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Kinase Fusion Gene:PCBP2_CDK11B |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: PCBP2_CDK11B | KinaseFusionDB ID: KFG4525 | FusionGDB2.0 ID: KFG4525 | Hgene | Tgene | Gene symbol | PCBP2 | CDK11B | Gene ID | 5094 | 984 | |
| Gene name | poly(rC) binding protein 2 | cyclin dependent kinase 11B | ||||||||||
| Synonyms | HNRNPE2|HNRPE2|hnRNP-E2 | CDC2L1|CDK11|CDK11-p110|CDK11-p46|CDK11-p58|CLK-1|PITSLREA|PK58|p58|p58CDC2L1|p58CLK-1 | ||||||||||
| Cytomap | 12q13.13 | 1p36.33 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | poly(rC)-binding protein 2alpha-CP2epididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2 | cyclin-dependent kinase 11BCDC-related protein kinase p58PITSLRE serine/threonine-protein kinase CDC2L1cell division cycle 2-like 1 (PITSLRE proteins)cell division protein kinase 11Bgalactosyltransferase-associated protein kinase p58/GTAp58 CLK-1 | ||||||||||
| Modification date | 20240411 | 20240407 | ||||||||||
| UniProtAcc | Q15366 | P21127 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000359282, ENST00000359462, ENST00000437231, ENST00000439930, ENST00000447282, ENST00000455667, ENST00000541275, ENST00000546463, ENST00000548933, ENST00000549863, ENST00000552296, ENST00000552819, ENST00000603815, | ENST00000317673, ENST00000340677, ENST00000341832, ENST00000407249, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PCBP2 [Title/Abstract] AND CDK11B [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PCBP2(53848593)-CDK11B(1577121), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PCBP2 | GO:0039694 | viral RNA genome replication | 12414943 |
| Hgene | PCBP2 | GO:0075522 | IRES-dependent viral translational initiation | 12414943 |
| Hgene | PCBP2 | GO:0160049 | negative regulation of cGAS/STING signaling pathway | 35322803 |
| Tgene | CDK11B | GO:0006468 | protein phosphorylation | 12501247 |
| Tgene | CDK11B | GO:0050684 | regulation of mRNA processing | 12501247 |
| Kinase Fusion gene breakpoints across PCBP2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CDK11B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BC033069 | PCBP2 | chr12 | 53848593 | CDK11B | chr1 | 1577121 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:53848593/:1577121) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PCBP2 | CDK11B |
| FUNCTION: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:7607214, PubMed:12414943). Major cellular poly(rC)-binding protein (PubMed:12414943). Binds also poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity). {ECO:0000250|UniProtKB:Q61990, ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:19881509, ECO:0000269|PubMed:35322803, ECO:0000269|PubMed:7607214}.; FUNCTION: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). {ECO:0000269|PubMed:12414943, ECO:0000269|PubMed:24371074}. | FUNCTION: Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PCBP2_CDK11B |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CDK11B | P21127 | human | AR | P10275 | S310 | TEDTAEysPFKGGYT | Androgen_recep |
| CDK11B | P21127 | human | EIF3F | O00303 | S46 | PAAAPASsSDPAAAA |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CDK11B | ID | Description | 0.00e+00 |
| CDK11B | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | 1.28e-02 |
| CDK11B | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 1.28e-02 |
| CDK11B | GO:0033327 | Leydig cell differentiation | 1.28e-02 |
| CDK11B | GO:0060601 | lateral sprouting from an epithelium | 1.28e-02 |
| CDK11B | GO:0060736 | prostate gland growth | 1.28e-02 |
| CDK11B | GO:0060742 | epithelial cell differentiation involved in prostate gland development | 1.28e-02 |
| CDK11B | GO:0060767 | epithelial cell proliferation involved in prostate gland development | 1.28e-02 |
| CDK11B | GO:0075522 | IRES-dependent viral translational initiation | 1.28e-02 |
| CDK11B | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway | 1.28e-02 |
| CDK11B | GO:0035112 | genitalia morphogenesis | 1.28e-02 |
| CDK11B | GO:0071394 | cellular response to testosterone stimulus | 1.28e-02 |
| CDK11B | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway | 1.28e-02 |
| CDK11B | GO:0030238 | male sex determination | 1.28e-02 |
| CDK11B | GO:0060572 | morphogenesis of an epithelial bud | 1.28e-02 |
| CDK11B | GO:0001732 | formation of cytoplasmic translation initiation complex | 1.28e-02 |
| CDK11B | GO:0072520 | seminiferous tubule development | 1.28e-02 |
| CDK11B | GO:0045945 | positive regulation of transcription by RNA polymerase III | 1.28e-02 |
| CDK11B | GO:0071391 | cellular response to estrogen stimulus | 1.28e-02 |
| CDK11B | GO:0060749 | mammary gland alveolus development | 1.28e-02 |
| CDK11B | GO:0061377 | mammary gland lobule development | 1.28e-02 |
| CDK11B | GO:0019081 | viral translation | 1.28e-02 |
| CDK11B | GO:0060444 | branching involved in mammary gland duct morphogenesis | 1.28e-02 |
| CDK11B | GO:0007530 | sex determination | 1.28e-02 |
| CDK11B | GO:0001759 | organ induction | 1.28e-02 |
| CDK11B | GO:0030539 | male genitalia development | 1.28e-02 |
| CDK11B | GO:0060571 | morphogenesis of an epithelial fold | 1.28e-02 |
| CDK11B | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway | 1.28e-02 |
| CDK11B | GO:0042659 | regulation of cell fate specification | 1.28e-02 |
| CDK11B | GO:0060740 | prostate gland epithelium morphogenesis | 1.28e-02 |
| CDK11B | GO:0003156 | regulation of animal organ formation | 1.29e-02 |
| CDK11B | GO:0060512 | prostate gland morphogenesis | 1.29e-02 |
| CDK11B | GO:0060603 | mammary gland duct morphogenesis | 1.30e-02 |
| CDK11B | GO:0006359 | regulation of transcription by RNA polymerase III | 1.30e-02 |
| CDK11B | GO:0003382 | epithelial cell morphogenesis | 1.32e-02 |
| CDK11B | GO:0031128 | developmental induction | 1.32e-02 |
| CDK11B | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway | 1.32e-02 |
| CDK11B | GO:0110110 | positive regulation of animal organ morphogenesis | 1.32e-02 |
| CDK11B | GO:0010092 | specification of animal organ identity | 1.32e-02 |
| CDK11B | GO:1905332 | positive regulation of morphogenesis of an epithelium | 1.32e-02 |
| CDK11B | GO:0002183 | cytoplasmic translational initiation | 1.43e-02 |
| CDK11B | GO:0010453 | regulation of cell fate commitment | 1.46e-02 |
| CDK11B | GO:0060443 | mammary gland morphogenesis | 1.46e-02 |
| CDK11B | GO:0033574 | response to testosterone | 1.50e-02 |
| CDK11B | GO:0048806 | genitalia development | 1.52e-02 |
| CDK11B | GO:0030521 | androgen receptor signaling pathway | 1.52e-02 |
| CDK11B | GO:0030850 | prostate gland development | 1.52e-02 |
| CDK11B | GO:0048009 | insulin-like growth factor receptor signaling pathway | 1.52e-02 |
| CDK11B | GO:0060688 | regulation of morphogenesis of a branching structure | 1.52e-02 |
| CDK11B | GO:1902895 | positive regulation of miRNA transcription | 1.52e-02 |
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Related Drugs to PCBP2_CDK11B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning PCBP2-CDK11B and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PCBP2_CDK11B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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