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Kinase Fusion Gene:PER1_IKBKB |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: PER1_IKBKB | KinaseFusionDB ID: KFG4621 | FusionGDB2.0 ID: KFG4621 | Hgene | Tgene | Gene symbol | PER1 | IKBKB | Gene ID | 5187 | 3551 | |
Gene name | period circadian regulator 1 | inhibitor of nuclear factor kappa B kinase subunit beta | ||||||||||
Synonyms | PER|RIGUI|hPER | IKK-2|IKK-beta|IKK2|IKKB|IMD15|IMD15A|IMD15B|NFKBIKB | ||||||||||
Cytomap | 17p13.1 | 8p11.21 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | period circadian protein homolog 1Period, drosophila, homolog ofcircadian clock protein PERIOD 1circadian pacemaker protein RIGUIhPER1period circadian clock 1period homolog 1 | inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betainhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase betanuclear factor kappa B kinase subun | ||||||||||
Modification date | 20240407 | 20240407 | ||||||||||
UniProtAcc | O15534 | O14920 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000317276, ENST00000354903, ENST00000578089, ENST00000581082, | ENST00000379708, ENST00000416505, ENST00000518983, ENST00000519735, ENST00000520810, ENST00000520835, ENST00000522147, ENST00000522785, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PER1 [Title/Abstract] AND IKBKB [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PER1(7870321)-IKBKB(42183128), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PER1 | GO:0032922 | circadian regulation of gene expression | 18411297|24005054 |
Tgene | IKBKB | GO:0006468 | protein phosphorylation | 15084260|20434986 |
Tgene | IKBKB | GO:0007249 | canonical NF-kappaB signal transduction | 9346484 |
Tgene | IKBKB | GO:0018105 | peptidyl-serine phosphorylation | 21399639|25326418 |
Tgene | IKBKB | GO:0042325 | regulation of phosphorylation | 26212789 |
Tgene | IKBKB | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 9346484 |
Tgene | IKBKB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055|23453807 |
Tgene | IKBKB | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15790681 |
Tgene | IKBKB | GO:0051604 | protein maturation | 11297557 |
Tgene | IKBKB | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
Kinase Fusion gene breakpoints across PER1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across IKBKB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | BC110917 | PER1 | chr17 | 7870321 | IKBKB | chr8 | 42183128 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:7870321/:42183128) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PER1 | IKBKB |
FUNCTION: Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1. {ECO:0000269|PubMed:24005054}. | FUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484, PubMed:30337470). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:19716809, PubMed:17213322). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:9346484}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PER1_IKBKB |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S432 | KMPNTNGsIGHsPLs | CYLD_phos_site |
IKBKB | O14920 | human | BBC3 | Q9BXH1 | S106 | LAEQHLEsPVPSAPG | PUMA |
IKBKB | O14920 | human | NFKB1 | P19838 | S923 | DELRDSDsVCDsGVE | |
IKBKB | O14920 | human | IRF3 | Q14653 | T404 | NsHPLsLtsDQYKAY | |
IKBKB | O14920 | human | FOS | P01100 | S308 | ADWEPLHsGSLGMGP | |
IKBKB | O14920 | human | COPS5 | Q92905 | S201 | kPPDEGPsEyQtIPL | |
IKBKB | O14920 | human | TP63 | Q9H3D4 | S43 | yRSTMSQsTQtNEFL | |
IKBKB | O14920 | human | TSC1 | Q92574 | S487 | AAIsRELsEItTAEA | Hamartin |
IKBKB | O14920 | human | BCL10 | O95999 | S138 | NNLsRsNsDEsNFsE | |
IKBKB | O14920 | human | TNFRSF1A | P19438 | S381 | FVRRLGLsDHEIDRL | Death |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S439 | sIGHsPLsLsAQsVM | CYLD_phos_site |
IKBKB | O14920 | human | BBC3 | Q9BXH1 | S96 | RPDGPQPsLSLAEQH | PUMA |
IKBKB | O14920 | human | TNFAIP3 | P21580 | S381 | EPsVPQLsLMDVKCE | |
IKBKB | O14920 | human | RAPGEF2 | Q9Y4G8 | S1254 | GsWTSCSsGsHDNIQ | |
IKBKB | O14920 | human | MTURN | Q8N3F0 | S58 | GDNFHVWsESEDCLP | DUF4581 |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S436 | TNGsIGHsPLsLsAQ | CYLD_phos_site |
IKBKB | O14920 | human | IRF3 | Q14653 | S398 | VDLHIsNsHPLsLts | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S43 | PAMLHLPsEQGAPEt | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S68 | LRDAIRQsNQILRER | NEMO |
IKBKB | O14920 | human | RELA | Q04206 | S536 | sGDEDFSsIADMDFS | |
IKBKB | O14920 | human | MAVS | Q7Z434 | S442 | CFEDLAIsASTSLGM | |
IKBKB | O14920 | human | RELA | Q04206 | S468 | AVFTDLAsVDNsEFQ | |
IKBKB | O14920 | human | DOK1 | Q99704 | S450 | sHNsALysQVQKSGA | |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S583 | PAPADFLsLssEtKP | |
IKBKB | O14920 | human | BCL10 | O95999 | S136 | AtNNLsRsNsDEsNF | |
IKBKB | O14920 | human | PFKFB3 | Q16875 | S269 | QGRIGGDsGLSsRGK | His_Phos_1 |
IKBKB | O14920 | human | BCL3 | P20749 | S454 | PsPAPGGs_______ | |
IKBKB | O14920 | human | ASB8 | Q9H765 | S31 | RTIAAIRsFPHDNVE | Ank_2 |
IKBKB | O14920 | human | BCL10 | O95999 | S144 | NsDEsNFsEkLRAST | |
IKBKB | O14920 | human | TSC1 | Q92574 | S511 | DsPFyRDsLPGsQRK | Hamartin |
IKBKB | O14920 | human | RPS3 | P23396 | S209 | kPLPDHVsIVEPkDE | |
IKBKB | O14920 | human | HTT | P42858 | S16 | kAFEsLksFQQQQQQ | |
IKBKB | O14920 | human | IRF3 | Q14653 | S402 | IsNsHPLsLtsDQYK | |
IKBKB | O14920 | human | IKBKB | O14920 | S258 | GTVKFsssLPyPNNL | Pkinase |
IKBKB | O14920 | human | OPTN | Q96CV9 | S513 | FEDGGRQsLMEMQsR | |
IKBKB | O14920 | human | MYC | P01106 | S82 | PLsPsRRsGLCsPSy | Myc_N |
IKBKB | O14920 | human | COPS5 | Q92905 | T205 | EGPsEyQtIPLNkIE | |
IKBKB | O14920 | human | RELA | Q04206 | S311 | RtyEtFksIMkksPF | |
IKBKB | O14920 | human | RELA | Q04206 | S42 | RYkCEGRsAGsIPGE | RHD_DNA_bind |
IKBKB | O14920 | human | NFKBIA | P25963 | S32 | LLDDRHDsGLDsMkD | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S85 | ELLHFQAsQREEKEF | NEMO |
IKBKB | O14920 | human | FOXO3 | O43524 | S644 | GLDFNFDsLISTQNV | FOXO-TAD |
IKBKB | O14920 | human | REL | Q04864 | S557 | SNTTVFVsQSDAFEG | |
IKBKB | O14920 | human | IRF5 | Q13568 | S446 | DsIRLQIsNPDLKDR | |
IKBKB | O14920 | human | NFKB1 | P19838 | S927 | DSDsVCDsGVETsFR | |
IKBKB | O14920 | human | DOK1 | Q99704 | S446 | sGIKsHNsALysQVQ | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S441 | GHsPLsLsAQsVMEE | CYLD_phos_site |
IKBKB | O14920 | human | RELA | Q04206 | S131 | RDLEQAIsQRIQtNN | RHD_DNA_bind |
IKBKB | O14920 | human | MYC | P01106 | S86 | sRRsGLCsPSyVAVt | Myc_N |
IKBKB | O14920 | human | RELA | Q04206 | S45 | CEGRsAGsIPGERST | RHD_DNA_bind |
IKBKB | O14920 | human | TP73 | O15350 | S471 | GEMSSSHsAQSMVSG | |
IKBKB | O14920 | human | TP63 | Q9H3D4 | S51 | TQtNEFLsPEVFQHI | |
IKBKB | O14920 | human | RELA | Q04206 | S261 | tPPYADPsLQAPVRV | RHD_dimer |
IKBKB | O14920 | human | DOK1 | Q99704 | S439 | EPGtATGsGIKsHNs | |
IKBKB | O14920 | human | NFKBIA | P25963 | S36 | RHDsGLDsMkDEEyE | |
IKBKB | O14920 | human | RELB | Q01201 | S472 | DFFSGTVsLPGLEPP | RelB_transactiv |
IKBKB | O14920 | human | TMIGD2 | Q96BF3 | S220 | GKDQRGQsIyStSFP | |
IKBKB | O14920 | human | NFKB1 | P19838 | S80 | sSEKNKKsYPQVKIC | RHD_DNA_bind |
IKBKB | O14920 | human | HTT | P42858 | S13 | kLMkAFEsLksFQQQ | |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S855 | GLQEKHKsLAFHRPP | |
IKBKB | O14920 | human | CDKN2A | P42771 | S8 | MEPAAGssMEPSADW | |
IKBKB | O14920 | human | IRF3 | Q14653 | S396 | NtVDLHIsNsHPLsL | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S31 | QDVLGEEsPLGKPAM | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S568 | LAFGGYLsEVVEENT | |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S107 | IVASsDssISskARG | |
IKBKB | O14920 | human | FOXO1 | Q12778 | S319 | TFRPRtssNAstIsG | |
IKBKB | O14920 | human | STAT1 | P42224 | T749 | EFDsMMNtV______ | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S444 | PLsLsAQsVMEELNT | CYLD_phos_site |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S422 | RFHsLPFsLtKMPNT | CYLD_phos_site |
IKBKB | O14920 | human | BBC3 | Q9BXH1 | S10 | RARQEGSsPEPVEGL | PUMA |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S405 | PDIFSSVsVPPSLKV | Ge1_WD40 |
IKBKB | O14920 | human | BCL10 | O95999 | S141 | sRsNsDEsNFsEkLR | |
IKBKB | O14920 | human | IRS1 | P35568 | S312 | tEsItAtsPAsMVGG | |
IKBKB | O14920 | human | IKBKB | O14920 | S177 | AkELDQGsLCtsFVG | Pkinase |
IKBKB | O14920 | human | IKBKB | O14920 | S181 | DQGsLCtsFVGTLQy | Pkinase |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S376 | PPAPAyLssPLALPs | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S418 | TTENRFHsLPFsLtK | CYLD_phos_site |
IKBKB | O14920 | human | NFKB1 | P19838 | S932 | CDsGVETsFRKLsFt | |
IKBKB | O14920 | human | HTT | P42858 | T3 | _____MAtLEkLMkA | |
IKBKB | O14920 | human | SNAP23 | O00161 | S95 | NRTkNFEsGkAykTt | SNAP-25 |
IKBKB | O14920 | human | BCL10 | O95999 | S134 | DGAtNNLsRsNsDEs | |
IKBKB | O14920 | human | DOK1 | Q99704 | S443 | ATGsGIKsHNsALys | |
IKBKB | O14920 | human | IRF3 | Q14653 | S405 | sHPLsLtsDQYKAYL |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
IKBKB | ID | Description | 0.00e+00 |
IKBKB | GO:0007249 | canonical NF-kappaB signal transduction | 1.34e-14 |
IKBKB | GO:0051090 | regulation of DNA-binding transcription factor activity | 4.75e-10 |
IKBKB | GO:0071356 | cellular response to tumor necrosis factor | 4.95e-10 |
IKBKB | GO:0034612 | response to tumor necrosis factor | 9.33e-10 |
IKBKB | GO:0043122 | regulation of canonical NF-kappaB signal transduction | 9.58e-10 |
IKBKB | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 1.28e-08 |
IKBKB | GO:0002757 | immune response-activating signaling pathway | 1.87e-08 |
IKBKB | GO:0002764 | immune response-regulating signaling pathway | 3.11e-08 |
IKBKB | GO:0038061 | non-canonical NF-kappaB signal transduction | 8.61e-08 |
IKBKB | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 6.12e-07 |
IKBKB | GO:0032479 | regulation of type I interferon production | 6.12e-07 |
IKBKB | GO:0032606 | type I interferon production | 6.12e-07 |
IKBKB | GO:0050851 | antigen receptor-mediated signaling pathway | 7.86e-07 |
IKBKB | GO:0009612 | response to mechanical stimulus | 9.86e-07 |
IKBKB | GO:0009615 | response to virus | 1.06e-06 |
IKBKB | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 1.06e-06 |
IKBKB | GO:0002753 | cytosolic pattern recognition receptor signaling pathway | 1.43e-06 |
IKBKB | GO:0002221 | pattern recognition receptor signaling pathway | 1.70e-06 |
IKBKB | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 1.70e-06 |
IKBKB | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 1.76e-06 |
IKBKB | GO:0031349 | positive regulation of defense response | 2.01e-06 |
IKBKB | GO:0050862 | positive regulation of T cell receptor signaling pathway | 2.42e-06 |
IKBKB | GO:0002758 | innate immune response-activating signaling pathway | 2.44e-06 |
IKBKB | GO:0002218 | activation of innate immune response | 4.31e-06 |
IKBKB | GO:2001233 | regulation of apoptotic signaling pathway | 4.68e-06 |
IKBKB | GO:0032495 | response to muramyl dipeptide | 5.13e-06 |
IKBKB | GO:0032608 | interferon-beta production | 6.80e-06 |
IKBKB | GO:0032648 | regulation of interferon-beta production | 6.80e-06 |
IKBKB | GO:0032727 | positive regulation of interferon-alpha production | 8.13e-06 |
IKBKB | GO:0035994 | response to muscle stretch | 9.29e-06 |
IKBKB | GO:2000630 | positive regulation of miRNA metabolic process | 9.29e-06 |
IKBKB | GO:0097193 | intrinsic apoptotic signaling pathway | 9.81e-06 |
IKBKB | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 1.17e-05 |
IKBKB | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | 1.33e-05 |
IKBKB | GO:0035872 | nucleotide-binding domai | 3.20e-07 |
IKBKB | GO:0045089 | positive regulation of innate immune response | 1.47e-05 |
IKBKB | GO:0032607 | interferon-alpha production | 1.55e-05 |
IKBKB | GO:0032647 | regulation of interferon-alpha production | 1.55e-05 |
IKBKB | GO:0030522 | intracellular receptor signaling pathway | 1.64e-05 |
IKBKB | GO:2001235 | positive regulation of apoptotic signaling pathway | 1.64e-05 |
IKBKB | GO:0031098 | stress-activated protein kinase signaling cascade | 1.64e-05 |
IKBKB | GO:0001819 | positive regulation of cytokine production | 1.84e-05 |
IKBKB | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 1.85e-05 |
IKBKB | GO:0002237 | response to molecule of bacterial origin | 2.06e-05 |
IKBKB | GO:0002833 | positive regulation of response to biotic stimulus | 2.06e-05 |
IKBKB | GO:2000628 | regulation of miRNA metabolic process | 2.71e-05 |
IKBKB | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 3.26e-05 |
IKBKB | GO:0001959 | regulation of cytokine-mediated signaling pathway | 3.67e-05 |
IKBKB | GO:0060759 | regulation of response to cytokine stimulus | 5.34e-05 |
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Related Drugs to PER1_IKBKB |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning PER1-IKBKB and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PER1_IKBKB |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |