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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:NACC2_NTRK2

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: NACC2_NTRK2
	KinaseFusionDB ID: KFG4054
	FusionGDB2.0 ID: KFG4054
		Hgene	Tgene
	Gene symbol	NACC2	NTRK2
	Gene ID	138151	4915
	Gene name	NACC family member 2	neurotrophic receptor tyrosine kinase 2
	Synonyms	BEND9\|BTBD14\|BTBD14A\|BTBD31\|NAC-2\|RBB	DEE58\|EIEE58\|GP145-TrkB\|OBHD\|TRKB\|trk-B
	Cytomap	9q34.3	9q21.33
	Type of gene	protein-coding	protein-coding
	Description	nucleus accumbens-associated protein 2BEN domain containing 9BTB (POZ) domain containing 14ABTB/POZ domain-containing protein 14ANACC family member 2, BEN and BTB (POZ) domain containingrepressor with BTB domain and BEN domaintranscription repressor	BDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
	Modification date	20240411	20240411
	UniProtAcc	Q96BF6	Q16620
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000371753, ENST00000277554, ENST00000467669,	ENST00000277120, ENST00000304053, ENST00000323115, ENST00000359847, ENST00000376208, ENST00000376213, ENST00000376214, ENST00000395866, ENST00000395882,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: NACC2 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NACC2	GO:0008285	negative regulation of cell population proliferation	22926524
Hgene	NACC2	GO:0031503	protein-containing complex localization	22926524
Hgene	NACC2	GO:0045892	negative regulation of DNA-templated transcription	22926524
Hgene	NACC2	GO:0051260	protein homooligomerization	22926524
Hgene	NACC2	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	22926524

Kinase Fusion gene breakpoints across NACC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerKB3	.	NACC2	chr9	138905709	NTRK2	chr9	87359887
COSMIC	ICGC_PA134	NACC2	chr9	138905045	NTRK2	chr9	87359888

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000371753	ENST00000376214	NACC2	chr9	138905045	NTRK2	chr9	87359888	4789	869
ENST00000277554	ENST00000376214	NACC2	chr9	138905709	NTRK2	chr9	87359887	4788	442

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000371753_ENST00000376214_NACC2_chr9_138905045_NTRK2_chr9_87359888_length(amino acids)=869
MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQ
QILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPL
LTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDS
PTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELV
AGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKYYGTAANDIGDTTNRSNEIPS
TDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSS
SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK
DFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFV
HRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVI

--------------------------------------------------------------

>ENST00000277554_ENST00000376214_NACC2_chr9_138905709_NTRK2_chr9_87359887_length(amino acids)=442
MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV
ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL
CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ
SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NACC2 Q96BF6	NTRK2 Q16620

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	8	12	295_365	242	322	Domain	Note=Ig-like C2-type 2
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	8	12	295_365	242	322	Domain	Note=Ig-like C2-type 2
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	11	20	538_807	398	823	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	11	21	538_807	398	839	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	8	12	538_807	242	322	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	8	12	538_807	398	478	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	8	17	538_807	398	823	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	9	13	538_807	398	478	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	9	14	538_807	398	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	9	15	538_807	398	554	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905045	NTRK2	87359888	ENST00000371753	9	19	538_807	398	839	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	11	20	538_807	398	823	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	11	21	538_807	398	839	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	8	12	538_807	242	322	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	8	12	538_807	398	478	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	8	17	538_807	398	823	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	9	13	538_807	398	478	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	9	14	538_807	398	538	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	9	15	538_807	398	554	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	NACC2	138905709	NTRK2	87359887	ENST00000277554	9	19	538_807	398	839	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>326_NACC2_NTRK2	ENST00000277554	ENST00000376214	NACC2	chr9	138905709	NTRK2	chr9	87359887	MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG	442
3D view using mol* of 326_NACC2_NTRK2

PDB file >>>TKFP_558_NACC2_NTRK2	ENST00000371753	ENST00000376214	NACC2	chr9	138905045	NTRK2	chr9	87359888	MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQ QILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPL LTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDS PTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELV AGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKYYGTAANDIGDTTNRSNEIPS TDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSS SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK DFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFV HRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVI	869_NACC2_NTRK2
PDB file >>>TKFP_559_NACC2_NTRK2	ENST00000277554	ENST00000376214	NACC2	chr9	138905709	NTRK2	chr9	87359887	MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG	442_NACC2_NTRK2
3D view using mol* of TKFP_559_NACC2_NTRK2

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/TKFP_558_NACC2_NTRK2_vs_TKFP_559_NACC2_NTRK2_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/TKFP_559_NACC2_NTRK2_vs_TKFP_558_NACC2_NTRK2.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

NACC2_NTRK2 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/326_NACC2_NTRK2.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_559_NACC2_NTRK2_updated_violin_plot.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

326_NACC2_NTRK2.png

TKFP_559_NACC2_NTRK2.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
TKFP_559_NACC2_NTRK2	1.021	504	1.041	1687.903	0.554	0.722	0.909	0.519	1.02	0.509	0.987	Chain A: 89,91,92,93,94,95,96,97,98,99,100,101,102 ,103,104,105,106,130,132,133,135,136,137,139,140,1 41,160,166,167,168,169,170,171,173,192,193,194,195 ,196,197,198,200,201,203,204,205,207,208,211,212,2 15,220,221,222,223,231,232,233,235,237,287,291,292 ,293,294,295,296,301,312,313,314,315,316,318,319,3 20,323,326,328,334,335,336,348,350,351,352

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

326_NACC2_NTRK2_ramachandran.png

TKFP_559_NACC2_NTRK2_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info

Drug

Docking score

Glide g score

Glide energy

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Kinase-Substrate Information of NACC2_NTRK2

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
NTRK2	Q16620	human	NTRK2	Q16620	Y516	PVIENPQyFGITNSQ
NTRK2	Q16620	human	SHC3	Q92529-2	Y218	GDGSDHPyyNSIPSK
NTRK2	Q16620	human	SHC3	Q92529-2	Y256	FAGKEQTyyQGRHLG
NTRK2	Q16620	human	KCNA3	P22001	Y499	EGEEQSQyMHVGsCQ
NTRK2	Q16620	human	KCNA3	P22001	Y161	PSFDAILyyyQSGGR	BTB_2
NTRK2	Q16620	human	KCNA3	P22001	Y162	SFDAILyyyQSGGRI	BTB_2
NTRK2	Q16620	human	SHC3	Q92529-2	Y301	PTGEAPTyVNTQQIP
NTRK2	Q16620	human	SHC3	Q92529-2	Y257	AGKEQTyyQGRHLGD
NTRK2	Q16620	human	SHC3	Q92529-2	Y283	RQGSSDIySTPEGKL
NTRK2	Q16620	human	SHC3	Q92529-2	Y219	DGSDHPyyNSIPSKM
NTRK2	Q16620	human	KCNA3	P22001	Y163	FDAILyyyQSGGRIR	BTB_2

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
NTRK2	ID	Description	0.00e+00
NTRK2	GO:0021537	telencephalon development	3.61e-02
NTRK2	GO:0030900	forebrain development	3.61e-02
NTRK2	GO:0099550	trans-synaptic signalin	1.59e-03
NTRK2	GO:0048935	peripheral nervous system neuron development	3.61e-02
NTRK2	GO:0060221	retinal rod cell differentiation	3.61e-02
NTRK2	GO:2000811	negative regulation of anoikis	3.61e-02
NTRK2	GO:0021554	optic nerve development	3.61e-02
NTRK2	GO:2000209	regulation of anoikis	3.61e-02
NTRK2	GO:0022038	corpus callosum development	3.61e-02
NTRK2	GO:0014047	glutamate secretion	3.61e-02
NTRK2	GO:0022011	myelination in peripheral nervous system	3.61e-02
NTRK2	GO:0032292	peripheral nervous system axon ensheathment	3.61e-02
NTRK2	GO:1902430	negative regulation of amyloid-beta formation	3.61e-02
NTRK2	GO:0060219	camera-type eye photoreceptor cell differentiation	3.61e-02
NTRK2	GO:0014044	Schwann cell development	3.61e-02
NTRK2	GO:1902992	negative regulation of amyloid precursor protein catabolic process	3.61e-02
NTRK2	GO:0042462	eye photoreceptor cell development	3.61e-02
NTRK2	GO:0043276	anoikis	3.61e-02
NTRK2	GO:0014037	Schwann cell differentiation	3.74e-02
NTRK2	GO:0038179	neurotrophin signaling pathway	3.74e-02
NTRK2	GO:1990090	cellular response to nerve growth factor stimulus	3.75e-02
NTRK2	GO:0001754	eye photoreceptor cell differentiation	3.75e-02
NTRK2	GO:1902003	regulation of amyloid-beta formation	3.75e-02
NTRK2	GO:1990089	response to nerve growth factor	3.75e-02
NTRK2	GO:0042461	photoreceptor cell development	3.75e-02
NTRK2	GO:1902991	regulation of amyloid precursor protein catabolic process	3.75e-02
NTRK2	GO:0034205	amyloid-beta formation	3.75e-02
NTRK2	GO:0021545	cranial nerve development	3.75e-02
NTRK2	GO:0051965	positive regulation of synapse assembly	3.75e-02
NTRK2	GO:0046530	photoreceptor cell differentiation	3.75e-02
NTRK2	GO:0050435	amyloid-beta metabolic process	3.75e-02
NTRK2	GO:0060042	retina morphogenesis in camera-type eye	3.75e-02
NTRK2	GO:0015800	acidic amino acid transport	3.75e-02
NTRK2	GO:0042490	mechanoreceptor differentiation	3.75e-02
NTRK2	GO:0042987	amyloid precursor protein catabolic process	3.75e-02
NTRK2	GO:0019226	transmission of nerve impulse	3.75e-02
NTRK2	GO:0050772	positive regulation of axonogenesis	4.05e-02
NTRK2	GO:0003407	neural retina development	4.05e-02
NTRK2	GO:0007422	peripheral nervous system development	4.05e-02
NTRK2	GO:0001570	vasculogenesis	4.05e-02
NTRK2	GO:0071230	cellular response to amino acid stimulus	4.05e-02
NTRK2	GO:0021954	central nervous system neuron development	4.05e-02
NTRK2	GO:0071229	cellular response to acid chemical	4.05e-02
NTRK2	GO:0042982	amyloid precursor protein metabolic process	4.05e-02
NTRK2	GO:0021675	nerve development	4.05e-02
NTRK2	GO:0006835	dicarboxylic acid transport	4.05e-02
NTRK2	GO:0033138	positive regulation of peptidyl-serine phosphorylation	4.05e-02
NTRK2	GO:0007631	feeding behavior	4.05e-02
NTRK2	GO:0048709	oligodendrocyte differentiation	4.05e-02

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Related Drugs to NACC2_NTRK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning NACC2-NTRK2 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1	Fusion gene - drug pair 2	PMID	Publication date	DOI	Study title
ETV6-NTRK3 AND Larotrectinib	NACC2-NTRK2 AND Larotrectinib	33093355	2020-10-21	10.1097/mph.0000000000001983	Adjuvant Maintenance Larotrectinib Therapy in 2 Children With NTRK Fusion-positive High-grade Cancers.

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Related Diseases to NACC2_NTRK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
NACC2	NTRK2	Squamous Cell Carcinoma	MyCancerGenome
NACC2	NTRK2	Cancer Of Unknown Primary	MyCancerGenome
NACC2	NTRK2	Nos	MyCancerGenome
NACC2	NTRK2	High-Grade Neuroepithelial Tumor	MyCancerGenome
NACC2	NTRK2	Invasive Breast Carcinoma	MyCancerGenome
NACC2	NTRK2	Lung Adenocarcinoma	MyCancerGenome

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NTRK2	C0011570	Mental Depression	5	PSYGENET
Tgene	NTRK2	C0011581	Depressive disorder	5	PSYGENET
Tgene	NTRK2	C0041696	Unipolar Depression	5	PSYGENET
Tgene	NTRK2	C1269683	Major Depressive Disorder	5	PSYGENET
Tgene	NTRK2	C0525045	Mood Disorders	5	PSYGENET
Tgene	NTRK2	C3151303	Obesity, Hyperphagia, and Developmental Delay	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	NTRK2	C4693367	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 58	3	GENOMICS_ENGLAND;UNIPROT
Tgene	NTRK2	C0005586	Bipolar Disorder	3	CTD_human;PSYGENET
Tgene	NTRK2	C0393734	Complex Partial Status Epilepticus	2	CTD_human
Tgene	NTRK2	C3887506	Hyperkinesia	2	CTD_human
Tgene	NTRK2	C0751524	Simple Partial Status Epilepticus	2	CTD_human
Tgene	NTRK2	C0751523	Non-Convulsive Status Epilepticus	2	CTD_human
Tgene	NTRK2	C0751522	Status Epilepticus, Subclinical	2	CTD_human
Tgene	NTRK2	C0751217	Hyperkinesia, Generalized	2	CTD_human
Tgene	NTRK2	C0600427	Cocaine Dependence	2	CTD_human
Tgene	NTRK2	C0311335	Grand Mal Status Epilepticus	2	CTD_human
Tgene	NTRK2	C0270823	Petit mal status	2	CTD_human
Tgene	NTRK2	C0236736	Cocaine-Related Disorders	2	CTD_human
Tgene	NTRK2	C0038220	Status Epilepticus	2	CTD_human
Tgene	NTRK2	C0036341	Schizophrenia	2	PSYGENET
Tgene	NTRK2	C0009171	Cocaine Abuse	2	CTD_human

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date