| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:MTCH1_CAMK1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MTCH1_CAMK1 | KinaseFusionDB ID: KFG3966 | FusionGDB2.0 ID: KFG3966 | Hgene | Tgene | Gene symbol | MTCH1 | CAMK1 | Gene ID | 23787 | 8536 | |
| Gene name | mitochondrial carrier 1 | calcium/calmodulin dependent protein kinase I | ||||||||||
| Synonyms | CGI-64|PIG60|PSAP|SLC25A49 | CAMKI | ||||||||||
| Cytomap | 6p21.2 | 3p25.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | mitochondrial carrier homolog 1cell proliferation-inducing protein 60presenilin-associated proteinsolute carrier family 25, member 49 | calcium/calmodulin-dependent protein kinase type 1caM kinase I alphacaM-KIcaMKI-alpha | ||||||||||
| Modification date | 20240403 | 20240403 | ||||||||||
| UniProtAcc | Q9NZJ7 | Q8IU85 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000373616, ENST00000373627, ENST00000471737, ENST00000538808, | ENST00000256460, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MTCH1 [Title/Abstract] AND CAMK1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MTCH1(36940526)-CAMK1(9804597), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTCH1 | GO:0045040 | protein insertion into mitochondrial outer membrane | 36264797 |
| Tgene | CAMK1 | GO:0006468 | protein phosphorylation | 11114197 |
| Tgene | CAMK1 | GO:0010976 | positive regulation of neuron projection development | 17442826 |
| Tgene | CAMK1 | GO:0032091 | negative regulation of protein binding | 23867755 |
| Tgene | CAMK1 | GO:0032880 | regulation of protein localization | 11114197 |
| Tgene | CAMK1 | GO:0043393 | regulation of protein binding | 11114197 |
| Tgene | CAMK1 | GO:0046827 | positive regulation of protein export from nucleus | 23867755 |
| Tgene | CAMK1 | GO:0051147 | regulation of muscle cell differentiation | 11114197 |
| Tgene | CAMK1 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 17442826 |
| Kinase Fusion gene breakpoints across MTCH1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CAMK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BQ188595 | MTCH1 | chr6 | 36940526 | CAMK1 | chr3 | 9804597 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36940526/:9804597) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTCH1 | CAMK1 |
| FUNCTION: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (By similarity). Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). May play a role in apoptosis (PubMed:12377771). {ECO:0000250|UniProtKB:Q9Y6C9, ECO:0000269|PubMed:12377771, ECO:0000269|PubMed:36264797}. | FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of MTCH1_CAMK1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CAMK1 | Q14012 | human | HDAC5 | Q9UQL6 | S498 | RPLSRtQsSPLPQsP | |
| CAMK1 | Q14012 | human | GCM1 | Q9NP62 | T174 | RAMKKVNtAPssVSL | |
| CAMK1 | Q14012 | human | CDKN1B | P46527 | T157 | GIRkrPAtDDSSTQN | |
| CAMK1 | Q14012 | human | CDKN1B | P46527 | T198 | PGLRRRQt_______ | |
| CAMK1 | Q14012 | human | GCM1 | Q9NP62 | S177 | KKVNtAPssVSLSLK | |
| CAMK1 | Q14012 | human | GCM1 | Q9NP62 | S47 | YAKHIYSsEDKNAQR | GCM |
| CAMK1 | Q14012 | human | EIF4G3 | O43432 | S1156 | NTFMRGGssKDLLDN | |
| CAMK1 | Q14012 | human | MYL9 | P24844 | S20 | KRPQRAtsNVFAMFD | |
| CAMK1 | Q14012 | human | GCM1 | Q9NP62 | S178 | KVNtAPssVSLSLKG | |
| CAMK1 | Q14012 | human | GCM1 | Q9NP62 | S269 | LYEKRKLsSSRTYsS | |
| CAMK1 | Q14012 | human | LIPE | Q05469 | S855 | EPMRRsVsEAALAQP | |
| CAMK1 | Q14012 | human | CAMK2A | Q9UQM7-2 | S332 | DGVKkRKssssVQLM | |
| CAMK1 | Q14012 | human | PPME1 | Q9Y570 | S15 | MHLGRLPsrPPLPGs | |
| CAMK1 | Q14012 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
| CAMK1 | Q14012 | human | RPS19 | P39019 | S59 | WFytrAAsTARHLYL | Ribosomal_S19e |
| CAMK1 | Q14012 | human | HDAC9 | Q9UKV0 | S220 | FPLRkTAsEPNLKVR | |
| CAMK1 | Q14012 | human | HDAC9 | Q9UKV0 | S451 | RPLNRtQsAPLPQST |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CAMK1 | ID | Description | 0.00e+00 |
| CAMK1 | GO:0043434 | response to peptide hormone | 2.01e-02 |
| CAMK1 | GO:0010830 | regulation of myotube differentiation | 4.85e-02 |
| CAMK1 | GO:0051146 | striated muscle cell differentiation | 4.85e-02 |
| CAMK1 | GO:0071375 | cellular response to peptide hormone stimulus | 4.85e-02 |
| CAMK1 | GO:0090049 | regulation of cell migration involved in sprouting angiogenesis | 5.17e-02 |
| CAMK1 | GO:1901653 | cellular response to peptide | 5.17e-02 |
| CAMK1 | GO:0002042 | cell migration involved in sprouting angiogenesis | 5.17e-02 |
| CAMK1 | GO:0051153 | regulation of striated muscle cell differentiation | 5.17e-02 |
| CAMK1 | GO:0042692 | muscle cell differentiation | 5.17e-02 |
| CAMK1 | GO:0044772 | mitotic cell cycle phase transition | 5.83e-02 |
| CAMK1 | GO:0043086 | negative regulation of catalytic activity | 5.83e-02 |
| CAMK1 | GO:0045814 | negative regulation of gene expressio | 1.75e-03 |
| CAMK1 | GO:0001890 | placenta development | 7.06e-02 |
| CAMK1 | GO:0030183 | B cell differentiation | 7.06e-02 |
| CAMK1 | GO:0043535 | regulation of blood vessel endothelial cell migration | 7.06e-02 |
| CAMK1 | GO:0051147 | regulation of muscle cell differentiation | 7.43e-02 |
| CAMK1 | GO:0043534 | blood vessel endothelial cell migration | 7.49e-02 |
| CAMK1 | GO:0002040 | sprouting angiogenesis | 7.49e-02 |
| CAMK1 | GO:0055001 | muscle cell development | 7.49e-02 |
| CAMK1 | GO:0032869 | cellular response to insulin stimulus | 7.49e-02 |
| CAMK1 | GO:2000241 | regulation of reproductive process | 7.49e-02 |
| CAMK1 | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | 7.49e-02 |
| CAMK1 | GO:0051346 | negative regulation of hydrolase activity | 7.49e-02 |
| CAMK1 | GO:0048742 | regulation of skeletal muscle fiber development | 7.49e-02 |
| CAMK1 | GO:0060767 | epithelial cell proliferation involved in prostate gland development | 7.49e-02 |
| CAMK1 | GO:0040029 | epigenetic regulation of gene expression | 7.49e-02 |
| CAMK1 | GO:0010594 | regulation of endothelial cell migration | 7.49e-02 |
| CAMK1 | GO:0006482 | protein demethylation | 7.49e-02 |
| CAMK1 | GO:0008214 | protein dealkylation | 7.49e-02 |
| CAMK1 | GO:0071236 | cellular response to antibiotic | 7.49e-02 |
| CAMK1 | GO:0021781 | glial cell fate commitment | 7.49e-02 |
| CAMK1 | GO:0060670 | branching involved in labyrinthine layer morphogenesis | 7.49e-02 |
| CAMK1 | GO:0071285 | cellular response to lithium ion | 7.49e-02 |
| CAMK1 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 7.49e-02 |
| CAMK1 | GO:0000082 | G1/S transition of mitotic cell cycle | 7.49e-02 |
| CAMK1 | GO:0010226 | response to lithium ion | 7.49e-02 |
| CAMK1 | GO:0032868 | response to insulin | 7.49e-02 |
| CAMK1 | GO:0002679 | respiratory burst involved in defense response | 7.49e-02 |
| CAMK1 | GO:0010832 | negative regulation of myotube differentiation | 7.49e-02 |
| CAMK1 | GO:0051004 | regulation of lipoprotein lipase activity | 7.49e-02 |
| CAMK1 | GO:0007000 | nucleolus organization | 7.49e-02 |
| CAMK1 | GO:0060192 | negative regulation of lipase activity | 7.49e-02 |
| CAMK1 | GO:0042113 | B cell activation | 7.49e-02 |
| CAMK1 | GO:0044843 | cell cycle G1/S phase transition | 7.49e-02 |
| CAMK1 | GO:0043542 | endothelial cell migration | 7.49e-02 |
| CAMK1 | GO:0006977 | DNA damage respons | 9.50e-03 |
| CAMK1 | GO:0060263 | regulation of respiratory burst | 7.49e-02 |
| CAMK1 | GO:0000028 | ribosomal small subunit assembly | 7.49e-02 |
| CAMK1 | GO:0010663 | positive regulation of striated muscle cell apoptotic process | 7.49e-02 |
Top |
Related Drugs to MTCH1_CAMK1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MTCH1-CAMK1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to MTCH1_CAMK1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |