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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MYH11_MYLK

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: MYH11_MYLK
KinaseFusionDB ID: KFG4007
FusionGDB2.0 ID: KFG4007
HgeneTgene
Gene symbol

MYH11

MYLK

Gene ID

4629

4638

Gene namemyosin heavy chain 11myosin light chain kinase
SynonymsAAT4|FAA4|SMHC|SMMHC|SMMS-1|VSCM2AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MMIHS1|MSTP083|MYLK-L|MYLK1|smMLCK
Cytomap

16p13.11

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionmyosin-11epididymis secretory sperm binding proteinmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth musclemyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin
Modification date2024040320240403
UniProtAcc

P35749

Q86YV6

Ensembl transtripts involved in fusion geneENST idsENST00000300036, ENST00000396324, 
ENST00000452625, ENST00000576790, 
ENST00000573908, 		ENST00000346322, 
ENST00000354792, ENST00000418370, 
ENST00000475616, ENST00000510775, 
ENST00000578202, ENST00000583087, 
ENST00000359169, ENST00000360304, 
ENST00000360772, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: MYH11 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MYH11(15809021)-MYLK(123383105), # samples:1
MYLK(123333009)-MYH11(15797744), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

TgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

TgeneMYLK

GO:0071476

cellular hypotonic response

11976941

TgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check buttonKinase Fusion gene breakpoints across MYH11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across MYLK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-3B-A9HR-01AMYH11chr16

15809021

MYLKchr3

123383105



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000452625ENST00000360772MYH11chr1615809021MYLKchr3123383105115392473

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000452625_ENST00000360772_MYH11_chr16_15809021_MYLK_chr3_123383105_length(amino acids)=2473
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTG
YIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQL
SILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFR
WILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER
PNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKF
VADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGV
LEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQ
AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ
LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV
TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA
SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE
LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG
QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV
STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR
LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME
DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE
LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE
DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE
SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQE
SEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEI
WDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKV
SDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERI
IDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY
ATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPL
NAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISD

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:15809021/chr3:123383105)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYH11

P35749

MYLK

Q86YV6

FUNCTION: Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneMYH1115809021MYLK123383105ENST00000452625031334_14260155DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TgeneMYH1115809021MYLK123383105ENST00000452625041334_14260155DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TgeneMYH1115809021MYLK123383105ENST0000045262518311334_142612771915DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TgeneMYH1115809021MYLK123383105ENST0000045262520331334_142612081846DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TgeneMYH1115809021MYLK123383105ENST0000045262521331334_142612771864DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TgeneMYH1115809021MYLK123383105ENST0000045262521341334_142612771915DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TgeneMYH1115809021MYLK123383105ENST0000045262522341334_142612771864DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
TgeneMYH1115809021MYLK123383105ENST000004526250333_1220155DomainNote=Ig-like C2-type 1
TgeneMYH1115809021MYLK123383105ENST000004526250433_1220155DomainNote=Ig-like C2-type 1
TgeneMYH1115809021MYLK123383105ENST0000045262503161_2490155DomainNote=Ig-like C2-type 2
TgeneMYH1115809021MYLK123383105ENST0000045262504161_2490155DomainNote=Ig-like C2-type 2
TgeneMYH1115809021MYLK123383105ENST0000045262503414_5030155DomainNote=Ig-like C2-type 3
TgeneMYH1115809021MYLK123383105ENST0000045262504414_5030155DomainNote=Ig-like C2-type 3
TgeneMYH1115809021MYLK123383105ENST0000045262503514_5990155DomainNote=Ig-like C2-type 4
TgeneMYH1115809021MYLK123383105ENST0000045262504514_5990155DomainNote=Ig-like C2-type 4
TgeneMYH1115809021MYLK123383105ENST0000045262503620_7110155DomainNote=Ig-like C2-type 5
TgeneMYH1115809021MYLK123383105ENST0000045262504620_7110155DomainNote=Ig-like C2-type 5
TgeneMYH1115809021MYLK123383105ENST0000045262503721_8210155DomainNote=Ig-like C2-type 6
TgeneMYH1115809021MYLK123383105ENST0000045262504721_8210155DomainNote=Ig-like C2-type 6
TgeneMYH1115809021MYLK123383105ENST00000452625031098_11860155DomainNote=Ig-like C2-type 7
TgeneMYH1115809021MYLK123383105ENST00000452625041098_11860155DomainNote=Ig-like C2-type 7
TgeneMYH1115809021MYLK123383105ENST00000452625031238_13260155DomainNote=Ig-like C2-type 8
TgeneMYH1115809021MYLK123383105ENST00000452625041238_13260155DomainNote=Ig-like C2-type 8
TgeneMYH1115809021MYLK123383105ENST0000045262520331238_132612081846DomainNote=Ig-like C2-type 8
TgeneMYH1115809021MYLK123383105ENST00000452625031809_18980155DomainNote=Ig-like C2-type 9
TgeneMYH1115809021MYLK123383105ENST00000452625041809_18980155DomainNote=Ig-like C2-type 9
TgeneMYH1115809021MYLK123383105ENST0000045262518311809_189812771915DomainNote=Ig-like C2-type 9
TgeneMYH1115809021MYLK123383105ENST0000045262520331809_189812081846DomainNote=Ig-like C2-type 9
TgeneMYH1115809021MYLK123383105ENST0000045262521331809_189812771864DomainNote=Ig-like C2-type 9
TgeneMYH1115809021MYLK123383105ENST0000045262521341809_189812771915DomainNote=Ig-like C2-type 9
TgeneMYH1115809021MYLK123383105ENST0000045262522341809_189812771864DomainNote=Ig-like C2-type 9
TgeneMYH1115809021MYLK123383105ENST00000452625031464_17190155DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneMYH1115809021MYLK123383105ENST00000452625041464_17190155DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneMYH1115809021MYLK123383105ENST0000045262518311464_171912771915DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneMYH1115809021MYLK123383105ENST0000045262520331464_171912081846DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneMYH1115809021MYLK123383105ENST0000045262521331464_171912771864DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneMYH1115809021MYLK123383105ENST0000045262521341464_171912771915DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneMYH1115809021MYLK123383105ENST0000045262522341464_171912771864DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>322_MYH11_MYLKENST00000452625ENST00000360772MYH11chr1615809021MYLKchr3123383105
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTG
YIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQL
SILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFR
WILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER
PNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKF
VADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGV
LEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQ
AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ
LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV
TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA
SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE
LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG
QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV
STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR
LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME
DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE
LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE
DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE
SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQE
SEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEI
WDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKV
SDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERI
IDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY
ATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPL
NAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISD
2473
3D view using mol* of 322_MYH11_MYLK
PDB file >>>TKFP_553_MYH11_MYLKENST00000452625ENST00000360772MYH11chr1615809021MYLKchr3123383105
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTG
YIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQL
SILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFR
WILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER
PNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKF
VADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGV
LEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQ
AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ
LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV
TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA
SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE
LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG
QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV
STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR
LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME
DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE
LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE
DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE
SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQE
SEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEI
WDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKV
SDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERI
IDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY
ATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPL
NAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISD
2473_MYH11_MYLK


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

MYH11_MYLK does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/322_MYH11_MYLK.png
check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
322_MYH11_MYLK.png
all structure sitemap plddt3 322_MYH11_MYLK.png
322_MYH11_MYLK.png
all structure sitemap plddt4 322_MYH11_MYLK.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

322_MYH11_MYLK_ramachandran.png
all structure MYH11-MYLK

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy

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Kinase-Substrate Information of MYH11_MYLK


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
MYLKQ15746humanMYL2P10916S15KRAGGANsNVFsMFE
MYLKQ15746humanMYL9P24844T19KKRPQRAtsNVFAMF
MYLKQ15746humanMYL12BO14950S20KRPQRAtsNVFAMFD
MYLKQ15746humanMYL9P24844S20KRPQRAtsNVFAMFD
MYLKQ15746humanMYL12BO14950T19KKRPQRAtsNVFAMF


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
MYLKIDDescription0.00e+00
MYLKGO:0030239myofibril assembly1.24e-03
MYLKGO:0055002striated muscle cell development1.24e-03
MYLKGO:0010927cellular component assembly involved in morphogenesis2.55e-03
MYLKGO:0006937regulation of muscle contraction3.36e-03
MYLKGO:0055001muscle cell development3.36e-03
MYLKGO:0031032actomyosin structure organization3.36e-03
MYLKGO:0090257regulation of muscle system process4.06e-03
MYLKGO:0051146striated muscle cell differentiation5.41e-03
MYLKGO:0006936muscle contraction6.36e-03
MYLKGO:0140694non-membrane-bounded organelle assembly7.40e-03
MYLKGO:0042692muscle cell differentiation7.40e-03
MYLKGO:0003012muscle system process7.89e-03
MYLKGO:0055003cardiac myofibril assembly1.27e-02
MYLKGO:0042693muscle cell fate commitment1.27e-02
MYLKGO:0002026regulation of the force of heart contraction1.54e-02
MYLKGO:0055010ventricular cardiac muscle tissue morphogenesis2.61e-02
MYLKGO:0003229ventricular cardiac muscle tissue development3.01e-02
MYLKGO:0055008cardiac muscle tissue morphogenesis3.01e-02
MYLKGO:0003208cardiac ventricle morphogenesis3.13e-02
MYLKGO:0070527platelet aggregation3.13e-02
MYLKGO:0060415muscle tissue morphogenesis3.13e-02
MYLKGO:0048644muscle organ morphogenesis3.26e-02
MYLKGO:0055013cardiac muscle cell development3.31e-02
MYLKGO:0055006cardiac cell development3.37e-02
MYLKGO:0034109homotypic cell-cell adhesion3.37e-02
MYLKGO:0006942regulation of striated muscle contraction3.37e-02
MYLKGO:0001708cell fate specification3.61e-02
MYLKGO:0003206cardiac chamber morphogenesis3.75e-02
MYLKGO:0003231cardiac ventricle development3.75e-02
MYLKGO:0055007cardiac muscle cell differentiation3.75e-02
MYLKGO:0030168platelet activation3.75e-02
MYLKGO:0060048cardiac muscle contraction3.75e-02
MYLKGO:0008360regulation of cell shape3.75e-02
MYLKGO:0035051cardiocyte differentiation4.24e-02
MYLKGO:0003205cardiac chamber development4.24e-02
MYLKGO:0006941striated muscle contraction4.50e-02
MYLKGO:0030308negative regulation of cell growth4.50e-02
MYLKGO:0008016regulation of heart contraction4.73e-02
MYLKGO:0007596blood coagulation4.73e-02
MYLKGO:0050817coagulation4.73e-02
MYLKGO:0007599hemostasis4.73e-02
MYLKGO:0060047heart contraction4.73e-02
MYLKGO:0022604regulation of cell morphogenesis4.73e-02
MYLKGO:0045926negative regulation of growth4.73e-02
MYLKGO:0048738cardiac muscle tissue development4.73e-02
MYLKGO:0003015heart process4.73e-02
MYLKGO:1903522regulation of blood circulation4.73e-02
MYLKGO:0003007heart morphogenesis4.73e-02
MYLKGO:0014706striated muscle tissue development4.73e-02

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Related Drugs to MYH11_MYLK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning MYH11-MYLK and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to MYH11_MYLK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYH11C4707243Familial thoracic aortic aneurysm and aortic dissection10CLINGEN;GENOMICS_ENGLAND
HgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneMYH11C0023479Acute myelomonocytic leukemia2CTD_human;ORPHANET
HgeneMYH11C0026998Acute Myeloid Leukemia, M12CTD_human
HgeneMYH11C1851504Aortic aneurysm, familial thoracic 42CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMYH11C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate