Description | nucleoside diphosphate kinase, mitochondrialNDKNDP kinase DNDP kinase, mitochondrialNDPKDnon-metastatic cells 4, protein expressed innucleoside diphosphate kinase D | breakpoint cluster region proteinBCR, RhoGEF and GTPase activating proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26 |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000219479, ENST00000397722, ENST00000382940, ENST00000450036,
| ENST00000305877, ENST00000359540, ENST00000398512, ENST00000436990,
|
Hgene | Tgene |
NME4
O00746 | BCR
P11274 |
FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as a mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663). {ECO:0000269|PubMed:10799505, ECO:0000269|PubMed:17028143, ECO:0000269|PubMed:18635542, ECO:0000269|PubMed:23150663, ECO:0000305, ECO:0000305|PubMed:24970086}. | FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}. |
Kinase | GOID | GO term | P.adjust |
BCR | ID | Description | 0.00e+00 |
BCR | GO:0007265 | Ras protein signal transduction | 4.45e-04 |
BCR | GO:2000404 | regulation of T cell migration | 8.95e-04 |
BCR | GO:0007264 | small GTPase mediated signal transduction | 8.95e-04 |
BCR | GO:0002685 | regulation of leukocyte migration | 1.08e-03 |
BCR | GO:2000401 | regulation of lymphocyte migration | 1.11e-03 |
BCR | GO:0072678 | T cell migration | 1.11e-03 |
BCR | GO:0048041 | focal adhesion assembly | 1.50e-03 |
BCR | GO:0007044 | cell-substrate junction assembly | 1.54e-03 |
BCR | GO:0034446 | substrate adhesion-dependent cell spreading | 1.54e-03 |
BCR | GO:0150115 | cell-substrate junction organization | 1.54e-03 |
BCR | GO:0032956 | regulation of actin cytoskeleton organization | 1.54e-03 |
BCR | GO:0110020 | regulation of actomyosin structure organization | 1.54e-03 |
BCR | GO:1905244 | regulation of modification of synaptic structure | 1.54e-03 |
BCR | GO:0031589 | cell-substrate adhesion | 1.74e-03 |
BCR | GO:0003188 | heart valve formation | 1.81e-03 |
BCR | GO:0032970 | regulation of actin filament-based process | 1.81e-03 |
BCR | GO:0072676 | lymphocyte migration | 1.81e-03 |
BCR | GO:0071675 | regulation of mononuclear cell migration | 1.81e-03 |
BCR | GO:1902903 | regulation of supramolecular fiber organization | 1.81e-03 |
BCR | GO:0050900 | leukocyte migration | 1.84e-03 |
BCR | GO:0007266 | Rho protein signal transduction | 2.09e-03 |
BCR | GO:2000377 | regulation of reactive oxygen species metabolic process | 2.47e-03 |
BCR | GO:0034329 | cell junction assembly | 2.55e-03 |
BCR | GO:0030010 | establishment of cell polarity | 2.70e-03 |
BCR | GO:0006312 | mitotic recombination | 3.06e-03 |
BCR | GO:0000724 | double-strand break repair via homologous recombination | 3.36e-03 |
BCR | GO:1902905 | positive regulation of supramolecular fiber organization | 3.36e-03 |
BCR | GO:0099563 | modification of synaptic structure | 3.36e-03 |
BCR | GO:0000725 | recombinational repair | 3.36e-03 |
BCR | GO:0051495 | positive regulation of cytoskeleton organization | 3.52e-03 |
BCR | GO:0061138 | morphogenesis of a branching epithelium | 3.58e-03 |
BCR | GO:0042770 | signal transduction in response to DNA damage | 3.58e-03 |
BCR | GO:0033688 | regulation of osteoblast proliferation | 3.59e-03 |
BCR | GO:0045907 | positive regulation of vasoconstriction | 3.71e-03 |
BCR | GO:0001763 | morphogenesis of a branching structure | 3.90e-03 |
BCR | GO:0050851 | antigen receptor-mediated signaling pathway | 3.90e-03 |
BCR | GO:0071674 | mononuclear cell migration | 3.90e-03 |
BCR | GO:2000406 | positive regulation of T cell migration | 3.90e-03 |
BCR | GO:0031032 | actomyosin structure organization | 3.90e-03 |
BCR | GO:0033687 | osteoblast proliferation | 4.01e-03 |
BCR | GO:0006282 | regulation of DNA repair | 4.09e-03 |
BCR | GO:0010810 | regulation of cell-substrate adhesion | 4.27e-03 |
BCR | GO:0071222 | cellular response to lipopolysaccharide | 4.52e-03 |
BCR | GO:0007163 | establishment or maintenance of cell polarity | 4.53e-03 |
BCR | GO:0072593 | reactive oxygen species metabolic process | 4.65e-03 |
BCR | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 4.65e-03 |
BCR | GO:2000403 | positive regulation of lymphocyte migration | 4.65e-03 |
BCR | GO:0007160 | cell-matrix adhesion | 4.67e-03 |
BCR | GO:0071219 | cellular response to molecule of bacterial origin | 4.67e-03 |