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Kinase Fusion Gene:ATM_ASPH |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: ATM_ASPH | KinaseFusionDB ID: KFG476 | FusionGDB2.0 ID: KFG476 | Hgene | Tgene | Gene symbol | ATM | ASPH | Gene ID | 472 | 444 | |
Gene name | ATM serine/threonine kinase | aspartate beta-hydroxylase | ||||||||||
Synonyms | AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1 | AAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin | ||||||||||
Cytomap | 11q22.3 | 8q12.3 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | serine-protein kinase ATMA-T mutatedAT mutatedTEL1, telomere maintenance 1, homologataxia telangiectasia mutatedserine/threonine kinase ATM | aspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase | ||||||||||
Modification date | 20240413 | 20240411 | ||||||||||
UniProtAcc | Q13315 | Q12797 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000278616, ENST00000452508, ENST00000525178, | ENST00000379454, ENST00000541428, ENST00000356457, ENST00000379449, ENST00000389204, ENST00000445642, ENST00000517661, ENST00000517847, ENST00000517856, ENST00000517903, ENST00000518068, ENST00000522603, ENST00000522835, ENST00000522919, ENST00000523897, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ATM [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ATM(108106442)-ASPH(62415173), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ATM | GO:0000077 | DNA damage checkpoint signaling | 30886146 |
Hgene | ATM | GO:0000425 | pexophagy | 26344566 |
Hgene | ATM | GO:0006302 | double-strand break repair | 26240375 |
Hgene | ATM | GO:0006468 | protein phosphorylation | 15448695|15916964 |
Hgene | ATM | GO:0006974 | DNA damage response | 9733515|16213212 |
Hgene | ATM | GO:0010212 | response to ionizing radiation | 9733515|11375976 |
Hgene | ATM | GO:0018105 | peptidyl-serine phosphorylation | 9733515|26323318 |
Hgene | ATM | GO:0034614 | cellular response to reactive oxygen species | 26344566 |
Hgene | ATM | GO:0042770 | signal transduction in response to DNA damage | 26774286 |
Hgene | ATM | GO:0046777 | protein autophosphorylation | 9733515|15790808 |
Hgene | ATM | GO:0071044 | histone mRNA catabolic process | 16086026 |
Hgene | ATM | GO:0071480 | cellular response to gamma radiation | 9925639|16213212 |
Hgene | ATM | GO:0071481 | cellular response to X-ray | 26323318 |
Hgene | ATM | GO:0071500 | cellular response to nitrosative stress | 23878245 |
Tgene | ASPH | GO:0045862 | positive regulation of proteolysis | 18387192 |
Tgene | ASPH | GO:0097202 | activation of cysteine-type endopeptidase activity | 18387192 |
Kinase Fusion gene breakpoints across ATM (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across ASPH (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | CB269353 | ATM | chr11 | 108106442 | ASPH | chr8 | 62415173 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:108106442/:62415173) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ATM | ASPH |
FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:9733514, PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15456891, PubMed:15448695, PubMed:15916964, PubMed:17923702). Recognizes the substrate consensus sequence [ST]-Q (PubMed:9733514, PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15456891, PubMed:15448695, PubMed:15916964, PubMed:17923702). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146, PubMed:26774286). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}. | FUNCTION: [Isoform 1]: Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}.; FUNCTION: [Isoform 8]: Membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ATM_ASPH |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
ATM | Q13315 | human | FANCI | Q9NVI1 | S972 | SLLNLLSsQEEDFNS | FANCI_S3 |
ATM | Q13315 | human | KHDC3L | Q587J8 | T145 | IEVREAGtQRSVEVR | |
ATM | Q13315 | human | NKX3-1 | Q99801 | T166 | kNLkLTEtQVKIWFQ | Homeodomain |
ATM | Q13315 | human | TP53BP1 | Q12888 | S29 | IEDsQPEsQVLEDDS | |
ATM | Q13315 | human | KHSRP | Q92945 | S670 | GPGAPPGsQPDySAA | DUF1897 |
ATM | Q13315 | human | DCLRE1C | Q96SD1 | S503 | NDEITDEsLENFPSS | |
ATM | Q13315 | human | RRM2B | Q7LG56 | S72 | TAEEVDLsKDLPHWN | Ribonuc_red_sm |
ATM | Q13315 | human | DBN1 | Q16643-3 | S647 | SEGYFSQsQEEEFAQ | |
ATM | Q13315 | human | KHDC3L | Q587J8 | T156 | VEVREAGtQRSVEVQ | |
ATM | Q13315 | human | CROCC | Q5TZA2-2 | S922 | TESELRAsQEKISKM | |
ATM | Q13315 | human | FANCD2 | Q9BXW9 | S222 | LPEILGDsQHADVGK | FancD2 |
ATM | Q13315 | human | FBXW7 | Q969H0 | S26 | LRGNPSssQVDEEQM | |
ATM | Q13315 | human | UIMC1 | Q96RL1 | S205 | sGsWDQSsQPVFENV | |
ATM | Q13315 | human | WAPL | Q7Z5K2 | S498 | PPESNDNsQDSQSGT | |
ATM | Q13315 | human | E2F1 | Q01094 | S31 | ALRLLDSsQIVIISA | |
ATM | Q13315 | human | MDM2 | Q00987 | S407 | SSSIIyssQEDVKEF | |
ATM | Q13315 | human | TP53 | P04637 | S37 | NVLsPLPsQAMDDLM | TAD2 |
ATM | Q13315 | human | CHEK2 | O96017 | S33 | tQsQGSSsQsQGIss | |
ATM | Q13315 | human | SLX4 | Q8IY92 | S1631 | PHCQTLAsQTYKPSR | |
ATM | Q13315 | human | NFAT5 | O94916 | S1247 | AMQSNSPsQEQQQQQ | |
ATM | Q13315 | human | TRIM24 | O15164 | S217 | PEAVGVTsQRPVFCP | |
ATM | Q13315 | human | POLL | Q9UGP5 | T204 | EASDGEEtQVSAADL | |
ATM | Q13315 | human | PTEN | P60484 | T398 | PFDEDQHtQItkV__ | |
ATM | Q13315 | human | XPA | P23025 | S196 | RSLEVWGsQEALEEA | |
ATM | Q13315 | human | FUS | P35637 | S42 | QQSYSGYsQSTDTSG | |
ATM | Q13315 | human | MDM2 | Q00987 | S386 | DDKITQAsQsQESED | |
ATM | Q13315 | human | USP2 | O75604 | S2 | ______MsQLSSTLK | |
ATM | Q13315 | human | HUWE1 | Q7Z6Z7 | S3797 | QAAtsESsQSEAsVR | |
ATM | Q13315 | human | SP1 | P08047 | S101 | DLTATQLsQGANGWQ | |
ATM | Q13315 | human | NRF1 | Q16656 | T259 | QKQRVSWtQALRTIV | Nrf1_DNA-bind |
ATM | Q13315 | human | MED1 | Q15648 | S872 | FNPDLLNsQsQSGFG | |
ATM | Q13315 | human | HSP90AA1 | P07900 | T7 | _MPEEtQtQDQPMEE | |
ATM | Q13315 | human | SMC3 | Q9UQE7 | S1067 | GDVEGsQsQDEGEGs | SMC_N |
ATM | Q13315 | human | NABP2 | Q9BQ15 | T117 | EPNPEYstQQAPNKA | |
ATM | Q13315 | human | YAP1 | P46937 | Y391 | PFLNsGtyHSRDEst | |
ATM | Q13315 | human | MCPH1 | Q8NEM0 | S322 | QKQAAGMsQETFEEk | Microcephalin |
ATM | Q13315 | human | DTYMK | P23919 | S88 | PLIkEKLsQGVtLVV | Thymidylate_kin |
ATM | Q13315 | human | RNF40 | O75150 | S853 | EkELTLRsQALELNK | |
ATM | Q13315 | human | TOP2B | Q02880-2 | S1134 | SSDsGTPsGPDFNYI | DNA_topoisoIV |
ATM | Q13315 | human | PPM1G | O15355 | S183 | GTGEEPGsQGLNGEA | |
ATM | Q13315 | human | AVEN | Q9NQS1 | S308 | NILPDQTsQDLKSKE | |
ATM | Q13315 | human | MEN1 | O00255-1 | S399 | EERPGEQsQGTQSQG | Menin |
ATM | Q13315 | human | TP53BP1 | Q12888 | S1778 | FNkQYTEsQLRAGAG | |
ATM | Q13315 | human | HUWE1 | Q7Z6Z7 | S3377 | kACsPCSsQSSSSGI | |
ATM | Q13315 | human | RPA2 | P15927 | S29 | QsPGGFGsPAPsQAE | |
ATM | Q13315 | human | DBF4 | Q9UBU7 | S502 | FSTDNSGsQPKQKsD | |
ATM | Q13315 | human | PPP1R2 | P41236 | S44 | DEELSKKsQKWDEMN | |
ATM | Q13315 | human | DCLRE1C | Q96SD1 | S649 | NADsQsssDFEVPst | |
ATM | Q13315 | human | CBL | P22681 | S866 | SEIENLMsQGYSYQD | UBA |
ATM | Q13315 | human | CHEK2 | O96017 | S28 | PHGsVtQsQGSSsQs | |
ATM | Q13315 | human | PRPF19 | Q9UMS4 | S149 | VPQAVPSsQPSVVGA | |
ATM | Q13315 | human | MAD1L1 | Q9Y6D9 | S214 | kIQELQAsQEARADH | MAD |
ATM | Q13315 | human | UCHL3 | P15374 | S75 | EEEEKIKsQGQDVTS | Peptidase_C12 |
ATM | Q13315 | human | RANBP9 | Q96S59 | S550 | NSINMSRsQQVNNFT | CTLH |
ATM | Q13315 | human | SMC3 | Q9UQE7 | S1083 | EsErGsGsQssVPSV | SMC_N |
ATM | Q13315 | human | ATM | Q13315 | S367 | DTRSLEIsQSyTttQ | |
ATM | Q13315 | human | PNKP | Q96T60 | S114 | EEtRtPEsQPDtPPG | |
ATM | Q13315 | human | TAOK1 | Q7L7X3 | T643 | EELNKRQtQKDLEHA | |
ATM | Q13315 | human | RBBP8 | Q99708 | S664 | IDPGADLsQYKMDVT | |
ATM | Q13315 | human | TP53 | P04637 | S46 | AMDDLMLsPDDIEQW | TAD2 |
ATM | Q13315 | human | TOPBP1 | Q92547 | S853 | LEtPGRPsQQkRKPs | |
ATM | Q13315 | human | NIPBL | Q6KC79 | S563 | sItQDSDsIKKPEEI | |
ATM | Q13315 | human | TAOK1 | Q7L7X3 | S990 | SrSTsVTsQIsNGSH | |
ATM | Q13315 | human | FANCI | Q9NVI1 | S1121 | TLSEEAssQATLPNQ | FANCI_S4 |
ATM | Q13315 | human | FANCD2 | Q9BXW9 | S717 | KDGGPVTsQESGQkL | FancD2 |
ATM | Q13315 | human | AVEN | Q9NQS1 | S135 | VNNESGEsQRGTDFS | |
ATM | Q13315 | human | HUWE1 | Q7Z6Z7 | S927 | ISVNQWGsQLGLSVL | |
ATM | Q13315 | human | MRE11 | P49959 | S678 | sskIMsQsQVsKGVD | |
ATM | Q13315 | human | ZEB1 | P37275 | S585 | GDGNLsPsQPPLKNL | |
ATM | Q13315 | human | FANCI | Q9NVI1 | S730 | LDksADFsQsTSIGI | FANCI_HD2 |
ATM | Q13315 | human | HUWE1 | Q7Z6Z7 | S2339 | GQPEVLSsQEMQVEN | |
ATM | Q13315 | human | ATM | Q13315 | T1885 | sQTSRsTtPANLDsE | |
ATM | Q13315 | human | MED1 | Q15648 | S1141 | sQGSSGSsQSKNSsQ | |
ATM | Q13315 | human | FANCD2 | Q9BXW9 | T691 | yGLEEYDtQDGIAIN | FancD2 |
ATM | Q13315 | human | L3MBTL2 | Q969R5 | S335 | RLEVVDKsQVsRTRM | MBT |
ATM | Q13315 | human | APLF | Q8IW19 | S116 | MQCTLRNsQVLDEDN | |
ATM | Q13315 | human | KDM2A | Q9Y2K7 | T632 | EVDQNEEtQDFEKKL | PHD_4 |
ATM | Q13315 | human | ID3 | Q02535 | S65 | VPRGTQLsQVEILQR | HLH |
ATM | Q13315 | human | ATM | Q13315 | S2996 | QECkRNLsDIDQSFN | |
ATM | Q13315 | human | BAG6 | P46379 | S26 | VLVktLDsQTRTFIV | ubiquitin |
ATM | Q13315 | human | SMC1A | Q14683 | S957 | IsQEEGssQGEDsVs | SMC_N |
ATM | Q13315 | human | DCLRE1C | Q96SD1 | T656 | sDFEVPstPEAELPK | |
ATM | Q13315 | human | BRCA1 | P38398 | S1524 | LQNRNYPsQEELIKV | |
ATM | Q13315 | human | TERF1 | P54274 | S367 | SRIPVSKsQPVtPEK | |
ATM | Q13315 | human | GIT2 | Q14161 | S384 | NNQHsVEsQDNDQPd | |
ATM | Q13315 | human | PDS5A | Q29RF7 | S1278 | GRRPKsEsQGNATKN | |
ATM | Q13315 | human | BRCA1 | P38398 | S1387 | EDCSGLSsQSDILTt | |
ATM | Q13315 | human | ATM | Q13315 | S1893 | PANLDsEsEHFFRCC | |
ATM | Q13315 | human | COPS5 | Q92905 | S320 | EAIHGLMsQVIkDkL | CSN5_C |
ATM | Q13315 | human | RNF138 | Q8WVD3 | S124 | IIPNFQIsQDsVGNS | |
ATM | Q13315 | human | SLX4 | Q8IY92 | S1271 | sRSRDCSsQtQISSL | |
ATM | Q13315 | human | ATF2 | P15336 | S490 | QSTEPALsQIVMAPS | |
ATM | Q13315 | human | MDC1 | Q14676 | T4 | ____MEDtQAIDWDV | |
ATM | Q13315 | human | HIF1A | Q16665 | S696 | NVLsVALsQRTtVPE | |
ATM | Q13315 | human | BLM | P54132 | T99 | NAPAGQEtQRGGSkS | BLM_N |
ATM | Q13315 | human | USP28 | Q96RU2 | S720 | SsQDYSTsQEPSVAS | |
ATM | Q13315 | human | USP10 | Q14694 | T42 | SGTVLCGtQAVDKLP | |
ATM | Q13315 | human | DCLRE1C | Q96SD1 | S645 | NLSTNADsQsssDFE | |
ATM | Q13315 | human | CREB1 | P16220 | S107 | sVDsVtDsQKRREIL | pKID |
ATM | Q13315 | human | EZH2 | Q15910-2 | S734 | LFFDYRYsQADALKY | |
ATM | Q13315 | human | UBR5 | O95071 | S1532 | SDQSSSSsQSQSSYI | |
ATM | Q13315 | human | USP34 | Q70CQ2 | S718 | ATHIAQGsQESCITR | |
ATM | Q13315 | human | MDM2 | Q00987 | S425 | EtQDKEEsVESsLPL | |
ATM | Q13315 | human | SMC1A | Q14683 | S360 | RMEEEsQsQGRDLtL | SMC_N |
ATM | Q13315 | human | KHDRBS1 | Q07666 | T61 | GARAsPAtQPPPLLP | |
ATM | Q13315 | human | HUWE1 | Q7Z6Z7 | S2636 | HDQsTAtsQAGTLSS | |
ATM | Q13315 | human | ATF2 | P15336 | S498 | QIVMAPSsQSQPSGS | |
ATM | Q13315 | human | WAPL | Q7Z5K2 | S305 | RANKTkssQGASNFD | |
ATM | Q13315 | human | DDX1 | Q92499 | S671 | EHLNCTIsQVEPDIK | |
ATM | Q13315 | human | TP53 | P04637 | S33 | LPENNVLsPLPsQAM | |
ATM | Q13315 | human | TERF1 | P54274 | S219 | SKLLMIIsQKDTFHS | TRF |
ATM | Q13315 | human | HNF1A | P20823 | S249 | IQRGVsPsQAQGLGS | |
ATM | Q13315 | human | ATM | Q13315 | S440 | SPLLMILsQLLPQQR | |
ATM | Q13315 | human | MDC1 | Q14676 | T98 | DCGsLNGtQILRPPK | FHA |
ATM | Q13315 | human | PPP2R5C | Q13362 | S520 | CRADELAsQDGR___ | |
ATM | Q13315 | human | RIF1 | Q5UIP0 | S1851 | sEAMsLEsQEsPNEN | |
ATM | Q13315 | human | BECN1 | Q14457 | T57 | AQAkPGEtQEEETNs | |
ATM | Q13315 | human | DYRK2 | Q92630 | T106 | NKRTVLTtQPNGLTT | |
ATM | Q13315 | human | MDM2 | Q00987 | S395 | sQESEDysQPSTSSS | |
ATM | Q13315 | human | SMC1A | Q14683 | S358 | EERMEEEsQsQGRDL | SMC_N |
ATM | Q13315 | human | BRCA1 | P38398 | S1423 | AVLEQHGsQPSNSYP | |
ATM | Q13315 | human | AATF | Q9NY61 | S189 | EGDDAEDsQGEsEED | |
ATM | Q13315 | human | MLLT1 | Q03111 | S398 | FEPsQNHsQGPLRsM | |
ATM | Q13315 | human | SMURF2 | Q9HAU4 | S384 | kILRQELsQQQPQAG | |
ATM | Q13315 | human | SMC1A | Q14683 | S966 | GEDsVsGsQRIssIy | SMC_N |
ATM | Q13315 | human | PELP1 | Q8IZL8 | S1033 | LAPEALPsQGEVERE | |
ATM | Q13315 | human | RAD17 | O75943 | S646 | ETWSLPLsQNSASEL | |
ATM | Q13315 | human | PIDD1 | Q9HB75 | T788 | DAETGFLtQSNLLSV | |
ATM | Q13315 | human | CHEK1 | O14757 | S345 | LVQGIsFsQPtCPDH | |
ATM | Q13315 | human | TP53BP1 | Q12888 | S1219 | DDtEsLHsQGEEEFD | |
ATM | Q13315 | human | NIPBL | Q6KC79 | S553 | HQAGRVDsQAsItQD | |
ATM | Q13315 | human | TOPBP1 | Q92547 | S554 | ITEEGLFsQKSFLVL | |
ATM | Q13315 | human | MED1 | Q15648 | S887 | EEYFDESsQSGDNDD | |
ATM | Q13315 | human | TP53BP1 | Q12888 | S25 | PCLIIEDsQPEsQVL | |
ATM | Q13315 | human | SLX4 | Q8IY92 | S1138 | PDHsSSRsQKSSSKL | |
ATM | Q13315 | human | CCDC6 | Q16204 | T434 | tPPPSPNtQTPVQPP | |
ATM | Q13315 | human | AGER | Q15109 | S391 | ERAELNQsEEPEAGE | |
ATM | Q13315 | human | BAG6 | P46379 | S218 | PEPVALSsQTSEPVE | |
ATM | Q13315 | human | MED1 | Q15648 | S1134 | LsSSMyssQGSSGSs | |
ATM | Q13315 | human | TDP1 | Q9NUW8 | S563 | KQKFFAGsQEPMATF | Tyr-DNA_phospho |
ATM | Q13315 | human | BRCA1 | P38398 | S1497 | EPGVERssPsKCPsL | |
ATM | Q13315 | human | BUB1 | O43683 | S314 | sHEDLPAsQERSEVN | |
ATM | Q13315 | human | BRCA1 | P38398 | S1189 | QKGELsRsPsPFtHT | |
ATM | Q13315 | human | SARS1 | P49591 | S241 | MQEVAQLsQFDEELy | |
ATM | Q13315 | human | APBB1 | O00213 | S228 | DSSWATLsQGSPSYG | |
ATM | Q13315 | human | HIC1 | Q14526 | S713 | DKAAEVLsQGAHLAA | |
ATM | Q13315 | human | SMC3 | Q9UQE7 | S383 | YAkQGRGsQFTsKEE | |
ATM | Q13315 | human | DGCR8 | Q8WYQ5 | S677 | RVGKQLAsQKILQLL | dsrm |
ATM | Q13315 | human | SMARCC2 | Q8TAQ2 | S969 | PPALPPGsQPIPPTG | |
ATM | Q13315 | human | USP10 | Q14694 | S337 | ASGTLPVsQPKsWAS | |
ATM | Q13315 | human | PRKDC | P78527 | T2638 | VAGQIRAtQQQHDFt | DNAPKcs_CC5 |
ATM | Q13315 | human | UFL1 | O94874 | S462 | DDDsDDEsQssHtGK | |
ATM | Q13315 | human | DCLRE1C | Q96SD1 | S648 | TNADsQsssDFEVPs | |
ATM | Q13315 | human | SMAD1 | Q15797 | S239 | DPMTQDGsQPMDTNM | |
ATM | Q13315 | human | VCP | P55072 | S326 | EVERRIVsQLLtLMD | AAA |
ATM | Q13315 | human | MCM3 | P25205 | S535 | ATDDPNFsQEDQQDT | |
ATM | Q13315 | human | CBL | P22681 | T640 | DVPRLGstFsLDtsM | |
ATM | Q13315 | human | NBN | O60934 | S343 | TtPGPsLsQGVsVDE | |
ATM | Q13315 | human | PRKDC | P78527 | T2609 | LtPMFVEtQAsQGtL | DNAPKcs_CC5 |
ATM | Q13315 | human | SP1 | P08047 | S56 | tGGGGQEsQPsPLAL | |
ATM | Q13315 | human | UBR5 | O95071 | S191 | VIPEELIsQAQVVLQ | E3_UbLigase_EDD |
ATM | Q13315 | human | RANBP9 | Q96S59 | S603 | tEMEVDSsQLRRQLC | CTLH |
ATM | Q13315 | human | TOPBP1 | Q92547 | T1062 | NDSkGVLtQtLEMRE | |
ATM | Q13315 | human | SARS1 | P49591 | S101 | ALANLkVsQIKKVRL | Seryl_tRNA_N |
ATM | Q13315 | human | NFAT5 | O94916 | S1197 | HIQTPMLsQEQAQPP | |
ATM | Q13315 | human | XRCC6 | P12956 | S27 | QEENLEAsGDykYsG | |
ATM | Q13315 | human | TAOK3 | Q9H2K8 | S359 | SMSVSTGsQSSSVNS | |
ATM | Q13315 | human | USP28 | Q96RU2 | S495 | STSTEsSsQDVESTF | UCH |
ATM | Q13315 | human | BTRC | Q9Y297 | S158 | EFVEHLIsQMCHYQH | Beta-TrCP_D |
ATM | Q13315 | human | ITCH | Q96J02-2 | S161 | TTCSESAsQNDDGSR | |
ATM | Q13315 | human | METTL3 | Q86U44 | S43 | rNPEAALsPTFRsDs | |
ATM | Q13315 | human | RFWD3 | Q6PCD5 | S63 | APAEVISsQATPPLL | |
ATM | Q13315 | human | ZNF148 | Q9UQR1 | S202 | GEkPFQCsQCDMRFI | zf-C2H2 |
ATM | Q13315 | human | PNKP | Q96T60 | S126 | PPGtPLVsQDEKRDA | |
ATM | Q13315 | human | RAD17 | O75943 | T633 | EESLGEPtQATVPET | |
ATM | Q13315 | human | RASSF1 | Q9NS23 | S135 | EWETPDLsQAEIEQk | |
ATM | Q13315 | human | NKX3-1 | Q99801 | T134 | SRAAFSHtQVIELER | Homeodomain |
ATM | Q13315 | human | ABRAXAS1 | Q6UWZ7 | S406 | GFGEYsRsPtF____ | |
ATM | Q13315 | human | DCLRE1C | Q96SD1 | S516 | SSTVAGGsQsPKLFS | |
ATM | Q13315 | human | CREB1 | P16220 | S119 | EILsRRPsyRkILND | pKID |
ATM | Q13315 | human | KHDRBS1 | Q07666 | S388 | EGYEGYysQsQGDSE | Sam68-YY |
ATM | Q13315 | human | SMC3 | Q9UQE7 | S1065 | KkGDVEGsQsQDEGE | SMC_N |
ATM | Q13315 | human | TAOK3 | Q9H2K8 | S551 | DLTTFLEsQKKQYKI | |
ATM | Q13315 | human | UBR5 | O95071 | S174 | rGsGLLGsQPQPVIP | |
ATM | Q13315 | human | SRPK1 | Q96SB4 | S408 | QNGDSSTsQETDSCT | |
ATM | Q13315 | human | CREB1 | P16220-1 | T100 | LKRLFsGtQISTIAE | |
ATM | Q13315 | human | CDKN1B | P46527 | S140 | PkTDPSDsQTGLAEQ | |
ATM | Q13315 | human | MED1 | Q15648 | S816 | DSSSSGHsQSTLFDS | |
ATM | Q13315 | human | CREB1 | P16220 | S97 | TIAEsEDsQEsVDsV | |
ATM | Q13315 | human | BRCA1 | P38398 | S1457 | SEKAVLTsQKsSEYP | |
ATM | Q13315 | human | EHMT2 | Q96KQ7 | S569 | APAPPPLsQDVPGRA | |
ATM | Q13315 | human | COP1 | Q8NHY2 | S387 | SDDSRTAsQLDEFQE | |
ATM | Q13315 | human | RBBP8 | Q99708 | S745 | SCLADSFsQAADEEE | |
ATM | Q13315 | human | XPA | P23025 | S173 | VKkNPHHsQWGDMKL | XPA_C |
ATM | Q13315 | human | RNF20 | Q5VTR2 | S545 | PDsEDLSsQSsAsKA | |
ATM | Q13315 | human | KIFC1 | Q9BW19 | S26 | RPLIkAPsQLPLsGs | |
ATM | Q13315 | human | PKM | P14618 | T328 | GkPVICAtQMLESMI | PK |
ATM | Q13315 | human | CHD4 | Q14839 | S1349 | QVNYNDGsQEDRDWQ | DUF1087 |
ATM | Q13315 | human | MRE11 | P49959 | S676 | tSsskIMsQsQVsKG | |
ATM | Q13315 | human | SLX4 | Q8IY92 | S1716 | GSDSSLSsQSSSSCE | |
ATM | Q13315 | human | ZNF420 | Q8TAQ5 | S68 | NTYETELsQWEMSDR | |
ATM | Q13315 | human | PRKDC | P78527 | T2647 | QQHDFtLtQTADGRs | DNAPKcs_CC5 |
ATM | Q13315 | human | HUWE1 | Q7Z6Z7 | S3695 | ENVVIVAsQkRPLGG | |
ATM | Q13315 | human | NUSAP1 | Q9BXS6 | S124 | QNHEKQEsQDLRATA | |
ATM | Q13315 | human | RAD18 | Q9NS91 | S403 | TSVTNHFsQSKLDsP | |
ATM | Q13315 | human | PRKDC | P78527 | S2612 | MFVEtQAsQGtLQtR | DNAPKcs_CC5 |
ATM | Q13315 | human | CTTN | Q14247 | S113 | skLskHCsQVDsVrG | HS1_rep |
ATM | Q13315 | human | NSD2 | O96028 | S102 | DAkLRFEsQEMKGIG | |
ATM | Q13315 | human | ZNF207 | O43670 | S104 | LEQktQEsQKKKQQD | |
ATM | Q13315 | human | USP34 | Q70CQ2 | S1751 | NIHIkDAsQTTLLDL | |
ATM | Q13315 | human | THOC5 | Q13769 | S312 | EDsQDDEsDsDAEEE | FmiP_Thoc5 |
ATM | Q13315 | human | MED1 | Q15648 | S874 | PDLLNsQsQSGFGEE | |
ATM | Q13315 | human | HSP90AA1 | P07900 | T5 | ___MPEEtQtQDQPM | |
ATM | Q13315 | human | ZBTB2 | Q8N680 | S115 | IQEASLAsQGAFSHP | BTB |
ATM | Q13315 | human | RNF40 | O75150 | S819 | EQVLGLksQVDAQLL | |
ATM | Q13315 | human | KHDRBS1 | Q07666 | S390 | YEGYysQsQGDSEyy | Sam68-YY |
ATM | Q13315 | human | MDM2 | Q00987 | T419 | KEFEREEtQDKEEsV | |
ATM | Q13315 | human | ABRAXAS1 | Q6UWZ7 | S404 | MkGFGEYsRsPtF__ | |
ATM | Q13315 | human | TP63 | Q9H3D4 | S479 | MNKLPsVsQLINPQQ | |
ATM | Q13315 | human | DCK | P27707 | S74 | EFEELtMsQkNGGNV | dNK |
ATM | Q13315 | human | KHSRP | Q92945 | S274 | MILIQDGsQNtNVDk | KH_1 |
ATM | Q13315 | human | BMAL1 | O00327 | S183 | VFKILNYsQNDLIGQ | |
ATM | Q13315 | human | CHUK | O15111 | S473 | KNTLISAsQQLKAKL | IKBKB_SDD |
ATM | Q13315 | human | DBF4 | Q9UBU7 | T449 | DDIRQNFtQLPLHkN | |
ATM | Q13315 | human | WRAP53 | Q9BUR4 | S64 | PVAGSAVsQELREGD | |
ATM | Q13315 | human | WWC1 | Q8IX03 | T1006 | RTWHSQLtQEISVLK | |
ATM | Q13315 | human | RNF40 | O75150 | S114 | ALLRCHEsQGELSSA | |
ATM | Q13315 | human | TP53 | P04637 | S20 | PLsQEtFsDLWkLLP | P53_TAD |
ATM | Q13315 | human | ESCO2 | Q56NI9 | S196 | SNAPRVLsQKIKPQV | |
ATM | Q13315 | human | MRE11 | P49959 | S264 | EQQLFYIsQPGSSVV | |
ATM | Q13315 | human | SLC2A1 | P11166 | S490 | FHPLGADsQV_____ | |
ATM | Q13315 | human | USP15 | Q9Y4E8 | S678 | LPSENENsQSEDSVG | UCH |
ATM | Q13315 | human | LARP7 | Q4G0J3 | T440 | ANREECRtQEKVNAt | |
ATM | Q13315 | human | RPA2 | P15927 | S23 | GAGGYtQsPGGFGsP | |
ATM | Q13315 | human | BRCA1 | P38398 | S1542 | EEQQLEEsGPHDLtE | |
ATM | Q13315 | human | CHEK2 | O96017 | S35 | sQGSSsQsQGIssss | |
ATM | Q13315 | human | TDP1 | Q9NUW8 | S365 | TPGrFQGsQkDNWGH | Tyr-DNA_phospho |
ATM | Q13315 | human | BLM | P54132 | T122 | PKEVVCTtQNtPtVk | BLM_N |
ATM | Q13315 | human | SIM2 | Q14190 | S115 | ASVHLGLsQVELTGN | PAS |
ATM | Q13315 | human | RASSF1 | Q9NS23-2 | S131 | EWETPDLsQAEIEQK | |
ATM | Q13315 | human | RANBP9 | Q96S59 | S181 | kFSYIGLsQNNLRVH | |
ATM | Q13315 | human | SMC3 | Q9UQE7 | S787 | ELGtDLLsQLsLEDQ | SMC_N |
ATM | Q13315 | human | UBR5 | O95071 | S1679 | SDSDSSSsQSDDIEQ | |
ATM | Q13315 | human | FBXO31 | Q5XUX0 | S278 | LMKFIytsQYDNCLt | |
ATM | Q13315 | human | GIT2 | Q14161 | T195 | VYGADPGtQDSSGKT | Ank_2 |
ATM | Q13315 | human | ATM | Q13315 | S1981 | sLAFEEGsQSTtIss | |
ATM | Q13315 | human | KAT8 | Q9H7Z6 | T392 | LSQMTSItQNDIIST | MOZ_SAS |
ATM | Q13315 | human | USP2 | O75604 | T137 | YDQGVTLtQKLDsQs | |
ATM | Q13315 | human | USP28 | Q96RU2 | S714 | ESSTNSSsQDYSTsQ | |
ATM | Q13315 | human | RFWD3 | Q6PCD5 | S46 | VPADVVSsQGVPSIL | |
ATM | Q13315 | human | SMC1A | Q14683 | S951 | kGtMDDIsQEEGssQ | SMC_N |
ATM | Q13315 | human | EP300 | Q09472 | S106 | GPGQVMAsQAQQSSP | |
ATM | Q13315 | human | RAD50 | Q92878 | S635 | KLFDVCGsQDFEsDL | |
ATM | Q13315 | human | PRKDC | P78527 | S3205 | tPLPEDNsMNVDQDG | FAT |
ATM | Q13315 | human | NBN | O60934 | S278 | VDTGITNsQTLIPDC | NIBRIN_BRCT_II |
ATM | Q13315 | human | TRIM28 | Q13263 | S824 | LPGAGLssQELsGGP | |
ATM | Q13315 | human | CHEK2 | O96017 | T68 | SsLEtVstQELYsIP | |
ATM | Q13315 | human | XRCC6 | P12956 | S33 | AsGDykYsGRDsLIF | |
ATM | Q13315 | human | SRPK1 | Q96SB4 | T326 | ENPPNKMtQEKLEEs | |
ATM | Q13315 | human | FANCI | Q9NVI1 | S559 | SLSSsQCsQSLSVsQ | FANCI_HD2 |
ATM | Q13315 | human | RPA2 | P15927 | T21 | yGGAGGYtQsPGGFG | |
ATM | Q13315 | human | H2AX | P16104 | S139 | GkkAtQAsQEy____ | |
ATM | Q13315 | human | TAOK1 | Q7L7X3 | T785 | SINEMLStQALRLDE | |
ATM | Q13315 | human | ESCO2 | Q56NI9 | T233 | NEPSLGRtQKSKSEV | |
ATM | Q13315 | human | RNF20 | Q5VTR2 | S522 | sGsALLQsQsstEDP | |
ATM | Q13315 | human | NOP53 | Q9NZM5 | T289 | PATEQAAtQESTFQE | Nop53 |
ATM | Q13315 | human | NOP53 | Q9NZM5 | S233 | ARLHTKPsQAPAVEV | Nop53 |
ATM | Q13315 | human | MDM4 | O15151 | S403 | DLAHSSEsQETISSM | |
ATM | Q13315 | human | RAD17 | O75943 | S656 | SASELPAsQPQPFSA | |
ATM | Q13315 | human | NHEJ1 | Q9H9Q4 | S251 | AsLQGIDsQCVNQPE | |
ATM | Q13315 | human | WRN | Q14191 | S1141 | PEKAYSSsQPVISAQ | |
ATM | Q13315 | human | PRKAA2 | P54646 | T172 | sDGEFLRtsCGsPNy | Pkinase |
ATM | Q13315 | human | PRKDC | P78527 | T4102 | EsGLSEEtQVkCLMD | |
ATM | Q13315 | human | MED1 | Q15648 | S1147 | SsQSKNSsQsGGKPG | |
ATM | Q13315 | human | TOPBP1 | Q92547 | S492 | QADEDLLsQyENGss | |
ATM | Q13315 | human | ESPL1 | Q14674 | S1660 | ADQLQGLsLQEMPGD | |
ATM | Q13315 | human | DAXX | Q9UER7 | S564 | LEEESPVsQLFELEI | |
ATM | Q13315 | human | EIF4EBP1 | Q13541 | S94 | DEPPMEAsQSHLRNs | eIF_4EBP |
ATM | Q13315 | human | TRIM24 | O15164 | S768 | TsLLLNSsQSstSEE | |
ATM | Q13315 | human | LAMTOR5 | O43504 | S26 | VGVLCTDsQGLNLGC | LAMTOR5 |
ATM | Q13315 | human | THOC5 | Q13769 | S314 | sQDDEsDsDAEEEQt | FmiP_Thoc5 |
ATM | Q13315 | human | DBF4 | Q9UBU7 | S539 | GLItINSsQEHLTVQ | |
ATM | Q13315 | human | CHEK2 | O96017 | T26 | sQPHGsVtQsQGSSs | |
ATM | Q13315 | human | NBN | O60934 | S615 | VPEssKIsQENEIGK | |
ATM | Q13315 | human | TP53 | P04637 | S15 | PsVEPPLsQEtFsDL | P53_TAD |
ATM | Q13315 | human | NFAT5 | O94916 | S1367 | LVQGSPSsQEQQVTL | |
ATM | Q13315 | human | TOPBP1 | Q92547 | S1138 | PDVNTEPsQNEQIIW | |
ATM | Q13315 | human | SMARCA4 | P51532 | S721 | VDDEyGVsQALARGL | |
ATM | Q13315 | human | TDP1 | Q9NUW8 | S81 | PKRQKsGsQEDLGWC | |
ATM | Q13315 | human | PTEN | P60484 | S113 | EDLDQWLsEDDNHVA | |
ATM | Q13315 | human | NBN | O60934 | S397 | EQKFRMLsQDAPtVK | |
ATM | Q13315 | human | RNF20 | Q5VTR2 | S172 | SSSEEMEsQLQERVE | |
ATM | Q13315 | human | UBR5 | O95071 | S2586 | LRQLILAsQSSDADA | HECT |
ATM | Q13315 | human | BUB3 | O43684 | S135 | PCNAGtFsQPEkVyT | |
ATM | Q13315 | human | DCLRE1C | Q96SD1 | S647 | STNADsQsssDFEVP | |
ATM | Q13315 | human | DYRK2 | Q92630 | S442 | IELLGMPsQKLLDAs | Pkinase |
ATM | Q13315 | human | SIAH1 | Q8IUQ4 | S19 | GtSkCPPsQRVPALT | |
ATM | Q13315 | human | EWSR1 | Q01844 | T79 | QPPTGYTtPTAPQAY | |
ATM | Q13315 | human | GPS1 | Q13098 | S474 | ksPPREGsQGELtPA | |
ATM | Q13315 | human | PAN2 | Q504Q3 | S1003 | TKSTIkPsQMSVARI | RNase_T |
ATM | Q13315 | human | RAD9A | Q99638 | S272 | LSDtDSHsQDLGsPE | |
ATM | Q13315 | human | MLH1 | P40692 | S406 | PLSkPLSsQPQAIVT | |
ATM | Q13315 | human | THOC5 | Q13769 | S307 | LFKPPEDsQDDEsDs | FmiP_Thoc5 |
ATM | Q13315 | human | TRIM24 | O15164 | S808 | kSEWLDPsQKsPLHV | |
ATM | Q13315 | human | FANCI | Q9NVI1 | S556 | VLGSLSSsQCsQSLS | FANCI_HD2 |
ATM | Q13315 | human | MLLT1 | Q03111 | S394 | SDSDFEPsQNHsQGP | |
ATM | Q13315 | human | PBRM1 | Q86U86 | S948 | SGLHRTYsQDCSFKN | |
ATM | Q13315 | human | EYA3 | Q99504 | S266 | PSTsPsLsQttPsKD | |
ATM | Q13315 | human | USP28 | Q96RU2 | S67 | DERVkEPsQDtVATE | |
ATM | Q13315 | human | UBQLN4 | Q9NRR5 | S318 | GNSDsSSsQPLRTEN | |
ATM | Q13315 | human | MED1 | Q15648 | S953 | LMEHHsGsQGPLLTT | |
ATM | Q13315 | human | MDM2 | Q00987 | S429 | KEEsVESsLPLNAIE | |
ATM | Q13315 | human | DDX1 | Q92499 | S377 | DEADGLLsQGysDFI | DEAD |
ATM | Q13315 | human | SPOP | O43791 | S119 | EETKAMEsQRAYRFV | MATH |
ATM | Q13315 | human | MATR3 | P43243 | S208 | DyDHGsRsQEsGyyD | |
ATM | Q13315 | human | PEX5 | P50542 | S141 | DYNETDWsQEFISEV |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
ATM | ID | Description | 0.00e+00 |
ATM | GO:0006302 | double-strand break repair | 6.77e-44 |
ATM | GO:0010948 | negative regulation of cell cycle process | 1.96e-40 |
ATM | GO:0000075 | cell cycle checkpoint signaling | 2.12e-40 |
ATM | GO:1901988 | negative regulation of cell cycle phase transition | 1.98e-39 |
ATM | GO:1901987 | regulation of cell cycle phase transition | 1.54e-38 |
ATM | GO:0045786 | negative regulation of cell cycle | 3.36e-37 |
ATM | GO:0000077 | DNA damage checkpoint signaling | 9.21e-37 |
ATM | GO:0031570 | DNA integrity checkpoint signaling | 1.03e-35 |
ATM | GO:0042770 | signal transduction in response to DNA damage | 5.23e-35 |
ATM | GO:0007093 | mitotic cell cycle checkpoint signaling | 5.23e-35 |
ATM | GO:0044773 | mitotic DNA damage checkpoint signaling | 5.26e-31 |
ATM | GO:0045930 | negative regulation of mitotic cell cycle | 1.15e-30 |
ATM | GO:0044774 | mitotic DNA integrity checkpoint signaling | 1.84e-30 |
ATM | GO:1901991 | negative regulation of mitotic cell cycle phase transition | 9.15e-29 |
ATM | GO:1901990 | regulation of mitotic cell cycle phase transition | 1.56e-27 |
ATM | GO:0044772 | mitotic cell cycle phase transition | 2.22e-26 |
ATM | GO:0010212 | response to ionizing radiation | 2.64e-26 |
ATM | GO:0006310 | DNA recombination | 1.14e-24 |
ATM | GO:0051054 | positive regulation of DNA metabolic process | 1.30e-20 |
ATM | GO:0000725 | recombinational repair | 1.72e-20 |
ATM | GO:0009314 | response to radiation | 2.84e-20 |
ATM | GO:0000724 | double-strand break repair via homologous recombination | 1.82e-19 |
ATM | GO:0006303 | double-strand break repair via nonhomologous end joining | 1.51e-18 |
ATM | GO:0044818 | mitotic G2/M transition checkpoint | 1.52e-18 |
ATM | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 2.47e-18 |
ATM | GO:0006260 | DNA replication | 4.07e-18 |
ATM | GO:1902750 | negative regulation of cell cycle G2/M phase transition | 5.23e-18 |
ATM | GO:0072331 | signal transduction by p53 class mediator | 5.26e-17 |
ATM | GO:0044839 | cell cycle G2/M phase transition | 6.89e-17 |
ATM | GO:1902749 | regulation of cell cycle G2/M phase transition | 8.29e-17 |
ATM | GO:0000086 | G2/M transition of mitotic cell cycle | 1.56e-16 |
ATM | GO:0007059 | chromosome segregation | 1.89e-16 |
ATM | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 2.30e-16 |
ATM | GO:0098813 | nuclear chromosome segregation | 7.51e-16 |
ATM | GO:0097193 | intrinsic apoptotic signaling pathway | 1.40e-14 |
ATM | GO:0007095 | mitotic G2 DNA damage checkpoint signaling | 2.77e-14 |
ATM | GO:0006282 | regulation of DNA repair | 4.94e-14 |
ATM | GO:0000280 | nuclear division | 3.42e-13 |
ATM | GO:0044843 | cell cycle G1/S phase transition | 8.23e-13 |
ATM | GO:0051053 | negative regulation of DNA metabolic process | 1.64e-12 |
ATM | GO:0010332 | response to gamma radiation | 1.87e-12 |
ATM | GO:0048285 | organelle fission | 3.51e-12 |
ATM | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | 3.51e-12 |
ATM | GO:0044819 | mitotic G1/S transition checkpoint signaling | 3.51e-12 |
ATM | GO:0045739 | positive regulation of DNA repair | 3.62e-12 |
ATM | GO:0071479 | cellular response to ionizing radiation | 3.67e-12 |
ATM | GO:0000723 | telomere maintenance | 4.25e-12 |
ATM | GO:0032200 | telomere organization | 6.53e-12 |
ATM | GO:0033044 | regulation of chromosome organization | 6.94e-12 |
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Related Drugs to ATM_ASPH |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning ATM-ASPH and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ATM_ASPH |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |