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Kinase Fusion Gene:NDST2_CAMK2G |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: NDST2_CAMK2G | KinaseFusionDB ID: KFG4087 | FusionGDB2.0 ID: KFG4087 | Hgene | Tgene | Gene symbol | NDST2 | CAMK2G | Gene ID | 8509 | 818 | |
| Gene name | N-deacetylase and N-sulfotransferase 2 | calcium/calmodulin dependent protein kinase II gamma | ||||||||||
| Synonyms | HSST2|N-HSST 2|NST2 | CAMK|CAMK-II|CAMKG|MRD59 | ||||||||||
| Cytomap | 10q22.2 | 10q22.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2N-heparan sulfate sulfotransferase 2glucosaminyl N-deacetylase/N-sulfotransferase 2 | calcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | P52849 | Q13555 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000309979, ENST00000299641, ENST00000398701, | ENST00000351293, ENST00000322635, ENST00000394762, ENST00000423381, ENST00000322680, ENST00000305762, ENST00000372765, ENST00000472912, ENST00000444854, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: NDST2 [Title/Abstract] AND CAMK2G [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Kinase Fusion gene breakpoints across NDST2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CAMK2G (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | TCCSUP | NDST2 | chr10 | 75562432 | CAMK2G | chr10 | 75597269 |
| CCLE | TCCSUP | NDST2 | chr10 | 75562432 | CAMK2G | chr10 | 75599359 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:/chr10:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDST2 | CAMK2G |
| FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16343444, ECO:0000269|PubMed:22660413}. | FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q923T9, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of NDST2_CAMK2G |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CAMK2G | Q13555 | human | CAMK2G | Q13555 | S319 | RNFsAAKsLLNKKsD | |
| CAMK2G | Q13555 | human | ITPKB | P27987 | S174 | PRLGRARsPsPCPFR | |
| CAMK2G | Q13555 | human | CAMK2G | Q13555 | S280 | CQRsTVAsMMHRQEt | |
| CAMK2G | Q13555 | human | DAB2 | P98082 | S723 | KPAPRQVsLPVTkst | |
| CAMK2G | Q13555 | human | NR1H2 | P55055 | S426 | RMLMKLVsLRTLsSV | Hormone_recep |
| CAMK2G | Q13555 | human | OCLN | Q16625 | S471 | LDDyREEsEEyMAAA | Occludin_ELL |
| CAMK2G | Q13555 | human | CACNA1H | O95180 | S1198 | tPLRRAEsLDPRPLR |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CAMK2G | ID | Description | 0.00e+00 |
| CAMK2G | GO:0032342 | aldosterone biosynthetic process | 6.72e-04 |
| CAMK2G | GO:0006705 | mineralocorticoid biosynthetic process | 6.72e-04 |
| CAMK2G | GO:0032341 | aldosterone metabolic process | 6.72e-04 |
| CAMK2G | GO:0008212 | mineralocorticoid metabolic process | 6.72e-04 |
| CAMK2G | GO:0034309 | primary alcohol biosynthetic process | 6.72e-04 |
| CAMK2G | GO:0046165 | alcohol biosynthetic process | 6.72e-04 |
| CAMK2G | GO:0046184 | aldehyde biosynthetic process | 6.72e-04 |
| CAMK2G | GO:0006700 | C21-steroid hormone biosynthetic process | 9.30e-04 |
| CAMK2G | GO:0120255 | olefinic compound biosynthetic process | 1.54e-03 |
| CAMK2G | GO:0042180 | cellular ketone metabolic process | 1.54e-03 |
| CAMK2G | GO:1901617 | organic hydroxy compound biosynthetic process | 1.91e-03 |
| CAMK2G | GO:0008207 | C21-steroid hormone metabolic process | 2.17e-03 |
| CAMK2G | GO:0120178 | steroid hormone biosynthetic process | 2.84e-03 |
| CAMK2G | GO:0042181 | ketone biosynthetic process | 3.14e-03 |
| CAMK2G | GO:1902074 | response to salt | 4.27e-03 |
| CAMK2G | GO:0006066 | alcohol metabolic process | 4.27e-03 |
| CAMK2G | GO:0042446 | hormone biosynthetic process | 4.91e-03 |
| CAMK2G | GO:0006081 | cellular aldehyde metabolic process | 5.22e-03 |
| CAMK2G | GO:0032370 | positive regulation of lipid transport | 7.46e-03 |
| CAMK2G | GO:0046889 | positive regulation of lipid biosynthetic process | 7.77e-03 |
| CAMK2G | GO:0034308 | primary alcohol metabolic process | 1.03e-02 |
| CAMK2G | GO:1905954 | positive regulation of lipid localization | 1.07e-02 |
| CAMK2G | GO:0010565 | regulation of cellular ketone metabolic process | 1.65e-02 |
| CAMK2G | GO:0045834 | positive regulation of lipid metabolic process | 1.65e-02 |
| CAMK2G | GO:0062013 | positive regulation of small molecule metabolic process | 1.65e-02 |
| CAMK2G | GO:0032368 | regulation of lipid transport | 1.72e-02 |
| CAMK2G | GO:0120254 | olefinic compound metabolic process | 1.85e-02 |
| CAMK2G | GO:1905952 | regulation of lipid localization | 2.22e-02 |
| CAMK2G | GO:0006694 | steroid biosynthetic process | 2.22e-02 |
| CAMK2G | GO:0046890 | regulation of lipid biosynthetic process | 2.23e-02 |
| CAMK2G | GO:0009755 | hormone-mediated signaling pathway | 2.23e-02 |
| CAMK2G | GO:0031334 | positive regulation of protein-containing complex assembly | 2.23e-02 |
| CAMK2G | GO:1902075 | cellular response to salt | 2.23e-02 |
| CAMK2G | GO:0071248 | cellular response to metal ion | 2.23e-02 |
| CAMK2G | GO:0071241 | cellular response to inorganic substance | 2.84e-02 |
| CAMK2G | GO:0042445 | hormone metabolic process | 3.05e-02 |
| CAMK2G | GO:0045017 | glycerolipid biosynthetic process | 3.07e-02 |
| CAMK2G | GO:0034651 | cortisol biosynthetic process | 3.07e-02 |
| CAMK2G | GO:1902645 | tertiary alcohol biosynthetic process | 3.07e-02 |
| CAMK2G | GO:1903532 | positive regulation of secretion by cell | 3.07e-02 |
| CAMK2G | GO:0030100 | regulation of endocytosis | 3.07e-02 |
| CAMK2G | GO:0010887 | negative regulation of cholesterol storage | 3.07e-02 |
| CAMK2G | GO:0030157 | pancreatic juice secretion | 3.07e-02 |
| CAMK2G | GO:2000344 | positive regulation of acrosome reaction | 3.07e-02 |
| CAMK2G | GO:2000833 | positive regulation of steroid hormone secretion | 3.07e-02 |
| CAMK2G | GO:0006650 | glycerophospholipid metabolic process | 3.07e-02 |
| CAMK2G | GO:0032957 | inositol trisphosphate metabolic process | 3.07e-02 |
| CAMK2G | GO:0034650 | cortisol metabolic process | 3.07e-02 |
| CAMK2G | GO:0048548 | regulation of pinocytosis | 3.07e-02 |
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Related Drugs to NDST2_CAMK2G |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning NDST2-CAMK2G and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to NDST2_CAMK2G |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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