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Kinase Fusion Gene:NOL4_PLK2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: NOL4_PLK2 | KinaseFusionDB ID: KFG4224 | FusionGDB2.0 ID: KFG4224 | Hgene | Tgene | Gene symbol | NOL4 | PLK2 | Gene ID | 8715 | 10769 | |
| Gene name | nucleolar protein 4 | polo like kinase 2 | ||||||||||
| Synonyms | CT125|HRIHFB2255|NOLP | SNK|hPlk2|hSNK | ||||||||||
| Cytomap | 18q12.1 | 5q11.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | nucleolar protein 4cancer/testis antigen 125nucleolar localized protein | serine/threonine-protein kinase PLK2PLK-2serine/threonine-protein kinase SNKserum-inducible kinase | ||||||||||
| Modification date | 20240403 | 20240305 | ||||||||||
| UniProtAcc | O94818 | Q9NYY3 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261592, ENST00000269185, ENST00000535384, ENST00000535475, ENST00000538587, ENST00000589544, ENST00000590846, | ENST00000274289, ENST00000502671, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: NOL4 [Title/Abstract] AND PLK2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NOL4(31712694)-PLK2(57749813), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PLK2 | GO:0006468 | protein phosphorylation | 20352051 |
| Tgene | PLK2 | GO:0007052 | mitotic spindle organization | 19001868 |
| Tgene | PLK2 | GO:0010508 | positive regulation of autophagy | 23983262 |
| Tgene | PLK2 | GO:0018105 | peptidyl-serine phosphorylation | 23983262 |
| Tgene | PLK2 | GO:0045732 | positive regulation of protein catabolic process | 23983262 |
| Tgene | PLK2 | GO:0046599 | regulation of centriole replication | 19001868|20352051|20531387 |
| Kinase Fusion gene breakpoints across NOL4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PLK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BI494851 | NOL4 | chr18 | 31712694 | PLK2 | chr5 | 57749813 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31712694/:57749813) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOL4 | PLK2 |
| FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:20531387}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of NOL4_PLK2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PLK2 | Q9NYY3 | human | CRYAB | P02511 | S19 | RPFFPFHsPsrLFDQ | Crystallin |
| PLK2 | Q9NYY3 | human | YWHAE | P62258 | T208 | DAIAELDtLsEEsyk | 14-3-3 |
| PLK2 | Q9NYY3 | human | CALU | O43852 | S44 | kVHNDAQsFDyDHDA | |
| PLK2 | Q9NYY3 | human | CENPJ | Q9HC77 | S595 | IsFSSNSsFVLKILE | |
| PLK2 | Q9NYY3 | human | FBXW7 | Q969H0 | S349 | IKPGFIHsPWKSAYI | |
| PLK2 | Q9NYY3 | human | CALU | O43852 | T60 | LGAEEAktFDQLtPE | |
| PLK2 | Q9NYY3 | human | SNCB | Q16143 | S118 | LMEPEGEsYEDPPQE | Synuclein |
| PLK2 | Q9NYY3 | human | PLK1 | P53350 | S137 | LELCRRRsLLELHkR | Pkinase |
| PLK2 | Q9NYY3 | human | SNCA | P37840 | S129 | NEAyEMPsEEGyQDy | Synuclein |
| PLK2 | Q9NYY3 | human | CENPJ | Q9HC77 | S589 | EQAADEIsFSSNSsF | |
| PLK2 | Q9NYY3 | human | TP73 | O15350 | S48 | VVGGTDssMDVFHLE | |
| PLK2 | Q9NYY3 | human | CALU | O43852 | T196 | KDIVVQEtMEDIDKN | EF-hand_5 |
| PLK2 | Q9NYY3 | human | NPM1 | P06748 | S4 | ____MEDsMDMDMsP | |
| PLK2 | Q9NYY3 | human | FBXW7 | Q969H0 | S176 | KRKLDHGsEVRSFSL | |
| PLK2 | Q9NYY3 | human | FBXW7 | Q969H0 | S25 | sLRGNPSssQVDEEQ |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PLK2 | ID | Description | 0.00e+00 |
| PLK2 | GO:1903829 | positive regulation of protein localization | 4.10e-05 |
| PLK2 | GO:0031647 | regulation of protein stability | 1.47e-04 |
| PLK2 | GO:0031648 | protein destabilization | 5.54e-04 |
| PLK2 | GO:0032886 | regulation of microtubule-based process | 1.43e-03 |
| PLK2 | GO:0031398 | positive regulation of protein ubiquitination | 3.51e-03 |
| PLK2 | GO:0045936 | negative regulation of phosphate metabolic process | 3.51e-03 |
| PLK2 | GO:0010563 | negative regulation of phosphorus metabolic process | 3.51e-03 |
| PLK2 | GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 3.51e-03 |
| PLK2 | GO:0031109 | microtubule polymerization or depolymerization | 3.51e-03 |
| PLK2 | GO:0007098 | centrosome cycle | 3.51e-03 |
| PLK2 | GO:0031400 | negative regulation of protein modification process | 3.51e-03 |
| PLK2 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity | 3.51e-03 |
| PLK2 | GO:0031023 | microtubule organizing center organization | 3.51e-03 |
| PLK2 | GO:1901987 | regulation of cell cycle phase transition | 3.51e-03 |
| PLK2 | GO:0046599 | regulation of centriole replication | 3.51e-03 |
| PLK2 | GO:1901875 | positive regulation of post-translational protein modification | 3.51e-03 |
| PLK2 | GO:0070507 | regulation of microtubule cytoskeleton organization | 3.51e-03 |
| PLK2 | GO:0006469 | negative regulation of protein kinase activity | 4.55e-03 |
| PLK2 | GO:0033673 | negative regulation of kinase activity | 5.30e-03 |
| PLK2 | GO:0090169 | regulation of spindle assembly | 5.30e-03 |
| PLK2 | GO:0031396 | regulation of protein ubiquitination | 5.41e-03 |
| PLK2 | GO:0050821 | protein stabilization | 6.33e-03 |
| PLK2 | GO:1902115 | regulation of organelle assembly | 6.33e-03 |
| PLK2 | GO:0051438 | regulation of ubiquitin-protein transferase activity | 6.33e-03 |
| PLK2 | GO:0051348 | negative regulation of transferase activity | 6.33e-03 |
| PLK2 | GO:0042417 | dopamine metabolic process | 6.33e-03 |
| PLK2 | GO:0043523 | regulation of neuron apoptotic process | 6.33e-03 |
| PLK2 | GO:0060236 | regulation of mitotic spindle organization | 6.33e-03 |
| PLK2 | GO:1990000 | amyloid fibril formation | 6.33e-03 |
| PLK2 | GO:0007099 | centriole replication | 6.42e-03 |
| PLK2 | GO:1903320 | regulation of protein modification by small protein conjugation or removal | 6.51e-03 |
| PLK2 | GO:0090224 | regulation of spindle organization | 6.89e-03 |
| PLK2 | GO:0010824 | regulation of centrosome duplication | 6.97e-03 |
| PLK2 | GO:0098534 | centriole assembly | 7.06e-03 |
| PLK2 | GO:0051402 | neuron apoptotic process | 8.45e-03 |
| PLK2 | GO:0046605 | regulation of centrosome cycle | 8.45e-03 |
| PLK2 | GO:1901873 | regulation of post-translational protein modification | 8.63e-03 |
| PLK2 | GO:0006584 | catecholamine metabolic process | 8.69e-03 |
| PLK2 | GO:0009712 | catechol-containing compound metabolic process | 8.69e-03 |
| PLK2 | GO:0007062 | sister chromatid cohesion | 9.08e-03 |
| PLK2 | GO:0001933 | negative regulation of protein phosphorylation | 9.50e-03 |
| PLK2 | GO:0034504 | protein localization to nucleus | 9.82e-03 |
| PLK2 | GO:1904951 | positive regulation of establishment of protein localization | 1.09e-02 |
| PLK2 | GO:0042326 | negative regulation of phosphorylation | 1.10e-02 |
| PLK2 | GO:0032386 | regulation of intracellular transport | 1.14e-02 |
| PLK2 | GO:0048488 | synaptic vesicle endocytosis | 1.14e-02 |
| PLK2 | GO:0140238 | presynaptic endocytosis | 1.15e-02 |
| PLK2 | GO:0051298 | centrosome duplication | 1.20e-02 |
| PLK2 | GO:0045862 | positive regulation of proteolysis | 1.20e-02 |
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Related Drugs to NOL4_PLK2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning NOL4-PLK2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to NOL4_PLK2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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