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Kinase Fusion Gene:NEK6_LHX2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: NEK6_LHX2 | KinaseFusionDB ID: KFG4144 | FusionGDB2.0 ID: KFG4144 | Hgene | Tgene | Gene symbol | NEK6 | LHX2 | Gene ID | 10783 | 9355 | |
| Gene name | NIMA related kinase 6 | LIM homeobox 2 | ||||||||||
| Synonyms | SID6-1512 | LH2|hLhx2 | ||||||||||
| Cytomap | 9q33.3 | 9q33.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase Nek6NIMA (never in mitosis gene a)-related kinase 6never in mitosis A-related kinase 6nimA-related protein kinase 6protein kinase SID6-1512putative serine-threonine protein kinase | LIM/homeobox protein Lhx2LIM HOX gene 2LIM homeobox protein 2homeobox protein LH-2 | ||||||||||
| Modification date | 20240305 | 20240305 | ||||||||||
| UniProtAcc | Q9HC98 | P50458 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000320246, ENST00000373600, ENST00000373603, ENST00000394199, ENST00000539416, ENST00000540326, ENST00000545174, ENST00000546191, | ENST00000373615, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: NEK6 [Title/Abstract] AND LHX2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NEK6(127020364)-LHX2(126776240), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEK6 | GO:0006468 | protein phosphorylation | 12840024|31409757 |
| Hgene | NEK6 | GO:0007059 | chromosome segregation | 14563848 |
| Hgene | NEK6 | GO:0018105 | peptidyl-serine phosphorylation | 19001501 |
| Hgene | NEK6 | GO:0030071 | regulation of mitotic metaphase/anaphase transition | 14563848 |
| Hgene | NEK6 | GO:0046777 | protein autophosphorylation | 14563848|20873783 |
| Kinase Fusion gene breakpoints across NEK6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across LHX2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-13-1405-01A | NEK6 | chr9 | 127020364 | LHX2 | chr9 | 126776240 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:127020364/:126776240) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEK6 | LHX2 |
| FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946, PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). {ECO:0000269|PubMed:11516946, ECO:0000269|PubMed:12054534, ECO:0000269|PubMed:14563848, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:19414596, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:21099361, ECO:0000269|PubMed:31409757}. | FUNCTION: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of NEK6_LHX2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| NEK6 | Q9HC98 | human | KIF20A | O95235 | S754 | ELQkLGEsLQsAERA | |
| NEK6 | Q9HC98 | human | SGK1 | O00141 | S377 | PPFNPNVsGPNDLRH | Pkinase_C |
| NEK6 | Q9HC98 | human | BSG | P35613-2 | S252 | GsAPLKSsGQHQNDK | |
| NEK6 | Q9HC98 | human | DDR1 | Q08345 | S788 | KIADFGMsRNLyAGD | PK_Tyr_Ser-Thr |
| NEK6 | Q9HC98 | human | ACD | Q96AP0 | S169 | sNAGLSLsQLLDEMR | |
| NEK6 | Q9HC98 | human | RBL2 | Q08999 | S659 | DTGGLGRsItsPttL | |
| NEK6 | Q9HC98 | human | RPS6KB1 | P23443 | T412 | NQVFLGFtyVAPsVL | Pkinase_C |
| NEK6 | Q9HC98 | human | NUP98 | P52948-2 | S591 | VLKNLNNsNLFsPVN | |
| NEK6 | Q9HC98 | human | EML4 | Q9HC35 | S144 | QsPQIRAsPsPQPss | |
| NEK6 | Q9HC98 | human | KIF11 | P52732 | S1033 | GINtLERskVEETTE | Microtub_bind |
| NEK6 | Q9HC98 | human | STAT3 | P40763 | S727 | NtIDLPMsPrTLDSL | |
| NEK6 | Q9HC98 | human | STAT3 | P40763 | Y705 | DPGsAAPyLktKFIC | |
| NEK6 | Q9HC98 | human | KIF20A | O95235 | S683 | RsQRLAAsAstQQLQ | |
| NEK6 | Q9HC98 | human | GRIN1 | Q05586 | S890 | ITSTLASsFKRRRss | |
| NEK6 | Q9HC98 | human | KIF20A | O95235 | S883 | RRsPLLKsGPFGKKY | |
| NEK6 | Q9HC98 | human | RPS6KB1 | P23443 | S403 | DDStLSEsANQVFLG | Pkinase_C |
| NEK6 | Q9HC98 | human | RPS6KB1 | P23443 | S53 | EGGQLNEsMDHGGVG | |
| NEK6 | Q9HC98 | human | KIF20A | O95235 | S240 | QEEELSTsLkRsVyI | Kinesin |
| NEK6 | Q9HC98 | human | SGK1 | O00141 | S422 | AEAFLGFsYAPPTDS | Pkinase_C |
| NEK6 | Q9HC98 | human | PSMD2 | Q13200 | S361 | ENNrFGGsGsQVDsA | |
| NEK6 | Q9HC98 | human | CDK7 | P50613 | S161 | ADFGLAksFGsPNRA | Pkinase |
| NEK6 | Q9HC98 | human | KIF20A | O95235 | S244 | LSTsLkRsVyIEsRI | Kinesin |
| NEK6 | Q9HC98 | human | HSPA1B | P0DMV8 | T66 | VALNPQNtVFDAkRL | HSP70 |
| NEK6 | Q9HC98 | human | ERCC2 | P18074 | T425 | IEPFDDRtPTIANPI | |
| NEK6 | Q9HC98 | human | NUP98 | P52948-2 | S822 | TSRCLIKsPDRLADI | Nucleoporin2 |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| NEK6 | ID | Description | 0.00e+00 |
| NEK6 | GO:0030218 | erythrocyte differentiation | 4.67e-02 |
| NEK6 | GO:0098781 | ncRNA transcription | 4.67e-02 |
| NEK6 | GO:0034101 | erythrocyte homeostasis | 4.67e-02 |
| NEK6 | GO:0045648 | positive regulation of erythrocyte differentiation | 4.67e-02 |
| NEK6 | GO:0007059 | chromosome segregation | 4.67e-02 |
| NEK6 | GO:0002262 | myeloid cell homeostasis | 4.67e-02 |
| NEK6 | GO:0000070 | mitotic sister chromatid segregation | 4.67e-02 |
| NEK6 | GO:0007616 | long-term memory | 4.67e-02 |
| NEK6 | GO:0044772 | mitotic cell cycle phase transition | 4.86e-02 |
| NEK6 | GO:0071383 | cellular response to steroid hormone stimulus | 4.98e-02 |
| NEK6 | GO:0045646 | regulation of erythrocyte differentiation | 4.98e-02 |
| NEK6 | GO:0000819 | sister chromatid segregation | 5.58e-02 |
| NEK6 | GO:0000082 | G1/S transition of mitotic cell cycle | 5.94e-02 |
| NEK6 | GO:0007566 | embryo implantation | 5.94e-02 |
| NEK6 | GO:0071384 | cellular response to corticosteroid stimulus | 5.94e-02 |
| NEK6 | GO:0097305 | response to alcohol | 5.94e-02 |
| NEK6 | GO:0032757 | positive regulation of interleukin-8 production | 6.03e-02 |
| NEK6 | GO:0007611 | learning or memory | 6.18e-02 |
| NEK6 | GO:0140014 | mitotic nuclear division | 6.18e-02 |
| NEK6 | GO:0044843 | cell cycle G1/S phase transition | 6.18e-02 |
| NEK6 | GO:0090307 | mitotic spindle assembly | 6.18e-02 |
| NEK6 | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 6.32e-02 |
| NEK6 | GO:0098813 | nuclear chromosome segregation | 7.17e-02 |
| NEK6 | GO:0048872 | homeostasis of number of cells | 7.17e-02 |
| NEK6 | GO:0050890 | cognition | 7.17e-02 |
| NEK6 | GO:0048545 | response to steroid hormone | 7.73e-02 |
| NEK6 | GO:0014909 | smooth muscle cell migration | 8.10e-02 |
| NEK6 | GO:0045862 | positive regulation of proteolysis | 8.10e-02 |
| NEK6 | GO:1901990 | regulation of mitotic cell cycle phase transition | 8.10e-02 |
| NEK6 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 8.10e-02 |
| NEK6 | GO:0032677 | regulation of interleukin-8 production | 8.10e-02 |
| NEK6 | GO:0045639 | positive regulation of myeloid cell differentiation | 8.10e-02 |
| NEK6 | GO:1901655 | cellular response to ketone | 8.10e-02 |
| NEK6 | GO:0032637 | interleukin-8 production | 8.10e-02 |
| NEK6 | GO:0014812 | muscle cell migration | 8.78e-02 |
| NEK6 | GO:0050000 | chromosome localization | 8.90e-02 |
| NEK6 | GO:0051090 | regulation of DNA-binding transcription factor activity | 8.90e-02 |
| NEK6 | GO:0045471 | response to ethanol | 8.90e-02 |
| NEK6 | GO:0007613 | memory | 8.90e-02 |
| NEK6 | GO:0001558 | regulation of cell growth | 8.90e-02 |
| NEK6 | GO:0043200 | response to amino acid | 8.90e-02 |
| NEK6 | GO:0030099 | myeloid cell differentiation | 8.90e-02 |
| NEK6 | GO:0043434 | response to peptide hormone | 8.90e-02 |
| NEK6 | GO:0007052 | mitotic spindle organization | 8.90e-02 |
| NEK6 | GO:0051225 | spindle assembly | 8.90e-02 |
| NEK6 | GO:0000280 | nuclear division | 8.90e-02 |
| NEK6 | GO:1901987 | regulation of cell cycle phase transition | 8.90e-02 |
| NEK6 | GO:0001101 | response to acid chemical | 8.90e-02 |
| NEK6 | GO:0072594 | establishment of protein localization to organelle | 8.90e-02 |
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Related Drugs to NEK6_LHX2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning NEK6-LHX2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to NEK6_LHX2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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