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Kinase Fusion Gene:ATP1B3_GRK7 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: ATP1B3_GRK7 | KinaseFusionDB ID: KFG487 | FusionGDB2.0 ID: KFG487 | Hgene | Tgene | Gene symbol | ATP1B3 | GRK7 | Gene ID | 483 | 131890 | |
| Gene name | ATPase Na+/K+ transporting subunit beta 3 | G protein-coupled receptor kinase 7 | ||||||||||
| Synonyms | ATPB-3|CD298 | GPRK7 | ||||||||||
| Cytomap | 3q23 | 3q23 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | sodium/potassium-transporting ATPase subunit beta-3ATPase, Na+/K+ transporting, beta 3 polypeptideNa, K-ATPase beta-3 polypeptidesodium pump subunit beta-3sodium-potassium ATPase subunit beta 3 (non-catalytic)sodium/potassium-dependent ATPase subunit | rhodopsin kinase GRK7g protein-coupled receptor kinase GRK7 | ||||||||||
| Modification date | 20240407 | 20240411 | ||||||||||
| UniProtAcc | P54709 | Q8WTQ7 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000462082, ENST00000539728, ENST00000286371, ENST00000484727, | ENST00000264952, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ATP1B3 [Title/Abstract] AND GRK7 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ATP1B3(141595752)-GRK7(141526487), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP1B3 | GO:0006883 | intracellular sodium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B3 | GO:0030007 | intracellular potassium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B3 | GO:0032781 | positive regulation of ATP-dependent activity | 10636900 |
| Hgene | ATP1B3 | GO:0036376 | sodium ion export across plasma membrane | 10636900|19542013 |
| Hgene | ATP1B3 | GO:0050821 | protein stabilization | 10636900 |
| Hgene | ATP1B3 | GO:0072659 | protein localization to plasma membrane | 18522992 |
| Hgene | ATP1B3 | GO:0086009 | membrane repolarization | 19542013 |
| Hgene | ATP1B3 | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity | 10636900 |
| Hgene | ATP1B3 | GO:1903278 | positive regulation of sodium ion export across plasma membrane | 10636900 |
| Hgene | ATP1B3 | GO:1903288 | positive regulation of potassium ion import across plasma membrane | 10636900 |
| Hgene | ATP1B3 | GO:1990573 | potassium ion import across plasma membrane | 10636900|19542013 |
| Kinase Fusion gene breakpoints across ATP1B3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across GRK7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-66-2771-01A | ATP1B3 | chr3 | 141595752 | GRK7 | chr3 | 141499216 |
| ChimerDB4 | TCGA-66-2792-01A | ATP1B3 | chr3 | 141595752 | GRK7 | chr3 | 141526487 |
| ChimerDB4 | TCGA-33-AASJ-01A | ATP1B3 | chr3 | 141634862 | GRK7 | chr3 | 141535556 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:141595752/chr3:141526487) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP1B3 | GRK7 |
| FUNCTION: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. | FUNCTION: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). {ECO:0000269|PubMed:15946941}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ATP1B3_GRK7 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| GRK7 | Q8WTQ7 | human | OCLN | Q16625 | S471 | LDDyREEsEEyMAAA | Occludin_ELL |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| GRK7 | ID | Description | 0.00e+00 |
| GRK7 | GO:0043117 | positive regulation of vascular permeability | 1.16e-02 |
| GRK7 | GO:0010592 | positive regulation of lamellipodium assembly | 1.16e-02 |
| GRK7 | GO:0031116 | positive regulation of microtubule polymerization | 1.16e-02 |
| GRK7 | GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 1.16e-02 |
| GRK7 | GO:1902745 | positive regulation of lamellipodium organization | 1.16e-02 |
| GRK7 | GO:0046326 | positive regulation of glucose import | 1.16e-02 |
| GRK7 | GO:0035633 | maintenance of blood-brain barrier | 1.16e-02 |
| GRK7 | GO:0010591 | regulation of lamellipodium assembly | 1.16e-02 |
| GRK7 | GO:0010828 | positive regulation of glucose transmembrane transport | 1.16e-02 |
| GRK7 | GO:0043114 | regulation of vascular permeability | 1.16e-02 |
| GRK7 | GO:1902743 | regulation of lamellipodium organization | 1.16e-02 |
| GRK7 | GO:0046324 | regulation of glucose import | 1.16e-02 |
| GRK7 | GO:0031113 | regulation of microtubule polymerization | 1.16e-02 |
| GRK7 | GO:0090303 | positive regulation of wound healing | 1.16e-02 |
| GRK7 | GO:0070830 | bicellular tight junction assembly | 1.16e-02 |
| GRK7 | GO:0030032 | lamellipodium assembly | 1.16e-02 |
| GRK7 | GO:0120192 | tight junction assembly | 1.16e-02 |
| GRK7 | GO:0043297 | apical junction assembly | 1.16e-02 |
| GRK7 | GO:0046323 | glucose import | 1.16e-02 |
| GRK7 | GO:1903036 | positive regulation of response to wounding | 1.16e-02 |
| GRK7 | GO:0010827 | regulation of glucose transmembrane transport | 1.16e-02 |
| GRK7 | GO:0120193 | tight junction organization | 1.16e-02 |
| GRK7 | GO:0032273 | positive regulation of protein polymerization | 1.16e-02 |
| GRK7 | GO:0097581 | lamellipodium organization | 1.16e-02 |
| GRK7 | GO:0046785 | microtubule polymerization | 1.16e-02 |
| GRK7 | GO:0031110 | regulation of microtubule polymerization or depolymerization | 1.16e-02 |
| GRK7 | GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 1.30e-02 |
| GRK7 | GO:1904659 | glucose transmembrane transport | 1.30e-02 |
| GRK7 | GO:0008645 | hexose transmembrane transport | 1.30e-02 |
| GRK7 | GO:0015749 | monosaccharide transmembrane transport | 1.30e-02 |
| GRK7 | GO:0061041 | regulation of wound healing | 1.31e-02 |
| GRK7 | GO:0031109 | microtubule polymerization or depolymerization | 1.31e-02 |
| GRK7 | GO:0034219 | carbohydrate transmembrane transport | 1.31e-02 |
| GRK7 | GO:0007043 | cell-cell junction assembly | 1.42e-02 |
| GRK7 | GO:0008643 | carbohydrate transport | 1.42e-02 |
| GRK7 | GO:0070507 | regulation of microtubule cytoskeleton organization | 1.42e-02 |
| GRK7 | GO:1903034 | regulation of response to wounding | 1.46e-02 |
| GRK7 | GO:1902905 | positive regulation of supramolecular fiber organization | 1.46e-02 |
| GRK7 | GO:0051495 | positive regulation of cytoskeleton organization | 1.50e-02 |
| GRK7 | GO:0031334 | positive regulation of protein-containing complex assembly | 1.52e-02 |
| GRK7 | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 1.52e-02 |
| GRK7 | GO:0032271 | regulation of protein polymerization | 1.52e-02 |
| GRK7 | GO:0060491 | regulation of cell projection assembly | 1.52e-02 |
| GRK7 | GO:0045216 | cell-cell junction organization | 1.53e-02 |
| GRK7 | GO:0034764 | positive regulation of transmembrane transport | 1.53e-02 |
| GRK7 | GO:0032886 | regulation of microtubule-based process | 1.78e-02 |
| GRK7 | GO:0003018 | vascular process in circulatory system | 1.81e-02 |
| GRK7 | GO:0001894 | tissue homeostasis | 1.81e-02 |
| GRK7 | GO:0060249 | anatomical structure homeostasis | 1.81e-02 |
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Related Drugs to ATP1B3_GRK7 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning ATP1B3-GRK7 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ATP1B3_GRK7 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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