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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PAK2_DLG1

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: PAK2_DLG1
	KinaseFusionDB ID: KFG4436
	FusionGDB2.0 ID: KFG4436
		Hgene	Tgene
	Gene symbol	PAK2	DLG1
	Gene ID	5586	1739
	Gene name	protein kinase N2	discs large MAGUK scaffold protein 1
	Synonyms	PAK2\|PRK2\|PRKCL2\|PRO2042\|Pak-2\|STK7	DLGH1\|SAP-97\|SAP97\|hdlg
	Cytomap	1p22.2	3q29
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2	disks large homolog 1dJ1061C18.1.1discs large homolog 1, scribble cell polarity complex componentpresynaptic protein SAP97synapse-associated protein 97
	Modification date	20240323	20240411
	UniProtAcc	Q13177	Q12959
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000327134,	ENST00000314062, ENST00000346964, ENST00000357674, ENST00000392382, ENST00000419354, ENST00000422288, ENST00000443183, ENST00000448528, ENST00000450955, ENST00000452595, ENST00000485409,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: PAK2 [Title/Abstract] AND DLG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DLG1(197009550)-PAK2(196534653), # samples:3 PAK2(196532254)-DLG1(196876667), # samples:3

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PAK2	GO:0006468	protein phosphorylation	17332740
Hgene	PAK2	GO:0010631	epithelial cell migration	21754995
Tgene	DLG1	GO:0001935	endothelial cell proliferation	14699157
Tgene	DLG1	GO:0007015	actin filament organization	14699157
Tgene	DLG1	GO:0030866	cortical actin cytoskeleton organization	14699157
Tgene	DLG1	GO:0042391	regulation of membrane potential	12970345
Tgene	DLG1	GO:0043268	positive regulation of potassium ion transport	12970345
Tgene	DLG1	GO:0070830	bicellular tight junction assembly	17332497
Tgene	DLG1	GO:0098609	cell-cell adhesion	14699157
Tgene	DLG1	GO:1902473	regulation of protein localization to synapse	23676497
Tgene	DLG1	GO:1903078	positive regulation of protein localization to plasma membrane	12970345

Kinase Fusion gene breakpoints across PAK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across DLG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-25-1328-01A	PAK2	chr3	196532254	DLG1	chr3	196876667
ChimerDB4	TCGA-25-1328-01A	PAK2	chr3	196532254	DLG1	chr3	196888609
ChimerDB4	TCGA-25-1328-01A	PAK2	chr3	196532254	DLG1	chr3	196869639
ChimerDB4	TCGA-JY-A6F8-01A	PAK2	chr3	196467028	DLG1	chr3	196921460

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000327134	ENST00000357674	PAK2	chr3	196532254	DLG1	chr3	196876667	5052	888
ENST00000327134	ENST00000357674	PAK2	chr3	196532254	DLG1	chr3	196869639	4998	870

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000327134_ENST00000357674_PAK2_chr3_196532254_DLG1_chr3_196876667_length(amino acids)=888
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAANPPPVLVNTDSLETPTYVNGTDA
DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK
RRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV
YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG
IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRT
SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKG
QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFP
DKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPI

--------------------------------------------------------------

>ENST00000327134_ENST00000357674_PAK2_chr3_196532254_DLG1_chr3_196869639_length(amino acids)=870
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA
VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF
SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP
KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP
PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL
RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK
DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPF
YKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
VDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:197009550/chr3:196534653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PAK2 Q13177	DLG1 Q12959
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:7744004, PubMed:19273597, PubMed:19923322, PubMed:9171063, PubMed:12853446, PubMed:16617111, PubMed:33693784). Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004). Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004). Full-length PAK2 stimulates cell survival and cell growth (PubMed:7744004). Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration (PubMed:21317288). Phosphorylates JUN and plays an important role in EGF-induced cell proliferation (PubMed:21177766). Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP (PubMed:21724829). Phosphorylates CASP7, thereby preventing its activity (PubMed:21555521, PubMed:27889207). Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis (PubMed:19273597, PubMed:19923322). On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway (PubMed:9171063, PubMed:12853446, PubMed:16617111). Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (PubMed:15234964). {ECO:0000269\|PubMed:12853446, ECO:0000269\|PubMed:15234964, ECO:0000269\|PubMed:16617111, ECO:0000269\|PubMed:19273597, ECO:0000269\|PubMed:19923322, ECO:0000269\|PubMed:21177766, ECO:0000269\|PubMed:21317288, ECO:0000269\|PubMed:21555521, ECO:0000269\|PubMed:21724829, ECO:0000269\|PubMed:27889207, ECO:0000269\|PubMed:33693784, ECO:0000269\|PubMed:7744004, ECO:0000269\|PubMed:9171063}.	FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000269\|PubMed:10656683, ECO:0000269\|PubMed:12445884, ECO:0000269\|PubMed:14699157, ECO:0000269\|PubMed:15263016, ECO:0000269\|PubMed:19213956, ECO:0000269\|PubMed:20605917, ECO:0000269\|PubMed:23676497}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

156156

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Hgene

PAK2

196532254

DLG1

196869639

ENST00000327134

74_87

525

Domain

Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057

Hgene

PAK2

196532254

DLG1

196876667

ENST00000327134

74_87

525

Domain

Note=CRIB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00057

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>190_PAK2_DLG1	ENST00000327134	ENST00000357674	PAK2	chr3	196532254	DLG1	chr3	196869639	MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPF YKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE VDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR	870
3D view using mol* of 190_PAK2_DLG1

PDB file >>>HKFP_276_PAK2_DLG1	ENST00000327134	ENST00000357674	PAK2	chr3	196532254	DLG1	chr3	196876667	MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAANPPPVLVNTDSLETPTYVNGTDA DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK RRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEG IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRT SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKG QSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFP DKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPI	888_PAK2_DLG1
PDB file >>>HKFP_277_PAK2_DLG1	ENST00000327134	ENST00000357674	PAK2	chr3	196532254	DLG1	chr3	196869639	MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDA VTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPAVNGTDADYEYEEITLERGNSGLGF SIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGP KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTK DSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPF YKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE VDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR	870_PAK2_DLG1
3D view using mol* of HKFP_277_PAK2_DLG1

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_276_PAK2_DLG1_vs_HKFP_277_PAK2_DLG1_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/HKFP_277_PAK2_DLG1_vs_HKFP_276_PAK2_DLG1.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

PAK2_DLG1 does not have any known PDB structures.

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pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

190_PAK2_DLG1.png

HKFP_277_PAK2_DLG1.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
HKFP_277_PAK2_DLG1	1.032	409	1.063	961.772	0.505	0.719	0.962	0.768	0.947	0.811	1.148	Chain A: 11,12,13,14,15,16,17,18,19,20,37,38,39,40 ,41,42,43,44,296,691,694,695,698,699,706,707,708,7 09,710,714,717,719,720,724,725,726,727,736,739,740 ,742,745,746,747,748,749,750,751,753,755,756,757,7 61,764,765,768,773,774,775,776,777,779,780,782,783 ,786

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

190_PAK2_DLG1_ramachandran.png

HKFP_277_PAK2_DLG1_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Ripretinib	-7.70552	-7.71252	-50.2643
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Ripretinib	-7.70552	-7.71252	-50.2643
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Axitinib	-6.926069999999998	-6.92927	-50.8995
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Lapatinib	-6.81767	-6.90647	-58.4623
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Acalabrutinib	-6.53604	-6.55014	-51.4479
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Acalabrutinib	-6.53604	-6.55014	-51.4479
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Lapatinib	-6.4894300000000005	-6.5782300000000005	-53.0537
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Erdafitinib	-6.43231	-6.43251	-37.0752
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Abrocitinib	-6.1797900000000014	-6.19089	-33.4456
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Abrocitinib	-6.1797900000000014	-6.19089	-33.4456
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Temsirolimus	-6.16424	-6.16564	-55.6261
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Abemaciclib	-6.06267	-6.26477	-48.6688
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Abemaciclib	-6.06267	-6.26477	-48.6688
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Abemaciclib	-6.06267	-6.26477	-48.6688
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Abemaciclib	-6.06267	-6.26477	-48.6688
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Ruxolitinib	-6.02963	-6.02963	-38.2843
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Tivozanib	-6.00515	-6.00515	-46.3396
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Larotrectinib	-6.00139	-6.00139	-48.5831
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Dabrafenib	-5.95169	-6.35709	-46.3626
HKFP_277_PAK2_DLG1_vsw_9-DOCK_HTVS_1-001	Tofacitinib	-5.9086	-5.9201	-37.2353
190_PAK2_DLG1-DOCK_HTVS_1-001	Netarsudil	-5.55924	-5.57034	-44.7887
190_PAK2_DLG1-DOCK_HTVS_1-001	Netarsudil	-5.55924	-5.57034	-44.7887
190_PAK2_DLG1-DOCK_HTVS_1-001	Lapatinib	-5.37098	-5.45978	-58.1976
190_PAK2_DLG1-DOCK_HTVS_1-001	Nilotinib	-5.2542599999999995	-5.39386	-29.6831
190_PAK2_DLG1-DOCK_HTVS_1-001	Nilotinib	-5.2542599999999995	-5.39386	-29.6831
190_PAK2_DLG1-DOCK_HTVS_1-001	Tofacitinib	-5.13585	-5.14735	-31.8735
190_PAK2_DLG1-DOCK_HTVS_1-001	Tofacitinib	-5.13585	-5.14735	-31.8735
190_PAK2_DLG1-DOCK_HTVS_1-001	Baricitinib	-5.05671	-5.05671	-47.018
190_PAK2_DLG1-DOCK_HTVS_1-001	Neratinib	-4.995480000000001	-5.17778	-58.0674
190_PAK2_DLG1-DOCK_HTVS_1-001	Neratinib	-4.995480000000001	-5.17778	-58.0674
190_PAK2_DLG1-DOCK_HTVS_1-001	Ruxolitinib	-4.86524	-4.86524	-36.1834
190_PAK2_DLG1-DOCK_HTVS_1-001	Afatinib	-4.7046	-4.8869	-41.0927
190_PAK2_DLG1-DOCK_HTVS_1-001	Afatinib	-4.7046	-4.8869	-41.0927
190_PAK2_DLG1-DOCK_HTVS_1-001	Pexidartinib	-4.70359	-5.40439	-38.0163
190_PAK2_DLG1-DOCK_HTVS_1-001	Pexidartinib	-4.70359	-5.40439	-38.0163
190_PAK2_DLG1-DOCK_HTVS_1-001	Afatinib	-4.7032	-4.8869	-41.0927
190_PAK2_DLG1-DOCK_HTVS_1-001	Ruxolitinib	-4.67865	-4.67865	-34.3508
190_PAK2_DLG1-DOCK_HTVS_1-001	Netarsudil	-4.61177	-4.62287	-42.2707
190_PAK2_DLG1-DOCK_HTVS_1-001	Netarsudil	-4.61177	-4.62287	-42.2707
190_PAK2_DLG1-DOCK_HTVS_1-001	Midostaurin	-4.58643	-4.58643	-40.5254

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Kinase-Substrate Information of PAK2_DLG1

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
PAK2	Q13177	human	MYC	P01106	S388	RRNELkRsFFALRDQ	HLH
PAK2	Q13177	human	ARHGAP15	Q53QZ3	S292	kVCERENsTVPWFVk
PAK2	Q13177	human	H4C1	P62805	S47	RGGVKrIsGLIyEEt	CENP-T_C
PAK2	Q13177	human	JUN	P05412	T2	______MtAKMETtF
PAK2	Q13177	human	CALD1	Q05682	S744	GLKVGVSsRINEWLT	Caldesmon
PAK2	Q13177	human	JUN	P05412	T286	RLEEKVKtLKAQNSE	bZIP_1
PAK2	Q13177	human	MYC	P01106	T373	EENVkRRtHNVLERQ	HLH
PAK2	Q13177	human	MICAL1	Q8TDZ2	S817	sPERQRLssLNLtPD
PAK2	Q13177	human	SORT1	Q99523	S793	RFLVHRYsVLQQHAE
PAK2	Q13177	human	CASP7	P55210	S239	WRsPGRGsWFVQALC	Peptidase_C14
PAK2	Q13177	human	ABL1	P00519	S619	PtPPKRsssFREMDG
PAK2	Q13177	human	PAK2	Q13177	S192	PRPDHTksIytRsVI
PAK2	Q13177	human	PAK2	Q13177	S141	tVkQKyLsFtPPEkd
PAK2	Q13177	human	SMAD2	Q15796	S467	sVRCssMs_______
PAK2	Q13177	human	NF2	P35240	S518	DTDMKRLsMEIEKEK	ERM_C
PAK2	Q13177	human	SMAD2	Q15796	S417	RMCTIRMsFVkGWGA	MH2
PAK2	Q13177	human	EIF4G1	Q04637	S895	RDIARRRsLGNIkFI	MIF4G
PAK2	Q13177	human	ARHGAP15	Q53QZ3	S4	____MQKsTNsDTSV
PAK2	Q13177	human	ARHGAP15	Q53QZ3	S43	DRLsQsksMILTDVG
PAK2	Q13177	human	PAK2	Q13177	T402	PEQSkRstMVGtPYW	Pkinase
PAK2	Q13177	human	JUN	P05412	T8	MtAKMETtFYDDALN	Jun
PAK2	Q13177	human	SMAD2	Q15796	S465	sPsVRCssMs_____
PAK2	Q13177	human	MYC	P01106	T415	VVILKkAtAYILsVQ	HLH
PAK2	Q13177	human	PXN	P49023	S272	ELDELMAsLsDFkIQ
PAK2	Q13177	human	CASP7	P55210	S30	DAKPDRssFVPsLFs
PAK2	Q13177	human	CALD1	Q05682	S714	EGVRNIksMWEkGNV	Caldesmon
PAK2	Q13177	human	ARHGAP15	Q53QZ3	S41	HHDRLsQsksMILTD
PAK2	Q13177	human	MAPK6	Q16659	S189	ySHKGHLsEGLVTkW	Pkinase
PAK2	Q13177	human	PXN	P49023	S274	DELMAsLsDFkIQGL
PAK2	Q13177	human	PAK2	Q13177	S197	TksIytRsVIDPVPA
PAK2	Q13177	human	CASP7	P55210	T173	FRGDRCktLLEkPKL	Peptidase_C14
PAK2	Q13177	human	CTNNB1	P35222	S552	QDtQRRtsMGGtQQQ
PAK2	Q13177	human	SMAD2	Q15796	S464	GsPsVRCssMs____
PAK2	Q13177	human	JUN	P05412	T89	QSSNGHItTtPtPtQ	Jun
PAK2	Q13177	human	PREX2	Q70Z35	S1107	DTISNRDsYSDCNSN
PAK2	Q13177	human	RAF1	P04049	S338	RPRGQRDssyyWEIE
PAK2	Q13177	human	MICAL1	Q8TDZ2	S960	ELALRRQssSPEQQK	bMERB_dom
PAK2	Q13177	human	HACE1	Q8IYU2	S385	LMKNKRDsTEITsIL
PAK2	Q13177	human	SLC25A5	P05141	T107	LGGVDkRtQFWLyFA
PAK2	Q13177	human	JUN	P05412	T93	GHItTtPtPtQFLCP	Jun
PAK2	Q13177	human	ABL1	P00519	S618	APtPPKRsssFREMD

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
PAK2	ID	Description	0.00e+00
PAK2	GO:0051017	actin filament bundle assembly	9.20e-06
PAK2	GO:0061572	actin filament bundle organization	9.20e-06
PAK2	GO:0051492	regulation of stress fiber assembly	7.93e-04
PAK2	GO:0110020	regulation of actomyosin structure organization	7.93e-04
PAK2	GO:0031400	negative regulation of protein modification process	7.93e-04
PAK2	GO:0032231	regulation of actin filament bundle assembly	7.93e-04
PAK2	GO:0030038	contractile actin filament bundle assembly	7.93e-04
PAK2	GO:0043149	stress fiber assembly	7.93e-04
PAK2	GO:0007015	actin filament organization	8.86e-04
PAK2	GO:0071560	cellular response to transforming growth factor beta stimulus	1.30e-03
PAK2	GO:0071559	response to transforming growth factor beta	1.31e-03
PAK2	GO:0001933	negative regulation of protein phosphorylation	1.43e-03
PAK2	GO:0048538	thymus development	1.75e-03
PAK2	GO:0042326	negative regulation of phosphorylation	1.75e-03
PAK2	GO:0051496	positive regulation of stress fiber assembly	1.76e-03
PAK2	GO:0032233	positive regulation of actin filament bundle assembly	2.69e-03
PAK2	GO:0045936	negative regulation of phosphate metabolic process	2.69e-03
PAK2	GO:0010563	negative regulation of phosphorus metabolic process	2.69e-03
PAK2	GO:0007440	foregut morphogenesis	3.13e-03
PAK2	GO:2001233	regulation of apoptotic signaling pathway	3.13e-03
PAK2	GO:0031032	actomyosin structure organization	3.71e-03
PAK2	GO:0009950	dorsal/ventral axis specification	4.07e-03
PAK2	GO:0051346	negative regulation of hydrolase activity	4.07e-03
PAK2	GO:0034333	adherens junction assembly	4.44e-03
PAK2	GO:0016358	dendrite development	4.84e-03
PAK2	GO:0048145	regulation of fibroblast proliferation	5.40e-03
PAK2	GO:0007264	small GTPase mediated signal transduction	5.67e-03
PAK2	GO:0045638	negative regulation of myeloid cell differentiation	5.67e-03
PAK2	GO:0060192	negative regulation of lipase activity	5.67e-03
PAK2	GO:0001657	ureteric bud development	5.67e-03
PAK2	GO:0048534	hematopoietic or lymphoid organ development	5.67e-03
PAK2	GO:0051098	regulation of binding	5.67e-03
PAK2	GO:0072163	mesonephric epithelium development	5.67e-03
PAK2	GO:0072164	mesonephric tubule development	5.67e-03
PAK2	GO:0001823	mesonephros development	6.19e-03
PAK2	GO:0110053	regulation of actin filament organization	6.19e-03
PAK2	GO:0048144	fibroblast proliferation	6.56e-03
PAK2	GO:0051056	regulation of small GTPase mediated signal transduction	7.89e-03
PAK2	GO:0007398	ectoderm development	8.04e-03
PAK2	GO:0002065	columnar/cuboidal epithelial cell differentiation	9.15e-03
PAK2	GO:0002053	positive regulation of mesenchymal cell proliferation	9.35e-03
PAK2	GO:0035994	response to muscle stretch	9.35e-03
PAK2	GO:0048011	neurotrophin TRK receptor signaling pathway	9.35e-03
PAK2	GO:0001704	formation of primary germ layer	9.35e-03
PAK2	GO:0044346	fibroblast apoptotic process	9.78e-03
PAK2	GO:0032956	regulation of actin cytoskeleton organization	1.08e-02
PAK2	GO:0031589	cell-substrate adhesion	1.30e-02
PAK2	GO:0033688	regulation of osteoblast proliferation	1.31e-02
PAK2	GO:0072073	kidney epithelium development	1.34e-02

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Related Drugs to PAK2_DLG1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning PAK2-DLG1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to PAK2_DLG1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date