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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MYLK_FLNA

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: MYLK_FLNA
KinaseFusionDB ID: KFG4020
FusionGDB2.0 ID: KFG4020
HgeneTgene
Gene symbol

MYLK

FLNA

Gene ID

4638

2316

Gene namemyosin light chain kinasefilamin A
SynonymsAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MMIHS1|MSTP083|MYLK-L|MYLK1|smMLCKABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVD
Cytomap

3q21.1

Xq28

Type of geneprotein-codingprotein-coding
Descriptionmyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokinfilamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinepididymis secretory sperm binding proteinfilamin A, alphafilamin-1non-muscle filamin
Modification date2024040320240407
UniProtAcc

Q86YV6

P21333

Ensembl transtripts involved in fusion geneENST idsENST00000346322, ENST00000354792, 
ENST00000359169, ENST00000360304, 
ENST00000360772, ENST00000418370, 
ENST00000475616, ENST00000578202, 
ENST00000583087, ENST00000510775, 
ENST00000498491, ENST00000344736, 
ENST00000360319, ENST00000369850, 
ENST00000369856, ENST00000422373, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: MYLK [Title/Abstract] AND FLNA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MYLK(123339054)-FLNA(153578575), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

HgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

HgeneMYLK

GO:0071476

cellular hypotonic response

11976941

HgeneMYLK

GO:0090303

positive regulation of wound healing

15825080

TgeneFLNA

GO:0016479

negative regulation of transcription by RNA polymerase I

22307607

TgeneFLNA

GO:0030036

actin cytoskeleton organization

10051605

TgeneFLNA

GO:0030334

regulation of cell migration

16291724

TgeneFLNA

GO:0034394

protein localization to cell surface

18322202

TgeneFLNA

GO:0043113

receptor clustering

10692483

TgeneFLNA

GO:0043433

negative regulation of DNA-binding transcription factor activity

15684392

TgeneFLNA

GO:0044319

wound healing, spreading of cells

16291724

TgeneFLNA

GO:0045184

establishment of protein localization

18322202

TgeneFLNA

GO:0051764

actin crosslink formation

10051605

TgeneFLNA

GO:0072659

protein localization to plasma membrane

24951510

TgeneFLNA

GO:0090307

mitotic spindle assembly

18548008

TgeneFLNA

GO:1901381

positive regulation of potassium ion transmembrane transport

24951510


check buttonKinase Fusion gene breakpoints across MYLK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across FLNA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-3B-A9HR-01AMYLKchr3

123339054

FLNAchrX

153578575



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(amino acids)
ENST00000360772ENST00000360319MYLKchr3123339054FLNAchrX15357857567052108

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000360772_ENST00000360319_MYLK_chr3_123339054_FLNA_chrX_153578575_length(amino acids)=2108
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP
ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK
FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG
LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS
SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK
FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD
CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL
LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG
EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY
EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH
TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP
PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA
SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL
CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ
FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD
PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT
TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI
MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK
LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR
KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP
GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP
RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:123339054/chrX:153578575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYLK

Q86YV6

FLNA

P21333

FUNCTION: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed:25358863). {ECO:0000250, ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117, ECO:0000269|PubMed:25358863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
17891720173817381789178917201738173817891789172017381738178917891720173817381789178917201738173817891789172017381738178917891720173817381789178917201738173817891789172017381738178917891720173817381789
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
HgeneMYLK123339054FLNA153578575ENST0000036077229311334_142611915DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HgeneMYLK123339054FLNA153578575ENST0000036077231331334_142611846DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HgeneMYLK123339054FLNA153578575ENST0000036077231331334_142611864DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HgeneMYLK123339054FLNA153578575ENST0000036077232341334_142611864DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HgeneMYLK123339054FLNA153578575ENST0000036077232341334_142611915DomainNote=Fibronectin type-III;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316
HgeneMYLK123339054FLNA153578575ENST00000360772293133_12211915DomainNote=Ig-like C2-type 1
HgeneMYLK123339054FLNA153578575ENST00000360772313333_12211846DomainNote=Ig-like C2-type 1
HgeneMYLK123339054FLNA153578575ENST00000360772313333_12211864DomainNote=Ig-like C2-type 1
HgeneMYLK123339054FLNA153578575ENST00000360772323433_12211864DomainNote=Ig-like C2-type 1
HgeneMYLK123339054FLNA153578575ENST00000360772323433_12211915DomainNote=Ig-like C2-type 1
HgeneMYLK123339054FLNA153578575ENST000003607722931161_24911915DomainNote=Ig-like C2-type 2
HgeneMYLK123339054FLNA153578575ENST000003607723133161_24911846DomainNote=Ig-like C2-type 2
HgeneMYLK123339054FLNA153578575ENST000003607723133161_24911864DomainNote=Ig-like C2-type 2
HgeneMYLK123339054FLNA153578575ENST000003607723234161_24911864DomainNote=Ig-like C2-type 2
HgeneMYLK123339054FLNA153578575ENST000003607723234161_24911915DomainNote=Ig-like C2-type 2
HgeneMYLK123339054FLNA153578575ENST000003607722931414_50311915DomainNote=Ig-like C2-type 3
HgeneMYLK123339054FLNA153578575ENST000003607723133414_50311846DomainNote=Ig-like C2-type 3
HgeneMYLK123339054FLNA153578575ENST000003607723133414_50311864DomainNote=Ig-like C2-type 3
HgeneMYLK123339054FLNA153578575ENST000003607723234414_50311864DomainNote=Ig-like C2-type 3
HgeneMYLK123339054FLNA153578575ENST000003607723234414_50311915DomainNote=Ig-like C2-type 3
HgeneMYLK123339054FLNA153578575ENST000003607722931514_59911915DomainNote=Ig-like C2-type 4
HgeneMYLK123339054FLNA153578575ENST000003607723133514_59911846DomainNote=Ig-like C2-type 4
HgeneMYLK123339054FLNA153578575ENST000003607723133514_59911864DomainNote=Ig-like C2-type 4
HgeneMYLK123339054FLNA153578575ENST000003607723234514_59911864DomainNote=Ig-like C2-type 4
HgeneMYLK123339054FLNA153578575ENST000003607723234514_59911915DomainNote=Ig-like C2-type 4
HgeneMYLK123339054FLNA153578575ENST000003607722931620_71111915DomainNote=Ig-like C2-type 5
HgeneMYLK123339054FLNA153578575ENST000003607723133620_71111846DomainNote=Ig-like C2-type 5
HgeneMYLK123339054FLNA153578575ENST000003607723133620_71111864DomainNote=Ig-like C2-type 5
HgeneMYLK123339054FLNA153578575ENST000003607723234620_71111864DomainNote=Ig-like C2-type 5
HgeneMYLK123339054FLNA153578575ENST000003607723234620_71111915DomainNote=Ig-like C2-type 5
HgeneMYLK123339054FLNA153578575ENST000003607722931721_82111915DomainNote=Ig-like C2-type 6
HgeneMYLK123339054FLNA153578575ENST000003607723133721_82111846DomainNote=Ig-like C2-type 6
HgeneMYLK123339054FLNA153578575ENST000003607723133721_82111864DomainNote=Ig-like C2-type 6
HgeneMYLK123339054FLNA153578575ENST000003607723234721_82111864DomainNote=Ig-like C2-type 6
HgeneMYLK123339054FLNA153578575ENST000003607723234721_82111915DomainNote=Ig-like C2-type 6
HgeneMYLK123339054FLNA153578575ENST0000036077229311098_118611915DomainNote=Ig-like C2-type 7
HgeneMYLK123339054FLNA153578575ENST0000036077231331098_118611846DomainNote=Ig-like C2-type 7
HgeneMYLK123339054FLNA153578575ENST0000036077231331098_118611864DomainNote=Ig-like C2-type 7
HgeneMYLK123339054FLNA153578575ENST0000036077232341098_118611864DomainNote=Ig-like C2-type 7
HgeneMYLK123339054FLNA153578575ENST0000036077232341098_118611915DomainNote=Ig-like C2-type 7
HgeneMYLK123339054FLNA153578575ENST0000036077229311238_132611915DomainNote=Ig-like C2-type 8
HgeneMYLK123339054FLNA153578575ENST0000036077231331238_132611846DomainNote=Ig-like C2-type 8
HgeneMYLK123339054FLNA153578575ENST0000036077231331238_132611864DomainNote=Ig-like C2-type 8
HgeneMYLK123339054FLNA153578575ENST0000036077232341238_132611864DomainNote=Ig-like C2-type 8
HgeneMYLK123339054FLNA153578575ENST0000036077232341238_132611915DomainNote=Ig-like C2-type 8
HgeneMYLK123339054FLNA153578575ENST0000036077229311464_171911915DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneMYLK123339054FLNA153578575ENST0000036077231331464_171911846DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneMYLK123339054FLNA153578575ENST0000036077231331464_171911864DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneMYLK123339054FLNA153578575ENST0000036077232341464_171911864DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneMYLK123339054FLNA153578575ENST0000036077232341464_171911915DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>171_MYLK_FLNAENST00000360772ENST00000360319MYLKchr3123339054FLNAchrX153578575
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP
ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK
FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG
LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS
SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK
FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD
CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL
LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG
EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY
EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH
TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP
PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA
SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL
CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ
FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD
PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT
TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI
MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK
LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR
KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP
GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP
RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV
2108
3D view using mol* of 171_MYLK_FLNA
PDB file >>>HKFP_250_MYLK_FLNAENST00000360772ENST00000360319MYLKchr3123339054FLNAchrX153578575
MCACGRGAPPSAGAPAPGPPSPRGKDSSKLTETNSGQLKRKNKAFLPSDGARLSLEWGSYDLQSNKVAPGCLCCSSEQLQELPSRELQDA
FPVPLAQLPQQTTEKTVTMGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQP
ITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPK
FATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQG
LDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTS
SSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVK
FRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKD
CAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYL
LPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAG
EVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQY
EILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQH
TEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVP
PPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSA
SKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSL
CSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ
FPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPD
PPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELT
TVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISI
MNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIK
LIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARR
KWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDP
GLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGP
RLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHV
2108_MYLK_FLNA


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

MYLK_FLNA does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
171_MYLK_FLNA.png
all structure sitemap plddt 171_MYLK_FLNA.png
171_MYLK_FLNA.png
all structure sitemap plddt2 171_MYLK_FLNA.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

171_MYLK_FLNA_ramachandran.png
all structure MYLK-FLNA

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
all structure MYLK-FLNA
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
171_MYLK_FLNA-DOCK_HTVS_1-001Nilotinib-6.8316300000000005-7.75643-59.181999999999995
171_MYLK_FLNA-DOCK_HTVS_1-001Nilotinib-6.8316300000000005-7.75643-59.181999999999995
171_MYLK_FLNA-DOCK_HTVS_1-001Tepotinib-6.44448-6.4455800000000005-54.3231
171_MYLK_FLNA-DOCK_HTVS_1-001Lapatinib-6.42349-7.591889999999999-60.9337
171_MYLK_FLNA-DOCK_HTVS_1-001Lapatinib-6.42349-7.591889999999999-60.9337
171_MYLK_FLNA-DOCK_HTVS_1-001Selpercatinib-6.255809999999999-6.28631-49.9285
171_MYLK_FLNA-DOCK_HTVS_1-001Selpercatinib-6.255809999999999-6.28631-49.9285
171_MYLK_FLNA-DOCK_HTVS_1-001Sorafenib-6.23022-6.242319999999999-45.3352
171_MYLK_FLNA-DOCK_HTVS_1-001Sorafenib-6.23022-6.242319999999999-45.3352
171_MYLK_FLNA-DOCK_HTVS_1-001Tivozanib-6.17404-6.17404-36.4743
171_MYLK_FLNA-DOCK_HTVS_1-001Ceritinib-6.14851-6.14851-39.0597
171_MYLK_FLNA-DOCK_HTVS_1-001Tucatinib-6.138330000000001-6.60113-38.193000000000005
171_MYLK_FLNA-DOCK_HTVS_1-001Tucatinib-6.138330000000001-6.60113-38.193000000000005
171_MYLK_FLNA-DOCK_HTVS_1-001Netarsudil-6.0978900000000005-6.10899-50.2007
171_MYLK_FLNA-DOCK_HTVS_1-001Netarsudil-6.0978900000000005-6.10899-50.2007
171_MYLK_FLNA-DOCK_HTVS_1-001Regorafenib-6.08085-6.08085-43.2275
171_MYLK_FLNA-DOCK_HTVS_1-001Encorafenib-6.01813-6.406630000000001-51.3761
171_MYLK_FLNA-DOCK_HTVS_1-001Tofacitinib-5.92788-5.93938-34.3159
171_MYLK_FLNA-DOCK_HTVS_1-001Tofacitinib-5.92788-5.93938-34.3159
171_MYLK_FLNA-DOCK_HTVS_1-001Sunitinib-5.91916-5.92336-38.0603

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Kinase-Substrate Information of MYLK_FLNA


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
MYLKQ15746humanMYL2P10916S15KRAGGANsNVFsMFE
MYLKQ15746humanMYL9P24844T19KKRPQRAtsNVFAMF
MYLKQ15746humanMYL12BO14950S20KRPQRAtsNVFAMFD
MYLKQ15746humanMYL9P24844S20KRPQRAtsNVFAMFD
MYLKQ15746humanMYL12BO14950T19KKRPQRAtsNVFAMF


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
MYLKIDDescription0.00e+00
MYLKGO:0030239myofibril assembly1.24e-03
MYLKGO:0055002striated muscle cell development1.24e-03
MYLKGO:0010927cellular component assembly involved in morphogenesis2.55e-03
MYLKGO:0006937regulation of muscle contraction3.36e-03
MYLKGO:0055001muscle cell development3.36e-03
MYLKGO:0031032actomyosin structure organization3.36e-03
MYLKGO:0090257regulation of muscle system process4.06e-03
MYLKGO:0051146striated muscle cell differentiation5.41e-03
MYLKGO:0006936muscle contraction6.36e-03
MYLKGO:0140694non-membrane-bounded organelle assembly7.40e-03
MYLKGO:0042692muscle cell differentiation7.40e-03
MYLKGO:0003012muscle system process7.89e-03
MYLKGO:0055003cardiac myofibril assembly1.27e-02
MYLKGO:0042693muscle cell fate commitment1.27e-02
MYLKGO:0002026regulation of the force of heart contraction1.54e-02
MYLKGO:0055010ventricular cardiac muscle tissue morphogenesis2.61e-02
MYLKGO:0003229ventricular cardiac muscle tissue development3.01e-02
MYLKGO:0055008cardiac muscle tissue morphogenesis3.01e-02
MYLKGO:0003208cardiac ventricle morphogenesis3.13e-02
MYLKGO:0070527platelet aggregation3.13e-02
MYLKGO:0060415muscle tissue morphogenesis3.13e-02
MYLKGO:0048644muscle organ morphogenesis3.26e-02
MYLKGO:0055013cardiac muscle cell development3.31e-02
MYLKGO:0055006cardiac cell development3.37e-02
MYLKGO:0034109homotypic cell-cell adhesion3.37e-02
MYLKGO:0006942regulation of striated muscle contraction3.37e-02
MYLKGO:0001708cell fate specification3.61e-02
MYLKGO:0003206cardiac chamber morphogenesis3.75e-02
MYLKGO:0003231cardiac ventricle development3.75e-02
MYLKGO:0055007cardiac muscle cell differentiation3.75e-02
MYLKGO:0030168platelet activation3.75e-02
MYLKGO:0060048cardiac muscle contraction3.75e-02
MYLKGO:0008360regulation of cell shape3.75e-02
MYLKGO:0035051cardiocyte differentiation4.24e-02
MYLKGO:0003205cardiac chamber development4.24e-02
MYLKGO:0006941striated muscle contraction4.50e-02
MYLKGO:0030308negative regulation of cell growth4.50e-02
MYLKGO:0008016regulation of heart contraction4.73e-02
MYLKGO:0007596blood coagulation4.73e-02
MYLKGO:0050817coagulation4.73e-02
MYLKGO:0007599hemostasis4.73e-02
MYLKGO:0060047heart contraction4.73e-02
MYLKGO:0022604regulation of cell morphogenesis4.73e-02
MYLKGO:0045926negative regulation of growth4.73e-02
MYLKGO:0048738cardiac muscle tissue development4.73e-02
MYLKGO:0003015heart process4.73e-02
MYLKGO:1903522regulation of blood circulation4.73e-02
MYLKGO:0003007heart morphogenesis4.73e-02
MYLKGO:0014706striated muscle tissue development4.73e-02

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Related Drugs to MYLK_FLNA


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning MYLK-FLNA and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to MYLK_FLNA


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate