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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PRKAA1_NIPBL

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PRKAA1_NIPBL
KinaseFusionDB ID: KFG4856
FusionGDB2.0 ID: KFG4856
HgeneTgene
Gene symbol

PRKAA1

NIPBL

Gene ID

5562

25836

Gene nameprotein kinase AMP-activated catalytic subunit alpha 1NIPBL cohesin loading factor
SynonymsAMPK|AMPK alpha 1|AMPKa1CDLS|CDLS1|IDN3|IDN3-B|Scc2
Cytomap

5p13.1

5p13.2

Type of geneprotein-codingprotein-coding
Description5'-AMP-activated protein kinase catalytic subunit alpha-15'-AMP-activated protein kinase, catalytic alpha-1 chainACACA kinaseAMP -activate kinase alpha 1 subunitAMP-activated protein kinase, catalytic, alpha-1AMPK subunit alpha-1AMPK, alpha, 1HMGCRnipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homolog
Modification date2024040820240407
UniProtAcc

Q13131

Q6KC79

Ensembl transtripts involved in fusion geneENST idsENST00000397128, ENST00000354209, 
ENST00000296800, 		ENST00000282516, 
ENST00000448238, ENST00000504430, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PRKAA1 [Title/Abstract] AND NIPBL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAA1

GO:0006468

protein phosphorylation

17028174

HgenePRKAA1

GO:0010508

positive regulation of autophagy

22012985|25891078

HgenePRKAA1

GO:0010628

positive regulation of gene expression

17028174

HgenePRKAA1

GO:0031669

cellular response to nutrient levels

25412657|30478170

HgenePRKAA1

GO:0042149

cellular response to glucose starvation

14651849|18439900|34077757|36732624

HgenePRKAA1

GO:1903944

negative regulation of hepatocyte apoptotic process

32029622

HgenePRKAA1

GO:1904262

negative regulation of TORC1 signaling

14651849|18439900|36732624|37079666

HgenePRKAA1

GO:1905691

lipid droplet disassembly

34077757

HgenePRKAA1

GO:1990044

protein localization to lipid droplet

34077757

TgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

TgeneNIPBL

GO:0006338

chromatin remodeling

18854353

TgeneNIPBL

GO:0007064

mitotic sister chromatid cohesion

22628566


check buttonKinase Fusion gene breakpoints across PRKAA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across NIPBL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLETN-2PRKAA1chr5

40798165

NIPBLchr5

36953720



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKAA1

Q13131

NIPBL

Q6KC79

FUNCTION: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (By similarity). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11554766, PubMed:11518699, PubMed:15866171, PubMed:17711846, PubMed:18184930). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:18439900, PubMed:20160076, PubMed:21205641). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (PubMed:36732624). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (PubMed:37079666). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641). In that process also activates WDR45/WIPI4 (PubMed:28561066). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:20074060, PubMed:12519745). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. {ECO:0000250|UniProtKB:P54645, ECO:0000250|UniProtKB:Q5EG47, ECO:0000269|PubMed:11518699, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:12519745, ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17486097, ECO:0000269|PubMed:17711846, ECO:0000269|PubMed:18184930, ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:20074060, ECO:0000269|PubMed:20160076, ECO:0000269|PubMed:21205641, ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:32029622, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:36732624, ECO:0000269|PubMed:37079666, ECO:0000269|PubMed:37821951, ECO:0000303|PubMed:17307971, ECO:0000303|PubMed:17712357}.FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PRKAA1_NIPBL


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKAA1Q13131humanPRKAB1Q9Y478S108skLPLTRsHNNFVAIAMPK1_CBM
PRKAA1Q13131humanMAPTP10636-8T231KKVAVVRtPPKsPss
PRKAA1Q13131humanALDH2P05091T356GNPFDSktEQGPQVDAldedh
PRKAA1Q13131humanATG9AQ7Z3C6S761QsIPRsAsYPCAAPR
PRKAA1Q13131humanCCNYQ8ND76S326SARKRsAsADNLtLP
PRKAA1Q13131humanDBIP07108S21RHLkTkPsDEEMLFI
PRKAA1Q13131humanNET1Q7Z628S100RPLARVTsLANLIsP
PRKAA1Q13131humanIRS1P35568S794QHLRLSTsSGRLLyA
PRKAA1Q13131humanFHP07954S75yGAQTVRsTMNFkIGLyase_1
PRKAA1Q13131humanCD274Q9NZQ7S283DTNsKkQsDtHLEEt
PRKAA1Q13131humanPRKNO60260S9IVFVRFNssHGFPVEubiquitin
PRKAA1Q13131humanAMOTL1Q8IY63S793SSLRPARsVPsIAAAAngiomotin_C
PRKAA1Q13131humanPRKAA1Q13131S494GtAtPQRsGsVsNyRAdenylateSensor
PRKAA1Q13131humanSNX17Q15036S437VkLSskLsAVsLRGI
PRKAA1Q13131humanHDAC5Q9UQL6S498RPLSRtQsSPLPQsP
PRKAA1Q13131humanHIPK2Q9H2X6S121LMRRStVsLLDTYQK
PRKAA1Q13131humanPTSQ03393T58HNYKVVVtVHGEIDPPTPS
PRKAA1Q13131humanMCUQ8NE86S57TVHQRIAsWQNLGAV
PRKAA1Q13131humanGAPDHP04406S122GAkRVIIsAPsADAP
PRKAA1Q13131humanGFPT1Q06210-2S243CNLsRVDsttCLFPV
PRKAA1Q13131humanDNM1LO00429S637VPVARKLsAREQRDC
PRKAA1Q13131humanNOS3P29474S1177TSRIRtQsFsLQERQ
PRKAA1Q13131humanVASPP50552T278LARRRKAtQVGEktP
PRKAA1Q13131humanACACAQ13085S80LHIRssMsGLHLVkQ
PRKAA1Q13131humanPRKAA1Q13131T388EtPRARHtLDELNPQ
PRKAA1Q13131humanPPP1R3CQ9UQK1S293LEStIFGsPRLASGL
PRKAA1Q13131humanTP53BP1Q12888S1317SSLHRtssGtsLSAM
PRKAA1Q13131humanJAK1P23458S518GSDRsFPsLGDLMsH
PRKAA1Q13131humanYAP1P46937S61IVHVRGDsEtDLEAL
PRKAA1Q13131humanSRSF1Q07955S133SGLPPSGsWQDLkDHRRM_1
PRKAA1Q13131humanBTRCQ9Y297S82SLRQTYNsCARLCLN
PRKAA1Q13131humanRACK1P63244T50WkLtrDEtNyGIPQR
PRKAA1Q13131humanPRKAB1Q9Y478S174MVDsQKCsDVsELss
PRKAA1Q13131humanEPM2AO95278S25PELLVVGsRPELGRWCBM_20
PRKAA1Q13131humanNFE2L2Q16236S374GDtLLGLsDsEVEEL
PRKAA1Q13131humanPRKAB1Q9Y478T158NIIQVKktDFEVFDAAMPK1_CBM
PRKAA1Q13131humanRUNX2Q13950S118AELVRTDsPNFLCSVRunt
PRKAA1Q13131humanRRN3Q9NYV6S635DTHFRsPssSVGsPP
PRKAA1Q13131humanKLC2Q9H0B6S545GsLRRsGsFGKLRDA
PRKAA1Q13131humanHIPK2Q9H2X6T119HNLMRRStVsLLDTY
PRKAA1Q13131humanPARP1P09874S177LGFRPEYsAsQLkGFzf-PARP
PRKAA1Q13131humanYAP1P46937S94RLRkLPDsFFkPPEP
PRKAA1Q13131humanNFE2L2Q16236S408GDMVQPLsPSQGQST
PRKAA1Q13131humanKPNA2P52292S105QAARkLLsREkQPPI
PRKAA1Q13131humanPDHA1P08559S314IQEVRSksDPIMLLkE1_dh
PRKAA1Q13131humanMAPTP10636-8S214GsRsRtPsLPtPPtR
PRKAA1Q13131humanEEF2KO00418S398DsLPssPssAtPHSQ
PRKAA1Q13131humanSMPD3Q9NY59S209GsIKRTAsVEyKGDG
PRKAA1Q13131humanPFKFB2O60825S466PVRMRRNsFtPLssS
PRKAA1Q13131humanCFTRP13569S737EPLERRLsLVPDSEQCFTR_R
PRKAA1Q13131humanEIF2AK3Q9NZJ5S715HIEIIAPsPQRsRSF
PRKAA1Q13131humanSTIM1Q13586S521RDLtHsDsEssLHMs
PRKAA1Q13131humanMAPTP10636-8S356rVQskIGsLDNItHVTubulin-binding
PRKAA1Q13131humanNOS3P29474S633WRRKRKEssNtDsAGFlavodoxin_1
PRKAA1Q13131humanKCNA5P22460S592KCNVKAKsNVDLRRS
PRKAA1Q13131humanFOXO3O43524S626SLECDMEsIIRSELMFOXO-TAD
PRKAA1Q13131humanCDKN1BP46527T198PGLRRRQt_______
PRKAA1Q13131humanEXO1Q9UQ84S746PGLYkSSsADsLStT
PRKAA1Q13131humanGLI1P08151S408GPLPRAPsISTVEPk
PRKAA1Q13131humanDDIT3P35638S30EDLQEVLssDENGGT
PRKAA1Q13131humanRBBP7Q16576S314LkLHTFEsHkDEIFQWD40
PRKAA1Q13131humanPRPS2P11908S180GGAkRVTsIADrLNV
PRKAA1Q13131humanPPP1R12CQ9BZL4S452AGLQRsAsssWLEGt
PRKAA1Q13131humanSTBD1O95210S175CFAEKLPssNLLKNR
PRKAA1Q13131humanPAQR3Q6TCH7T32PRGIRLYtyEQIPGS
PRKAA1Q13131humanKLC2Q9H0B6S582PRMKRAssLNFLNKs
PRKAA1Q13131humanTP53P04637T18EPPLsQEtFsDLWkLP53_TAD
PRKAA1Q13131humanEGFRP00533T892SILHRIytHQSDVWSPK_Tyr_Ser-Thr
PRKAA1Q13131humanPRKAA1Q13131S486DEItEAksGtAtPQRAdenylateSensor
PRKAA1Q13131humanGBF1Q92538T1338GKIHRsAtDADVVNs
PRKAA1Q13131humanMAPTP10636-8S396GAEIVyKsPVVsGDt
PRKAA1Q13131humanUMPSP11172S214VAANHNGsPLsIkEA
PRKAA1Q13131humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
PRKAA1Q13131humanPRPS1P60891S180GGAkRVTsIADrLNV
PRKAA1Q13131humanTNNI3P19429S23PAPIRRRssNyRAyATroponin-I_N
PRKAA1Q13131humanPDHA1P08559S295RyHGHsMsDPGVsyRE1_dh
PRKAA1Q13131humanSTIM1Q13586S257GLHRAEQsLHDLQER
PRKAA1Q13131humanBECN1Q14457S93ARMMstEsANsFTLI
PRKAA1Q13131humanEGLN1Q9GZT9S61HKLVCQGsEGALGHG
PRKAA1Q13131humanRPTORQ8N122S792DKMRRAssYSsLNSL
PRKAA1Q13131humanPRKAA1Q13131S496AtPQRsGsVsNyRSCAdenylateSensor
PRKAA1Q13131humanEIF2AK3Q9NZJ5S856SEATLsIsPPRPTTL
PRKAA1Q13131humanSIRT1Q96EB6T344GkLLRNYtQNIDTLESIR2
PRKAA1Q13131humanSLC12A1Q13621S130GPKVNRPsLLEIHEQAA_permease_N
PRKAA1Q13131humanPIAS1O75925S510sPVsRtPsLPAVDTS
PRKAA1Q13131humanMAPTP10636-8S262NVKskIGstENLkHQTubulin-binding
PRKAA1Q13131humanPPP2R5CQ13362S298KYWPKTHsPKEVMFLB56
PRKAA1Q13131humanHNF4AP41235S313GkIkRLRsQVQVsLEHormone_recep
PRKAA1Q13131humanPRKAA1Q13131T183sDGEFLRtsCGsPNyPkinase
PRKAA1Q13131humanCSNK1EP49674S389rGAPANVsssDLtGR
PRKAA1Q13131humanERBB2P04626T900SILRRRFtHQSDVWSPK_Tyr_Ser-Thr
PRKAA1Q13131humanUSP10Q14694S76DtLPRtPsySISstL
PRKAA1Q13131humanKCNA5P22460S559VQRKVsGsRGSFCKA
PRKAA1Q13131humanMKNK1Q9BUB5-2S353QVLQRNSsTMDLTLF
PRKAA1Q13131humanSIRT7Q9NRC8T153TLTHMSItRLHEQKLSIR2
PRKAA1Q13131humanPRKAB1Q9Y478T80APAQARPtVFRWTGGAMPK1_CBM
PRKAA1Q13131humanFANCAO15360S347VQMQREWsFARtHPLFanconi_A_N
PRKAA1Q13131humanBECN1Q14457T388EEVEKGEtRFCLPYRAPG6
PRKAA1Q13131humanRASAL2Q9UJF2-2S351TLFARTTsKTKADNIC2
PRKAA1Q13131humanGSDMEO60443T6__MFAkAtRNFLREVGasdermin
PRKAA1Q13131humanKIF4AO95239S801KLRRRtFsLTEVRGQ
PRKAA1Q13131humanULK1O75385S638FDFPKtPssQNLLAL
PRKAA1Q13131humanFOXO3O43524S555RALsNsVsNMGLSES
PRKAA1Q13131humanNCLP19338S328PELktGIsDVFAkNDRRM_1
PRKAA1Q13131humanPPP1R3CQ9UQK1S33MRLCLAHsPPVKSFL
PRKAA1Q13131humanPRKAB1Q9Y478S177sQKCsDVsELsssPP
PRKAA1Q13131humanZNF692Q9BU19S470VAAHRSKsHPALLLA
PRKAA1Q13131humanHIPK2Q9H2X6T1114APAALGStGTVAHLV
PRKAA1Q13131humanCHKAP35790S279kKLHKLLsYNLPLELCholine_kinase
PRKAA1Q13131humanTP73O15350S426GGMNKLPsVNQLVGQ
PRKAA1Q13131humanTSC2P49815S1387QPLsKssssPELQtL
PRKAA1Q13131humanLIPEQ05469S855EPMRRsVsEAALAQP
PRKAA1Q13131humanFOXO3O43524T179SSPDKRLtLSQIyEWForkhead
PRKAA1Q13131humanFOXO3O43524S588QTLSDSLsGSSLYST
PRKAA1Q13131humanFOXO3O43524S30EPQsRPRsCtWPLQR
PRKAA1Q13131humanBECN1Q14457S96MstEsANsFTLIGEA
PRKAA1Q13131humanPPP2R5CQ13362S336RQLAkCVsSPHFQVAB56
PRKAA1Q13131humanFOXO3O43524S413GLMQRSSsFPYTTKG
PRKAA1Q13131humanGFPT1Q06210S261CNLsRVDsttCLFPV
PRKAA1Q13131humanTET2Q6N021S99GGIKRtVsEPsLSGL
PRKAA1Q13131humanEZH2Q15910T311NtYkRKNtETALDNk
PRKAA1Q13131humanSREBF1P36956-3S372TAVHKSKsLKDLVSA
PRKAA1Q13131humanSCFD1Q8WVM8S316PKRKNKksYDLTPVDSec1
PRKAA1Q13131humanGSRP00390T507TkADFDNtVAIHPtsPyr_redox_dim
PRKAA1Q13131humanULK1O75385S556GLGCRLHsAPNLsDL
PRKAA1Q13131humanEP300Q09472S89SELLRSGsSPNLNMG
PRKAA1Q13131humanCFTRP13569S768LQARRRQsVLNLMtHCFTR_R
PRKAA1Q13131humanTBC1D1Q86TI0T596AFRRRANtLsHFPIE
PRKAA1Q13131humanFOXO3O43524S399DNItLPPsQPsPTGG
PRKAA1Q13131humanZDHHC13Q8IUH4S208FLLKFNPsLNVVDkI
PRKAA1Q13131humanTXNIPQ9H3M7S308GLssRTssMASRTsS
PRKAA1Q13131humanHDAC5Q9UQL6S259FPLRkTAsEPNLKVR
PRKAA1Q13131humanKLC1Q07866S521ENMEkRRsREsLNVD
PRKAA1Q13131humanPRKAB1Q9Y478S24HKtPRRDssGGtKDG
PRKAA1Q13131humanULK1O75385S317SHLASPPsLGEMQQL
PRKAA1Q13131humanDNMT1P26358-2S730DNIPEMPsPKKMHQG
PRKAA1Q13131humanGAPVD1Q14C86S902ErLVRsRssDIVSsV
PRKAA1Q13131humanHSF1Q00613S121NIkRkVtsVSTLksE
PRKAA1Q13131humanPFKFB3Q16875S461NPLMRRNsVtPLAsP
PRKAA1Q13131humanNAMPTP43490S314PLIIRPDsGNPLDTVNAPRTase
PRKAA1Q13131humanPRKAA1Q13131S360LAtsPPDsFLDDHHL
PRKAA1Q13131humanCGNQ9P2M7S137GKLLRsHsQAsLAGP
PRKAA1Q13131humanSIRT2Q8IXJ6T101PDFRSPStGLyDNLESIR2
PRKAA1Q13131humanPOU2F1P14859S335RFEALNLsFKNMCKLPou
PRKAA1Q13131humanCTBP1Q13363S158REGTRVQsVEQIREV2-Hacid_dh_C; 2-Hacid_dh
PRKAA1Q13131humanSKP2Q13309S256QTLLSSCsRLDELNL
PRKAA1Q13131humanSLC12A2P55011S77RPLGPtPsQsRFQVD
PRKAA1Q13131humanTBC1D1Q86TI0S237RPMRKsFsQPGLRSL
PRKAA1Q13131humanCTTNQ14247T401QARAKtQtPPVsPAP
PRKAA1Q13131humanSCFD1Q8WVM8S303EssGVENsPAGARPKSec1
PRKAA1Q13131humanSLC12A2P55011S242GEkLLRPsLAELHDEAA_permease_N
PRKAA1Q13131humanCD274Q9NZQ7S195EKLFNVtsTLRINTTC2-set_2
PRKAA1Q13131humanBRAFP15056S729PKIHRSAsEPsLNRA
PRKAA1Q13131humanNFE2L2Q16236S433PEKELPVsPGHrktP
PRKAA1Q13131humanMAPTP10636-8S422GsIDMVDsPQLAtLA
PRKAA1Q13131humanEGLN1Q9GZT9S136AAAGGQGsAVAAEAE
PRKAA1Q13131humanSCN5AQ14524T101IVLNKGKtIFRFSAT
PRKAA1Q13131humanPRKAB1Q9Y478T148IVTsQLGtVNNIIQVAMPK1_CBM
PRKAA1Q13131humanTNNI3P19429S150tLRrVrIsADAMMQATroponin
PRKAA1Q13131humanHAT1O14929S190MWFIETAsFIDVDDE
PRKAA1Q13131humanCFTRP13569S813DIYsRRLsQEtGLEICFTR_R
PRKAA1Q13131humanFOXO1Q12778T649PHSVKTttHsWVsG_
PRKAA1Q13131humanBECN1Q14457S90IPPARMMstEsANsF
PRKAA1Q13131humanNEDD4LQ96PU5S795VDLKPNGsEIMVTNEHECT
PRKAA1Q13131humanINSIG1O15503T222ItIAFLAtLITQFLVTM; INSIG
PRKAA1Q13131humanRPTORQ8N122S722PrLrsVssyGNIRAV
PRKAA1Q13131humanFOXO1Q12778S22EPLPRPRsCtWPLPR
PRKAA1Q13131humanSYKP43405S178GKISREEsEQIVLIGSH2
PRKAA1Q13131humanACSS2Q9NR19S659PGLPKTRsGKIMRRVAMP-binding_C
PRKAA1Q13131humanTNNI3P19429S24APIRRRssNyRAyAtTroponin-I_N
PRKAA1Q13131humanCCAR2Q8N163S808ALVsHNGsLINVGsL
PRKAA1Q13131humanJAK1P23458S515SLHGSDRsFPsLGDL
PRKAA1Q13131humanACACBO00763S222PtMRPsMsGLHLVKR
PRKAA1Q13131humanSQSTM1Q13501S294ssCCsDPskPGGNVE


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKAA1IDDescription0.00e+00
PRKAA1GO:0062197cellular response to chemical stress1.11e-14
PRKAA1GO:0010506regulation of autophagy6.81e-14
PRKAA1GO:0034599cellular response to oxidative stress1.56e-13
PRKAA1GO:0006979response to oxidative stress5.34e-12
PRKAA1GO:0000302response to reactive oxygen species2.04e-09
PRKAA1GO:1903008organelle disassembly4.28e-09
PRKAA1GO:0071241cellular response to inorganic substance6.34e-09
PRKAA1GO:0034614cellular response to reactive oxygen species6.34e-09
PRKAA1GO:0071248cellular response to metal ion1.13e-08
PRKAA1GO:0031667response to nutrient levels1.16e-08
PRKAA1GO:0062012regulation of small molecule metabolic process1.17e-08
PRKAA1GO:0048511rhythmic process1.51e-08
PRKAA1GO:0010038response to metal ion2.65e-08
PRKAA1GO:0097193intrinsic apoptotic signaling pathway3.91e-08
PRKAA1GO:0006109regulation of carbohydrate metabolic process4.17e-08
PRKAA1GO:2001242regulation of intrinsic apoptotic signaling pathway4.46e-08
PRKAA1GO:0019318hexose metabolic process4.58e-08
PRKAA1GO:0006006glucose metabolic process4.81e-08
PRKAA1GO:0070482response to oxygen levels8.35e-08
PRKAA1GO:0007623circadian rhythm8.60e-08
PRKAA1GO:0000422autophagy of mitochondrion8.67e-08
PRKAA1GO:0061726mitochondrion disassembly8.67e-08
PRKAA1GO:0031669cellular response to nutrient levels8.99e-08
PRKAA1GO:0042542response to hydrogen peroxide1.07e-07
PRKAA1GO:0005996monosaccharide metabolic process1.38e-07
PRKAA1GO:0042594response to starvation1.49e-07
PRKAA1GO:0036293response to decreased oxygen levels1.61e-07
PRKAA1GO:1901653cellular response to peptide1.98e-07
PRKAA1GO:0031668cellular response to extracellular stimulus2.99e-07
PRKAA1GO:0010508positive regulation of autophagy2.99e-07
PRKAA1GO:0006476protein deacetylation3.00e-07
PRKAA1GO:0010821regulation of mitochondrion organization3.22e-07
PRKAA1GO:2001233regulation of apoptotic signaling pathway4.10e-07
PRKAA1GO:0001666response to hypoxia5.58e-07
PRKAA1GO:1903829positive regulation of protein localization7.14e-07
PRKAA1GO:0001558regulation of cell growth7.27e-07
PRKAA1GO:0035601protein deacylation7.95e-07
PRKAA1GO:0070301cellular response to hydrogen peroxide7.95e-07
PRKAA1GO:0071375cellular response to peptide hormone stimulus8.03e-07
PRKAA1GO:0043434response to peptide hormone1.01e-06
PRKAA1GO:0071453cellular response to oxygen levels1.02e-06
PRKAA1GO:0098732macromolecule deacylation1.02e-06
PRKAA1GO:0010906regulation of glucose metabolic process1.30e-06
PRKAA1GO:0009267cellular response to starvation1.30e-06
PRKAA1GO:0042149cellular response to glucose starvation1.89e-06
PRKAA1GO:0071496cellular response to external stimulus2.71e-06
PRKAA1GO:0036294cellular response to decreased oxygen levels4.22e-06
PRKAA1GO:0032869cellular response to insulin stimulus5.05e-06
PRKAA1GO:0016049cell growth6.12e-06

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Related Drugs to PRKAA1_NIPBL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PRKAA1-NIPBL and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PRKAA1_NIPBL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate