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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PPP1R1B_DDR1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PPP1R1B_DDR1
KinaseFusionDB ID: KFG4821
FusionGDB2.0 ID: KFG4821
HgeneTgene
Gene symbol

PPP1R1B

DDR1

Gene ID

84152

780

Gene nameprotein phosphatase 1 regulatory inhibitor subunit 1Bdiscoidin domain receptor tyrosine kinase 1
SynonymsDARPP-32|DARPP32CAK|CD167|DDR|EDDR1|HGK2|MCK10|NEP|NTRK4|PTK3|PTK3A|RTK6|TRKE
Cytomap

17q12

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32epithelial discoidin domain-containing receptor 1CD167 antigen-like family member APTK3A protein tyrosine kinase 3Acell adhesion kinasemammary carcinoma kinase 10neuroepithelial tyrosine kinaseneurotrophic tyrosine kinase, receptor, type 4protein-t
Modification date2024040320240411
UniProtAcc

Q9UD71

Q08345

Ensembl transtripts involved in fusion geneENST idsENST00000254079, ENST00000394265, 
ENST00000394267, ENST00000579000, 
ENST00000580825, 		ENST00000324771, 
ENST00000376567, ENST00000376568, 
ENST00000376569, ENST00000376570, 
ENST00000376575, ENST00000418800, 
ENST00000446312, ENST00000452441, 
ENST00000454612, ENST00000259875, 
ENST00000361741, ENST00000383377, 
ENST00000400410, ENST00000400411, 
ENST00000400414, ENST00000400486, 
ENST00000400488, ENST00000400489, 
ENST00000400491, ENST00000400492, 
ENST00000412329, ENST00000415092, 
ENST00000419412, ENST00000421229, 
ENST00000422628, ENST00000427053, 
ENST00000429699, ENST00000430933, 
ENST00000434428, ENST00000449518, 
ENST00000453510, ENST00000454774, 
ENST00000462241, ENST00000468225, 
ENST00000483193, ENST00000487780, 
ENST00000488414, ENST00000490712, 
ENST00000508312, ENST00000508472, 
ENST00000513240, ENST00000548133, 
ENST00000548693, ENST00000548962, 
ENST00000549026, ENST00000550384, 
ENST00000550395, ENST00000550666, 
ENST00000552068, ENST00000552434, 
ENST00000552721, ENST00000553015, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PPP1R1B [Title/Abstract] AND DDR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP1R1B(37792159)-DDR1(30867277), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R1B

GO:0032515

negative regulation of phosphoprotein phosphatase activity

10807923

TgeneDDR1

GO:0038063

collagen-activated tyrosine kinase receptor signaling pathway

9659899|21044884

TgeneDDR1

GO:0038083

peptidyl-tyrosine autophosphorylation

21044884

TgeneDDR1

GO:0046777

protein autophosphorylation

9659899


check buttonKinase Fusion gene breakpoints across PPP1R1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across DDR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0BF923651PPP1R1Bchr17

37792159

DDR1chr6

30867277



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37792159/:30867277)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R1B

Q9UD71

DDR1

Q08345

FUNCTION: Inhibitor of protein-phosphatase 1.FUNCTION: Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed:19401332, ECO:0000269|PubMed:20093046, ECO:0000269|PubMed:20432435, ECO:0000269|PubMed:20884741, ECO:0000269|PubMed:21044884, ECO:0000269|PubMed:9659899}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PPP1R1B_DDR1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
DDR1Q08345humanDDR1Q08345Y569PQNSVPHyAEADIVT
DDR1Q08345humanDDR1Q08345Y586GVTGGNTyAVPALPP


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
DDR1IDDescription0.00e+00
DDR1GO:0038063collagen-activated tyrosine kinase receptor signaling pathway9.22e-03
DDR1GO:0038065collagen-activated signaling pathway9.22e-03
DDR1GO:0010715regulation of extracellular matrix disassembly9.22e-03
DDR1GO:0038083peptidyl-tyrosine autophosphorylation9.22e-03
DDR1GO:0060749mammary gland alveolus development9.22e-03
DDR1GO:0061377mammary gland lobule development9.22e-03
DDR1GO:0060444branching involved in mammary gland duct morphogenesis9.22e-03
DDR1GO:0060603mammary gland duct morphogenesis1.02e-02
DDR1GO:0044319wound healin1.96e-03
DDR1GO:0090504epiboly1.02e-02
DDR1GO:0007595lactation1.02e-02
DDR1GO:0060443mammary gland morphogenesis1.02e-02
DDR1GO:0002011morphogenesis of an epithelial sheet1.12e-02
DDR1GO:0007566embryo implantation1.12e-02
DDR1GO:0022617extracellular matrix disassembly1.12e-02
DDR1GO:1903053regulation of extracellular matrix organization1.12e-02
DDR1GO:0061180mammary gland epithelium development1.13e-02
DDR1GO:0007589body fluid secretion1.46e-02
DDR1GO:0014909smooth muscle cell migration1.48e-02
DDR1GO:0014812muscle cell migration1.61e-02
DDR1GO:0022612gland morphogenesis1.67e-02
DDR1GO:0001952regulation of cell-matrix adhesion1.67e-02
DDR1GO:0030879mammary gland development1.70e-02
DDR1GO:0048754branching morphogenesis of an epithelial tube1.87e-02
DDR1GO:0010976positive regulation of neuron projection development1.87e-02
DDR1GO:0051897positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction1.89e-02
DDR1GO:1990138neuron projection extension1.89e-02
DDR1GO:0007565female pregnancy1.89e-02
DDR1GO:0061138morphogenesis of a branching epithelium1.89e-02
DDR1GO:0046777protein autophosphorylation1.89e-02
DDR1GO:0001763morphogenesis of a branching structure1.89e-02
DDR1GO:0044703multi-organism reproductive process1.89e-02
DDR1GO:0044706multi-multicellular organism process1.89e-02
DDR1GO:0010810regulation of cell-substrate adhesion1.89e-02
DDR1GO:0043583ear development1.89e-02
DDR1GO:0007160cell-matrix adhesion1.91e-02
DDR1GO:0048588developmental cell growth1.91e-02
DDR1GO:0060560developmental growth involved in morphogenesis1.91e-02
DDR1GO:0051896regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction1.91e-02
DDR1GO:0018108peptidyl-tyrosine phosphorylation2.03e-02
DDR1GO:0018212peptidyl-tyrosine modification2.03e-02
DDR1GO:0043491phosphatidylinositol 3-kinase/protein kinase B signal transduction2.07e-02
DDR1GO:0030198extracellular matrix organization2.16e-02
DDR1GO:0043062extracellular structure organization2.16e-02
DDR1GO:0045229external encapsulating structure organization2.16e-02
DDR1GO:0060562epithelial tube morphogenesis2.16e-02
DDR1GO:0033674positive regulation of kinase activity2.16e-02
DDR1GO:0031346positive regulation of cell projection organization2.19e-02
DDR1GO:0031589cell-substrate adhesion2.19e-02

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Related Drugs to PPP1R1B_DDR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PPP1R1B-DDR1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PPP1R1B_DDR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate