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Kinase Fusion Gene:ARRB1_PAK1 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: ARRB1_PAK1 | KinaseFusionDB ID: KFG449 | FusionGDB2.0 ID: KFG449 | Hgene | Tgene | Gene symbol | ARRB1 | PAK1 | Gene ID | 408 | 5585 | |
Gene name | arrestin beta 1 | protein kinase N1 | ||||||||||
Synonyms | ARB1|ARR1 | DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1 | ||||||||||
Cytomap | 11q13.4 | 19p13.12 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | beta-arrestin-1arrestin 2non-visual arrestin-2 | serine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase N | ||||||||||
Modification date | 20240407 | 20240305 | ||||||||||
UniProtAcc | P49407 | Q16512 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000360025, ENST00000393505, ENST00000420843, | ENST00000278568, ENST00000356341, ENST00000530617, ENST00000525542, ENST00000528203, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ARRB1 [Title/Abstract] AND PAK1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ARRB1(75062632)-PAK1(77103586), # samples:3 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARRB1 | GO:0031397 | negative regulation of protein ubiquitination | 16378096 |
Hgene | ARRB1 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 16378096 |
Hgene | ARRB1 | GO:0032715 | negative regulation of interleukin-6 production | 16378096 |
Hgene | ARRB1 | GO:0032717 | negative regulation of interleukin-8 production | 16378096 |
Hgene | ARRB1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10644702 |
Tgene | PAK1 | GO:0006357 | regulation of transcription by RNA polymerase II | 12514133 |
Tgene | PAK1 | GO:0006468 | protein phosphorylation | 17332740 |
Tgene | PAK1 | GO:0043687 | post-translational protein modification | 18066052 |
Kinase Fusion gene breakpoints across ARRB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across PAK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-YG-AA3P-06A | ARRB1 | chr11 | 74993006 | PAK1 | chr11 | 77103583 |
ChimerDB4 | TCGA-YG-AA3P-06A | ARRB1 | chr11 | 75062632 | PAK1 | chr11 | 77103586 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:75062632/:77103586) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARRB1 | PAK1 |
FUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (PubMed:23886940). {ECO:0000250, ECO:0000269|PubMed:12464600, ECO:0000269|PubMed:14711824, ECO:0000269|PubMed:15475570, ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:15671180, ECO:0000269|PubMed:15878855, ECO:0000269|PubMed:16144840, ECO:0000269|PubMed:16280323, ECO:0000269|PubMed:16378096, ECO:0000269|PubMed:16492667, ECO:0000269|PubMed:16709866, ECO:0000269|PubMed:18337459, ECO:0000269|PubMed:18419762, ECO:0000269|PubMed:19620252, ECO:0000269|PubMed:19643177, ECO:0000269|PubMed:22457824, ECO:0000269|PubMed:23341447, ECO:0000269|PubMed:23633677, ECO:0000269|PubMed:23886940}. | FUNCTION: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ARRB1_PAK1 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
PAK1 | Q13153 | human | FXR1 | P51114 | S420 | sERkDELsDWsLAGE | FXMRP1_C_core |
PAK1 | Q13153 | human | ARPC1B | O15143 | T21 | HAWNkDRtQIAICPN | |
PAK1 | Q13153 | human | GNAZ | P19086 | S16 | EKEAARRsRRIDRHL | G-alpha |
PAK1 | Q13153 | human | ARHGEF2 | Q92974 | S886 | PVDPRRRsLPAGDAL | |
PAK1 | Q13153 | human | MAP3K1 | Q13233 | S67 | RQLRKVRsVELDQLP | |
PAK1 | Q13153 | human | TBCB | Q99426 | S128 | VRsFLKRsKLGRyNE | |
PAK1 | Q13153 | human | CRK | P46108 | S41 | VFLVRDsstsPGDyV | SH2 |
PAK1 | Q13153 | human | CTNNB1 | P35222 | S675 | QDykKRLsVELtsSL | |
PAK1 | Q13153 | human | GDI2 | P50395 | T248 | LSAIyGGtYMLNkPI | GDI |
PAK1 | Q13153 | human | MICAL1 | Q8TDZ2 | S817 | sPERQRLssLNLtPD | |
PAK1 | Q13153 | human | PXN | P49023 | S258 | tQQQtRIsAssAtRE | |
PAK1 | Q13153 | human | GDI2 | P50395 | S382 | PIEQkFVsIsDLLVP | GDI |
PAK1 | Q13153 | human | TBCB | Q99426 | S65 | GVDDKFYskLDQEDA | Ubiquitin_2 |
PAK1 | Q13153 | human | PXN | P49023-2 | S272 | ELDELMAsLSDFKFM | |
PAK1 | Q13153 | human | PLK1 | P53350 | S49 | EVLVDPRsRRRYVRG | |
PAK1 | Q13153 | human | H3C1 | P68431 | S10 | tkQtArkstGGkAPr | Histone |
PAK1 | Q13153 | human | PAK1 | Q13153 | S204 | tKsVyTRsVIEPLPV | |
PAK1 | Q13153 | human | SNAI1 | O95863 | S246 | QACARTFsRMsLLHK | |
PAK1 | Q13153 | human | FLNA | P21333 | S2292 | FEDRkDGsCGVAYVV | Filamin |
PAK1 | Q13153 | human | ARHGDIA | P52565 | S174 | kGMLARGsYsIkSRF | Rho_GDI |
PAK1 | Q13153 | human | PCBP1 | Q15365 | T60 | NCPERIItLTGPTNA | KH_1 |
PAK1 | Q13153 | human | CTTN | Q14247 | S405 | KtQtPPVsPAPQPtE | |
PAK1 | Q13153 | human | DYNLL1 | P63167 | S88 | VAILLFKsG______ | Dynein_light |
PAK1 | Q13153 | human | ARL4A | P40617 | S143 | QDLRNSLsLSEIEKL | Arf |
PAK1 | Q13153 | human | NLRP3 | Q96P20 | S198 | GKTKTCEsPVSPIKM | FISNA |
PAK1 | Q13153 | human | ARL4D | P49703 | S144 | QDQPGALsAAEVEkR | Arf |
PAK1 | Q13153 | human | SPEN | Q96T58 | T3568 | EGVARRMtVETDYCL | SPOC |
PAK1 | Q13153 | human | ARHGEF2 | Q92974-2 | S885 | PVDPRRRsLPAGDAL | |
PAK1 | Q13153 | human | AURKA | O14965 | S342 | QETYKRIsRVEFTFP | Pkinase |
PAK1 | Q13153 | human | STMN1 | P16949 | S38 | sVPEFPLsPPkKkDL | Stathmin |
PAK1 | Q13153 | human | GIT1 | Q9Y2X7 | S700 | PALEPVRsSLRLLNA | GIT1_C |
PAK1 | Q13153 | human | PCBP1 | Q15365 | T127 | IKEIREStGAQVQVA | KH_1 |
PAK1 | Q13153 | human | NF2 | P35240 | S518 | DTDMKRLsMEIEKEK | ERM_C |
PAK1 | Q13153 | human | PA2G4 | Q9UQ80 | T261 | QyGLkMktSRAFFsE | Peptidase_M24 |
PAK1 | Q13153 | human | RUNX3 | Q13761 | T209 | ERLRMRVtPstPsPr | |
PAK1 | Q13153 | human | ARHGDIA | P52565 | S101 | LEsFKkQsFVLkEGV | Rho_GDI |
PAK1 | Q13153 | human | STMN1 | P16949 | S16 | kELEKrAsGQAFELI | Stathmin |
PAK1 | Q13153 | human | MAP2K1 | Q02750 | S298 | RtPGRPLssyGMDSR | Pkinase |
PAK1 | Q13153 | human | BAD | Q92934 | S99 | PFrGrsRsAPPNLWA | Bcl-2_BAD |
PAK1 | Q13153 | human | KIF2C | Q99661 | S111 | kEsLRsRstRMstVS | |
PAK1 | Q13153 | human | AURKA | O14965 | T288 | APSsRRttLCGtLDy | Pkinase |
PAK1 | Q13153 | human | PGM1 | P36871 | T467 | SANDKVYtVEkADNF | |
PAK1 | Q13153 | human | PAK1 | Q13153 | S199 | PRPEHtKsVyTRsVI | |
PAK1 | Q13153 | human | RAF1 | P04049 | S339 | PRGQRDssyyWEIEA | |
PAK1 | Q13153 | human | ILK | Q13418 | S246 | CPRLRIFsHPNVLPV | PK_Tyr_Ser-Thr |
PAK1 | Q13153 | human | BAD | Q92934 | S75 | EIRsRHssyPAGtED | Bcl-2_BAD |
PAK1 | Q13153 | human | KIF2C | Q99661 | S192 | VNsVRRKsCLVkEVE | |
PAK1 | Q13153 | human | PGAM1 | P18669 | S23 | WNLENrFsGWyDADL | His_Phos_1 |
PAK1 | Q13153 | human | ARHGDIA | P52565 | S176 | MLARGsYsIkSRFTD | Rho_GDI |
PAK1 | Q13153 | human | ELF3 | P78545 | S207 | GTGASRSsHSSDsGG | |
PAK1 | Q13153 | human | MORC2 | Q9Y6X9 | S739 | AtPsRKRsVAVsDEE | |
PAK1 | Q13153 | human | CTTN | Q14247 | S113 | skLskHCsQVDsVrG | HS1_rep |
PAK1 | Q13153 | human | NLRP3 | Q96P20 | T659 | KIEINLStRMDHMVS | |
PAK1 | Q13153 | human | BAD | Q92934 | S118 | GRELRRMsDEFVDsF | Bcl-2_BAD |
PAK1 | Q13153 | human | GIT1 | Q9Y2X7 | S508 | RRDRQAFsMyEPGsA | |
PAK1 | Q13153 | human | ITGB3BP | Q13352 | S28 | SkITRKKsVITysPT | CENP-R |
PAK1 | Q13153 | human | BAD | Q92934 | S74 | VEIRsRHssyPAGtE | Bcl-2_BAD |
PAK1 | Q13153 | human | NLRP3 | Q96P20 | S163 | ARLGEsVsLNKRYTR | FISNA |
PAK1 | Q13153 | human | MYL9 | P24844 | S20 | KRPQRAtsNVFAMFD | |
PAK1 | Q13153 | human | FLNA | P21333 | S2152 | tRRRRAPsVANVGsH | Filamin |
PAK1 | Q13153 | human | SNAI2 | O43623 | S251 | KNCsKTFsRMsLLHK | zf-C2H2 |
PAK1 | Q13153 | human | FLNA | P21333 | S2370 | AIDAkVHsPsGALEE | Filamin |
PAK1 | Q13153 | human | BRAF | P15056 | S446 | KtLGRRDssDDWEIP | |
PAK1 | Q13153 | human | PGAM1 | P18669 | S118 | QVkIWRRsyDVPPPP | His_Phos_1 |
PAK1 | Q13153 | human | CTNNB1 | P35222 | S552 | QDtQRRtsMGGtQQQ | |
PAK1 | Q13153 | human | SPEN | Q96T58 | S3486 | QPAPKQDssPHLTSQ | |
PAK1 | Q13153 | human | CTTN | Q14247 | S418 | tEErLPssPVyEDAA | |
PAK1 | Q13153 | human | LIMK1 | P53667 | T508 | PDRKKRYtVVGNPYW | PK_Tyr_Ser-Thr |
PAK1 | Q13153 | human | PAK1 | Q13153 | S144 | sNsQKyMsFtDksAE | |
PAK1 | Q13153 | human | RAF1 | P04049 | S338 | RPRGQRDssyyWEIE | |
PAK1 | Q13153 | human | PREX2 | Q70Z35 | S1107 | DTISNRDsYSDCNSN | |
PAK1 | Q13153 | human | ILK | Q13418 | T173 | DTFWkGttRTRPRNG | |
PAK1 | Q13153 | human | CTBP1 | Q13363 | S158 | REGTRVQsVEQIREV | 2-Hacid_dh_C; 2-Hacid_dh |
PAK1 | Q13153 | human | PAK1 | Q13153 | T423 | PEQSkRstMVGtPYW | Pkinase |
PAK1 | Q13153 | human | MICAL1 | Q8TDZ2 | S960 | ELALRRQssSPEQQK | bMERB_dom |
PAK1 | Q13153 | human | HACE1 | Q8IYU2 | S385 | LMKNKRDsTEITsIL | |
PAK1 | Q13153 | human | ESR1 | P03372 | S305 | IkRSkkNsLALSLtA | |
PAK1 | Q13153 | human | MYLK | Q15746 | S1772 | SGLsGRKsstGsPts | |
PAK1 | Q13153 | human | BAD | Q92934 | S134 | KGLPRPKsAGtAtQM | Bcl-2_BAD |
PAK1 | Q13153 | human | VIM | P08670 | S56 | srsLyAssPGGVyAt | Filament_head |
PAK1 | Q13153 | human | ATG5 | Q9H1Y0 | T101 | SALPWNItVHFKSFP | APG5 |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
PAK1 | ID | Description | 0.00e+00 |
PAK1 | GO:0051017 | actin filament bundle assembly | 7.15e-06 |
PAK1 | GO:0061572 | actin filament bundle organization | 7.15e-06 |
PAK1 | GO:0032233 | positive regulation of actin filament bundle assembly | 7.15e-06 |
PAK1 | GO:0032231 | regulation of actin filament bundle assembly | 7.15e-06 |
PAK1 | GO:1902905 | positive regulation of supramolecular fiber organization | 8.29e-06 |
PAK1 | GO:0051495 | positive regulation of cytoskeleton organization | 9.71e-06 |
PAK1 | GO:0007015 | actin filament organization | 9.71e-06 |
PAK1 | GO:1902903 | regulation of supramolecular fiber organization | 1.82e-05 |
PAK1 | GO:0051492 | regulation of stress fiber assembly | 4.26e-05 |
PAK1 | GO:0051496 | positive regulation of stress fiber assembly | 4.66e-05 |
PAK1 | GO:0032956 | regulation of actin cytoskeleton organization | 4.66e-05 |
PAK1 | GO:0110020 | regulation of actomyosin structure organization | 6.18e-05 |
PAK1 | GO:0030038 | contractile actin filament bundle assembly | 6.98e-05 |
PAK1 | GO:0043149 | stress fiber assembly | 6.98e-05 |
PAK1 | GO:0007264 | small GTPase mediated signal transduction | 7.90e-05 |
PAK1 | GO:0110053 | regulation of actin filament organization | 7.90e-05 |
PAK1 | GO:0032970 | regulation of actin filament-based process | 8.07e-05 |
PAK1 | GO:0031032 | actomyosin structure organization | 1.50e-04 |
PAK1 | GO:0010720 | positive regulation of cell development | 2.67e-04 |
PAK1 | GO:0007265 | Ras protein signal transduction | 3.33e-04 |
PAK1 | GO:0031589 | cell-substrate adhesion | 4.35e-04 |
PAK1 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 4.38e-04 |
PAK1 | GO:0022411 | cellular component disassembly | 5.51e-04 |
PAK1 | GO:1903034 | regulation of response to wounding | 5.70e-04 |
PAK1 | GO:0034446 | substrate adhesion-dependent cell spreading | 5.74e-04 |
PAK1 | GO:0048538 | thymus development | 6.92e-04 |
PAK1 | GO:0046578 | regulation of Ras protein signal transduction | 6.98e-04 |
PAK1 | GO:0071470 | cellular response to osmotic stress | 8.16e-04 |
PAK1 | GO:0051056 | regulation of small GTPase mediated signal transduction | 9.24e-04 |
PAK1 | GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 1.44e-03 |
PAK1 | GO:0048732 | gland development | 1.44e-03 |
PAK1 | GO:0031109 | microtubule polymerization or depolymerization | 1.86e-03 |
PAK1 | GO:0007266 | Rho protein signal transduction | 2.00e-03 |
PAK1 | GO:0061311 | cell surface receptor signaling pathway involved in heart development | 2.67e-03 |
PAK1 | GO:2001234 | negative regulation of apoptotic signaling pathway | 2.67e-03 |
PAK1 | GO:0044342 | type B pancreatic cell proliferation | 3.17e-03 |
PAK1 | GO:0032886 | regulation of microtubule-based process | 3.47e-03 |
PAK1 | GO:0006970 | response to osmotic stress | 3.47e-03 |
PAK1 | GO:0039694 | viral RNA genome replication | 3.47e-03 |
PAK1 | GO:0048679 | regulation of axon regeneration | 3.47e-03 |
PAK1 | GO:0070507 | regulation of microtubule cytoskeleton organization | 3.47e-03 |
PAK1 | GO:0035023 | regulation of Rho protein signal transduction | 3.47e-03 |
PAK1 | GO:0030878 | thyroid gland development | 3.60e-03 |
PAK1 | GO:0050767 | regulation of neurogenesis | 3.60e-03 |
PAK1 | GO:0061351 | neural precursor cell proliferation | 3.66e-03 |
PAK1 | GO:0070570 | regulation of neuron projection regeneration | 3.72e-03 |
PAK1 | GO:2001233 | regulation of apoptotic signaling pathway | 3.83e-03 |
PAK1 | GO:0031110 | regulation of microtubule polymerization or depolymerization | 5.14e-03 |
PAK1 | GO:0042060 | wound healing | 5.36e-03 |
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Related Drugs to ARRB1_PAK1 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning ARRB1-PAK1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ARRB1_PAK1 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |