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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PDIA4_PRKACA

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PDIA4_PRKACA
KinaseFusionDB ID: KFG4569
FusionGDB2.0 ID: KFG4569
HgeneTgene
Gene symbol

PDIA4

PRKACA

Gene ID

9601

5578

Gene nameprotein disulfide isomerase family A member 4protein kinase C alpha
SynonymsERP70|ERP72|ERp-72AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA
Cytomap

7q36.1

17q24.2

Type of geneprotein-codingprotein-coding
Descriptionprotein disulfide-isomerase A4ER protein 70ER protein 72endoplasmic reticulum resident protein 70endoplasmic reticulum resident protein 72protein disulfide isomerase related protein (calcium-binding protein, intestinal-related)protein disulfide isomprotein kinase C alpha typePKC-Aaging-associated gene 6
Modification date2024040720240403
UniProtAcc

P13667

P17612

Ensembl transtripts involved in fusion geneENST idsENST00000286091, ENST00000308677, 
ENST00000350356, ENST00000589994, 
ENST00000590853, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PDIA4 [Title/Abstract] AND PRKACA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PDIA4(148700781)-PRKACA(14209629), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKACA

GO:0006468

protein phosphorylation

10770950

TgenePRKACA

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

TgenePRKACA

GO:0043687

post-translational protein modification

20228790

TgenePRKACA

GO:0090330

regulation of platelet aggregation

12724315

TgenePRKACA

GO:0110063

positive regulation of angiotensin-activated signaling pathway

25313067


check buttonKinase Fusion gene breakpoints across PDIA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across PRKACA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0AX261401PDIA4chr7

148700781

PRKACAchr19

14209629



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:148700781/:14209629)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PDIA4

P13667

PRKACA

P17612

FUNCTION: Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:31112131). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Required for phosphorylation of GLI transcription factors which inhibits them and prevents transcriptional activation of Hedgehog signaling pathway target genes (By similarity). GLI transcription factor phosphorylation is inhibited by interaction of PRKACA with SMO which sequesters PRKACA at the cell membrane (By similarity). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis most probably through the regulation of OFD1 in ciliogenesis (PubMed:33934390). Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984, ECO:0000269|PubMed:31112131, ECO:0000269|PubMed:33934390}.; FUNCTION: [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PDIA4_PRKACA


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKACAP17612humanGLI1P08151T374PGCTkRYtDPSSLRKzf-C2H2
PRKACAP17612humanCUX1P39880S1270YQQKPYPsPKTIEDLHomeodomain
PRKACAP17612humanCDK16Q00536S119EDINkRLsLPADIRL
PRKACAP17612humanNOS3P29474T495TGITRKKtFKEVANA
PRKACAP17612humanMAP2P11137S1679NVKsKIGstDNIKYQTubulin-binding
PRKACAP17612humanCIITAP33076S1050AASLLRLsLYNNCICLRR_6
PRKACAP17612humanMAPKAPK5Q8IW41S115GELFHRIsQHRHFTEPkinase
PRKACAP17612humanCAMKK2Q96RR4S495kTMIRKRsFGNPFEG
PRKACAP17612humanNEDD4LQ96PU5S342ssRLRsCsVtDAVAE
PRKACAP17612humanNCOA3Q9Y6Q9S857PPYNRAVsLDsPVsV
PRKACAP17612humanPPP2R5DQ14738S75QLSkIkysGGPQIVk
PRKACAP17612humanRB1P06400S780strPPtLsPIPHIPrRb_C
PRKACAP17612humanHEXIM1O94992S158KKHRRRPsKKKRHWk
PRKACAP17612humanGLI3P10071S980VHAPRRCsDGGAHGY
PRKACAP17612humanCACNA1CQ13936S1535DYLTRDWsILGPHHLIon_trans
PRKACAP17612humanKCNQ2O43526-4S455SKVPKSWsFGDRSRAKCNQ_channel
PRKACAP17612humanPLCG1P19174S1248HGrAREGsFEsRyQQ
PRKACAP17612humanASIC1P78348-1S525QKEAKRSsADKGVAL
PRKACAP17612humanDISC1Q9NRI5S58GPGIGFLsPAVGTLF
PRKACAP17612humanCASP9P55211S99NRQAAkLskPTLENL
PRKACAP17612humanMYBPC3Q14896S284AGGGRRIsDsHEDtG
PRKACAP17612humanGATA4P43694S262IkPQRRLsAsRRVGL
PRKACAP17612humanPPP1R9AQ9ULJ8S460ANRKIKFsSAPIKVFPDZ_5
PRKACAP17612humanCHCHD3Q9NX63T11TTSTRRVtFEADENE
PRKACAP17612humanE2F1Q01094T130GEkSRYEtSLNLttKE2F_TDP
PRKACAP17612humanDACT1Q9NYF0S827KKILRFRsGSLKLMTDapper
PRKACAP17612humanMARK3P27448T507GGMtRRNtyVCsERT
PRKACAP17612humanRASGRF1Q13972S927KEKYRRMsLASAGFP
PRKACAP17612humanCFTRP13569S670TETLHRFsLEGDAPVCFTR_R
PRKACAP17612humanCCND1P24385S197ATDVKFIsNPPSMVACyclin_C
PRKACAP17612humanDUOX1Q9NRD9S955KDLCRRAsyIsQDMI
PRKACAP17612humanSCN5AQ14524S524RTsMKPRssrGsIFtNa_trans_cytopl
PRKACAP17612humanNFKB1P19838S337FVQLRRKsDLETSEPRHD_dimer
PRKACAP17612humanSTK26Q9P289T178DtQIkRNtFVGtPFWPkinase
PRKACAP17612humanKCNH2Q12809S1137EGPTRRLsLPGQLGA
PRKACAP17612humanPLNP26678S16RSAIRRAstIEMPQQPhospholamban
PRKACAP17612humanFOXO1Q12778S153AGQPRKSsSSRRNAW
PRKACAP17612humanMYBPC3Q14896S311sFRtPRDsKLEAPAE
PRKACAP17612humanCAPN1P07384S474ANAsRARsEQFINLRCalpain_III
PRKACAP17612humanCAMKK2Q96RR4S511RREERsLsAPGNLLT
PRKACAP17612humanPHOX2AO14813S153RKQERAAsAkGAAGA
PRKACAP17612humanGFAPP14136S38LGPGTRLsLARMPPPFilament_head
PRKACAP17612humanETV1P50549S216PMYQRQMsEPNIPFPETS_PEA3_N
PRKACAP17612humanSRFP11831T159DNkLRRYtTFsKRkTSRF-TF
PRKACAP17612humanDNM1LO00429S637VPVARKLsAREQRDC
PRKACAP17612humanLIPEQ05469S951GFHPRRssQGAtQMPAbhydrolase_3
PRKACAP17612humanVASPP50552T278LARRRKAtQVGEktP
PRKACAP17612humanKCNH2Q12809S890RQRKRKLsFRRRtDK
PRKACAP17612humanTRPC5Q9UL62S794SGGARAKsKsVSFNL
PRKACAP17612humanIGFBP1P08833S199ETsGEEIsKFYLPNCThyroglobulin_1
PRKACAP17612humanDESP17661T17RVssYRRtFGGAPGFFilament_head
PRKACAP17612humanCHKBQ9Y259S39TPKRRRAssLsRDAE
PRKACAP17612humanADRB2P07550S345ELLCLRRssLKAyGN
PRKACAP17612humanCEACAM1P13688S461FGKtGRAsDQRDLTE
PRKACAP17612humanHSD17B13Q7Z5P4S33FIPQRRKsVAGEIVL
PRKACAP17612humanPDE4DQ08499-2S13NFPFRRHsWICFDVD
PRKACAP17612humanIGFBP1P08833S144NFHLMAPsEEDHSIL
PRKACAP17612humanYWHAZP63104S58VVGARRssWRVVssI14-3-3
PRKACAP17612humanTBXA2RP21731-2T332TRPRRsLtLWPSLEY
PRKACAP17612humanBRSK2Q8IWQ3T260VDAARRLtLEHIQKHPkinase
PRKACAP17612humanNDE1Q9NXR1-1S306DGGERRPsstsVPLGNUDE_C
PRKACAP17612humanHIF1AQ16665S465tPkPLRSsADPALNQ
PRKACAP17612humanPARP1P09874S465FLQDVSAsTkSLQEL
PRKACAP17612humanTRPC6Q9Y210T70RLAHRRQtVLREKGR
PRKACAP17612humanCTPS1P17812T455MRLGKRRtLFQTkNsGATase
PRKACAP17612humanNFATC1O95644S245PSTsPRAsVTEEsWL
PRKACAP17612humanDDX25Q9UHL0T239KLKLIDLtKIRVFVLDEAD
PRKACAP17612humanHRH1P35367S398WKRLRsHsRQyVSGL7tm_1
PRKACAP17612humanRGS18Q9NS28S216PTNLRRRsRsFTCNE
PRKACAP17612humanTPH1P17752S260TQYVRHSsDPFYTPEBiopterin_H
PRKACAP17612humanSCN5AQ14524S525TsMKPRssrGsIFtFNa_trans_cytopl
PRKACAP17612humanRETP07949S696SSGARRPsLDsMENQ
PRKACAP17612humanCFTRP13569S753EAILPRIsVISTGPTCFTR_R
PRKACAP17612humanTFAP2AP05549S239AEVQRRLsPPECLNATF_AP-2
PRKACAP17612humanPDE4BQ07343S133GHSQRREsFLYRsDs
PRKACAP17612humanTBXA2RP21731-2S330LSTRPRRsLtLWPSL
PRKACAP17612humanCHKBQ9Y259S40PKRRRAssLsRDAER
PRKACAP17612humanOFD1O75665S735GTSSRRLsstPLPkA
PRKACAP17612humanAICDAQ9GZX7S38YVVKRRDsATsFsLDAPOBEC2
PRKACAP17612humanHSPB1P04792T143RCFtRkytLPPGVDPHSP20
PRKACAP17612humanKCNJ5P48544S412EPKGLGGsREARGSV
PRKACAP17612humanENSAO43768S109DLPQRkssLVtskLAEndosulfine
PRKACAP17612humanTRPA1O75762S972AEVQKHAsLKRIAMQIon_trans
PRKACAP17612humanRGS13O14921T41SFENLMAtKYGPVVyRGS
PRKACAP17612humanCTNNB1P35222S675QDykKRLsVELtsSL
PRKACAP17612humanGSTA4O15217S189QEYTVKLsNIPtIKRGST_C_3
PRKACAP17612humanPFKFB2O60825S466PVRMRRNsFtPLssS
PRKACAP17612humanCFTRP13569S737EPLERRLsLVPDSEQCFTR_R
PRKACAP17612humanMAPTP10636-2S320DTsPRHLsNVSSTGS
PRKACAP17612humanRRADP55042S273AGTRRREsLGKKAKR
PRKACAP17612humanTHP07101-4S44RFIGRRQsLIEDARKTOH_N
PRKACAP17612humanRAP1GAPP47736S499PFGsRRssAIGIENI
PRKACAP17612humanKCNN2Q9H2S1S464QAIHQLRsVkMEQRKCaMBD
PRKACAP17612humanNFATC1O95644S269PCNKRKYsLNGRQPP
PRKACAP17612humanPPP1R1AQ13522T35QIRRRRPtPATLVLTDARPP-32
PRKACAP17612humanTRIM71Q2Q1W2S3_____MAsFPETDFQ
PRKACAP17612humanSIK3Q9Y2K2S626FsPVRRFsDGAAsIQ
PRKACAP17612humanCACNA1HO95180S1107LPDsRRGsSsSGDPP
PRKACAP17612humanMYOM2P54296S76RVCAKRVstQEDEEQ
PRKACAP17612humanCFTRP13569S712INsIRKFsIVQKTPLCFTR_R
PRKACAP17612humanHIF1AQ16665T63KASVMRLtISyLRVR
PRKACAP17612humanPKD2L1Q9P0L9S685KLGRsIVssPQGKSG
PRKACAP17612humanABCA1O95477S1042GGMQRKLsVALAFVGTM; ABC_tran
PRKACAP17612humanVTNP04004S397NQNsRRPsRATWLSL
PRKACAP17612humanORAI1Q96D31S34sRRsRRRsGDGEPPG
PRKACAP17612humanKCNN4O15554S334KHtRRKEsHAARRHQCaMBD
PRKACAP17612humanAKAP12Q02952S772LVtPRKksKSkLEEKWSK
PRKACAP17612humanMAPTP10636-8S320VDLskVTskCGsLGNTubulin-binding
PRKACAP17612humanPPP1R14AQ96A00T38QkRHARVtVkYDRREPP1_inhibitor
PRKACAP17612humanGCM1Q9NP62S275LsSSRTYsSGDLLPP
PRKACAP17612humanNCF1P14598S320QRsRKRLsQDAYRRNNECFESHC
PRKACAP17612humanRAP1GAP2Q684P5S7_MFGRKRsVsFGGFG
PRKACAP17612humanNOXA1Q86UR1S172DQVQRRGsLPPRQVP
PRKACAP17612humanUHRF1Q96T88S298DNPMRRKsGPSCkHC
PRKACAP17612humanESR1P03372S236IDKNRRKsCQACRLRzf-C4
PRKACAP17612humanSMN1Q16637S187sDNIkPksAPWNsFLSMN
PRKACAP17612humanMYBPC3Q14896S304SLLKKRDsFRtPRDs
PRKACAP17612humanHIF1AQ16665S727RkMEHDGsLFQAVGI
PRKACAP17612humanKDM3AQ9Y4C1S265GAVKRKssENNGTLV
PRKACAP17612humanMEF2BQ02080-2S324sIkSERLsPAPGGPG
PRKACAP17612humanPHF2O75151S899RSKKRKGsDDAPYsP
PRKACAP17612humanPHF2O75151S1056FLTQRRPsAssPNNN
PRKACAP17612humanTNNI3P19429S23PAPIRRRssNyRAyATroponin-I_N
PRKACAP17612humanHDAC4P56524S265QKVAERRssPLLRRK
PRKACAP17612humanPFN1P07737S138MAsHLRRsQy_____Profilin
PRKACAP17612humanCDK16Q00536S110NHPPRkIstEDINkR
PRKACAP17612humanTFAMQ00059S56CPKkPVssYLRFskEHMG_box
PRKACAP17612humanGPKOWQ92917T316GTASSRktLWNQELy
PRKACAP17612humanATG16L1Q676U5-3S269RAATKRLsQPAGGLL
PRKACAP17612humanPDE4DQ08499-6S126VHSQRREsFLYRSDs
PRKACAP17612humanPTPN12Q05209S435KKLERNLsFEIKKVP
PRKACAP17612humanLRRK2Q5S007S1443FNIKARAsssPVILVRoc
PRKACAP17612humanPJA2O43164T389RVItQREtENNQMTs
PRKACAP17612humanGRK7Q8WTQ7S36ELQRRRRsLALPGLQ
PRKACAP17612humanSTMN1P16949S63AAEERRksHEAEVLkStathmin
PRKACAP17612humanMCOLN1Q9GZU1S559kFRRGsGsACsLLCC
PRKACAP17612humanAPOBEC3BQ9UH17T214LVLRRRQtYLCYEVENAD2
PRKACAP17612humanPIN1Q13526S71HsQSRRPssWRQEKIRotamase
PRKACAP17612humanPSMC5P62195S120RVALRNDsyTLHkILProt_ATP_ID_OB
PRKACAP17612humanRARAP10276S369YVRKRRPsRPHMFPKHormone_recep
PRKACAP17612humanAQP2P41181S256REVRRRQsVELHsPQ
PRKACAP17612humanSERPINF1P36955S227KFDSRKTsLEDFYLDSerpin
PRKACAP17612humanCAMKK1Q8N5S9S74sLsARkLsLQERPAG
PRKACAP17612humanURI1O94763S372AKRKRKNstGsGHsA
PRKACAP17612humanPDE4CQ08493-2S13PHSQRREsFLYRSDS
PRKACAP17612humanCTNNB1P35222S45GATtTAPsLsGkGNP
PRKACAP17612humanE2F1Q01094S364PLLSRMGsLRAPVDE
PRKACAP17612humanMAPTP10636-8S262NVKskIGstENLkHQTubulin-binding
PRKACAP17612humanTNNI3P19429S166LGARAKEsLDLRAHLTroponin
PRKACAP17612humanMAPTP10636S726DtsPRHLsNVsstGs
PRKACAP17612humanADRB2P07550S346LLCLRRssLKAyGNG
PRKACAP17612humanATP5IF1Q9UII2S39NVDRGAGsIrEAGGAIATP
PRKACAP17612humanTRPV5Q9NQA5T708WEILRQNtLGHLNLG
PRKACAP17612humanRAP1AP62834S180KKKPKKKsCLLL___
PRKACAP17612humanNCOR1O75376S70QQLRRRPsLLsEFHP
PRKACAP17612humanPDE11AQ9HCR9S117GNLQRRAsQKELRKS
PRKACAP17612humanSTK38Q15208S11tGstPCssMsNHtkE
PRKACAP17612humanCAMKK1Q8N5S9S475RrEErsMsAPGNLLV
PRKACAP17612humanTRPC5Q9UL62S796GARAKsKsVSFNLGC
PRKACAP17612humanHDAC4P56524S266KVAERRssPLLRRKD
PRKACAP17612humanSMN1Q16637S5___MAMssGGsGGGV
PRKACAP17612humanKSR1Q8IVT5S888PKLNRRLsHPGHFWK
PRKACAP17612humanGLI1P08151S544VsLERRSssSSSISS
PRKACAP17612humanAKAP12Q02952S698RARRGsssDEEGGPK
PRKACAP17612humanZFP36L1Q07352S54GGFPRRHsVtLPSSkTis11B_N
PRKACAP17612humanDOCK1Q14185S1250HAKLLKWsEDVCVAHDHR-2_Lobe_A
PRKACAP17612humanLCP1P13796S5___MARGsVsDEEMM
PRKACAP17612humanSIK3Q9Y2K2S551GPLGRRAsDGGANIQ
PRKACAP17612humanSOX9P48436S64EPDLkKEsEEDkFPVSox_N
PRKACAP17612humanARHGDIAP52565S174kGMLARGsYsIkSRFRho_GDI
PRKACAP17612humanNEDD4LQ96PU5S448IRRPRsLssPtVtLS
PRKACAP17612humanHIF1AQ16665S809VNAPIQGsRNLLQGEHIF-1a_CTAD
PRKACAP17612humanRGS10O43665S176QTAAKRAsRIYNT__
PRKACAP17612humanCLDN3O15551T192PPREKKytAtkVVys
PRKACAP17612humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
PRKACAP17612humanH3-3AP84243S10tkQTARkstGGkAPRHistone
PRKACAP17612humanSUN2Q9UH99S54SSNMKRLsPAPQLGP
PRKACAP17612humanPPP1R14CQ8TAE6T73RHQQGKVtVkYDRKEPP1_inhibitor
PRKACAP17612humanATG16L1Q676U5-2S268SRAAtRRsVSSFPVP
PRKACAP17612humanCSKP41240S364ALREKKFsTKSDVWSPK_Tyr_Ser-Thr
PRKACAP17612humanLCKP06239S42tLLIRNGsEVRDPLV
PRKACAP17612humanSTK24Q9Y6E0T18ALNKRRAtLPHPGGS
PRKACAP17612humanTPH2Q8IWU9S19YWARRGFsLDSAVPE
PRKACAP17612humanCAPN2P17655S369DGNWRRGstAGGCRNCalpain_III
PRKACAP17612humanLRRK2Q5S007S935NLQRHsNsLGPIFDH
PRKACAP17612humanTRPA1O75762S317ETMLHRAsLFDHHELAnk_2
PRKACAP17612humanBCAMP50895S621sGGARGGsGGFGDEC
PRKACAP17612humanAKAP12Q02952S696kKRARRGsssDEEGG
PRKACAP17612humanGJA1P17302S373RAssRAssRPRPDDL
PRKACAP17612humanH3-3AP84243S28ATkAARksAPsTGGVHistone
PRKACAP17612humanIGFBP1P08833S126GsPEsPEstEITEEE
PRKACAP17612humanAKAP13Q12802S1565LsPFRRHsWGPGKNA
PRKACAP17612humanRAF1P04049S259sQRQRststPNVHMV
PRKACAP17612humanCARM1Q86X55S447LIANkRQsYDISIVA
PRKACAP17612humanDAP3P51398T186DQPLEAstWLkNFkTDAP3
PRKACAP17612humanPDE4DQ08499-2S54VHSQRREsFLYRSDS
PRKACAP17612humanH1-4P10412S36GAAkRkAsGPPVsEL
PRKACAP17612humanNLRP3Q96P20S295HKIVRKPsRILFLMDNACHT
PRKACAP17612humanGLI3P10071S865YLSSRRssGISPCFs
PRKACAP17612humanPIN1Q13526S16PGWEkRMsRSSGRVyWW
PRKACAP17612humanTRPA1O75762S428CRQGGPGsVNNLLGFAnk_2
PRKACAP17612humanTBXA2RP21731S331sTRPRsLsLQPQLtQ
PRKACAP17612humanAPPP05067S679DAEFRHDsGYEVHHQBeta-APP
PRKACAP17612humanTPPPO94811T92VIDGRNVtVTDVDIVp25-alpha
PRKACAP17612humanVDRP11473S182tPSFSGDsSSSCSDH
PRKACAP17612humanALOX5P09917S272CsLERQLsLEQEVQQLipoxygenase
PRKACAP17612humanGLI3P10071S849NMLNRRDssAStIsS
PRKACAP17612humanDTNBO60941T424GNVtRPPtDLsFNFD
PRKACAP17612humanCYP17A1P05093S258KEKFRSDsITNMLDTp450
PRKACAP17612humanGFPT1Q06210S235TARTQIGsKFTRWGs
PRKACAP17612humanADRB2P07550S261TGHGLRRssKFcLKE7tm_1
PRKACAP17612humanCFTRP13569S768LQARRRQsVLNLMtHCFTR_R
PRKACAP17612humanRASGRP2Q7LDG7S587PRPGRrGsRPPEIRE
PRKACAP17612humanCSNK1A1P48729S242KISEKkMsTPVEVLCPkinase
PRKACAP17612humanSLC4A4Q9Y6R1S1026KKKKKKGsLDsDNDD
PRKACAP17612humanSNAP25P60880T29ADESLEstRRMLQLV
PRKACAP17612humanMAPTP10636-8S316VykPVDLskVTskCGTubulin-binding
PRKACAP17612humanCCND1P24385S234YRLTRFLsRVIkCDPCyclin_C
PRKACAP17612humanVIMP08670S72ssAVrLrssVPGVRLFilament_head
PRKACAP17612humanSRSF2Q01130S171RSARRsKsksSsVsR
PRKACAP17612humanARHGAP17Q68EM7S702LsAPRRYsssLsPIQ
PRKACAP17612humanPTPN7P35236S44RLQERrGsNVALMLD
PRKACAP17612humanGFAPP14136S13ItsAArrsyVSsGEMFilament_head
PRKACAP17612humanDESP17661T76LRAsRLGttRtPssyFilament_head
PRKACAP17612humanTBXA2RP21731S324RRLQPRLsTRPRsLs
PRKACAP17612humanNF2P35240S518DTDMKRLsMEIEKEKERM_C
PRKACAP17612humanCYP3A4P08684S116GPVGFMksAIsIAEDp450
PRKACAP17612humanTBXA2RP21731S329RLsTRPRsLsLQPQL
PRKACAP17612humanTGS1Q96RS0S656AQRYRLFsRFDDGIk
PRKACAP17612humanMAP1LC3AQ9H492S12RPFKQRRsFADRCKE
PRKACAP17612humanSTARP49675S195RCAKRRGsTCVLAGMSTART
PRKACAP17612humanOFD1O75665S899QREERRQsNLQEVLE
PRKACAP17612humanNCF1P14598S370PAVPPRPsADLILNRp47_phox_C
PRKACAP17612humanGFPT1Q06210-2S205AVGTRRGsPLLIGVR
PRKACAP17612humanCASP9P55211S195EkLRRRFssLHFMVEPeptidase_C14
PRKACAP17612humanPFKFB3Q16875S461NPLMRRNsVtPLAsP
PRKACAP17612humanMLXIPLQ9NP71S196KKRLRKPsREDDLLA
PRKACAP17612humanPKD1P98161S4252SLQGRRssRAPAGSS
PRKACAP17612humanSTMN1P16949S16kELEKrAsGQAFELIStathmin
PRKACAP17612humanWT1P19544S393KTCQRKFsRSDHLKTzf-C2H2
PRKACAP17612humanPDZK1Q5T2W1S505MAKERAHstAsHsss
PRKACAP17612humanITGB4P16144S1364PSGsQRPsVSDDTGC
PRKACAP17612humanSNAPINO95295S50HVHAVREsQVELREQSnapin_Pallidin
PRKACAP17612humanTRPV1Q8NER1S502YFLQRRPsMKTLFVDIon_trans
PRKACAP17612humanLRRK2Q5S007S1444NIKARAsssPVILVGRoc
PRKACAP17612humanNDE1Q9NXR1-1T131LERAKRAtIMSLEDF
PRKACAP17612humanCAPN1P07384S418GDREsGCsFVLALMQCalpain_III
PRKACAP17612humanMAPTP10636-8S293NVQskCGsKDNIkHVTubulin-binding
PRKACAP17612humanNDRG1Q92597T366GtRsRsHtsEGAHLD
PRKACAP17612humanMAPTP10636S579NVKSKIGstENLKHQTubulin-binding
PRKACAP17612humanAKAP12Q02952S627KKRVRRPsEsDKEDEWSK
PRKACAP17612humanMAPTP10636S531GsRsRtPsLPtPPtR
PRKACAP17612humanABCB1P08183S683QAQDRKLstKEALDE
PRKACAP17612humanBADQ92934S99PFrGrsRsAPPNLWABcl-2_BAD
PRKACAP17612humanRPS19P39019S59WFytrAAsTARHLYLRibosomal_S19e
PRKACAP17612humanAKAP9Q99996S43QkKKRKTsSsKHDVS
PRKACAP17612humanAURKAO14965T288APSsRRttLCGtLDyPkinase
PRKACAP17612humanINVSQ9Y283T795CAPQKRRtQELrGGR
PRKACAP17612humanPOLD3Q15054S458GkANRQVsITGFFQRCDC27
PRKACAP17612humanPPP1R1AQ13522T75PRQRKKMtRItPTMKDARPP-32
PRKACAP17612humanMAPTP10636S673RVQSKIGsLDNITHVTubulin-binding
PRKACAP17612humanGRIN2BQ13224S1166sDDFKRDsVsGGGPCNMDAR2_C
PRKACAP17612humanSOX9P48436S181YQPRRRKsVKNGQAE
PRKACAP17612humanTPI1P60174-3S58KMNGRKQsLGELIGTTIM
PRKACAP17612humanKCNA4P22459T601LKKFRSStSSSLGDK
PRKACAP17612humanKCNN2Q9H2S1S135FEKRKRLsDYALIFGSK_channel
PRKACAP17612humanAPOBEC3GQ9HC16T32PILSRRNtVWLCYEVNAD2
PRKACAP17612humanMCOLN1Q9GZU1S557SGkFRRGsGsACsLL
PRKACAP17612humanGPKOWQ92917S27sFGFtRtsARRRLAD
PRKACAP17612humanGMFBP60983S83QHDDGRVsyPLCFIFCofilin_ADF
PRKACAP17612humanRAP1GAPP47736S490KsPtRKKsGPFGsRR
PRKACAP17612humanESPL1Q14674S1501TDNWRKMsFEILRGs
PRKACAP17612humanCDK16Q00536S153sRRLRRVsLsEIGFG
PRKACAP17612humanCYP2E1P05181S256RVkEHHQsLDPNCPRp450
PRKACAP17612humanGRK1Q15835S21AFIAARGsFDGSSSQ
PRKACAP17612humanKCNK9Q9NPC2S373RLMKRRKsV______
PRKACAP17612humanCAMKK2Q96RR4S100HLsGRkLsLQERSQG
PRKACAP17612humanMAPTP10636-8S409DtsPRHLsNVsstGs
PRKACAP17612humanAVPR2P30518S255RRGRRTGsPGEGAHV7tm_1
PRKACAP17612humanCADP27708S1406GAGGRRLssFVtkGYMGS
PRKACAP17612humanCAPN1P07384S256GCsIDIssVLDMEAIPeptidase_C2
PRKACAP17612humanKCNJ3P48549S385NSKERHNsVECLDGL
PRKACAP17612humanGJA1P17302S369RPssRAssRAssRPR
PRKACAP17612humanRELAQ04206S42RYkCEGRsAGsIPGERHD_DNA_bind
PRKACAP17612humanMYBPC3Q14896S275LSAFRRtsLAGGGRR
PRKACAP17612humanARPP19P56211S104DLPQRkPsLVAskLAEndosulfine
PRKACAP17612humanGFAPP14136S8MERRRItsAArrsyVFilament_head
PRKACAP17612humanCA9Q16790T443RRQHRRGtKGGVsyR
PRKACAP17612humanDDB1Q16531S645LRtFRSLstTNVFAC
PRKACAP17612humanGSK3AP49840S21sGrARtssFAEPGGG
PRKACAP17612humanPDE5AO76074S102GTPTRKIsAsEFDRP
PRKACAP17612humanCBX3Q13185S93kDGtKRksLsDsEsD
PRKACAP17612humanHSPB1P04792S82RALsRQLssGVsEIr
PRKACAP17612humanSREBF1P36956S338IEkRYRSsINDkIIEHLH
PRKACAP17612humanKCNH2Q12809T895KLsFRRRtDKDTEQP
PRKACAP17612humanETV5P41161S367PPYQRRGsLQLWQFL
PRKACAP17612humanFRAT1Q92837S188RLQQRRGsQPETRTGGSK-3_bind
PRKACAP17612humanHIF1AQ16665T700VALsQRTtVPEEELN
PRKACAP17612humanVASPP50552S239GAKLRKVsKQEEASG
PRKACAP17612humanRAP1BP61224S179PGkARKKsscQLL__
PRKACAP17612humanRAF1P04049S621PKINRsAsEPsLHRA
PRKACAP17612humanTPH1P17752S58RKSKRRNsEFEIFVD
PRKACAP17612humanPPP2R5DQ14738S573KVLLRRksELPQDVy
PRKACAP17612humanNOS3P29474S615SYKIRFNsISCSDPLFlavodoxin_1
PRKACAP17612humanSEC14L2O76054S289VQISRGSsHQVEyEI
PRKACAP17612humanFHIP2BQ86V87S325GISWRLPsAPSDEASRAI16-like
PRKACAP17612humanHSPA1BP0DMV8S418TALIkrNstIPTkQTHSP70
PRKACAP17612humanLRRK2Q5S007S910LVKKKsNsIsVGEFY
PRKACAP17612humanCYP2E1P05181S129WKDIRRFsLttLRNYp450
PRKACAP17612humanTGS1Q96RS0S851DLIRRPAsET_____
PRKACAP17612humanCTNNB1P35222S179AVMVHQLskKEAsRH
PRKACAP17612humanCUL5Q93034S730MkMRKKIsNAQLQTECullin_Nedd8
PRKACAP17612humanLRP6O75581T1548yAPsRRMtSVATAkG
PRKACAP17612humanUBE3AQ05086-2T485MYSERRItVLYsLVQ
PRKACAP17612humanHSP90AB1P08238T89RtLtLVDtGIGMtkAHATPase_c
PRKACAP17612humanGJA1P17302S365IVDQRPssRAssRAs
PRKACAP17612humanPTPN11Q06124-1S189GGGERFDsLTDLVEHSH2
PRKACAP17612humanMARK2Q7KZI7S409NPKQRRFsDQAAGPA
PRKACAP17612humanPIK3CGP48736T1024YLALRHHtNLLIILFPI3_PI4_kinase
PRKACAP17612humanGLI3P10071S1006GHGVRRAsDPVRTGS
PRKACAP17612humanPRKD1Q15139S421KHTKRKSstVMKEGW
PRKACAP17612humanRELAQ04206S45CEGRsAGsIPGERSTRHD_DNA_bind
PRKACAP17612humanKDELR1P24390S209VLKGKKLsLPA____
PRKACAP17612humanNOXA1Q86UR1S461VPAGPRMsGAPGRLP
PRKACAP17612humanCTBP2P56545S164REGTRVQsVEQIREV2-Hacid_dh_C; 2-Hacid_dh
PRKACAP17612humanERBB2P04626T686QQKIRKYtMRRLLQE
PRKACAP17612humanCYP3A4P08684S478TQIPLKLsLGGLLQPp450
PRKACAP17612humanULK2Q8IYT8S1027CSIERRLsALCHSTADUF3543
PRKACAP17612humanLRP1Q07954S4520GGHGsRHsLAsTDEk
PRKACAP17612humanKCND2Q9NZV8S552VSGSHQGsIQELSTI
PRKACAP17612humanBNIP3Q12983T188IYIGRRLttststF_BNIP3
PRKACAP17612humanPRKAR2BP31323S114NRFTRRAsVCAEAyN
PRKACAP17612humanRHOAP61586S188ARRGKKKsGCLVL__
PRKACAP17612humanCTBP1Q13363T144LNLYRRAtWLHQALR2-Hacid_dh_C; 2-Hacid_dh
PRKACAP17612humanCRHR1P34998-2S301LMTKLRAsTTSETIQ7tm_2
PRKACAP17612humanHSPB1P04792S78PAysRALsRQLssGV
PRKACAP17612humanBADQ92934S75EIRsRHssyPAGtEDBcl-2_BAD
PRKACAP17612humanFXYD1O00168S83EEGtFRssIRRLstR
PRKACAP17612humanRAP1BP61224S180GkARKKsscQLL___
PRKACAP17612humanSCN5AQ14524S528KPRssrGsIFtFRRRNa_trans_cytopl
PRKACAP17612humanPFN1P07737S72tLGGQkCsVIRDsLLProfilin
PRKACAP17612humanSLC8B1Q6J4K2S258YQRQRRGsLFCPMPV
PRKACAP17612humanUSP20Q9Y2K6S333RMKDRKFsWGQQRtN
PRKACAP17612humanADRB2P07550S262GHGLRRssKFcLKEH7tm_1
PRKACAP17612humanTNFRSF1AP19438T411LAtWRRRtPRREAtLDeath
PRKACAP17612humanPDE4AP27815S145ATSQRREsFLYRSDs
PRKACAP17612humanSTK38Q15208S10MtGstPCssMsNHtk
PRKACAP17612humanABCB1P08183S667SsLIRKRsTRRsVRG
PRKACAP17612humanHDAC8Q9BY41S39AKIPKRAsMVHsLIEHist_deacetyl
PRKACAP17612humanMAP2P11137S1710HVTsKCGsLKNIRHRTubulin-binding
PRKACAP17612humanTNNI3P19429S39EPHAKKKskIsAsRK
PRKACAP17612humanSNAP25P60880S187RIMEKADsNKTRIDE
PRKACAP17612humanNOS3P29474S1177TSRIRtQsFsLQERQ
PRKACAP17612humanBIRC5O15392S20FLkDHRIstFkNWPFBIR
PRKACAP17612humanKCNQ2O43526-4S438QTVRRsPsADQSLEDKCNQ_channel
PRKACAP17612humanSTIM1Q13586T389KIKKKRNtLFGtFHVSOAR
PRKACAP17612humanUFD1Q92890S229ELGFRAFsGsGNRLD
PRKACAP17612humanCREB1P16220S119EILsRRPsyRkILNDpKID
PRKACAP17612humanPOU5F1Q01860S288RRQKGKRsssDyAQR
PRKACAP17612humanGFAPP14136T7_MERRRItsAArrsyFilament_head
PRKACAP17612humanKCNN2Q9H2S1S569sRRRrsssTAPPtSS
PRKACAP17612humanAPPL1Q9UKG1S410sFQQRHEsLRPAAGQ
PRKACAP17612humanCUX1P39880S1215AYMKRRHssVsDSQP
PRKACAP17612humanSEPTIN7Q16181T198PLIAkADtLTPEECQSeptin
PRKACAP17612humanDTNBO60941T11ESGNKRktMAEKRQL
PRKACAP17612humanRYR2Q92736S2031TIRGRLLsLVEKVTy
PRKACAP17612humanKCNJ5P48544T199QPKKRAEtLMFsNNA
PRKACAP17612humanNEDD4LQ96PU5T367AGRARsstVtGGEEP
PRKACAP17612humanCIITAP33076S834QELPGRLsFLGtRLT
PRKACAP17612humanCSNK1A1P48729S218LMYFNRTsLPWQGLkPkinase
PRKACAP17612humanTRPM8Q7Z2W7S9SFRAARLsMRNRRND
PRKACAP17612humanPKD2L1Q9P0L9S682EIEKLGRsIVssPQG
PRKACAP17612humanMFN2O95140S442AEEIRRLsVLVDDYQ
PRKACAP17612humanGSK3BP49841S9SGRPRttsFAEsCkP
PRKACAP17612humanPAHP00439S16PGLGRKLsDFGQETS
PRKACAP17612humanSCN5AQ14524S516LsLTrGLsRTsMKPRNa_trans_cytopl
PRKACAP17612humanPDE4DQ08499-7S126VHSQRREsFLYRSDS
PRKACAP17612humanEMDP50402S49EtQRRRLsPPsssAA
PRKACAP17612humanPDE3BQ13370S318CkIFRRPsLPCIsRE
PRKACAP17612humanGRK7Q8WTQ7S23YLQARKPsDCDSKEL
PRKACAP17612humanFXYD1O00168S88RssIRRLstRRR___
PRKACAP17612humanAICDAQ9GZX7T27WAKGRREtYLCYVVKAPOBEC2
PRKACAP17612humanCETN2P41208S170LRIMkKTsLY_____
PRKACAP17612humanGLI1P08151S640AGVTRRAsDPAQAAD
PRKACAP17612humanGLI3P10071S907TDAsRRSsEASQSDG
PRKACAP17612humanWT1P19544S365KDCERRFsRSDQLKRzf-C2H2
PRKACAP17612humanHSPB8Q9UJY1S57DWALPRLsSAWPGtL
PRKACAP17612humanGRIA1P42261S863TStLPRNsGAGASSG
PRKACAP17612humanPDE3BQ13370S296IRPRRRssCVsLGEt
PRKACAP17612humanPDE3AQ14432S428IPKRLRRsLPPGLLR
PRKACAP17612humanCCND1P24385S90NYLDRFLsLEPVkkSCyclin_N
PRKACAP17612humanSMN1Q16637S8MAMssGGsGGGVPEQ
PRKACAP17612humanMAPTP10636-8S214GsRsRtPsLPtPPtR
PRKACAP17612humanCAPN1P07384S415DDyGDREsGCsFVLACalpain_III
PRKACAP17612humanABCB1P08183S671RKRsTRRsVRGsQAQ
PRKACAP17612humanGJA1P17302S364AIVDQRPssRAssRA
PRKACAP17612humanPTPN12Q05209S39FMRLRRLstKYRTEK
PRKACAP17612humanPDE8AO60658S359HKDRRKGsLDVkAVA
PRKACAP17612humanMAPTP10636-8S356rVQskIGsLDNItHVTubulin-binding
PRKACAP17612humanDMTNQ08495S403NELKKKAsLF_____VHP
PRKACAP17612humanSNAP25P60880T138GGFIRRVtNDARENESNAP-25
PRKACAP17612humanPRKACAP17612T198RVKGRtWtLCGtPEyPkinase
PRKACAP17612humanRAF1P04049S43FGyQRRAsDDGKLtD
PRKACAP17612humanNOS3P29474S633WRRKRKEssNtDsAGFlavodoxin_1
PRKACAP17612humanKCNH2Q12809S283CASVRRAssADDIEA
PRKACAP17612humanPARK7Q99497T154EkDGLILtSRGPGTSDJ-1_PfpI
PRKACAP17612humanHIF1AQ16665T455LAMsPLPtAEtPkPL
PRKACAP17612humanSTK11Q15831S428SSkIRRLsACkQQ__
PRKACAP17612humanDISC1Q9NRI5S713QLQEARGsLSVEDER
PRKACAP17612humanPDE10AQ9Y233-2T16AScFRRLtECFLSPS
PRKACAP17612humanPPP1R1BQ9UD71T34MIrRRRPtPAMLFRLDARPP-32
PRKACAP17612humanLASP1Q14847S146MEPERRDsQDGssyR
PRKACAP17612humanETV1P50549S191HRFRRQLsEPCNSFPETS_PEA3_N
PRKACAP17612humanCAPN2P17655T370GNWRRGstAGGCRNYCalpain_III
PRKACAP17612humanTNFRSF1AP19438T417RtPRREAtLELLGRVDeath
PRKACAP17612humanFYNP06241S21LTEERDGsLNQssGy
PRKACAP17612humanGAD1Q99259T91RDARFRRtETDFSNL
PRKACAP17612humanPDE3BQ13370S73PQQPRRCsPFCRARL
PRKACAP17612humanSRSF1Q07955S119yGPPsRRsENRVVVS
PRKACAP17612humanGLI1P08151S560YTVSRRSsLASPFPP
PRKACAP17612humanBADQ92934S118GRELRRMsDEFVDsFBcl-2_BAD
PRKACAP17612humanTHP07101S40GQGAPGPsLTGSPWPTOH_N
PRKACAP17612humanPJA2O43164S342RHEAkQRsVQRWREA
PRKACAP17612humanEZRP15311S66LkLDKkVsAQEVRkEFERM_N
PRKACAP17612humanRPTORQ8N122S791IDKMRRAssYSsLNS
PRKACAP17612humanTTNQ8WZ42S4065RDLLSKEsLLsGIPE
PRKACAP17612humanNR5A2O00482S510LPEIRAIsMQAEEYLHormone_recep
PRKACAP17612humanKCNQ5Q9NR82S88GKQGARMsLLGKPLS
PRKACAP17612humanTPPPO94811S159sGVtKAIssPtVSRLp25-alpha
PRKACAP17612humanTFAMQ00059S55SCPKkPVssYLRFskHMG_box
PRKACAP17612humanHSF1Q00613S320AsPGRPssVDtLLsPVert_HS_TF
PRKACAP17612humanPSMD2Q13200S361ENNrFGGsGsQVDsA
PRKACAP17612humanKLHL3Q9UH77S433PMNTRRSsVGVGVVEKelch_1
PRKACAP17612humanTTNQ8WZ42S4185IQQGAKtsLQEEMDs
PRKACAP17612humanPPP1R1AQ13522S67LKSTLAMsPRQRKKMDARPP-32
PRKACAP17612humanVIMP08670S73sAVrLrssVPGVRLLFilament_head
PRKACAP17612humanPTPN11Q06124-1T73YGGEKFAtLAELVQYSH2
PRKACAP17612humanDLX3O60479S10GSFDRKLsSILTDIS
PRKACAP17612humanTRPV4Q9HBA0S824LRRDRWssVVPRVVE
PRKACAP17612humanTENT2Q6PIY7S116LsGERRYsMPPLFHT
PRKACAP17612humanNSFL1CQ9UNZ2S176AGEkRQHssQDVHVV
PRKACAP17612humanTFAMQ00059S61VssYLRFskEQLPIFHMG_box
PRKACAP17612humanKCNA1Q09470S446SDLSRRssStMSKSE
PRKACAP17612humanCACNA1CQ13936S1981ASLGRRAsFHLECLK
PRKACAP17612humanPDE3AQ14432S312SKSHRRTsLPCIPRE
PRKACAP17612humanCD44P16070S697AVEDRkPsGLNGEAs
PRKACAP17612humanDUOX1Q9NRD9S1217SHHFRRRsFRGFWLTFerric_reduct
PRKACAP17612humanRARAP10276S219NSSEQRVsLDIDLWD
PRKACAP17612humanRCAN1P53805-2S93AQTLHIGsSHLAPPNCalcipressin
PRKACAP17612humanPHF2O75151S757NARVKKEsGSSAAGI
PRKACAP17612humanZFP36L1Q07352S334LPIFsRLsIsDD___
PRKACAP17612humanDAP3P51398S220REstEkGsPLGEVVEDAP3
PRKACAP17612humanLIPEQ05469S853IAEPMRRsVsEAALA
PRKACAP17612humanDACT1Q9NYF0S237GAVCRSLsTPQFNSLDapper
PRKACAP17612humanANXA1P04083T216AGERRkGtDVNVFNTAnnexin
PRKACAP17612humanSMN1Q16637S4____MAMssGGsGGG
PRKACAP17612humanCFTRP13569S660FSAERRNsILTETLHCFTR_R
PRKACAP17612humanMAPTP10636-8T245sAKsRLQtAPVPMPDTubulin-binding
PRKACAP17612humanPPM1BO75688S195MIQRVNGsLAVSRALPP2C
PRKACAP17612humanHIF1AQ16665S692PRsPNVLsVALsQRT
PRKACAP17612humanMAPTP10636-2S267RVQSKIGsLDNITHVTubulin-binding
PRKACAP17612humanATXN1P54253S775AtRKRRWsAPESRKL
PRKACAP17612humanCADP27708S1859PPRIhRAsDPGLPAE
PRKACAP17612humanPOU3F2P20265S360RKRKKRTsIEVSVKGHomeodomain
PRKACAP17612humanPSMD11O00231S14VEFQrAQsLLSTDrERPN6_N
PRKACAP17612humanPDE3AQ14432S438PGLLRRVsstWtttt
PRKACAP17612humanHLA-AP04439S337VMWRRKSsDRkGGsyMHC_I_C
PRKACAP17612humanSIK3Q9Y2K2T469YLSMRRHtVGVADPR
PRKACAP17612humanKRASP01116-2S181GKKKKkKskTkCVIM
PRKACAP17612humanATP1A1P05023S943ICKTRRNsVFQQGMkCation_ATPase_C
PRKACAP17612humanRELAQ04206S276sMQLRRPsDRELsEPRHD_dimer
PRKACAP17612humanABCA1O95477S2054GGNkRKLsTAMALIGABC_tran
PRKACAP17612humanTRPA1O75762S86MEKITRDsSLEVLHEAnk_2
PRKACAP17612humanARFGEF1Q9Y6D6S883EIAGkKIsMKETKEL
PRKACAP17612humanFLNAP21333S2152tRRRRAPsVANVGsHFilamin
PRKACAP17612humanFOXO1Q12778S276RAAKKkAsLQSGQEG
PRKACAP17612humanCDC37Q16543S97QLRkEERsWEQkLEECDC37_N
PRKACAP17612humanTHP07101-2S67RFIGRRQsLIEDARKTOH_N
PRKACAP17612humanNDRG1Q92597S330LMRsRtAsGssVtsL
PRKACAP17612humanCEBPBP17676S288NNIAVRKsRDKAKMRbZIP_2
PRKACAP17612humanSRCP12931S17DAsQRRRsLEPAENV
PRKACAP17612humanNF2P35240S10GAIASRMsFSsLkRK
PRKACAP17612humanTPRP12270S2108IQMTRrQsVGrGLQL
PRKACAP17612humanADD1P35611S726KKKFRtPsFLKKsKK
PRKACAP17612humanIQGAP2Q13576T716EyMHRRQtFIDNTDS
PRKACAP17612humanSMN1Q16637T85NKsQKkNtAAsLQQWSMN
PRKACAP17612humanTFAMQ00059S160GkPKRPRsAYNVyVAHMG_box_2
PRKACAP17612humanTAL1P17542S172NRVKRRPsPYEMEIT
PRKACAP17612humanVIMP08670S39ttstrtysLGsALrPFilament_head
PRKACAP17612humanPKD2Q13563S829HSSRRRGsISSGVSY
PRKACAP17612humanDNAJC5Q9H3Z4S10DQRQRsLstsGEsLy
PRKACAP17612humanCYP3A4P08684S119GFMksAIsIAEDEEWp450
PRKACAP17612humanMSNP26038T558LGRDKyKtLRQIRQGERM_C
PRKACAP17612humanHLA-AP04439S343SsDRkGGsytQAAssMHC_I_C
PRKACAP17612humanNCF1P14598S328QDAYRRNsVRFLQQRNECFESHC
PRKACAP17612humanGFPT1Q06210S205AVGtRRGsPLLIGVR
PRKACAP17612humanDAP3P51398S31MGTQARQsIAAHLDN
PRKACAP17612humanSNAP25P60880S28LADESLEstRRMLQL
PRKACAP17612humanETV1P50549S334PTYQRRGsLQLWQFL
PRKACAP17612humanKCNN2Q9H2S1S567SSsRRRrsssTAPPt
PRKACAP17612humanMAP2P11137S1782GAEIItQsPGRssVA
PRKACAP17612humanTP53P04637S378skkGQstsRHkkLMF
PRKACAP17612humanGCM1Q9NP62S269LYEKRKLsSSRTYsS
PRKACAP17612humanEMSYQ7Z589T207KPRKRRRtNsssssP
PRKACAP17612humanCAPN1P07384S255LGCsIDIssVLDMEAPeptidase_C2
PRKACAP17612humanLAMTOR4Q0VGL1S67NVPFkRLsVVFGEHT
PRKACAP17612humanDYNLRB1Q9NP97S73LtFLRIRsKkNEIMVRobl_LC7
PRKACAP17612humanPTBP1P26599-1S16AVGtkRGsDELFstC
PRKACAP17612humanSRSF2Q01130S121GyGrRSRsPRRRRRs
PRKACAP17612humanSORBS2O94875S259DFRKRRKsEPAVGPP
PRKACAP17612humanGNA13Q14344T203ILLARRPtkGIHEYDG-alpha
PRKACAP17612humanITGA4P13612S1021QEENRRDsWsyINSk
PRKACAP17612humanPRKACAP17612S339EEEEIRVsINEkCGk
PRKACAP17612humanSGK1O00141T369DLINKkItPPFNPNV
PRKACAP17612humanPTK2BQ14289S778HNVFKRHsMREEDFI
PRKACAP17612humanCYP2E1P05181T373SNLPHEAtRDtIFrGp450
PRKACAP17612humanTHP07101S71RFIGRRQsLIEDARKTOH_N
PRKACAP17612humanPDE11AQ9HCR9S162RALLRKAssLPPTTA
PRKACAP17612humanALOX5P09917S524GMRGRKSsGFPkSVKLipoxygenase
PRKACAP17612humanPARP1P09874S782ySLLrGGsDDsskDPPARP_reg
PRKACAP17612humanPIK3R1P27986S83yIGRKKIsPPtPKPR
PRKACAP17612humanCYP3A4P08684S134kRLRsLLsPtFTsGKp450
PRKACAP17612humanDAP3P51398S185FDQPLEAstWLkNFkDAP3
PRKACAP17612humanMORC2Q9Y6X9T582LEALQkTtPIRSQAD
PRKACAP17612humanKCNJ13O60928S287EICQRRTsYLPSEIMIRK_C
PRKACAP17612humanCFTRP13569S795TAsTRKVsLAPQANLCFTR_R
PRKACAP17612humanPREX1Q8TCU6S436KDRRRKLstVPKCFLDEP
PRKACAP17612humanADRB1P08588S312RAGKRRPsRLVALRE7tm_1
PRKACAP17612humanCTNNB1P35222S552QDtQRRtsMGGtQQQ
PRKACAP17612humanPOU5F1Q01860S289RQKGKRsssDyAQRE
PRKACAP17612humanCDKN2DP55273T141RRDARGLtPLELALQAnk_2
PRKACAP17612humanHIF1AQ16665S761RVKGCKssEQNGMEQ
PRKACAP17612humanCASP9P55211S183GLRTRTGsNIDCEkLPeptidase_C14
PRKACAP17612humanCUX1P39880S1237tEysQGAsPQPQHQL
PRKACAP17612humanCTNNB1P35222T41GIHsGATtTAPsLsG
PRKACAP17612humanFCER1GP30273S69DGVytGLstRNQEtyITAM
PRKACAP17612humanPHF2O75151S954QKSKKKKsAKRKLTP
PRKACAP17612humanCFTRP13569S700FGEKRkNsILNPINsCFTR_R
PRKACAP17612humanTRIP10Q15642T225DMDERRAtRLGAGYG
PRKACAP17612humanHDAC4P56524S584EPGQRQPsEQELLFR
PRKACAP17612humanHNRNPDQ14103S87sNssPRHsEAAtAQr
PRKACAP17612humanRGS10O43665-1S168QTAAkRAsRIyNT__
PRKACAP17612humanDSPP15924S2849RsGsRRGsFDAtGNs
PRKACAP17612humanDESP17661S12ysSSQRVssYRRtFGFilament_head
PRKACAP17612humanGMFBP60983T27KFRFRKEtNNAAIIMCofilin_ADF
PRKACAP17612humanATRQ13535S435sPKRRRLsssLNPsk
PRKACAP17612humanCDK9P50750S347APPRRkGsQItQQst
PRKACAP17612humanSUN2Q9UH99S12SQRLtRysQGDDDGs
PRKACAP17612humanTAGLN2P37802S163kENPRNFsDNQLQEG
PRKACAP17612humanHSP90AA1P07900T90NkQDRtLtIVDtGIGHATPase_c
PRKACAP17612humanPRKAB1Q9Y478S24HKtPRRDssGGtKDG
PRKACAP17612humanCYP2E1P05181S145MGKQGNEsRIQREAHp450
PRKACAP17612humanPPP2R5DQ14738S60PsSNKRPsNstPPPt
PRKACAP17612humanSIK2Q9H0K1S358DGRQRRPstIAEQTV
PRKACAP17612humanTGM2P21980S215GRDCsRRssPVyVGR
PRKACAP17612humanNDUFS4O43181S173WNkRTRVsTK_____
PRKACAP17612humanMAPTP10636-2S156GSRSRTPsLPTPPTR
PRKACAP17612humanKCNN2Q9H2S1S568SsRRRrsssTAPPtS
PRKACAP17612humanRASD2Q96D21S239SPFARRPsVNSDLKY
PRKACAP17612humanMYLKQ15746S1773GLsGRKsstGsPtsP
PRKACAP17612humanSRCP12931Y419RLIEDNEytARQGAkPK_Tyr_Ser-Thr
PRKACAP17612humanSPTBN1Q01082T2159NGAtEQRtssKEssP
PRKACAP17612humanNFATC1O95644S294PHGsPRVsVTDDSWL
PRKACAP17612humanARHGEF6Q15052S684GSSTRkDsIPQVLLP
PRKACAP17612humanCYP3A4P08684S259SVKRMKEsRLEDtQKp450
PRKACAP17612humanPLECQ15149S4642RAGsRrGsFDAtGsG
PRKACAP17612humanSNAI1O95863S11SFLVRKPsDPNRKPN
PRKACAP17612humanPLCB3Q01970S1105LDRKRHNsIsEAKMRPLC-beta_C
PRKACAP17612humanAQP5P55064S156STDSRRTsPVGSPALMIP
PRKACAP17612humanTTNQ8WZ42S4010VRIEEGKsLRFPLAL
PRKACAP17612humanHIF1AQ16665S760KRVKGCKssEQNGME
PRKACAP17612humanPPP1R1CQ8WVI7T34QIRKRRPtPASLVILDARPP-32
PRKACAP17612humanHDAC5Q9UQL6S279KVAERRssPLLRRKD
PRKACAP17612humanSRSF2Q01130S128sPRRRRRsRsRSRSR
PRKACAP17612humanSTARP49675S57NQVRRRssLLGsRLE
PRKACAP17612humanTGM2P21980S216RDCsRRssPVyVGRV
PRKACAP17612humanSREBF1P36956-3S314IEKRYRSsINDKIIEHLH
PRKACAP17612humanSLKQ9H2G2S189RtIQRRDsFIGtPyWPkinase
PRKACAP17612humanRASSF1Q9NS23-2S203TsVRRRtsFYLPKDARA
PRKACAP17612humanGFPT1Q06210-2S235TGkDKkGsCNLsRVD
PRKACAP17612humanNCF1P14598S359EERQtQRsKPQPAVPp47_phox_C
PRKACAP17612humanGLI3P10071S877CFssRRssEASQAEG
PRKACAP17612humanVASPP50552S157EHIERRVsNAGGPPA
PRKACAP17612humanESR1P03372S305IkRSkkNsLALSLtA
PRKACAP17612humanPARP1P09874S785LrGGsDDsskDPIDVPARP_reg
PRKACAP17612humanNPR1P16066S529RHLRSAGsRLtLsGR
PRKACAP17612humanACADVLP49748S586VVVLSRAsRSLSEGH
PRKACAP17612humanNKD2Q969F2S223sAHVRRPstDPQPCs
PRKACAP17612humanCADP27708H1856FHLPPRIhRAsDPGL
PRKACAP17612humanHTTP42858S2548TRFGRKLsIIRGIVE
PRKACAP17612humanHSPB6O14558S16PSWLRRAsAPLPGLSCrystallin
PRKACAP17612humanPAK6Q9NQU5S113TSRRRAQsLGLLGDE
PRKACAP17612humanRXRAP19793S27tsPTGRGsMAAPsLHNuc_recep-AF1
PRKACAP17612humanTHP07101-3S40RFIGRRQsLIEDARKTOH_N
PRKACAP17612humanSLC26A4O43511T717DDNIRKDtFFLTVHDSTAS
PRKACAP17612humanPKD2L1Q9P0L9S686LGRsIVssPQGKSGP
PRKACAP17612humanCFTRP13569S813DIYsRRLsQEtGLEICFTR_R
PRKACAP17612humanGATA3P23771S308IKPkRRLsAARRAGT
PRKACAP17612humanTPPPO94811S32DRAAKRLsLEsEGAG
PRKACAP17612humanAKAP13Q12802S2733sVsPKRNsISRTHKD
PRKACAP17612humanSUN2Q9UH99S116GsEssRAsGLVGRKA
PRKACAP17612humanCDK16Q00536S12KKIKRQLsMtLRGGr
PRKACAP17612humanKCNJ2P63252S425PRPLRREsEI_____
PRKACAP17612humanALOX5P09917S448MKDLtyAsLCFPEAILipoxygenase
PRKACAP17612humanTNNI3P19429S24APIRRRssNyRAyAtTroponin-I_N
PRKACAP17612humanSUFUQ9UMX1S346RAPsRkDsLEsDSstSUFU_C
PRKACAP17612humanIMMTQ16891S528ELQFRRLsQEQVDNFMitofilin
PRKACAP17612humanAQP4P55087S276AAQQTKGsyMEVEDN
PRKACAP17612humanTRPM8Q7Z2W7T17MRNRRNDtLDSTRTL
PRKACAP17612humanSRSF2Q01130S130RRRRRsRsRSRSRSR
PRKACAP17612humanRYR2Q92736S2808YNRTRRIsQTSQVsV
PRKACAP17612humanALOX5P09917S671sPDRIPNsVAI____
PRKACAP17612humanMAPTP10636-8S416sNVsstGsIDMVDsP
PRKACAP17612humanIGFBP1P08833S194LAKAQETsGEEIsKFThyroglobulin_1
PRKACAP17612humanMC4RP32245T312RSQELRKtFKEIICC
PRKACAP17612humanGPR15P49685S357FARRRKRsVsL____
PRKACAP17612humanCEACAM1P13688S472DLTEHKPsVSNHTQD
PRKACAP17612humanKCNK3O14649S393GLMKRRssV______
PRKACAP17612humanCASTP20810S133DKKKEKKsLtPAVPVCalpain_inhib
PRKACAP17612humanKCNQ1P51787S27LPGARRGsAGLAKKC
PRKACAP17612humanE2F1Q01094S235TTQLRLLsEDTDSQRE2F_CC-MB
PRKACAP17612humanMAPTP10636-8S305kHVPGGGsVQIVykPTubulin-binding
PRKACAP17612humanTACC3Q9Y6A5S558ESALRKQsLyLkFDP
PRKACAP17612humanCEACAM1P13688S512QPTsAsPsLTATEII
PRKACAP17612-2humanSEPTIN12Q8IYM1S198PVIARADsLTMEERESeptin


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKACAIDDescription0.00e+00
PRKACAGO:0003015heart process4.32e-21
PRKACAGO:0003012muscle system process1.98e-19
PRKACAGO:0060047heart contraction2.60e-19
PRKACAGO:0042391regulation of membrane potential1.32e-18
PRKACAGO:1903522regulation of blood circulation1.32e-18
PRKACAGO:0008016regulation of heart contraction7.38e-18
PRKACAGO:0006936muscle contraction1.42e-17
PRKACAGO:0060048cardiac muscle contraction1.15e-15
PRKACAGO:0006941striated muscle contraction1.94e-14
PRKACAGO:0006816calcium ion transport5.59e-14
PRKACAGO:0090257regulation of muscle system process6.29e-14
PRKACAGO:0086003cardiac muscle cell contraction1.07e-13
PRKACAGO:0019932second-messenger-mediated signaling1.11e-13
PRKACAGO:0034765regulation of monoatomic ion transmembrane transport4.45e-13
PRKACAGO:0070588calcium ion transmembrane transport7.23e-13
PRKACAGO:0048732gland development9.23e-13
PRKACAGO:0006937regulation of muscle contraction9.23e-13
PRKACAGO:0006942regulation of striated muscle contraction9.97e-13
PRKACAGO:0009410response to xenobiotic stimulus2.16e-12
PRKACAGO:0070252actin-mediated cell contraction2.97e-12
PRKACAGO:0062012regulation of small molecule metabolic process5.25e-12
PRKACAGO:0014074response to purine-containing compound1.30e-11
PRKACAGO:0043254regulation of protein-containing complex assembly1.68e-11
PRKACAGO:0009612response to mechanical stimulus1.70e-11
PRKACAGO:0032386regulation of intracellular transport2.41e-11
PRKACAGO:0030048actin filament-based movement2.44e-11
PRKACAGO:0042063gliogenesis2.59e-11
PRKACAGO:0062197cellular response to chemical stress2.59e-11
PRKACAGO:0051098regulation of binding4.40e-11
PRKACAGO:0006874intracellular calcium ion homeostasis6.73e-11
PRKACAGO:1901653cellular response to peptide6.83e-11
PRKACAGO:0055074calcium ion homeostasis7.22e-11
PRKACAGO:0043393regulation of protein binding7.24e-11
PRKACAGO:0051591response to cAMP7.53e-11
PRKACAGO:0071214cellular response to abiotic stimulus8.17e-11
PRKACAGO:0104004cellular response to environmental stimulus8.17e-11
PRKACAGO:0010038response to metal ion9.99e-11
PRKACAGO:0043434response to peptide hormone1.11e-10
PRKACAGO:0086002cardiac muscle cell action potential involved in contraction1.27e-10
PRKACAGO:0055117regulation of cardiac muscle contraction2.06e-10
PRKACAGO:0010959regulation of metal ion transport2.89e-10
PRKACAGO:0061337cardiac conduction5.84e-10
PRKACAGO:0046683response to organophosphorus5.90e-10
PRKACAGO:0006813potassium ion transport1.10e-09
PRKACAGO:0016049cell growth1.31e-09
PRKACAGO:0097553calcium ion transmembrane import into cytosol1.45e-09
PRKACAGO:0086001cardiac muscle cell action potential1.58e-09
PRKACAGO:1903829positive regulation of protein localization1.59e-09
PRKACAGO:0086009membrane repolarization2.41e-09

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Related Drugs to PDIA4_PRKACA


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PDIA4-PRKACA and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PDIA4_PRKACA


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate