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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PCMT1_LATS1

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: PCMT1_LATS1
	KinaseFusionDB ID: KFG4538
	FusionGDB2.0 ID: KFG4538
		Hgene	Tgene
	Gene symbol	PCMT1	LATS1
	Gene ID	5110	9113
	Gene name	protein-L-isoaspartate (D-aspartate) O-methyltransferase	large tumor suppressor kinase 1
	Synonyms	PIMT	WARTS\|wts
	Cytomap	6q25.1	6q25.1
	Type of gene	protein-coding	protein-coding
	Description	protein-L-isoaspartate(D-aspartate) O-methyltransferaseL-isoaspartyl protein carboxyl methyltransferaseepididymis secretory sperm binding proteinprotein L-isoaspartyl/D-aspartyl methyltransferaseprotein-beta-aspartate methyltransferase	serine/threonine-protein kinase LATS1LATS (large tumor suppressor, Drosophila) homolog 1LATS, large tumor suppressor, homolog 1WARTS protein kinaseh-wartslarge tumor suppressor homolog 1
	Modification date	20240407	20240407
	UniProtAcc	P22061	O95835
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367384, ENST00000367378, ENST00000464889, ENST00000367380, ENST00000544496, ENST00000480010,	ENST00000543571, ENST00000253339, ENST00000542747, ENST00000392273,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: PCMT1 [Title/Abstract] AND LATS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PCMT1	GO:0006479	protein methylation	3167043
Tgene	LATS1	GO:0000086	G2/M transition of mitotic cell cycle	15122335
Tgene	LATS1	GO:0000819	sister chromatid segregation	15122335
Tgene	LATS1	GO:0006468	protein phosphorylation	10518011
Tgene	LATS1	GO:0030833	regulation of actin filament polymerization	15220930
Tgene	LATS1	GO:0033138	positive regulation of peptidyl-serine phosphorylation	20412773
Tgene	LATS1	GO:0035329	hippo signaling	20412773
Tgene	LATS1	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	9988268

Kinase Fusion gene breakpoints across PCMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across LATS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
CCLE	NCI-H1838	PCMT1	chr6	150094305	LATS1	chr6	150016357

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000367384	ENST00000543571	PCMT1	chr6	150094305	LATS1	chr6	150016357	7272	1179

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000367384_ENST00000543571_PCMT1_chr6_150094305_LATS1_chr6_150016357_length(amino acids)=1179
MQSPGSGSSHRGGRLGHTPPPPSAPPGRTLSRAASQSACVPRGMPGARSGGSGGDGSNSGSYSGDASGAVTVWEVVSLLGKLLGTVVALK
VVLYLLRVCLAMAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMDMVIQALQKTNNRSI
EAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGIS
AFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMN
PPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYT
NGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITP
APIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSK
EDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRV
GLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEAD
NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCT
GFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILF
EMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKIT
HPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSE

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:/chr6:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PCMT1 P22061	LATS1 O95835
FUNCTION: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250\|UniProtKB:P23506, ECO:0000269\|PubMed:3167043, ECO:0000269\|PubMed:6469980}.	FUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). {ECO:0000269\|PubMed:10518011, ECO:0000269\|PubMed:10831611, ECO:0000269\|PubMed:15122335, ECO:0000269\|PubMed:15220930, ECO:0000269\|PubMed:18158288, ECO:0000269\|PubMed:19927127, ECO:0000269\|PubMed:28068668}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Tgene

PCMT1

150094305

LATS1

150016357

ENST00000367384

1011_1090

116

1131

Domain

Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618

Tgene

PCMT1

150094305

LATS1

150016357

ENST00000367384

1011_1090

116

691

Domain

Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618

Tgene

PCMT1

150094305

LATS1

150016357

ENST00000367384

1011_1090

116

1131

Domain

Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618

Tgene

PCMT1

150094305

LATS1

150016357

ENST00000367384

705_1010

116

1131

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

PCMT1

150094305

LATS1

150016357

ENST00000367384

705_1010

116

691

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

PCMT1

150094305

LATS1

150016357

ENST00000367384

705_1010

116

1131

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>368_PCMT1_LATS1	ENST00000367384	ENST00000543571	PCMT1	chr6	150094305	LATS1	chr6	150016357	MQSPGSGSSHRGGRLGHTPPPPSAPPGRTLSRAASQSACVPRGMPGARSGGSGGDGSNSGSYSGDASGAVTVWEVVSLLGKLLGTVVALK VVLYLLRVCLAMAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMDMVIQALQKTNNRSI EAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGIS AFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMN PPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYT NGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITP APIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSK EDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRV GLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEAD NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCT GFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILF EMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKIT HPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSE	1179
3D view using mol* of 368_PCMT1_LATS1

PDB file >>>TKFP_638_PCMT1_LATS1	ENST00000367384	ENST00000543571	PCMT1	chr6	150094305	LATS1	chr6	150016357	MQSPGSGSSHRGGRLGHTPPPPSAPPGRTLSRAASQSACVPRGMPGARSGGSGGDGSNSGSYSGDASGAVTVWEVVSLLGKLLGTVVALK VVLYLLRVCLAMAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMDMVIQALQKTNNRSI EAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGIS AFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMN PPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYT NGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITP APIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSK EDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRV GLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEAD NEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCT GFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILF EMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKIT HPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSE	1179_PCMT1_LATS1

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

PCMT1_LATS1 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/368_PCMT1_LATS1.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

368_PCMT1_LATS1.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

368_PCMT1_LATS1_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info

Drug

Docking score

Glide g score

Glide energy

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Kinase-Substrate Information of PCMT1_LATS1

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
LATS1	O95835	human	INCENP	Q9NQS7	S894	RYHKRtssAVWNsPP
LATS1	O95835	human	YAP1	P46937	S397	tyHSRDEstDsGLsM
LATS1	O95835	human	YAP1	P46937	S61	IVHVRGDsEtDLEAL
LATS1	O95835	human	MAP3K11	Q16584	T477	HVRRRRGtFKRSKLR
LATS1	O95835	human	SASH1	O94885	S407	LSHGRtCsFGGFDLT	SLY
LATS1	O95835	human	CDC26	Q8NHZ8	T7	_MLRRKPtRLELKLD	ANAPC_CDC26
LATS1	O95835	human	RPTOR	Q8N122	S606	SAHEkLYsLLSDPIP	HEAT
LATS1	O95835	human	SNAI2	O43623	T208	QGHIRtHtGEkPFSC
LATS1	O95835	human	LATS1	O95835	S674	EMMRVGLsQDAQDQM
LATS1	O95835	human	LATS1	O95835	S909	HQRCLAHsLVGTPNY	Pkinase
LATS1	O95835	human	YAP1	P46937	S381	LRTMTTNssDPFLNs
LATS1	O95835	human	YAP1	P46937-2	S61	IVHVRGDsEtDLEAL
LATS1	O95835	human	MTF1	Q14872	S152	EGCPRTysTAGNLRT	zf-C2H2
LATS1	O95835	human	PRPS1	P60891	S285	EDkMKHCsKIQVIDI	Pribosyl_synth
LATS1	O95835	human	RAF1	P04049	S259	sQRQRststPNVHMV
LATS1	O95835	human	KIF23	Q02241	S814	LRHRRsRsAGDRWVD	MKLP1_Arf_bdg
LATS1	O95835	human	AMOT	Q4VCS5	S175	QGHVRSLsERLMQMS
LATS1	O95835	human	YAP1	P46937-2	S109	KsHsRQAstDAGtAG
LATS1	O95835	human	KIF23	Q02241	S716	QLHRRsNsCsSISVA
LATS1	O95835	human	YAP1	P46937	S127	PQHVRAHssPAsLQL
LATS1	O95835	human	LATS1	O95835	S1049	VDPDkLWsDDNEEEN
LATS1	O95835	human	PRPS2	P11908	T285	EDkMkHCtKIQVIDI	Pribosyl_synth
LATS1	O95835	human	YAP1	P46937-2	S127	PQHVRAHssPASLQL
LATS1	O95835	human	YAP1	P46937	S109	ksHsRQAstDAGtAG
LATS1	O95835	human	YAP1	P46937-2	S164	AQHLRQssFEIPDDV
LATS1	O95835	human	YAP1	P46937-2	S381	TYHSRDEsTDsGLsM
LATS1	O95835	human	WWTR1	Q9GZV5	S89	AQHVRsHssPAsLQL

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
LATS1	ID	Description	0.00e+00
LATS1	GO:0035329	hippo signaling	2.51e-05
LATS1	GO:0051256	mitotic spindle midzone assembly	4.29e-03
LATS1	GO:0000022	mitotic spindle elongation	4.29e-03
LATS1	GO:0072182	regulation of nephron tubule epithelial cell differentiation	4.29e-03
LATS1	GO:0060828	regulation of canonical Wnt signaling pathway	4.29e-03
LATS1	GO:0051231	spindle elongation	4.29e-03
LATS1	GO:0051255	spindle midzone assembly	4.29e-03
LATS1	GO:0072160	nephron tubule epithelial cell differentiation	4.29e-03
LATS1	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	4.29e-03
LATS1	GO:0071900	regulation of protein serine/threonine kinase activity	4.29e-03
LATS1	GO:2000696	regulation of epithelial cell differentiation involved in kidney development	4.29e-03
LATS1	GO:0033138	positive regulation of peptidyl-serine phosphorylation	4.29e-03
LATS1	GO:0060070	canonical Wnt signaling pathway	5.11e-03
LATS1	GO:0006098	pentose-phosphate shunt	5.52e-03
LATS1	GO:0030111	regulation of Wnt signaling pathway	5.52e-03
LATS1	GO:0072234	metanephric nephron tubule development	5.52e-03
LATS1	GO:0006740	NADPH regeneration	5.52e-03
LATS1	GO:0072202	cell differentiation involved in metanephros development	5.52e-03
LATS1	GO:0033135	regulation of peptidyl-serine phosphorylation	5.52e-03
LATS1	GO:0071902	positive regulation of protein serine/threonine kinase activity	5.52e-03
LATS1	GO:0090090	negative regulation of canonical Wnt signaling pathway	5.52e-03
LATS1	GO:0072170	metanephric tubule development	5.52e-03
LATS1	GO:0072243	metanephric nephron epithelium development	5.52e-03
LATS1	GO:1900180	regulation of protein localization to nucleus	5.52e-03
LATS1	GO:0045598	regulation of fat cell differentiation	5.63e-03
LATS1	GO:0045667	regulation of osteoblast differentiation	5.86e-03
LATS1	GO:0051156	glucose 6-phosphate metabolic process	6.13e-03
LATS1	GO:0072207	metanephric epithelium development	6.13e-03
LATS1	GO:2001236	regulation of extrinsic apoptotic signaling pathway	6.13e-03
LATS1	GO:0043507	positive regulation of JUN kinase activity	6.59e-03
LATS1	GO:0030856	regulation of epithelial cell differentiation	7.23e-03
LATS1	GO:0030178	negative regulation of Wnt signaling pathway	7.25e-03
LATS1	GO:0009156	ribonucleoside monophosphate biosynthetic process	7.42e-03
LATS1	GO:0033146	regulation of intracellular estrogen receptor signaling pathway	7.42e-03
LATS1	GO:0016055	Wnt signaling pathway	7.86e-03
LATS1	GO:0198738	cell-cell signaling by wnt	7.86e-03
LATS1	GO:0050673	epithelial cell proliferation	8.91e-03
LATS1	GO:0009124	nucleoside monophosphate biosynthetic process	9.99e-03
LATS1	GO:0006739	NADP metabolic process	9.99e-03
LATS1	GO:0043506	regulation of JUN kinase activity	9.99e-03
LATS1	GO:0001825	blastocyst formation	1.02e-02
LATS1	GO:0010837	regulation of keratinocyte proliferation	1.04e-02
LATS1	GO:0032467	positive regulation of cytokinesis	1.04e-02
LATS1	GO:0035850	epithelial cell differentiation involved in kidney development	1.04e-02
LATS1	GO:0000819	sister chromatid segregation	1.11e-02
LATS1	GO:0097191	extrinsic apoptotic signaling pathway	1.14e-02
LATS1	GO:0030520	intracellular estrogen receptor signaling pathway	1.28e-02
LATS1	GO:2001234	negative regulation of apoptotic signaling pathway	1.30e-02
LATS1	GO:0045444	fat cell differentiation	1.34e-02

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Related Drugs to PCMT1_LATS1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning PCMT1-LATS1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

Top

Related Diseases to PCMT1_LATS1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Top

Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date