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Kinase Fusion Gene:PRH1_STYK1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: PRH1_STYK1 | KinaseFusionDB ID: KFG4852 | FusionGDB2.0 ID: KFG4852 | Hgene | Tgene | Gene symbol | PRH1 | STYK1 | Gene ID | 5554 | 55359 | |
| Gene name | proline rich protein HaeIII subfamily 1 | serine/threonine/tyrosine kinase 1 | ||||||||||
| Synonyms | Db-s|PA|PIF-S|PRH2|PRP-1/PRP-2|Pr1/Pr2 | NOK|SuRTK106 | ||||||||||
| Cytomap | 12p13.2 | 12p13.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | salivary acidic proline-rich phosphoprotein 1/2parotid acidic proteinparotid double-band proteinparotid isoelectric focusing variant proteinparotid proline-rich protein 1/2protein C | tyrosine-protein kinase STYK1novel oncogene with kinase domainprotein PK-unique | ||||||||||
| Modification date | 20240411 | 20240411 | ||||||||||
| UniProtAcc | P02810 | Q6J9G0 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000428168, | ENST00000075503, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRH1 [Title/Abstract] AND STYK1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Kinase Fusion gene breakpoints across PRH1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across STYK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | QGP-1 | PRH1 | chr12 | 11324021 | STYK1 | chr12 | 10772947 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRH1 | STYK1 |
| FUNCTION: PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth. | FUNCTION: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PRH1_STYK1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| STYK1 | Q6J9G0 | human | BECN1 | Q14457 | S93 | ARMMstEsANsFTLI | |
| STYK1 | Q6J9G0 | human | BECN1 | Q14457 | S90 | IPPARMMstEsANsF |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| STYK1 | ID | Description | 0.00e+00 |
| STYK1 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore | 1.03e-02 |
| STYK1 | GO:0006995 | cellular response to nitrogen starvation | 1.03e-02 |
| STYK1 | GO:0043562 | cellular response to nitrogen levels | 1.03e-02 |
| STYK1 | GO:1905671 | regulation of lysosome organization | 1.03e-02 |
| STYK1 | GO:0090235 | regulation of metaphase plate congression | 1.03e-02 |
| STYK1 | GO:1902902 | negative regulation of autophagosome assembly | 1.03e-02 |
| STYK1 | GO:0043652 | engulfment of apoptotic cell | 1.03e-02 |
| STYK1 | GO:0035821 | modulation of process of another organism | 1.03e-02 |
| STYK1 | GO:2000786 | positive regulation of autophagosome assembly | 1.03e-02 |
| STYK1 | GO:0010288 | response to lead ion | 1.03e-02 |
| STYK1 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore | 1.03e-02 |
| STYK1 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | 1.03e-02 |
| STYK1 | GO:0098780 | response to mitochondrial depolarisation | 1.03e-02 |
| STYK1 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process | 1.03e-02 |
| STYK1 | GO:0044090 | positive regulation of vacuole organization | 1.03e-02 |
| STYK1 | GO:0071280 | cellular response to copper ion | 1.03e-02 |
| STYK1 | GO:0051984 | positive regulation of chromosome segregation | 1.03e-02 |
| STYK1 | GO:0032801 | receptor catabolic process | 1.03e-02 |
| STYK1 | GO:0010039 | response to iron ion | 1.03e-02 |
| STYK1 | GO:0016242 | negative regulation of macroautophagy | 1.03e-02 |
| STYK1 | GO:0006622 | protein targeting to lysosome | 1.03e-02 |
| STYK1 | GO:0010613 | positive regulation of cardiac muscle hypertrophy | 1.03e-02 |
| STYK1 | GO:0014742 | positive regulation of muscle hypertrophy | 1.03e-02 |
| STYK1 | GO:0045324 | late endosome to vacuole transport | 1.03e-02 |
| STYK1 | GO:0046688 | response to copper ion | 1.03e-02 |
| STYK1 | GO:0000423 | mitophagy | 1.03e-02 |
| STYK1 | GO:0071364 | cellular response to epidermal growth factor stimulus | 1.03e-02 |
| STYK1 | GO:0045022 | early endosome to late endosome transport | 1.03e-02 |
| STYK1 | GO:0070849 | response to epidermal growth factor | 1.03e-02 |
| STYK1 | GO:1902116 | negative regulation of organelle assembly | 1.03e-02 |
| STYK1 | GO:2000785 | regulation of autophagosome assembly | 1.03e-02 |
| STYK1 | GO:0006623 | protein targeting to vacuole | 1.03e-02 |
| STYK1 | GO:0043277 | apoptotic cell clearance | 1.03e-02 |
| STYK1 | GO:0006911 | phagocytosi | 2.60e-03 |
| STYK1 | GO:0098927 | vesicle-mediated transport between endosomal compartments | 1.03e-02 |
| STYK1 | GO:2000378 | negative regulation of reactive oxygen species metabolic process | 1.03e-02 |
| STYK1 | GO:0042149 | cellular response to glucose starvation | 1.03e-02 |
| STYK1 | GO:0034198 | cellular response to amino acid starvation | 1.03e-02 |
| STYK1 | GO:0006968 | cellular defense response | 1.03e-02 |
| STYK1 | GO:0033047 | regulation of mitotic sister chromatid segregation | 1.03e-02 |
| STYK1 | GO:1990928 | response to amino acid starvation | 1.03e-02 |
| STYK1 | GO:0007080 | mitotic metaphase chromosome alignment | 1.03e-02 |
| STYK1 | GO:0044088 | regulation of vacuole organization | 1.03e-02 |
| STYK1 | GO:0099024 | plasma membrane invagination | 1.03e-02 |
| STYK1 | GO:0097352 | autophagosome maturation | 1.03e-02 |
| STYK1 | GO:0061462 | protein localization to lysosome | 1.03e-02 |
| STYK1 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 1.03e-02 |
| STYK1 | GO:0010324 | membrane invagination | 1.03e-02 |
| STYK1 | GO:0050435 | amyloid-beta metabolic process | 1.03e-02 |
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Related Drugs to PRH1_STYK1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning PRH1-STYK1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PRH1_STYK1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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