cell cycle phase transition | 4.20e-07 |
GSK3B | GO:0070482 | response to oxygen levels | 4.74e-07 |
GSK3B | GO:0030099 | myeloid cell differentiation | 4.76e-07 |
GSK3B | GO:0043434 | response to peptide hormone | 4.76e-07 |
GSK3B | GO:0031349 | positive regulation of defense response | 5.40e-07 |
GSK3B | GO:0050673 | epithelial cell proliferation | 5.40e-07 |
GSK3B | GO:0002573 | myeloid leukocyte differentiation | 6.33e-07 |
GSK3B | GO:1904029 | regulation of cyclin-dependent protein kinase activity | 6.57e-07 |
GSK3B | GO:0035270 | endocrine system development | 7.11e-07 |
GSK3B | GO:0036293 | response to decreased oxygen levels | 7.13e-07 |
GSK3B | GO:0062197 | cellular response to chemical stress | 7.68e-07 |
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Related Drugs to MSL2_GSK3B |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning MSL2-GSK3B and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MSL2_GSK3B |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |