Ensembl transtripts involved in fusion gene | ENST ids | ENST00000370505, ENST00000370513, ENST00000370521, ENST00000544045, ENST00000316005, ENST00000495119,
| ENST00000343258, ENST00000370056, ENST00000371846, ENST00000415432, ENST00000527011, ENST00000544443,
|
Hgene | Tgene |
PKN2
Q16513 | VAV3
Q9UKW4 |
FUNCTION: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. | FUNCTION: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity). {ECO:0000250}. |
Kinase | GOID | GO term | P.adjust |
PKN2 | ID | Description | 0.00e+00 |
PKN2 | GO:0032102 | negative regulation of response to external stimulus | 2.18e-02 |
PKN2 | GO:0014745 | negative regulation of muscle adaptation | 2.18e-02 |
PKN2 | GO:0006527 | arginine catabolic process | 2.18e-02 |
PKN2 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly | 2.18e-02 |
PKN2 | GO:0030728 | ovulation | 2.18e-02 |
PKN2 | GO:0141086 | negative regulation of inflammasome-mediated signaling pathway | 2.18e-02 |
PKN2 | GO:0030810 | positive regulation of nucleotide biosynthetic process | 2.18e-02 |
PKN2 | GO:1900373 | positive regulation of purine nucleotide biosynthetic process | 2.18e-02 |
PKN2 | GO:0010544 | negative regulation of platelet activation | 2.18e-02 |
PKN2 | GO:0003184 | pulmonary valve morphogenesis | 2.18e-02 |
PKN2 | GO:0032695 | negative regulation of interleukin-12 production | 2.18e-02 |
PKN2 | GO:0006525 | arginine metabolic process | 2.18e-02 |
PKN2 | GO:0045981 | positive regulation of nucleotide metabolic process | 2.18e-02 |
PKN2 | GO:1900544 | positive regulation of purine nucleotide metabolic process | 2.18e-02 |
PKN2 | GO:0003177 | pulmonary valve development | 2.18e-02 |
PKN2 | GO:0019430 | removal of superoxide radicals | 2.18e-02 |
PKN2 | GO:0071450 | cellular response to oxygen radical | 2.18e-02 |
PKN2 | GO:0071451 | cellular response to superoxide | 2.18e-02 |
PKN2 | GO:0002026 | regulation of the force of heart contraction | 2.18e-02 |
PKN2 | GO:0009065 | glutamine family amino acid catabolic process | 2.18e-02 |
PKN2 | GO:0000303 | response to superoxide | 2.18e-02 |
PKN2 | GO:0000305 | response to oxygen radical | 2.18e-02 |
PKN2 | GO:0007263 | nitric oxide mediated signal transduction | 2.18e-02 |
PKN2 | GO:0070168 | negative regulation of biomineral tissue development | 2.18e-02 |
PKN2 | GO:0032682 | negative regulation of chemokine production | 2.18e-02 |
PKN2 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 2.18e-02 |
PKN2 | GO:0030808 | regulation of nucleotide biosynthetic process | 2.18e-02 |
PKN2 | GO:1900371 | regulation of purine nucleotide biosynthetic process | 2.18e-02 |
PKN2 | GO:0034405 | response to fluid shear stress | 2.18e-02 |
PKN2 | GO:1900225 | regulation of NLRP3 inflammasome complex assembly | 2.18e-02 |
PKN2 | GO:0048873 | homeostasis of number of cells within a tissue | 2.18e-02 |
PKN2 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway | 2.18e-02 |
PKN2 | GO:0043267 | negative regulation of potassium ion transport | 2.18e-02 |
PKN2 | GO:0044546 | NLRP3 inflammasome complex assembly | 2.18e-02 |
PKN2 | GO:0070269 | pyroptosis | 2.18e-02 |
PKN2 | GO:0141085 | regulation of inflammasome-mediated signaling pathway | 2.18e-02 |
PKN2 | GO:0001990 | regulation of systemic arterial blood pressure by hormone | 2.18e-02 |
PKN2 | GO:0003180 | aortic valve morphogenesis | 2.18e-02 |
PKN2 | GO:0031281 | positive regulation of cyclase activity | 2.18e-02 |
PKN2 | GO:0140632 | canonical inflammasome complex assembly | 2.18e-02 |
PKN2 | GO:0051349 | positive regulation of lyase activity | 2.18e-02 |
PKN2 | GO:0003203 | endocardial cushion morphogenesis | 2.18e-02 |
PKN2 | GO:0045454 | cell redox homeostasis | 2.18e-02 |
PKN2 | GO:1900016 | negative regulation of cytokine production involved in inflammatory response | 2.18e-02 |
PKN2 | GO:0141084 | inflammasome-mediated signaling pathway | 2.18e-02 |
PKN2 | GO:0003176 | aortic valve development | 2.18e-02 |
PKN2 | GO:0060412 | ventricular septum morphogenesis | 2.18e-02 |
PKN2 | GO:0032691 | negative regulation of interleukin-1 beta production | 2.18e-02 |
PKN2 | GO:0003044 | regulation of systemic arterial blood pressure mediated by a chemical signal | 2.18e-02 |