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Kinase Fusion Gene:MYLK_PARP1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MYLK_PARP1 | KinaseFusionDB ID: KFG4028 | FusionGDB2.0 ID: KFG4028 | Hgene | Tgene | Gene symbol | MYLK | PARP1 | Gene ID | 4638 | 142 | |
| Gene name | myosin light chain kinase | poly(ADP-ribose) polymerase 1 | ||||||||||
| Synonyms | AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MMIHS1|MSTP083|MYLK-L|MYLK1|smMLCK | ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PARS|PPOL|Poly-PARP|pADPRT-1 | ||||||||||
| Cytomap | 3q21.1 | 1q42.12 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | myosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin | poly [ADP-ribose] polymerase 1ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)ADP-ribosyltransferase NAD(+)ADP-ribosyltransferase diphtheria toxin-like 1DNA ADP-ribosyltransferase PARP1NAD(+) ADP-ribosyltransferase 1poly (ADP-ribose) poly | ||||||||||
| Modification date | 20240403 | 20240413 | ||||||||||
| UniProtAcc | Q86YV6 | Q9H0J9 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000359169, ENST00000360304, ENST00000346322, ENST00000354792, ENST00000360772, ENST00000418370, ENST00000475616, ENST00000510775, ENST00000578202, ENST00000583087, | ENST00000366790, ENST00000366791, ENST00000366792, ENST00000366794, ENST00000490921, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MYLK [Title/Abstract] AND PARP1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MYLK(123331145)-PARP1(224102800), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYLK | GO:0030335 | positive regulation of cell migration | 19826488 |
| Hgene | MYLK | GO:0051928 | positive regulation of calcium ion transport | 16284075 |
| Hgene | MYLK | GO:0071476 | cellular hypotonic response | 11976941 |
| Hgene | MYLK | GO:0090303 | positive regulation of wound healing | 15825080 |
| Tgene | PARP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15607977|22464733 |
| Tgene | PARP1 | GO:0006281 | DNA repair | 30104678|30675909|31796734|32028527|33186521|34874266 |
| Tgene | PARP1 | GO:0006302 | double-strand break repair | 24906880|27568560|28190768|32028527 |
| Tgene | PARP1 | GO:0006915 | apoptotic process | 15565177 |
| Tgene | PARP1 | GO:0006974 | DNA damage response | 22683995|32358582|35013556|35393539|37823600 |
| Tgene | PARP1 | GO:0030592 | DNA ADP-ribosylation | 27471034 |
| Tgene | PARP1 | GO:0032786 | positive regulation of DNA-templated transcription, elongation | 27256882 |
| Tgene | PARP1 | GO:0032869 | cellular response to insulin stimulus | 19303849 |
| Tgene | PARP1 | GO:0034244 | negative regulation of transcription elongation by RNA polymerase II | 35393539 |
| Tgene | PARP1 | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 22464733 |
| Tgene | PARP1 | GO:0045824 | negative regulation of innate immune response | 35460603 |
| Tgene | PARP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11112786 |
| Tgene | PARP1 | GO:0050790 | regulation of catalytic activity | 25749521 |
| Tgene | PARP1 | GO:0070212 | protein poly-ADP-ribosylation | 15674325|19470756|25043379 |
| Tgene | PARP1 | GO:0070213 | protein auto-ADP-ribosylation | 15607977|20388712|29234005|30675909|32358582|34210965|34625544 |
| Tgene | PARP1 | GO:0071168 | protein localization to chromatin | 34874266 |
| Tgene | PARP1 | GO:0071932 | replication fork reversal | 33412112 |
| Tgene | PARP1 | GO:0160049 | negative regulation of cGAS/STING signaling pathway | 35460603 |
| Tgene | PARP1 | GO:1905051 | regulation of base-excision repair | 34102106 |
| Tgene | PARP1 | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 26344098|30356214 |
| Tgene | PARP1 | GO:1990966 | ATP generation from poly-ADP-D-ribose | 27257257 |
| Kinase Fusion gene breakpoints across MYLK (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PARP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-HB-A3L4-01A | MYLK | chr3 | 123331145 | PARP1 | chr1 | 224102800 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:123331145/:224102800) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYLK | PARP1 |
| FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. {ECO:0000269|PubMed:25043379}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MYLK_PARP1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MYLK | Q15746 | human | MYL2 | P10916 | S15 | KRAGGANsNVFsMFE | |
| MYLK | Q15746 | human | MYL9 | P24844 | T19 | KKRPQRAtsNVFAMF | |
| MYLK | Q15746 | human | MYL12B | O14950 | S20 | KRPQRAtsNVFAMFD | |
| MYLK | Q15746 | human | MYL9 | P24844 | S20 | KRPQRAtsNVFAMFD | |
| MYLK | Q15746 | human | MYL12B | O14950 | T19 | KKRPQRAtsNVFAMF |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MYLK | ID | Description | 0.00e+00 |
| MYLK | GO:0030239 | myofibril assembly | 1.24e-03 |
| MYLK | GO:0055002 | striated muscle cell development | 1.24e-03 |
| MYLK | GO:0010927 | cellular component assembly involved in morphogenesis | 2.55e-03 |
| MYLK | GO:0006937 | regulation of muscle contraction | 3.36e-03 |
| MYLK | GO:0055001 | muscle cell development | 3.36e-03 |
| MYLK | GO:0031032 | actomyosin structure organization | 3.36e-03 |
| MYLK | GO:0090257 | regulation of muscle system process | 4.06e-03 |
| MYLK | GO:0051146 | striated muscle cell differentiation | 5.41e-03 |
| MYLK | GO:0006936 | muscle contraction | 6.36e-03 |
| MYLK | GO:0140694 | non-membrane-bounded organelle assembly | 7.40e-03 |
| MYLK | GO:0042692 | muscle cell differentiation | 7.40e-03 |
| MYLK | GO:0003012 | muscle system process | 7.89e-03 |
| MYLK | GO:0055003 | cardiac myofibril assembly | 1.27e-02 |
| MYLK | GO:0042693 | muscle cell fate commitment | 1.27e-02 |
| MYLK | GO:0002026 | regulation of the force of heart contraction | 1.54e-02 |
| MYLK | GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 2.61e-02 |
| MYLK | GO:0003229 | ventricular cardiac muscle tissue development | 3.01e-02 |
| MYLK | GO:0055008 | cardiac muscle tissue morphogenesis | 3.01e-02 |
| MYLK | GO:0003208 | cardiac ventricle morphogenesis | 3.13e-02 |
| MYLK | GO:0070527 | platelet aggregation | 3.13e-02 |
| MYLK | GO:0060415 | muscle tissue morphogenesis | 3.13e-02 |
| MYLK | GO:0048644 | muscle organ morphogenesis | 3.26e-02 |
| MYLK | GO:0055013 | cardiac muscle cell development | 3.31e-02 |
| MYLK | GO:0055006 | cardiac cell development | 3.37e-02 |
| MYLK | GO:0034109 | homotypic cell-cell adhesion | 3.37e-02 |
| MYLK | GO:0006942 | regulation of striated muscle contraction | 3.37e-02 |
| MYLK | GO:0001708 | cell fate specification | 3.61e-02 |
| MYLK | GO:0003206 | cardiac chamber morphogenesis | 3.75e-02 |
| MYLK | GO:0003231 | cardiac ventricle development | 3.75e-02 |
| MYLK | GO:0055007 | cardiac muscle cell differentiation | 3.75e-02 |
| MYLK | GO:0030168 | platelet activation | 3.75e-02 |
| MYLK | GO:0060048 | cardiac muscle contraction | 3.75e-02 |
| MYLK | GO:0008360 | regulation of cell shape | 3.75e-02 |
| MYLK | GO:0035051 | cardiocyte differentiation | 4.24e-02 |
| MYLK | GO:0003205 | cardiac chamber development | 4.24e-02 |
| MYLK | GO:0006941 | striated muscle contraction | 4.50e-02 |
| MYLK | GO:0030308 | negative regulation of cell growth | 4.50e-02 |
| MYLK | GO:0008016 | regulation of heart contraction | 4.73e-02 |
| MYLK | GO:0007596 | blood coagulation | 4.73e-02 |
| MYLK | GO:0050817 | coagulation | 4.73e-02 |
| MYLK | GO:0007599 | hemostasis | 4.73e-02 |
| MYLK | GO:0060047 | heart contraction | 4.73e-02 |
| MYLK | GO:0022604 | regulation of cell morphogenesis | 4.73e-02 |
| MYLK | GO:0045926 | negative regulation of growth | 4.73e-02 |
| MYLK | GO:0048738 | cardiac muscle tissue development | 4.73e-02 |
| MYLK | GO:0003015 | heart process | 4.73e-02 |
| MYLK | GO:1903522 | regulation of blood circulation | 4.73e-02 |
| MYLK | GO:0003007 | heart morphogenesis | 4.73e-02 |
| MYLK | GO:0014706 | striated muscle tissue development | 4.73e-02 |
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Related Drugs to MYLK_PARP1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MYLK-PARP1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MYLK_PARP1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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