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Kinase Fusion Gene:MYD88_MYLK |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: MYD88_MYLK | KinaseFusionDB ID: KFG4004 | FusionGDB2.0 ID: KFG4004 | Hgene | Tgene | Gene symbol | MYD88 | MYLK | Gene ID | 4615 | 4638 | |
Gene name | MYD88 innate immune signal transduction adaptor | myosin light chain kinase | ||||||||||
Synonyms | IMD68|MYD88D|WM1 | AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MMIHS1|MSTP083|MYLK-L|MYLK1|smMLCK | ||||||||||
Cytomap | 3p22.2 | 3q21.1 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | myeloid differentiation primary response protein MyD88TLR adaptor MYD88mutant myeloid differentiation primary response 88myeloid differentiation primary response 88myeloid differentiation primary response gene (88) | myosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin | ||||||||||
Modification date | 20240411 | 20240403 | ||||||||||
UniProtAcc | Q99836 | Q86YV6 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000481122, ENST00000396334, ENST00000417037, ENST00000443433, ENST00000424893, ENST00000495303, | ENST00000359169, ENST00000360304, ENST00000360772, ENST00000346322, ENST00000354792, ENST00000418370, ENST00000475616, ENST00000510775, ENST00000578202, ENST00000583087, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MYD88 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MYD88(38181436)-MYLK(123383107), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MYD88 | GO:0032731 | positive regulation of interleukin-1 beta production | 33718825 |
Hgene | MYD88 | GO:0034142 | toll-like receptor 4 signaling pathway | 16751103 |
Hgene | MYD88 | GO:0034158 | toll-like receptor 8 signaling pathway | 33718825 |
Hgene | MYD88 | GO:0038172 | interleukin-33-mediated signaling pathway | 18802081 |
Hgene | MYD88 | GO:0051607 | defense response to virus | 33718825 |
Hgene | MYD88 | GO:0070498 | interleukin-1-mediated signaling pathway | 9430229 |
Hgene | MYD88 | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15294994 |
Tgene | MYLK | GO:0030335 | positive regulation of cell migration | 19826488 |
Tgene | MYLK | GO:0051928 | positive regulation of calcium ion transport | 16284075 |
Tgene | MYLK | GO:0071476 | cellular hypotonic response | 11976941 |
Tgene | MYLK | GO:0090303 | positive regulation of wound healing | 15825080 |
Kinase Fusion gene breakpoints across MYD88 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across MYLK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | BP285827 | MYD88 | chr3 | 38181436 | MYLK | chr3 | 123383107 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38181436/:123383107) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MYD88 | MYLK |
FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). {ECO:0000250|UniProtKB:P22366, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19506249, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:24316379, ECO:0000269|PubMed:33718825, ECO:0000269|PubMed:9013863}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MYD88_MYLK |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
MYLK | Q15746 | human | MYL2 | P10916 | S15 | KRAGGANsNVFsMFE | |
MYLK | Q15746 | human | MYL9 | P24844 | T19 | KKRPQRAtsNVFAMF | |
MYLK | Q15746 | human | MYL12B | O14950 | S20 | KRPQRAtsNVFAMFD | |
MYLK | Q15746 | human | MYL9 | P24844 | S20 | KRPQRAtsNVFAMFD | |
MYLK | Q15746 | human | MYL12B | O14950 | T19 | KKRPQRAtsNVFAMF |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
MYLK | ID | Description | 0.00e+00 |
MYLK | GO:0030239 | myofibril assembly | 1.24e-03 |
MYLK | GO:0055002 | striated muscle cell development | 1.24e-03 |
MYLK | GO:0010927 | cellular component assembly involved in morphogenesis | 2.55e-03 |
MYLK | GO:0006937 | regulation of muscle contraction | 3.36e-03 |
MYLK | GO:0055001 | muscle cell development | 3.36e-03 |
MYLK | GO:0031032 | actomyosin structure organization | 3.36e-03 |
MYLK | GO:0090257 | regulation of muscle system process | 4.06e-03 |
MYLK | GO:0051146 | striated muscle cell differentiation | 5.41e-03 |
MYLK | GO:0006936 | muscle contraction | 6.36e-03 |
MYLK | GO:0140694 | non-membrane-bounded organelle assembly | 7.40e-03 |
MYLK | GO:0042692 | muscle cell differentiation | 7.40e-03 |
MYLK | GO:0003012 | muscle system process | 7.89e-03 |
MYLK | GO:0055003 | cardiac myofibril assembly | 1.27e-02 |
MYLK | GO:0042693 | muscle cell fate commitment | 1.27e-02 |
MYLK | GO:0002026 | regulation of the force of heart contraction | 1.54e-02 |
MYLK | GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 2.61e-02 |
MYLK | GO:0003229 | ventricular cardiac muscle tissue development | 3.01e-02 |
MYLK | GO:0055008 | cardiac muscle tissue morphogenesis | 3.01e-02 |
MYLK | GO:0003208 | cardiac ventricle morphogenesis | 3.13e-02 |
MYLK | GO:0070527 | platelet aggregation | 3.13e-02 |
MYLK | GO:0060415 | muscle tissue morphogenesis | 3.13e-02 |
MYLK | GO:0048644 | muscle organ morphogenesis | 3.26e-02 |
MYLK | GO:0055013 | cardiac muscle cell development | 3.31e-02 |
MYLK | GO:0055006 | cardiac cell development | 3.37e-02 |
MYLK | GO:0034109 | homotypic cell-cell adhesion | 3.37e-02 |
MYLK | GO:0006942 | regulation of striated muscle contraction | 3.37e-02 |
MYLK | GO:0001708 | cell fate specification | 3.61e-02 |
MYLK | GO:0003206 | cardiac chamber morphogenesis | 3.75e-02 |
MYLK | GO:0003231 | cardiac ventricle development | 3.75e-02 |
MYLK | GO:0055007 | cardiac muscle cell differentiation | 3.75e-02 |
MYLK | GO:0030168 | platelet activation | 3.75e-02 |
MYLK | GO:0060048 | cardiac muscle contraction | 3.75e-02 |
MYLK | GO:0008360 | regulation of cell shape | 3.75e-02 |
MYLK | GO:0035051 | cardiocyte differentiation | 4.24e-02 |
MYLK | GO:0003205 | cardiac chamber development | 4.24e-02 |
MYLK | GO:0006941 | striated muscle contraction | 4.50e-02 |
MYLK | GO:0030308 | negative regulation of cell growth | 4.50e-02 |
MYLK | GO:0008016 | regulation of heart contraction | 4.73e-02 |
MYLK | GO:0007596 | blood coagulation | 4.73e-02 |
MYLK | GO:0050817 | coagulation | 4.73e-02 |
MYLK | GO:0007599 | hemostasis | 4.73e-02 |
MYLK | GO:0060047 | heart contraction | 4.73e-02 |
MYLK | GO:0022604 | regulation of cell morphogenesis | 4.73e-02 |
MYLK | GO:0045926 | negative regulation of growth | 4.73e-02 |
MYLK | GO:0048738 | cardiac muscle tissue development | 4.73e-02 |
MYLK | GO:0003015 | heart process | 4.73e-02 |
MYLK | GO:1903522 | regulation of blood circulation | 4.73e-02 |
MYLK | GO:0003007 | heart morphogenesis | 4.73e-02 |
MYLK | GO:0014706 | striated muscle tissue development | 4.73e-02 |
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Related Drugs to MYD88_MYLK |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning MYD88-MYLK and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MYD88_MYLK |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |