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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:NUDT3_MAPK8

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: NUDT3_MAPK8
KinaseFusionDB ID: KFG4318
FusionGDB2.0 ID: KFG4318
HgeneTgene
Gene symbol

NUDT3

MAPK8

Gene ID

11165

5599

Gene namenudix hydrolase 3mitogen-activated protein kinase 8
SynonymsDIPP|DIPP-1|DIPP1JNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1c
Cytomap

6p21.31

10q11.22

Type of geneprotein-codingprotein-coding
Descriptiondiphosphoinositol polyphosphate phosphohydrolase 1ap6A hydrolasediadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1diadenosine hexaphosphate hydrolaseendopolyphosphatasem7GpppN-mRNA hydrolasem7GpppX diphosphatasenucleoside diphosphate-linked moietymitogen-activated protein kinase 8JUN N-terminal kinaseMAP kinase 8c-Jun N-terminal kinase 1stress-activated protein kinase 1stress-activated protein kinase 1c
Modification date2024040720240411
UniProtAcc

O95989

Q9UPT6

Ensembl transtripts involved in fusion geneENST idsENST00000607016, ENST00000459755, 
ENST00000374174, ENST00000395611, 
ENST00000360332, ENST00000374182, 
ENST00000374189, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: NUDT3 [Title/Abstract] AND MAPK8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NUDT3(34360041)-MAPK8(49639236), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNUDT3

GO:0071544

diphosphoinositol polyphosphate catabolic process

10585413

HgeneNUDT3

GO:0110154

RNA decapping

32727897

HgeneNUDT3

GO:1901909

diadenosine hexaphosphate catabolic process

34788624

TgeneMAPK8

GO:0006979

response to oxidative stress

22966201

TgeneMAPK8

GO:0007254

JNK cascade

8654373

TgeneMAPK8

GO:0007258

JUN phosphorylation

14967141

TgeneMAPK8

GO:0007258

JUN phosphorylation

21095239

TgeneMAPK8

GO:0009411

response to UV

14967141

TgeneMAPK8

GO:0018105

peptidyl-serine phosphorylation

15850461|21095239|22966201

TgeneMAPK8

GO:0018107

peptidyl-threonine phosphorylation

21095239

TgeneMAPK8

GO:0032091

negative regulation of protein binding

21095239

TgeneMAPK8

GO:0032880

regulation of protein localization

20027304

TgeneMAPK8

GO:0034198

cellular response to amino acid starvation

11096076

TgeneMAPK8

GO:0034599

cellular response to oxidative stress

27568560

TgeneMAPK8

GO:0034614

cellular response to reactive oxygen species

34048572

TgeneMAPK8

GO:0043066

negative regulation of apoptotic process

14967141

TgeneMAPK8

GO:0043066

negative regulation of apoptotic process

21095239

TgeneMAPK8

GO:0051403

stress-activated MAPK cascade

11096076

TgeneMAPK8

GO:0071222

cellular response to lipopolysaccharide

23776175

TgeneMAPK8

GO:1900227

positive regulation of NLRP3 inflammasome complex assembly

28943315


check buttonKinase Fusion gene breakpoints across NUDT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across MAPK8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-G9-6338-01ANUDT3chr6

34360041

MAPK8chr10

49639236



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:34360041/:49639236)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NUDT3

O95989

MAPK8

Q9UPT6

FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:12370170, PubMed:9822604, PubMed:10585413). InsP6 (inositol hexakisphosphate) is not a substrate (PubMed:9822604). Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (PubMed:12370170, PubMed:10419486). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (PubMed:12370170). Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170). Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility (PubMed:26932476). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (PubMed:32727897). Can hydrolyze unmethylated capped RNAs (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (PubMed:34788624). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions (PubMed:34788624). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (PubMed:34788624). {ECO:0000250|UniProtKB:Q9JI46, ECO:0000269|PubMed:10419486, ECO:0000269|PubMed:10585413, ECO:0000269|PubMed:12370170, ECO:0000269|PubMed:34788624, ECO:0000269|PubMed:9822604, ECO:0000305|PubMed:26932476}.FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604). {ECO:0000250|UniProtKB:Q9ESN9, ECO:0000269|PubMed:12189133, ECO:0000269|PubMed:21775604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of NUDT3_MAPK8


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
MAPK8P45983-2humanEWSR1Q01844T79QPPTGYTtPTAPQAY
MAPK8P45983humanSIRT1Q96EB6S47DGPGLERsPGEPGGA
MAPK8P45983humanYAP1P46937-3T154VVSGPAAtPTAQHLR
MAPK8P45983humanMAPTP10636-8T231KKVAVVRtPPKsPss
MAPK8P45983humanJUNBP17275T102SNGVITTtPtPPGQyJun
MAPK8P45983humanEIF4ENIF1Q9NRA8S513NLEsHLMsPAEIPGQEIF4E-T
MAPK8P45983humanEEF1A2Q05639S358GQISAGYsPVIDCHTGTP_EFTU_D3
MAPK8P45983humanATF2P15336T69sVIVADQtPtPtRFL
MAPK8P45983humanAPPP05067-4T668VEVDAAVtPEERHLsAPP_amyloid
MAPK8P45983humanFOXO3O43524S574SAkHQQQsPVSQSMQ
MAPK8P45983humanRARAP10276S461RSSPATHsP______
MAPK8P45983humanATF2P15336T71IVADQtPtPtRFLkN
MAPK8P45983humanATN1P54259S739EEyETPEsPVPPARsAtrophin-1
MAPK8P45983humanNR4A1P22736S95TSSSSATsPASASFk
MAPK8P45983humanWDR62O43379T1053PsssLPQtPEQEKFL
MAPK8P45983humanSP1P08047T278SVSAATLtPSSQAVT
MAPK8P45983humanSFNP31947S186FHYEIANsPEEAISL14-3-3
MAPK8P45983humanMAPK8IP1Q9UQF2T205PLKtGEQtPPHEHIC
MAPK8P45983humanEIF4ENIF1Q9NRA8S301DAVLPEQsPGDFDFNEIF4E-T
MAPK8P45983humanRBM17Q96I25S222EEQDRPRsPtGPsNs
MAPK8P45983humanLATO43561-2T155PSAPALStPGIRDSALAT
MAPK8P45983humanSTAT6P42226S707IPPYQGLsPEESVNVSTAT6_C
MAPK8P45983humanCTBP1Q13363S422AHPPHAPsPGQTVkP
MAPK8P45983humanNFATC4Q14934S217GLGsPLPsPRAsPRP
MAPK8P45983humanJUNDP17535S100LGLLkLAsPELERLIJun
MAPK8P45983humanNFE2L2Q16236S408GDMVQPLsPSQGQST
MAPK8P45983humanEIF4ENIF1Q9NRA8S693ASITSMLsPSFTPTSEIF4E-T
MAPK8P45983humanLIMD1Q9UGP4S277RVsPGLPsPNLENGA
MAPK8P45983humanLIMD1Q9UGP4S272TASsQRVsPGLPsPN
MAPK8P45983humanCTNNB1P35222S37yLDsGIHsGATtTAP
MAPK8P45983humanBCL2L1Q07817T115LTSQLHItPGTAYQSBcl-2
MAPK8P45983humanGRB7Q14451S194KyELFKssPHSLFPE
MAPK8P45983humanGLE1Q53GS7S99ssAFsPAsPAtPNGT
MAPK8P45983humanCDT1Q9H211S391LRSAAPssPGsPrPA
MAPK8P45983humanATF2P15336S90GLFNELAsPFENEFk
MAPK8P45983humanMCL1Q07820S64IGGSAGAsPPStLtP
MAPK8P45983humanCDC25CP30307S168SEMKyLGsPIttVPK
MAPK8P45983humanRPTORQ8N122S696EKNyALPsPAttEGG
MAPK8P45983humanMAPTP10636-8S396GAEIVyKsPVVsGDt
MAPK8P45983humanYAP1P46937-3S317GTQNPVSsPGMSQEL
MAPK8P45983humanNEIL1Q96FI4S207ALQQHRPsPELTLSQ
MAPK8P45983humanPPARGP37231S112AIkVEPAsPPYYSEK
MAPK8P45983humanCDT1Q9H211T402PrPALPAtPPAtPPA
MAPK8P45983humanBIDP55957T59EGyDELQtDGNRsSHBID
MAPK8P45983humanNCOA3Q9Y6Q9S860NRAVsLDsPVsVGss
MAPK8P45983humanEIF4ENIF1Q9NRA8S752PsADRDssPttNSkL
MAPK8P45983humanKRT8P05787S74tVNQsLLsPLVLEVDKeratin_2_head
MAPK8P45983humanBCL2L11O43521-2S58DKSTQtPsPPCQAFN
MAPK8P45983humanJUNP05412T91SNGHItTtPtPtQFLJun
MAPK8P45983humanPKMP14618-2T365CIMLSGEtAKGDyPLPK
MAPK8P45983humanLIMD1Q9UGP4S421LGSVLLDsPssPRVr
MAPK8P45983humanPIN1Q13526S115sQFSDCssAkARGDLRotamase
MAPK8P45983humanSTMN2Q93045S73EAPRTLAsPKKkDLsStathmin
MAPK8P45983humanNLRP3Q96P20S198GKTKTCEsPVSPIKMFISNA
MAPK8P45983humanNCOA3Q9Y6Q9S543SLLSTLSsPGPKLDNNCOA_u2
MAPK8P45983humanARP10275S651GEASSTTsPTEETTQ
MAPK8P45983humanSTAT3P40763S727NtIDLPMsPrTLDSL
MAPK8P45983humanMCL1Q07820S121PAADAIMsPEEELDG
MAPK8P45983humanCDT1Q9H211S411PAtPPAAsPsALkGV
MAPK8P45983humanSP1P08047T739sEGSGtAtPSALITT
MAPK8P45983humanHNRNPKP61978S353DSAIDTWsPSEWQMA
MAPK8P45983humanBCL2L11O43521-2S44QTEPQDRsPAPMSCD
MAPK8P45983humanBCL2L1Q07817S62PSWHLADsPAVNGAT
MAPK8P45983humanDIABLOQ9NR28S6__MAALKsWLsRsVt
MAPK8P45983humanOSBP2Q969R2S762ECSKVMHssPssPsSOxysterol_BP
MAPK8P45983humanNFE2L2Q16236S577DEDGkPysPSEYSLQ
MAPK8P45983humanNOS3P29474S114RKLQGRPsPGPPAPE
MAPK8P45983humanNCOA3Q9Y6Q9T24KRKLPCDtPGQGLtC
MAPK8P45983humanCDKN1AP38936S98GGRRPGTsPALLQGT
MAPK8P45983humanCDC25BP30305-2S103GLCMDsPsPMDPHMAM-inducer_phosp
MAPK8P45983humanGLI2P10070T1546QNSSRLTtPRNSLTL
MAPK8P45983humanSTMN3Q9NZ72S60sFEVILksPSDLsPEStathmin
MAPK8P45983humanNFE2Q16621S346DESGNSYsPEEYALQ
MAPK8P45983humanSIRT1Q96EB6S27ADREAAssPAGEPLR
MAPK8P45983humanOSBP2Q969R2S766VMHssPssPsSDGKQOxysterol_BP
MAPK8P45983humanFOXO4P98177T451PIPKALGtPVLtPPt
MAPK8P45983humanGLE1Q53GS7T102FsPAsPAtPNGTKGk
MAPK8P45983humanSREBF1P36956S117YPSMPAFsPGPGIkE
MAPK8P45983humanNR3C1P04150S226IDENCLLsPLAGEDDGCR
MAPK8P45983humanTP53P04637T81APAPAAPtPAAPAPA
MAPK8P45983humanBCL2P10415S87AAAGPALsPVPPVVH
MAPK8P45983humanRBM17Q96I25T71DDrQIVDtPPHVAAG
MAPK8P45983humanSYT4Q9H2B2S135EGEKESVsPESLKSS
MAPK8P45983humanSREBF1P36956-3T81SPPQPAPtPLKMYPS
MAPK8P45983humanCDT1Q9H211T29PPkLACRtPsPARPA
MAPK8P45983humanMAPTP10636-8S202sGyssPGsPGtPGsR
MAPK8P45983humanMYCP01106S86sRRsGLCsPSyVAVtMyc_N
MAPK8P45983humanBCL2L11O43521-2T56SCDKSTQtPsPPCQA
MAPK8P45983humanCDKN1AP38936S130sGEQAEGsPGGPGDs
MAPK8P45983humanSARM1Q6SZW1S548AAREMLHsPLPCTGG
MAPK8P45983humanRXRAP19793S260NMGLNPssPNDPVtNHormone_recep
MAPK8P45983humanTP63Q9H3D4S51TQtNEFLsPEVFQHI
MAPK8P45983humanEEF1A2Q05639S205GDNMLEPsPNMPWFKGTP_EFTU
MAPK8P45983humanPXNP49023S178PPLPGALsPLyGVPEPaxillin
MAPK8P45983humanBCL2L1Q07817T47GTESEMEtPsAINGN
MAPK8P45983humanRUNX2Q13950S118AELVRTDsPNFLCSVRunt
MAPK8P45983humanELAVL1Q15717S221QAQrFrFsPMGVDHM
MAPK8P45983humanARHGAP8P85298S455tKPtLPPsPLMAARR
MAPK8P45983humanBCL2P10415S70RDPVARtsPLQtPAA
MAPK8P45983humanNCOA3Q9Y6Q9S867sPVsVGssPPVKNIS
MAPK8P45983humanTWIST1Q15672S68GGGDEPGsPAQGkRG
MAPK8P45983humanNFATC4Q14934S213ASRFGLGsPLPsPRA
MAPK8P45983humanDIABLOQ9NR28S9AALKsWLsRsVtSFFSmac_DIABLO
MAPK8P45983humanELF4Q99607S641SGSLLTRsPtPAPFs
MAPK8P45983humanJUNP05412S73VGLLkLAsPELERLIJun
MAPK8P45983humanSREBF1P36956-3S93YPSMPAFsPGPGIKE
MAPK8P45983humanCDC25BP30305-2S101DAGLCMDsPsPMDPHM-inducer_phosp
MAPK8P45983humanSTK4Q13043S82SIMQQCDsPHVVKYYPkinase
MAPK8P45983humanDGCR8Q8WYQ5S153AECGLLLsPVSGDVH
MAPK8P45983humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
MAPK8P45983humanEIF4ENIF1Q9NRA8S587yLrPrIPsPIGFtPGEIF4E-T
MAPK8P45983humanAIMP1Q12904S140KKEKkQQsIAGsADS
MAPK8P45983humanRPTORQ8N122S863LtQsAPAsPtNkGVH
MAPK8P45983humanNFE2L2Q16236S215VETTMVPsPEAKLTE
MAPK8P45983humanMAPTP10636-8T181ktPPAPktPPssGEP
MAPK8P45983humanMARCKSP29966S46VKVNGDAsPAAAEsGMARCKS
MAPK8P45983humanJUNP05412S63kNsDLLtsPDVGLLkJun
MAPK8P45983humanSIRT6Q8N6T7S10VNYAAGLsPYADKGk
MAPK8P45983humanMCL1Q07820T163tDGsLPstPPPAEEE
MAPK8P45983humanBCL2P10415T69SRDPVARtsPLQtPA
MAPK8P45983humanCDT1Q9H211S491GSCCTIMsPGEMEKHCDT1_C
MAPK8P45983humanOSBP2Q969R2S768HssPssPsSDGKQKTOxysterol_BP
MAPK8P45983humanBMFQ96LC9S74DKATQTLsPAsPSQGBMF
MAPK8P45983humanSND1Q7KZF4T103CFtIENktPQGrEyGSNase
MAPK8P45983humanMYCP01106S77LLPtPPLsPsRRsGLMyc_N
MAPK8P45983humanNEIL1Q96FI4S61KELRLILsPLPGAQPFapy_DNA_glyco
MAPK8P45983humanCDK4P11802T172YSYQMALtPVVVTLWPkinase
MAPK8P45983humanCTNNB1P35222S33QQQsyLDsGIHsGAT
MAPK8P45983humanRPTORQ8N122T706ttEGGsLtPVRDsPC
MAPK8P45983humanGNMTQ14749S10DSVYRtRsLGVAAEG
MAPK8P45983humanNFATC1O95644S172YRDPsCLsPASSLSS
MAPK8P45983humanEIF4ENIF1Q9NRA8S374GLEQAILsPGQNsGNEIF4E-T
MAPK8P45983humanSIRT1Q96EB6T530YLSELPPtPLHVsED
MAPK8P45983humanJUNBP17275T104GVITTtPtPPGQyFyJun
MAPK8P45983humanRARAP10276T181CSESYTLtPEVGELI
MAPK8P45983humanOSBP2Q969R2S763CSKVMHssPssPsSDOxysterol_BP
MAPK8P45983humanIRS1P35568S312tEsItAtsPAsMVGG
MAPK8P45983humanTAB1Q15750S438tPTLTNQsPTLtLQS
MAPK8P45983humanMAPK8IP1Q9UQF2T103LIDAtGDtPGAEDDE
MAPK8P45983humanCTNNB1P35222T41GIHsGATtTAPsLsG
MAPK8P45983humanLIMD1Q9UGP4S424VLLDsPssPRVrLPC
MAPK8P45983humanGLE1Q53GS7S93PKsPDAssAFsPAsP
MAPK8P45983humanYWHAZP63104S184FyYEILNsPEKACSL14-3-3
MAPK8P45983humanFOXO4P98177T455ALGtPVLtPPtEAAS
MAPK8P45983humanNEIL1Q96FI4S306KSKATQLsPEDRVED
MAPK8P45983humanYWHABP31946S186FyYEILNsPEKACSL14-3-3
MAPK8P45983humanFOXO4P98177T227PAPPEGAtPTsPVGH
MAPK8P45983humanFOXO4P98177S230PEGAtPTsPVGHFAK
MAPK8P45983humanGLE1Q53GS7S92VPKsPDAssAFsPAs
MAPK8P45983humanRARAP10276S445APPPGSCsPSLSPSS
MAPK8P45983humanCDT1Q9H211T406LPAtPPAtPPAAsPs
MAPK8P45983humanHNRNPKP61978S216ILDLIsEsPIkGRAQ
MAPK8P45983humanGLE1Q53GS7S88QPSFVPKsPDAssAF
MAPK8P45983humanIRF3Q14653S173PCPQPLRsPsLDNPt
MAPK8P45983humanKRT8P05787S432sAyGGLtsPGLsysL
MAPK8P45983humanCDKN1AP38936T57NFDFVtEtPLEGDFACDI
MAPK8P45983humanYAP1P46937-3T362SSySVPRtPDDFLNS
MAPK8P45983humanDCP1AQ9NPI6S315PtytIPLsPVLsPtL
MAPK8P45983humanNCOA3Q9Y6Q9S505SPVAGVHsPMAsSGNNCOA_u2
MAPK8P45983humanJUNP05412T93GHItTtPtPtQFLCPJun
MAPK8P45983humanAPLP2Q06481T736VEVDPMLtPEERHLNAPP_amyloid
MAPK8P45983humanNFE2Q16621S157LNYSDAEsLELEGTE


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
MAPK8IDDescription0.00e+00
MAPK8GO:0050673epithelial cell proliferation4.85e-13
MAPK8GO:1902893regulation of miRNA transcription4.85e-13
MAPK8GO:0061614miRNA transcription4.85e-13
MAPK8GO:0010586miRNA metabolic process1.42e-12
MAPK8GO:2000628regulation of miRNA metabolic process3.19e-12
MAPK8GO:0097193intrinsic apoptotic signaling pathway3.19e-12
MAPK8GO:0051402neuron apoptotic process4.46e-12
MAPK8GO:0140747regulation of ncRNA transcription4.77e-12
MAPK8GO:0050678regulation of epithelial cell proliferation1.07e-11
MAPK8GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage1.37e-11
MAPK8GO:2001233regulation of apoptotic signaling pathway7.77e-11
MAPK8GO:0098781ncRNA transcription3.77e-10
MAPK8GO:1902895positive regulation of miRNA transcription4.82e-10
MAPK8GO:2000630positive regulation of miRNA metabolic process3.20e-09
MAPK8GO:0050679positive regulation of epithelial cell proliferation4.98e-09
MAPK8GO:2001242regulation of intrinsic apoptotic signaling pathway1.48e-08
MAPK8GO:0031667response to nutrient levels1.90e-08
MAPK8GO:0001836release of cytochrome c from mitochondria3.11e-08
MAPK8GO:0006979response to oxidative stress7.21e-08
MAPK8GO:0009267cellular response to starvation1.02e-07
MAPK8GO:0030522intracellular receptor signaling pathway1.28e-07
MAPK8GO:1901653cellular response to peptide2.52e-07
MAPK8GO:0031669cellular response to nutrient levels2.52e-07
MAPK8GO:0008637apoptotic mitochondrial changes2.64e-07
MAPK8GO:0009299mRNA transcription3.74e-07
MAPK8GO:0001701in utero embryonic development3.97e-07
MAPK8GO:0062012regulation of small molecule metabolic process5.82e-07
MAPK8GO:0042594response to starvation5.83e-07
MAPK8GO:1903131mononuclear cell differentiation5.83e-07
MAPK8GO:0031668cellular response to extracellular stimulus6.84e-07
MAPK8GO:0043525positive regulation of neuron apoptotic process6.84e-07
MAPK8GO:0097191extrinsic apoptotic signaling pathway8.52e-07
MAPK8GO:0043523regulation of neuron apoptotic process9.45e-07
MAPK8GO:0072091regulation of stem cell proliferation1.22e-06
MAPK8GO:0061138morphogenesis of a branching epithelium1.39e-06
MAPK8GO:2001234negative regulation of apoptotic signaling pathway1.40e-06
MAPK8GO:0030217T cell differentiation1.49e-06
MAPK8GO:0048863stem cell differentiation1.50e-06
MAPK8GO:0071375cellular response to peptide hormone stimulus1.58e-06
MAPK8GO:2001235positive regulation of apoptotic signaling pathway1.81e-06
MAPK8GO:0062197cellular response to chemical stress1.92e-06
MAPK8GO:0071456cellular response to hypoxia1.95e-06
MAPK8GO:0001649osteoblast differentiation2.08e-06
MAPK8GO:0001763morphogenesis of a branching structure2.41e-06
MAPK8GO:0097284hepatocyte apoptotic process2.45e-06
MAPK8GO:0048754branching morphogenesis of an epithelial tube2.97e-06
MAPK8GO:0060562epithelial tube morphogenesis2.97e-06
MAPK8GO:0036294cellular response to decreased oxygen levels3.16e-06
MAPK8GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator3.16e-06

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Related Drugs to NUDT3_MAPK8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning NUDT3-MAPK8 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to NUDT3_MAPK8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate