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Kinase Fusion Gene:PPP6R2_AURKC |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: PPP6R2_AURKC | KinaseFusionDB ID: KFG4843 | FusionGDB2.0 ID: KFG4843 | Hgene | Tgene | Gene symbol | PPP6R2 | AURKC | Gene ID | 9701 | 6795 | |
| Gene name | protein phosphatase 6 regulatory subunit 2 | aurora kinase C | ||||||||||
| Synonyms | KIAA0685|PP6R2|SAP190|SAPS2 | AIE2|AIK3|ARK3|AurC|HEL-S-90|SPGF5|STK13|aurora-C | ||||||||||
| Cytomap | 22q13.33 | 19q13.43 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein phosphatase 6 regulatory subunit 2SAPS domain family, member 2 | aurora kinase CARK-3aurora 3aurora-related kinase 3aurora/IPL1-related kinase 3aurora/IPL1/EG2 protein 2epididymis secretory protein Li 90serine/threonine kinase 13 (aurora/IPL1-like)serine/threonine-protein kinase 13serine/threonine-protein kina | ||||||||||
| Modification date | 20240403 | 20240305 | ||||||||||
| UniProtAcc | O75170 | Q9UQB9 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000216061, ENST00000359139, ENST00000395741, ENST00000395744, | ENST00000302804, ENST00000448930, ENST00000598785, ENST00000599062, ENST00000415300, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PPP6R2 [Title/Abstract] AND AURKC [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PPP6R2(50862043)-AURKC(57743110), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AURKC | GO:0006468 | protein phosphorylation | 15670791 |
| Kinase Fusion gene breakpoints across PPP6R2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across AURKC (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-DX-A6YR-01A | PPP6R2 | chr22 | 50862043 | AURKC | chr19 | 57743110 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50862043/:57743110) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP6R2 | AURKC |
| FUNCTION: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. | FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654, ECO:0000269|PubMed:15670791, ECO:0000269|PubMed:15938719, ECO:0000269|PubMed:21493633, ECO:0000269|PubMed:21531210, ECO:0000269|PubMed:27332895}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PPP6R2_AURKC |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| AURKC | Q9UQB9 | human | H3C1 | P68431 | S10 | tkQtArkstGGkAPr | Histone |
| AURKC | Q9UQB9 | human | NFKBIA | P25963 | S262 | QLTWGRPsTRIQQQL | |
| AURKC | Q9UQB9 | human | NFKBIA | P25963 | S32 | LLDDRHDsGLDsMkD | |
| AURKC | Q9UQB9 | human | INCENP | Q9NQS7 | S894 | RYHKRtssAVWNsPP | |
| AURKC | Q9UQB9 | human | BIRC5 | O15392 | S20 | FLkDHRIstFkNWPF | BIR |
| AURKC | Q9UQB9 | human | TACC1 | O75410 | S228 | ELVPsRRsKLRKPkP | |
| AURKC | Q9UQB9 | human | INCENP | Q9NQS7 | T892 | KPRYHKRtssAVWNs | |
| AURKC | Q9UQB9 | human | NFKBIA | P25963 | S63 | PQEVPRGsEPWkQQL | |
| AURKC | Q9UQB9 | human | INCENP | Q9NQS7 | S893 | PRYHKRtssAVWNsP |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| AURKC | ID | Description | 0.00e+00 |
| AURKC | GO:0051256 | mitotic spindle midzone assembly | 1.03e-04 |
| AURKC | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore | 1.03e-04 |
| AURKC | GO:1902412 | regulation of mitotic cytokinesis | 1.03e-04 |
| AURKC | GO:0007052 | mitotic spindle organization | 1.03e-04 |
| AURKC | GO:0000022 | mitotic spindle elongation | 1.03e-04 |
| AURKC | GO:0090232 | positive regulation of spindle checkpoint | 1.03e-04 |
| AURKC | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint | 1.03e-04 |
| AURKC | GO:0090235 | regulation of metaphase plate congression | 1.03e-04 |
| AURKC | GO:0051231 | spindle elongation | 1.03e-04 |
| AURKC | GO:0051255 | spindle midzone assembly | 1.03e-04 |
| AURKC | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 1.14e-04 |
| AURKC | GO:1901970 | positive regulation of mitotic sister chromatid separation | 1.26e-04 |
| AURKC | GO:1901978 | positive regulation of cell cycle checkpoint | 1.26e-04 |
| AURKC | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore | 1.26e-04 |
| AURKC | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | 1.26e-04 |
| AURKC | GO:0090231 | regulation of spindle checkpoint | 1.26e-04 |
| AURKC | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint | 1.26e-04 |
| AURKC | GO:1903504 | regulation of mitotic spindle checkpoint | 1.26e-04 |
| AURKC | GO:0007051 | spindle organization | 1.26e-04 |
| AURKC | GO:0051984 | positive regulation of chromosome segregation | 1.98e-04 |
| AURKC | GO:1905820 | positive regulation of chromosome separation | 2.18e-04 |
| AURKC | GO:0007094 | mitotic spindle assembly checkpoint signaling | 3.93e-04 |
| AURKC | GO:0071173 | spindle assembly checkpoint signaling | 3.93e-04 |
| AURKC | GO:0071174 | mitotic spindle checkpoint signaling | 3.93e-04 |
| AURKC | GO:1901976 | regulation of cell cycle checkpoint | 3.93e-04 |
| AURKC | GO:0031577 | spindle checkpoint signaling | 3.93e-04 |
| AURKC | GO:0032467 | positive regulation of cytokinesis | 3.93e-04 |
| AURKC | GO:0033046 | negative regulation of sister chromatid segregation | 3.93e-04 |
| AURKC | GO:0033048 | negative regulation of mitotic sister chromatid segregation | 3.93e-04 |
| AURKC | GO:0045841 | negative regulation of mitotic metaphase/anaphase transition | 3.93e-04 |
| AURKC | GO:2000816 | negative regulation of mitotic sister chromatid separation | 3.93e-04 |
| AURKC | GO:0008608 | attachment of spindle microtubules to kinetochore | 3.93e-04 |
| AURKC | GO:0051985 | negative regulation of chromosome segregation | 3.93e-04 |
| AURKC | GO:1902100 | negative regulation of metaphase/anaphase transition of cell cycle | 3.93e-04 |
| AURKC | GO:1905819 | negative regulation of chromosome separation | 3.93e-04 |
| AURKC | GO:0033047 | regulation of mitotic sister chromatid segregation | 4.46e-04 |
| AURKC | GO:0045839 | negative regulation of mitotic nuclear division | 4.67e-04 |
| AURKC | GO:0007080 | mitotic metaphase chromosome alignment | 4.71e-04 |
| AURKC | GO:0010965 | regulation of mitotic sister chromatid separation | 4.92e-04 |
| AURKC | GO:0051306 | mitotic sister chromatid separation | 5.30e-04 |
| AURKC | GO:0051784 | negative regulation of nuclear division | 5.34e-04 |
| AURKC | GO:0090307 | mitotic spindle assembly | 6.63e-04 |
| AURKC | GO:1905818 | regulation of chromosome separation | 7.04e-04 |
| AURKC | GO:0051304 | chromosome separation | 8.24e-04 |
| AURKC | GO:0000281 | mitotic cytokinesis | 9.52e-04 |
| AURKC | GO:0030071 | regulation of mitotic metaphase/anaphase transition | 9.58e-04 |
| AURKC | GO:0032465 | regulation of cytokinesis | 9.58e-04 |
| AURKC | GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | 9.58e-04 |
| AURKC | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 9.58e-04 |
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Related Drugs to PPP6R2_AURKC |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning PPP6R2-AURKC and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PPP6R2_AURKC |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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