| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:PRKAG2_ADCK2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: PRKAG2_ADCK2 | KinaseFusionDB ID: KFG4881 | FusionGDB2.0 ID: KFG4881 | Hgene | Tgene | Gene symbol | PRKAG2 | ADCK2 | Gene ID | 51422 | 90956 | |
| Gene name | protein kinase AMP-activated non-catalytic subunit gamma 2 | aarF domain containing kinase 2 | ||||||||||
| Synonyms | AAKG|AAKG2|CMH6|H91620p|WPWS | AARF | ||||||||||
| Cytomap | 7q36.1 | 7q34 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | 5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2epididymis secretory sperm binding proteinprotein kinase, AMP-activated, gamma 2 non-catalytic subunit | uncharacterized aarF domain-containing protein kinase 2putative ubiquinone biosynthesis protein AarF | ||||||||||
| Modification date | 20240403 | 20240403 | ||||||||||
| UniProtAcc | Q9UGJ0 | Q7Z695 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000287878, ENST00000392801, ENST00000418337, ENST00000433631, ENST00000461529, ENST00000492843, | ENST00000072869, ENST00000476491, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRKAG2 [Title/Abstract] AND ADCK2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKAG2(151573592)-ADCK2(140374411), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRKAG2 | GO:0006469 | negative regulation of protein kinase activity | 17255938 |
| Tgene | ADCK2 | GO:0010795 | regulation of ubiquinone biosynthetic process | 31480808 |
| Kinase Fusion gene breakpoints across PRKAG2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Kinase Fusion gene breakpoints across ADCK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-97-A4M1-01A | PRKAG2 | chr7 | 151573592 | ADCK2 | chr7 | 140374411 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151573592/chr7:140374411) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRKAG2 | ADCK2 |
| FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}. | FUNCTION: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). Involved in the mitochondrial import of CoQ precursors, plays a role in muscle mitochondrial function and fatty acid beta-oxidation (PubMed:31480808). {ECO:0000269|PubMed:31480808, ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of PRKAG2_ADCK2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PRKAG2 | Q9UGJ0 | human | TP53BP1 | Q12888 | S1317 | SSLHRtssGtsLSAM | |
| PRKAG2 | Q9UGJ0 | human | SRSF1 | Q07955 | S133 | SGLPPSGsWQDLkDH | RRM_1 |
| PRKAG2 | Q9UGJ0 | human | RRN3 | Q9NYV6 | S635 | DTHFRsPssSVGsPP | |
| PRKAG2 | Q9UGJ0 | human | PDHA1 | P08559 | S314 | IQEVRSksDPIMLLk | E1_dh |
| PRKAG2 | Q9UGJ0 | human | STIM1 | Q13586 | S521 | RDLtHsDsEssLHMs | |
| PRKAG2 | Q9UGJ0 | human | PDHA1 | P08559 | S295 | RyHGHsMsDPGVsyR | E1_dh |
| PRKAG2 | Q9UGJ0 | human | STIM1 | Q13586 | S257 | GLHRAEQsLHDLQER | |
| PRKAG2 | Q9UGJ0 | human | SKP2 | Q13309 | S256 | QTLLSSCsRLDELNL | |
| PRKAG2 | Q9UGJ0 | human | NEDD4L | Q96PU5 | S795 | VDLKPNGsEIMVTNE | HECT |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
Top |
Related Drugs to PRKAG2_ADCK2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning PRKAG2-ADCK2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to PRKAG2_ADCK2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |