| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:PKN3_FAM118A |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: PKN3_FAM118A | KinaseFusionDB ID: KFG4717 | FusionGDB2.0 ID: KFG4717 | Hgene | Tgene | Gene symbol | PKN3 | FAM118A | Gene ID | 29941 | 55007 | |
| Gene name | protein kinase N3 | family with sequence similarity 118 member A | ||||||||||
| Synonyms | UTDP4-1 | C22orf8 | ||||||||||
| Cytomap | 9q34.11 | 22q13.31 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase N3protein kinase PKN-betaprotein-kinase C-related kinase 3 | protein FAM118AbK268H5.C22.4 | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | Q6P5Z2 | Q9NWS6 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000291906, ENST00000485301, | ENST00000405548, ENST00000216214, ENST00000405673, ENST00000441876, ENST00000491671, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PKN3 [Title/Abstract] AND FAM118A [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PKN3(131465218)-FAM118A(45726484), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PKN3 | GO:0010631 | epithelial cell migration | 21754995 |
| Kinase Fusion gene breakpoints across PKN3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across FAM118A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-HU-A4GN-01A | PKN3 | chr9 | 131465218 | FAM118A | chr22 | 45726484 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131465218/:45726484) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PKN3 | FAM118A |
| FUNCTION: Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of PKN3_FAM118A |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PKN3 | Q6P5Z2 | human | EGFR | P00533 | T678 | RHIVRKRtLRRLLQE | |
| PKN3 | Q6P5Z2 | human | CLIP1 | P30622 | S312 | AsLKRsPsAssLsSM |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PKN3 | ID | Description | 0.00e+00 |
| PKN3 | GO:0010749 | regulation of nitric oxide mediated signal transduction | 3.00e-02 |
| PKN3 | GO:0061029 | eyelid development in camera-type eye | 3.00e-02 |
| PKN3 | GO:0070141 | response to UV-A | 3.00e-02 |
| PKN3 | GO:1905208 | negative regulation of cardiocyte differentiation | 3.00e-02 |
| PKN3 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 3.00e-02 |
| PKN3 | GO:0038083 | peptidyl-tyrosine autophosphorylation | 3.00e-02 |
| PKN3 | GO:0038128 | ERBB2 signaling pathway | 3.00e-02 |
| PKN3 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity | 3.00e-02 |
| PKN3 | GO:0060571 | morphogenesis of an epithelial fold | 3.00e-02 |
| PKN3 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | 3.00e-02 |
| PKN3 | GO:0007202 | activation of phospholipase C activity | 3.00e-02 |
| PKN3 | GO:0007263 | nitric oxide mediated signal transduction | 3.00e-02 |
| PKN3 | GO:0050999 | regulation of nitric-oxide synthase activity | 3.00e-02 |
| PKN3 | GO:0007435 | salivary gland morphogenesis | 3.00e-02 |
| PKN3 | GO:0031116 | positive regulation of microtubule polymerization | 3.00e-02 |
| PKN3 | GO:1901185 | negative regulation of ERBB signaling pathway | 3.00e-02 |
| PKN3 | GO:1905207 | regulation of cardiocyte differentiation | 3.00e-02 |
| PKN3 | GO:0007431 | salivary gland development | 3.00e-02 |
| PKN3 | GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 3.00e-02 |
| PKN3 | GO:0010863 | positive regulation of phospholipase C activity | 3.00e-02 |
| PKN3 | GO:0071276 | cellular response to cadmium ion | 3.00e-02 |
| PKN3 | GO:0045740 | positive regulation of DNA replication | 3.00e-02 |
| PKN3 | GO:0071392 | cellular response to estradiol stimulus | 3.00e-02 |
| PKN3 | GO:1900274 | regulation of phospholipase C activity | 3.00e-02 |
| PKN3 | GO:0071364 | cellular response to epidermal growth factor stimulus | 3.00e-02 |
| PKN3 | GO:0032768 | regulation of monooxygenase activity | 3.00e-02 |
| PKN3 | GO:0035272 | exocrine system development | 3.00e-02 |
| PKN3 | GO:0070849 | response to epidermal growth factor | 3.00e-02 |
| PKN3 | GO:0021795 | cerebral cortex cell migration | 3.00e-02 |
| PKN3 | GO:0010518 | positive regulation of phospholipase activity | 3.00e-02 |
| PKN3 | GO:0048546 | digestive tract morphogenesis | 3.00e-02 |
| PKN3 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | 3.00e-02 |
| PKN3 | GO:1902895 | positive regulation of miRNA transcription | 3.00e-02 |
| PKN3 | GO:0048146 | positive regulation of fibroblast proliferation | 3.00e-02 |
| PKN3 | GO:0010517 | regulation of phospholipase activity | 3.00e-02 |
| PKN3 | GO:0031122 | cytoplasmic microtubule organization | 3.00e-02 |
| PKN3 | GO:0046686 | response to cadmium ion | 3.00e-02 |
| PKN3 | GO:0060193 | positive regulation of lipase activity | 3.00e-02 |
| PKN3 | GO:0022029 | telencephalon cell migration | 3.00e-02 |
| PKN3 | GO:0031113 | regulation of microtubule polymerization | 3.00e-02 |
| PKN3 | GO:1903078 | positive regulation of protein localization to plasma membrane | 3.00e-02 |
| PKN3 | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 3.00e-02 |
| PKN3 | GO:0021885 | forebrain cell migration | 3.00e-02 |
| PKN3 | GO:2000630 | positive regulation of miRNA metabolic process | 3.00e-02 |
| PKN3 | GO:1902808 | positive regulation of cell cycle G1/S phase transition | 3.00e-02 |
| PKN3 | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction | 3.00e-02 |
| PKN3 | GO:1901184 | regulation of ERBB signaling pathway | 3.00e-02 |
| PKN3 | GO:1902893 | regulation of miRNA transcription | 3.00e-02 |
| PKN3 | GO:0061614 | miRNA transcription | 3.00e-02 |
Top |
Related Drugs to PKN3_FAM118A |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning PKN3-FAM118A and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to PKN3_FAM118A |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |