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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PKN2_COL24A1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PKN2_COL24A1
KinaseFusionDB ID: KFG4711
FusionGDB2.0 ID: KFG4711
HgeneTgene
Gene symbol

PKN2

COL24A1

Gene ID

5586

255631

Gene nameprotein kinase N2collagen type XXIV alpha 1 chain
SynonymsPAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7-
Cytomap

1p22.2

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2collagen alpha-1(XXIV) chaincollagen, type XXIV, alpha 1
Modification date2024032320240305
UniProtAcc

Q16513

Q17RW2

Ensembl transtripts involved in fusion geneENST idsENST00000316005, ENST00000370513, 
ENST00000370521, ENST00000370505, 
ENST00000495119, ENST00000544045, 
ENST00000485434, ENST00000370571, 
ENST00000436319, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PKN2 [Title/Abstract] AND COL24A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PKN2(89150311)-COL24A1(86453337), # samples:3
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePKN2

GO:0006468

protein phosphorylation

17332740

HgenePKN2

GO:0010631

epithelial cell migration

21754995


check buttonKinase Fusion gene breakpoints across PKN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across COL24A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-AN-A0FV-01APKN2chr1

89150311

COL24A1chr1

86453337



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)
Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:89150311/chr1:86453337)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PKN2

Q16513

COL24A1

Q17RW2

FUNCTION: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}.FUNCTION: May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. {ECO:0000269|PubMed:12874293}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PKN2_COL24A1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PKN2Q16513humanNOS3P29474S1179RIRtQsFsLQERQLR
PKN2Q16513humanMEFVO15553S208VRLRRNAssAGRLQG
PKN2Q16513humanMEFVO15553S242SGKMRPRsLEVTIST


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PKN2IDDescription0.00e+00
PKN2GO:0032102negative regulation of response to external stimulus2.18e-02
PKN2GO:0014745negative regulation of muscle adaptation2.18e-02
PKN2GO:0006527arginine catabolic process2.18e-02
PKN2GO:1900226negative regulation of NLRP3 inflammasome complex assembly2.18e-02
PKN2GO:0030728ovulation2.18e-02
PKN2GO:0141086negative regulation of inflammasome-mediated signaling pathway2.18e-02
PKN2GO:0030810positive regulation of nucleotide biosynthetic process2.18e-02
PKN2GO:1900373positive regulation of purine nucleotide biosynthetic process2.18e-02
PKN2GO:0010544negative regulation of platelet activation2.18e-02
PKN2GO:0003184pulmonary valve morphogenesis2.18e-02
PKN2GO:0032695negative regulation of interleukin-12 production2.18e-02
PKN2GO:0006525arginine metabolic process2.18e-02
PKN2GO:0045981positive regulation of nucleotide metabolic process2.18e-02
PKN2GO:1900544positive regulation of purine nucleotide metabolic process2.18e-02
PKN2GO:0003177pulmonary valve development2.18e-02
PKN2GO:0019430removal of superoxide radicals2.18e-02
PKN2GO:0071450cellular response to oxygen radical2.18e-02
PKN2GO:0071451cellular response to superoxide2.18e-02
PKN2GO:0002026regulation of the force of heart contraction2.18e-02
PKN2GO:0009065glutamine family amino acid catabolic process2.18e-02
PKN2GO:0000303response to superoxide2.18e-02
PKN2GO:0000305response to oxygen radical2.18e-02
PKN2GO:0007263nitric oxide mediated signal transduction2.18e-02
PKN2GO:0070168negative regulation of biomineral tissue development2.18e-02
PKN2GO:0032682negative regulation of chemokine production2.18e-02
PKN2GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors2.18e-02
PKN2GO:0030808regulation of nucleotide biosynthetic process2.18e-02
PKN2GO:1900371regulation of purine nucleotide biosynthetic process2.18e-02
PKN2GO:0034405response to fluid shear stress2.18e-02
PKN2GO:1900225regulation of NLRP3 inflammasome complex assembly2.18e-02
PKN2GO:0048873homeostasis of number of cells within a tissue2.18e-02
PKN2GO:0039532negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway2.18e-02
PKN2GO:0043267negative regulation of potassium ion transport2.18e-02
PKN2GO:0044546NLRP3 inflammasome complex assembly2.18e-02
PKN2GO:0070269pyroptosis2.18e-02
PKN2GO:0141085regulation of inflammasome-mediated signaling pathway2.18e-02
PKN2GO:0001990regulation of systemic arterial blood pressure by hormone2.18e-02
PKN2GO:0003180aortic valve morphogenesis2.18e-02
PKN2GO:0031281positive regulation of cyclase activity2.18e-02
PKN2GO:0140632canonical inflammasome complex assembly2.18e-02
PKN2GO:0051349positive regulation of lyase activity2.18e-02
PKN2GO:0003203endocardial cushion morphogenesis2.18e-02
PKN2GO:0045454cell redox homeostasis2.18e-02
PKN2GO:1900016negative regulation of cytokine production involved in inflammatory response2.18e-02
PKN2GO:0141084inflammasome-mediated signaling pathway2.18e-02
PKN2GO:0003176aortic valve development2.18e-02
PKN2GO:0060412ventricular septum morphogenesis2.18e-02
PKN2GO:0032691negative regulation of interleukin-1 beta production2.18e-02
PKN2GO:0003044regulation of systemic arterial blood pressure mediated by a chemical signal2.18e-02

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Related Drugs to PKN2_COL24A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PKN2-COL24A1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PKN2_COL24A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate