UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Kinase Fusion Gene Summary

leaf

Kinase Fusion Gene Sample Information

leaf

Kinase Fusion ORF Analysis

leaf

Kinase Fusion Amino Acid Sequences

leaf

Multiple Sequence Alignment of All Fusion Protein Isoforms

leaf

Kinase Fusion Protein Functional Features

leaf

Kinase Fusion Protein Structures

leaf

Comparison of Fusion Protein Isoforms

leaf

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

leaf

pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

leaf

Ramachandran Plot of Kinase Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Virtual Screening Results

leaf

Kinase-Substrate Information

leaf

Related Drugs with This Kinase Fusion Protein

leaf

Related Disease with This Kinase Fusion Protein

leaf

Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:OXSR1_CALR

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: OXSR1_CALR
KinaseFusionDB ID: KFG4374
FusionGDB2.0 ID: KFG4374
HgeneTgene
Gene symbol

OXSR1

CALR

Gene ID

9943

811

Gene nameoxidative stress responsive kinase 1calreticulin
SynonymsOSR1CALR1|CRT|HEL-S-99n|RO|SSA|cC1qR
Cytomap

3p22.2

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase OSR1oxidative stress responsive 1oxidative stress-responsive 1 proteincalreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60
Modification date2024040320240416
UniProtAcc

O95747

P27797

Ensembl transtripts involved in fusion geneENST idsENST00000311806, ENST00000446845, 
ENST00000492714, 		ENST00000316448, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: OXSR1 [Title/Abstract] AND CALR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)OXSR1(38284244)-CALR(13051124), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneOXSR1

GO:0006468

protein phosphorylation

14707132

HgeneOXSR1

GO:0006884

cell volume homeostasis

36318922

HgeneOXSR1

GO:0018107

peptidyl-threonine phosphorylation

24393035

HgeneOXSR1

GO:0035556

intracellular signal transduction

14707132

HgeneOXSR1

GO:0046777

protein autophosphorylation

22052202

HgeneOXSR1

GO:0070294

renal sodium ion absorption

18270262

HgeneOXSR1

GO:0071474

cellular hyperosmotic response

36318922

TgeneCALR

GO:0000122

negative regulation of transcription by RNA polymerase II

8107809

TgeneCALR

GO:0002502

peptide antigen assembly with MHC class I protein complex

35948544

TgeneCALR

GO:0006611

protein export from nucleus

11149926

TgeneCALR

GO:0017148

negative regulation of translation

14726956

TgeneCALR

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

8107809

TgeneCALR

GO:0034504

protein localization to nucleus

15998798

TgeneCALR

GO:0045665

negative regulation of neuron differentiation

8107809

TgeneCALR

GO:0045892

negative regulation of DNA-templated transcription

8107809

TgeneCALR

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

8107809


check buttonKinase Fusion gene breakpoints across OXSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across CALR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0BE005287OXSR1chr3

38284244

CALRchr19

13051124



Top

Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

Top

Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



Top

Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:38284244/chr19:13051124)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
OXSR1

O95747

CALR

P27797

FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:21321328, PubMed:34289367). Specifically recognizes and binds proteins with a RFXV motif (PubMed:16669787, PubMed:21321328, PubMed:17721439). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:17721439). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (PubMed:16669787, PubMed:21321328). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:16669787, PubMed:19665974, PubMed:21321328). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (PubMed:18270262). Also acts as a regulator of angiogenesis in endothelial cells downstream of WNK1 (PubMed:23386621, PubMed:25362046). Acts as an activator of inward rectifier potassium channels KCNJ2/Kir2.1 and KCNJ4/Kir2.3 downstream of WNK1: recognizes and binds the RXFXV/I variant motif on KCNJ2/Kir2.1 and KCNJ4/Kir2.3 and regulates their localization to the cell membrane without mediating their phosphorylation (PubMed:29581290). Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764). Phosphorylates PAK1 (PubMed:14707132). Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202). {ECO:0000269|PubMed:14707132, ECO:0000269|PubMed:16389068, ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:17721439, ECO:0000269|PubMed:18270262, ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:21321328, ECO:0000269|PubMed:22052202, ECO:0000269|PubMed:23386621, ECO:0000269|PubMed:25362046, ECO:0000269|PubMed:28688764, ECO:0000269|PubMed:29581290, ECO:0000269|PubMed:34289367}.FUNCTION: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


Top

Kinase-Substrate Information of OXSR1_CALR


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
OXSR1O95747humanSLC12A1Q13621T105LQtFGHNtMDAVPKIAA_permease_N
OXSR1O95747humanSLC12A2P55011T207YYDtHTNtyYLRtFGAA_permease_N
OXSR1O95747humanSLC12A1Q13621T118KIEYYRNtGsISGPKAA_permease_N
OXSR1O95747humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
OXSR1O95747humanSLC12A3P55017T60MRtFGYNtIDVVPtYAA_permease_N
OXSR1O95747humanSLC12A3P55017S73tYEHyANstQPGEPRAA_permease_N
OXSR1O95747humanSMAD3P84022T179PQSNIPEtPPPGYLS
OXSR1O95747humanSLC12A2P55011T212TNtyYLRtFGHNtMDAA_permease_N
OXSR1O95747humanSLC12A2P55011T230RIDHyRHtAAQLGEkAA_permease_N
OXSR1O95747humanSLC12A2P55011T203HQHYYYDtHTNtyYLAA_permease_N
OXSR1O95747humanSLC12A1Q13621S120EYYRNtGsISGPKVNAA_permease_N
OXSR1O95747humanSLC12A1Q13621T95AYDsHTNtYYLQtFGAA_permease_N
OXSR1O95747humanMAPTP10636-8T30RKDQGGytMHQDQEG
OXSR1O95747humanSLC12A1Q13621T100TNtYYLQtFGHNtMDAA_permease_N
OXSR1O95747humanSLC12A3P55017T46SSHPSHLtHSStFCMAA_permease_N
OXSR1O95747humanSLC12A3P55017T55SStFCMRtFGYNtIDAA_permease_N
OXSR1O95747humanSMAD2Q15796T220QSNYIPEtPPPGYIS
OXSR1O95747humanSLC12A2P55011T217LRtFGHNtMDAVPRIAA_permease_N


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
OXSR1IDDescription0.00e+00
OXSR1GO:0055064chloride ion homeostasis6.72e-06
OXSR1GO:0055081monoatomic anion homeostasis6.72e-06
OXSR1GO:0055075potassium ion homeostasis1.56e-05
OXSR1GO:0006884cell volume homeostasis1.56e-05
OXSR1GO:0008361regulation of cell size1.56e-05
OXSR1GO:0055078sodium ion homeostasis2.19e-05
OXSR1GO:1990573potassium ion import across plasma membrane2.19e-05
OXSR1GO:0032535regulation of cellular component size1.50e-04
OXSR1GO:0007440foregut morphogenesis1.96e-04
OXSR1GO:0048340paraxial mesoderm morphogenesis1.96e-04
OXSR1GO:1902476chloride transmembrane transport1.96e-04
OXSR1GO:0006821chloride transport2.64e-04
OXSR1GO:0098661inorganic anion transmembrane transport2.79e-04
OXSR1GO:0098659inorganic cation import across plasma membrane2.79e-04
OXSR1GO:0099587inorganic ion import across plasma membrane2.79e-04
OXSR1GO:0098656monoatomic anion transmembrane transport3.23e-04
OXSR1GO:0048339paraxial mesoderm development4.12e-04
OXSR1GO:0015698inorganic anion transport4.12e-04
OXSR1GO:0060039pericardium development4.12e-04
OXSR1GO:0006820monoatomic anion transport4.12e-04
OXSR1GO:0031053primary miRNA processing4.12e-04
OXSR1GO:0038092nodal signaling pathway4.12e-04
OXSR1GO:0035725sodium ion transmembrane transport4.12e-04
OXSR1GO:0023019signal transduction involved in regulation of gene expression4.59e-04
OXSR1GO:0098739import across plasma membrane6.19e-04
OXSR1GO:0071805potassium ion transmembrane transport6.38e-04
OXSR1GO:0030325adrenal gland development6.66e-04
OXSR1GO:0006813potassium ion transport8.10e-04
OXSR1GO:0006814sodium ion transport8.52e-04
OXSR1GO:0048701embryonic cranial skeleton morphogenesis1.57e-03
OXSR1GO:0035196miRNA processing1.66e-03
OXSR1GO:0032924activin receptor signaling pathway1.69e-03
OXSR1GO:0048546digestive tract morphogenesis1.69e-03
OXSR1GO:0072132mesenchyme morphogenesis2.23e-03
OXSR1GO:0010718positive regulation of epithelial to mesenchymal transition2.32e-03
OXSR1GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process2.99e-03
OXSR1GO:1904888cranial skeletal system development3.27e-03
OXSR1GO:0009880embryonic pattern specification3.28e-03
OXSR1GO:0001707mesoderm formation3.28e-03
OXSR1GO:0061045negative regulation of wound healing3.28e-03
OXSR1GO:0048332mesoderm morphogenesis3.37e-03
OXSR1GO:0007492endoderm development3.83e-03
OXSR1GO:0060395SMAD protein signal transduction3.83e-03
OXSR1GO:0070918regulatory ncRNA processing3.92e-03
OXSR1GO:0048704embryonic skeletal system morphogenesis4.58e-03
OXSR1GO:1903035negative regulation of response to wounding4.67e-03
OXSR1GO:0001657ureteric bud development4.67e-03
OXSR1GO:0072163mesonephric epithelium development4.67e-03
OXSR1GO:0072164mesonephric tubule development4.67e-03

Top

Related Drugs to OXSR1_CALR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning OXSR1-CALR and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

Top

Related Diseases to OXSR1_CALR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


Top

Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate