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Kinase Fusion Gene:PRKCA_IGF2BP1 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: PRKCA_IGF2BP1 | KinaseFusionDB ID: KFG4900 | FusionGDB2.0 ID: KFG4900 | Hgene | Tgene | Gene symbol | PRKCA | IGF2BP1 | Gene ID | 5578 | 10642 | |
Gene name | protein kinase C alpha | insulin like growth factor 2 mRNA binding protein 1 | ||||||||||
Synonyms | AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA | CRD-BP|CRDBP|IMP-1|IMP1|VICKZ1|ZBP1 | ||||||||||
Cytomap | 17q24.2 | 17q21.32 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | protein kinase C alpha typePKC-Aaging-associated gene 6 | insulin-like growth factor 2 mRNA-binding protein 1IGF-II mRNA-binding protein 1IGF2 mRNA-binding protein 1VICKZ family member 1ZBP-1coding region determinant-binding proteininsulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBPzipcode-bi | ||||||||||
Modification date | 20240403 | 20240411 | ||||||||||
UniProtAcc | P17252 | Q9NZI8 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000583361, ENST00000413366, | ENST00000290341, ENST00000431824, ENST00000515586, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRKCA [Title/Abstract] AND IGF2BP1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKCA(64302245)-IGF2BP1(47126714), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRKCA | GO:0006468 | protein phosphorylation | 10770950 |
Hgene | PRKCA | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
Hgene | PRKCA | GO:0043687 | post-translational protein modification | 20228790 |
Hgene | PRKCA | GO:0090330 | regulation of platelet aggregation | 12724315 |
Hgene | PRKCA | GO:0110063 | positive regulation of angiotensin-activated signaling pathway | 25313067 |
Tgene | IGF2BP1 | GO:0017148 | negative regulation of translation | 9891060 |
Tgene | IGF2BP1 | GO:0070934 | CRD-mediated mRNA stabilization | 19029303|29476152 |
Tgene | IGF2BP1 | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 19029303 |
Tgene | IGF2BP1 | GO:2000767 | positive regulation of cytoplasmic translation | 19029303 |
Kinase Fusion gene breakpoints across PRKCA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across IGF2BP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-AC-A6IV-01A | PRKCA | chr17 | 64302245 | IGF2BP1 | chr17 | 47126714 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:64302245/chr17:47126714) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PRKCA | IGF2BP1 |
FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. | FUNCTION: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152, PubMed:32245947). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence preventing MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD (PubMed:29476152). Binding to MYC mRNA is enhanced by m6A-modification of the CRD (PubMed:29476152). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:32245947, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PRKCA_IGF2BP1 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
PRKCA | P17252 | human | NOS3 | P29474 | T495 | TGITRKKtFKEVANA | |
PRKCA | P17252 | human | TACSTD2 | P09758 | S303 | VITNRRKsGKYKKVE | |
PRKCA | P17252 | human | JPH2 | Q9BR39 | S165 | PLRTsLssLRsEHsN | |
PRKCA | P17252 | human | TOP1 | P11387 | S21 | ADFRLNDsHKHKDKH | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S247 | AEVKEyVsERVkEHH | p450 |
PRKCA | P17252 | human | NCF4 | Q15080 | S315 | RQARGLPsQKRLFPW | PB1 |
PRKCA | P17252 | human | ANXA1 | P04083 | S28 | yVQtVksskGGPGsA | |
PRKCA | P17252 | human | PTPN1 | P18031 | S378 | RSRVVGGsLrGAQAA | |
PRKCA | P17252 | human | PLCG1 | P19174 | S1248 | HGrAREGsFEsRyQQ | |
PRKCA | P17252 | human | MAPT | P10636-8 | S352 | DFKDrVQskIGsLDN | Tubulin-binding |
PRKCA | P17252 | human | ADAP1 | O75689 | T276 | GFRkRWFtMDDRRLM | PH |
PRKCA | P17252 | human | SLC6A4 | P31645 | T603 | RLIITPGtFKERIIK | |
PRKCA | P17252 | human | ITGB2 | P05107 | S745 | FEkEKLksQWNNDNP | Integrin_b_cyt |
PRKCA | P17252 | human | GNAZ | P19086 | S16 | EKEAARRsRRIDRHL | G-alpha |
PRKCA | P17252 | human | C5AR1 | P21730 | S314 | FQGRLRKsLPsLLRN | |
PRKCA | P17252 | human | CDC42EP4 | Q9H3Q1 | S18 | sVHskRRsRADLtAE | |
PRKCA | P17252 | human | ARHGDIA | P52565 | S34 | ykPPAQKsIQEIQEL | Rho_GDI |
PRKCA | P17252 | human | CSNK1D | P48730 | T174 | YRENkNLtGtARYAs | Pkinase |
PRKCA | P17252 | human | XRCC6 | P12956 | S77 | VYISKIIssDRDLLA | Ku_N |
PRKCA | P17252 | human | CSNK1D | P48730 | S181 | tGtARYAsINTHLGI | Pkinase |
PRKCA | P17252 | human | NHERF1 | O14745 | S340 | RAHQKRssKRAPQMD | EBP50_C |
PRKCA | P17252 | human | ADAM17 | P78536 | T735 | kPFPAPQtPGRLQPA | |
PRKCA | P17252 | human | RRAD | P55042 | S257 | QIRLRRDsKEANARR | |
PRKCA | P17252 | human | SRF | P11831 | S162 | LRRYtTFsKRkTGIM | SRF-TF |
PRKCA | P17252 | human | VTN | P04004 | S393 | sRGRNQNsRRPsRAT | |
PRKCA | P17252 | human | ATP5F1C | P36542 | S146 | GILYRtHsDQFLVAF | ATP-synt |
PRKCA | P17252 | human | EGLN2 | Q96KS0 | S226 | LRDGQLVsQRAIPPR | |
PRKCA | P17252 | human | PPARA | Q07869 | S230 | VKARVILsGKASNNP | |
PRKCA | P17252 | human | EZR | P15311 | T567 | QGRDkyKtLRQIRQG | ERM_C |
PRKCA | P17252 | human | CDKN1A | P38936 | S146 | GRkRRQtsMTDFyHs | |
PRKCA | P17252 | human | SRF | P11831 | T159 | DNkLRRYtTFsKRkT | SRF-TF |
PRKCA | P17252 | human | CDC42EP4 | Q9H3Q1 | S80 | SskRsLLsRKFRGSK | PBD |
PRKCA | P17252 | human | GMFB | P60983 | S72 | QPRFIVYsYkYQHDD | Cofilin_ADF |
PRKCA | P17252 | human | CELF1 | Q92879 | S179 | QtMEGCssPMVVkFA | |
PRKCA | P17252 | human | KCNH2 | Q12809 | S890 | RQRKRKLsFRRRtDK | |
PRKCA | P17252 | human | ARHGAP35 | Q9NRY4 | S1236 | PKPKPRPsITKATWE | RhoGAP_pG1_pG2 |
PRKCA | P17252 | human | SPN | P16150 | S351 | tFFGRRKsRQGsLAM | |
PRKCA | P17252 | human | TRPV5 | Q9NQA5 | S299 | FLELVVSsDKREARQ | |
PRKCA | P17252 | human | FLOT1 | O75955 | S315 | QAEAEAAsVRMRGEA | |
PRKCA | P17252 | human | IGFBP1 | P08833 | S144 | NFHLMAPsEEDHSIL | |
PRKCA | P17252 | human | FLNC | Q14315 | S2624 | sSssRGssyssIPkF | |
PRKCA | P17252 | human | EIF6 | P56537 | S235 | QPstIAtsMRDsLID | |
PRKCA | P17252 | human | PTPN11 | Q06124 | S591 | GLMQQQksFR_____ | |
PRKCA | P17252 | human | CELF1 | Q92879 | S28 | GQVPrtWsEkDLREL | RRM_1 |
PRKCA | P17252 | human | MYH9 | P35579 | S1916 | AMNREVssLkNkLRr | Myosin_tail_1 |
PRKCA | P17252 | human | KCNE3 | Q9Y6H6 | S82 | LILGYTRsRKVDKRS | ISK_Channel |
PRKCA | P17252 | human | CTPS1 | P17812 | T455 | MRLGKRRtLFQTkNs | GATase |
PRKCA | P17252 | human | HRH1 | P35367 | S398 | WKRLRsHsRQyVSGL | 7tm_1 |
PRKCA | P17252 | human | CYP2E1 | P05181 | T69 | QRFGPVFtLYVGsQR | p450 |
PRKCA | P17252 | human | ANXA2 | P07355 | S26 | tPPsAyGsVkAytNF | |
PRKCA | P17252 | human | CYP3A4 | P08684 | T264 | KEsRLEDtQKHRVDF | p450 |
PRKCA | P17252 | human | NR1I2 | O75469 | T408 | RSINAQHtQRLLRIQ | Hormone_recep |
PRKCA | P17252 | human | SLC6A2 | P23975 | T258 | SLWKGVKtsGKVVWI | SNF |
PRKCA | P17252 | human | CSNK1D | P48730 | S53 | HPQLHIEskIYkMMQ | Pkinase |
PRKCA | P17252 | human | PLAU | P00749 | S158 | CADGKKPsSPPEELK | |
PRKCA | P17252 | human | CDKN2A | Q8N726 | T8 | MVRRFLVtLRIRRAC | P19Arf_N |
PRKCA | P17252 | human | CYSLTR1 | Q9Y271 | S315 | tFRKHsLssVTYVPR | |
PRKCA | P17252 | human | HDAC4 | P56524 | S632 | RPLSRAQssPAsAtF | |
PRKCA | P17252 | human | IL2RA | P01589 | S268 | WQRRQRKsRRtI___ | |
PRKCA | P17252 | human | SLC6A4 | P31645 | S149 | yHRNGCIsIWRKICP | SNF |
PRKCA | P17252 | human | CFTR | P13569 | S737 | EPLERRLsLVPDSEQ | CFTR_R |
PRKCA | P17252 | human | PPP2R5A | Q15172 | S41 | RQKRsQGssQFRsQG | |
PRKCA | P17252 | human | CFTR | P13569 | T682 | APVSWTEtKKQsFKQ | CFTR_R |
PRKCA | P17252 | human | RRAD | P55042 | S273 | AGTRRREsLGKKAKR | |
PRKCA | P17252 | human | ITGB4 | P16144 | S1356 | ysDDVLRsPSGsQRP | |
PRKCA | P17252 | human | KCNAB2 | Q13303 | S266 | IPPYSRAsLkGYQWL | Aldo_ket_red |
PRKCA | P17252 | human | MMP2 | P08253 | T377 | DGKMWCAttANYDDD | Peptidase_M10; fn2 |
PRKCA | P17252 | human | GRIN2A | Q12879 | S929 | ADFIQRGsLIMDMVS | NMDAR2_C |
PRKCA | P17252 | human | AQP1 | P29972 | T157 | VLCVLATtDRRRRDL | MIP |
PRKCA | P17252 | human | ITGB2 | P05107 | T758 | NPLFksAtttVMNPk | Integrin_b_cyt |
PRKCA | P17252 | human | CYP2E1 | P05181 | S56 | ELKNIPKsFtRLAQR | p450 |
PRKCA | P17252 | human | FLNC | Q14315 | S2623 | KsSssRGssyssIPk | |
PRKCA | P17252 | human | PRKCE | Q02156 | S316 | tPDKITNsGQRRkKL | |
PRKCA | P17252 | human | PLAU | P00749 | S323 | TGFGKENsTDYLYPE | Trypsin |
PRKCA | P17252 | human | LRP1 | Q07954 | S4523 | GsRHsLAsTDEkREL | |
PRKCA | P17252 | human | PDE3A | Q14432 | S293 | FkRRRRsssVVsAEM | |
PRKCA | P17252 | human | ADD2 | P35612 | S726 | KKKEKVEs_______ | |
PRKCA | P17252 | human | ULK1 | O75385 | S423 | GRAGPFSsSRCGAsV | |
PRKCA | P17252 | human | RRAD | P55042 | S214 | LVRSREVsVDEGRAC | Ras |
PRKCA | P17252 | human | TRPV6 | Q9H1D0 | T742 | WERLRQGtLRRDLRG | |
PRKCA | P17252 | human | KCNJ1 | P48048 | T193 | KKRAKtItFSKNAVI | IRK_C |
PRKCA | P17252 | human | VTN | P04004 | S397 | NQNsRRPsRATWLSL | |
PRKCA | P17252 | human | ADRA1D | P25100 | S334 | HtFRssLsVRLLKFS | 7tm_1 |
PRKCA | P17252 | human | ITGB1 | P05556 | S785 | GENPIyksAVttVVN | Integrin_b_cyt |
PRKCA | P17252 | human | EGLN2 | Q96KS0 | S132 | GGDAPsPsKRPWARQ | |
PRKCA | P17252 | human | ITGB4 | P16144-2 | S1424 | tLTRDyNsLTRSEHS | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S131 | EEWkRLRsLLsPtFT | p450 |
PRKCA | P17252 | human | MAPKAP1 | Q9BPZ7 | S128 | kSLFEKKsLKEKPPI | SIN1 |
PRKCA | P17252 | human | AKT1 | P31749 | S473 | RPHFPQFsysAsGtA | Pkinase_C |
PRKCA | P17252 | human | PPP1R14A | Q96A00 | T38 | QkRHARVtVkYDRRE | PP1_inhibitor |
PRKCA | P17252 | human | NCF1 | P14598 | S320 | QRsRKRLsQDAYRRN | NECFESHC |
PRKCA | P17252 | human | TP53 | P04637 | S376 | LkskkGQstsRHkkL | |
PRKCA | P17252 | human | NOXA1 | Q86UR1 | S172 | DQVQRRGsLPPRQVP | |
PRKCA | P17252 | human | CD4 | P01730 | S440 | sQIkRLLsEKKTCQC | Tcell_CD4_C |
PRKCA | P17252 | human | RALB | P11234 | S198 | KSSKNKKsFKERCCL | |
PRKCA | P17252 | human | RALBP1 | Q15311 | S118 | VFKKPsFsKKKEKDF | |
PRKCA | P17252 | human | TNNI3 | P19429 | S23 | PAPIRRRssNyRAyA | Troponin-I_N |
PRKCA | P17252 | human | TUBA1C | Q9BQE3 | S165 | sVDyGkkskLEFSIy | Tubulin |
PRKCA | P17252 | human | EPHA2 | P29317 | S892 | ADFDPRVsIRLPsts | |
PRKCA | P17252 | human | ARHGDIB | P52566 | S31 | ykPPPQksLkELQEM | Rho_GDI |
PRKCA | P17252 | human | SLC18A2 | Q05940 | S15 | LVRWLQEsRRsRKLI | |
PRKCA | P17252 | human | AQP4 | P55087 | S180 | TIFASCDsKRTDVTG | MIP |
PRKCA | P17252 | human | PTPN12 | Q05209 | S435 | KKLERNLsFEIKKVP | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S100 | VLVKECYsVFtNRRP | p450 |
PRKCA | P17252 | human | EGFR | P00533 | T678 | RHIVRKRtLRRLLQE | |
PRKCA | P17252 | human | GRK7 | Q8WTQ7 | S36 | ELQRRRRsLALPGLQ | |
PRKCA | P17252 | human | TFRC | P02786 | S24 | PLsytRFsLARQVDG | |
PRKCA | P17252 | human | INSR | P06213 | S1062 | AVkTVNEsAsLRERI | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | KCNC4 | Q03721 | S21 | KsGNKPPsKTCLKEE | Potassium_chann |
PRKCA | P17252 | human | AQP2 | P41181 | S256 | REVRRRQsVELHsPQ | |
PRKCA | P17252 | human | PRKAA1 | Q13131 | S496 | AtPQRsGsVsNyRSC | AdenylateSensor |
PRKCA | P17252 | human | PTPN11 | Q06124 | S576 | CAEMREDsARVyENV | |
PRKCA | P17252 | human | PRKG1 | Q13976 | T59 | THIGPRTtRAQGIsA | |
PRKCA | P17252 | human | SLC6A2 | P23975 | S259 | LWKGVKtsGKVVWIT | SNF |
PRKCA | P17252 | human | NOX5 | Q96PH1-4 | T494 | KRLsRSVtMRKsQRS | FAD_binding_8 |
PRKCA | P17252 | human | CASR | P41180 | S875 | TIEEVRCsTAAHAFK | |
PRKCA | P17252 | human | NCOR1 | O75376 | S70 | QQLRRRPsLLsEFHP | |
PRKCA | P17252 | human | EPB41 | P11171-4 | S312 | QAQTRQAsALIDRPA | FA |
PRKCA | P17252 | human | ADRA1D | P25100 | S332 | KGHtFRssLsVRLLK | 7tm_1 |
PRKCA | P17252 | human | CDKN1A | P38936 | S153 | sMTDFyHskRrLIFS | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S424 | ENGkFkYsDYFkPFs | p450 |
PRKCA | P17252 | human | GRIA1 | P42261 | S836 | cYKsRsEsKRMKGFC | |
PRKCA | P17252 | human | RIGI | O95786 | T170 | DkENWPktLkLALEk | CARD_2 |
PRKCA | P17252 | human | PPARA | Q07869 | S179 | RFGRMPRsEKAKLkA | |
PRKCA | P17252 | human | TNNI3 | P19429 | T143 | RGKFKRPtLRrVrIs | Troponin |
PRKCA | P17252 | human | RSC1A1 | Q92681 | S366 | LHELLVVsSkPASEN | |
PRKCA | P17252 | human | ADAP1 | O75689 | S87 | AARARFEsKVPSFYY | ArfGap |
PRKCA | P17252 | human | NHERF1 | O14745 | S339 | ERAHQKRssKRAPQM | EBP50_C |
PRKCA | P17252 | human | LCP1 | P13796 | S5 | ___MARGsVsDEEMM | |
PRKCA | P17252 | human | ARHGEF1 | Q92888 | S240 | TkSGDKKsGRNFFRK | |
PRKCA | P17252 | human | NRGN | Q92686 | S36 | AAAKIQAsFrGHMAR | IQ |
PRKCA | P17252 | human | MAPT | P10636-8 | S324 | kVTskCGsLGNIHHk | Tubulin-binding |
PRKCA | P17252 | human | VIM | P08670 | S8 | MStrsVssssyrrMF | Filament_head |
PRKCA | P17252 | human | UGT1A3 | P35503 | S43 | IDGSHWLsMREVLRE | UDPGT |
PRKCA | P17252 | human | GRIN2B | Q13224 | S1323 | ALAPRSVsLKDKGRF | NMDAR2_C |
PRKCA | P17252 | human | LCK | P06239 | S42 | tLLIRNGsEVRDPLV | |
PRKCA | P17252 | human | VIM | P08670 | S9 | StrsVssssyrrMFG | Filament_head |
PRKCA | P17252 | human | L1CAM | P32004 | T1172 | ARPMkDEtFGEyRSL | Bravo_FIGEY |
PRKCA | P17252 | human | RRAD | P55042 | S290 | GRIVARNsRKMAFRA | |
PRKCA | P17252 | human | PITPNC1 | Q9UKF7 | S274 | SVRsAPSsAPstPLs | |
PRKCA | P17252 | human | PGR | P06401 | S400 | GAEAsARsPRSYLVA | Prog_receptor |
PRKCA | P17252 | human | CYP2E1 | P05181 | T387 | GYLIPKGtVVVPTLD | p450 |
PRKCA | P17252 | human | MARCKS | P29966 | S163 | KRFsFkKsFkLsGFs | MARCKS |
PRKCA | P17252 | human | TRPM4 | Q8TD43 | S1152 | sERLKRTsQKVDLAL | |
PRKCA | P17252 | human | CELF1 | Q92879 | T173 | kAMHQAQtMEGCssP | RRM_1 |
PRKCA | P17252 | human | FBXW7 | Q969H0 | S10 | QELLSVGsKRRRTGG | |
PRKCA | P17252 | human | JAK2 | O60674 | S518 | VFRTNGVsDVPtsPT | |
PRKCA | P17252 | human | CFL1 | P23528 | S23 | NDMkVRksstPEEVk | Cofilin_ADF |
PRKCA | P17252 | human | PRKCE | Q02156 | S234 | EtPDQVGsQRFSVNM | |
PRKCA | P17252 | human | CYSLTR1 | Q9Y271 | S313 | LstFRKHsLssVTYV | |
PRKCA | P17252 | human | IGFBP1 | P08833 | S126 | GsPEsPEstEITEEE | |
PRKCA | P17252 | human | CELF1 | Q92879 | S302 | TSSGSsPsSSSSNSV | |
PRKCA | P17252 | human | FFAR4 | Q5NUL3-1 | S366 | GAILtDtsVKRNDLs | |
PRKCA | P17252 | human | KCNJ1 | P48048 | S4 | ____MNAsSRNVFDT | |
PRKCA | P17252 | human | IGFBP1 | P08833 | S123 | AEAGsPEsPEstEIT | |
PRKCA | P17252 | human | CASR | P41180 | T888 | FKVAARAtLRRsNVs | |
PRKCA | P17252 | human | DOCK8 | Q8NF50 | S2082 | VEsQKRDsFHRSsFR | |
PRKCA | P17252 | human | RELA | Q04206 | S536 | sGDEDFSsIADMDFS | |
PRKCA | P17252 | human | NOXO1 | Q8NFA2-3 | T341 | AIQSRCCtVTRRALE | |
PRKCA | P17252 | human | CHAT | P28329-3 | S440 | VPTYESAsIRRFQEG | Carn_acyltransf |
PRKCA | P17252 | human | PHB2 | Q99623 | S39 | VAyGVREsVFTVEGG | |
PRKCA | P17252 | human | FBXW7 | Q969H0 | S18 | KRRRTGGsLRGNPSs | |
PRKCA | P17252 | human | PLD2 | O14939 | T252 | LLYMCLEtGAISFVQ | |
PRKCA | P17252 | human | TBXA2R | P21731 | S331 | sTRPRsLsLQPQLtQ | |
PRKCA | P17252 | human | GRIN2B | Q13224 | S1415 | QPtVAGAsKARPDFR | NMDAR2_C |
PRKCA | P17252 | human | GRIK2 | Q13002 | S868 | MVEELRMsLKcQRRL | |
PRKCA | P17252 | human | LRP1 | Q07954 | T4460 | GFQHQRMtNGAMNVE | |
PRKCA | P17252 | human | NR1H4 | Q96RI1-2 | S154 | CKGFFRRsITKNAVY | zf-C4 |
PRKCA | P17252 | human | C5AR1 | P21730 | S332 | EEsVVREsKsFTRsT | |
PRKCA | P17252 | human | NLGN4X | Q8N0W4 | T707 | KDKRRHEtHRRPSPQ | |
PRKCA | P17252 | human | ARHGDIA | P52565 | S96 | DLTGDLEsFKkQsFV | Rho_GDI |
PRKCA | P17252 | human | HSPB1 | P04792 | S15 | FsLLrGPsWDPFrDW | |
PRKCA | P17252 | human | ARRB1 | P49407 | S163 | EkIHKRNsVRLVIRK | Arrestin_N |
PRKCA | P17252 | human | TNNI3 | P19429 | S44 | KKskIsAsRKLQLKt | |
PRKCA | P17252 | human | LRP1 | Q07954 | S4517 | LyMGGHGsRHsLAsT | |
PRKCA | P17252 | human | TBXA2R | P21731 | S324 | RRLQPRLsTRPRsLs | |
PRKCA | P17252 | human | CHAT | P28329-3 | S347 | LKHVTQssRKLIRAD | Carn_acyltransf |
PRKCA | P17252 | human | CYP3A4 | P08684 | S116 | GPVGFMksAIsIAED | p450 |
PRKCA | P17252 | human | TBXA2R | P21731 | S329 | RLsTRPRsLsLQPQL | |
PRKCA | P17252 | human | DTNB | O60941 | T212 | MLNMFLDtMMADPPP | EF-hand_3 |
PRKCA | P17252 | human | CSNK1D | P48730 | S298 | NMLKFGAsRAADDAE | |
PRKCA | P17252 | human | CORO1A | P31146 | T412 | RVNRGLDtGRRRAAP | Trimer_CC |
PRKCA | P17252 | human | CHAT | P28329-3 | T255 | TVLVKDStNRDSLDM | Carn_acyltransf |
PRKCA | P17252 | human | NCF1 | P14598 | S370 | PAVPPRPsADLILNR | p47_phox_C |
PRKCA | P17252 | human | NPHS1 | O60500 | T1125 | QWtGERDtQSSTVST | |
PRKCA | P17252 | human | PFKFB3 | Q16875 | S461 | NPLMRRNsVtPLAsP | |
PRKCA | P17252 | human | RRAD | P55042 | S299 | KMAFRAKsKsCHDLS | |
PRKCA | P17252 | human | EIF2S3 | P41091 | T66 | kAISGVHtVRFkNEL | GTP_EFTU |
PRKCA | P17252 | human | CYP3A4 | P08684 | T284 | DSQNSkEtESHKALS | p450 |
PRKCA | P17252 | human | ITGB2 | P05107 | T760 | LFksAtttVMNPkFA | Integrin_b_cyt |
PRKCA | P17252 | human | KCNMA1 | Q12791 | S1200 | SHSsQSSsKKSSsVH | |
PRKCA | P17252 | human | ITGB4 | P16144 | S1364 | PSGsQRPsVSDDTGC | |
PRKCA | P17252 | human | TRPV1 | Q8NER1 | S502 | YFLQRRPsMKTLFVD | Ion_trans |
PRKCA | P17252 | human | PTPN22 | Q9Y2R2 | S751 | kSFtRSKsLKILRNM | |
PRKCA | P17252 | human | MAPT | P10636-8 | S293 | NVQskCGsKDNIkHV | Tubulin-binding |
PRKCA | P17252 | human | CYP2E1 | P05181 | S431 | sDYFkPFstGkRVCA | p450 |
PRKCA | P17252 | human | TRPM2 | O94759-3 | S39 | NLRRSNSsLFKSWRL | |
PRKCA | P17252 | human | CELF1 | Q92879 | S300 | VLTSSGSsPsSSSSN | |
PRKCA | P17252 | human | SH2B1 | Q9NRF2 | S165 | VGRsVRGsVRGILQW | |
PRKCA | P17252 | human | TBXA2R | P21731 | T337 | LsLQPQLtQRSGLQ_ | |
PRKCA | P17252 | human | PPP1R1A | Q13522 | T75 | PRQRKKMtRItPTMK | DARPP-32 |
PRKCA | P17252 | human | TNNI3 | P19429 | S42 | AKKKskIsAsRKLQL | |
PRKCA | P17252 | human | BCL11B | Q9C0K0 | S2 | ______MsRRKQGNP | |
PRKCA | P17252 | human | KIT | P10721 | S746 | RRsVRIGsyIERDVT | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | NCF1 | P14598 | S304 | GAPPRRssIRNAHsI | NECFESHC |
PRKCA | P17252 | human | AQP1 | P29972 | T239 | APRSsDLtDRVKVWT | |
PRKCA | P17252 | human | C5AR1 | P21730 | S327 | RNVLtEEsVVREsKs | |
PRKCA | P17252 | human | BNC1 | Q01954 | S541 | KKksRKSsMPIkIEK | |
PRKCA | P17252 | human | LRRK1 | Q38SD2 | S1064 | NRKVTIysFTGNQRN | |
PRKCA | P17252 | human | HRH1 | P35367 | S396 | FTWKRLRsHsRQyVS | 7tm_1 |
PRKCA | P17252 | human | MMP2 | P08253 | S160 | DVTPLRFsRIHDGEA | Peptidase_M10 |
PRKCA | P17252 | human | KRT20 | P35900 | S13 | RSFHRsLsSSLQAPV | |
PRKCA | P17252 | human | TUBA1A | Q71U36 | S165 | sVDyGkkskLEFSIy | Tubulin |
PRKCA | P17252 | human | RORA | P35398 | S100 | CKGFFRRsQQSNATY | zf-C4 |
PRKCA | P17252 | human | PRKD2 | Q9BZL6 | S706 | ARIIGEksFRRsVVG | Pkinase |
PRKCA | P17252 | human | PRKD1 | Q15139 | S412 | PLMRVVQsVKHTKRK | |
PRKCA | P17252 | human | PRKD2 | Q9BZL6 | S710 | GEksFRRsVVGtPAy | Pkinase |
PRKCA | P17252 | human | PLEK | P08567 | S117 | ARKstRRsIRLPEtI | |
PRKCA | P17252 | human | EWSR1 | Q01844 | S266 | SSYGQQSsFRQDHPS | |
PRKCA | P17252 | human | CD226 | Q15762 | S329 | yVNyPTFsRRPKTRV | |
PRKCA | P17252 | human | GSK3A | P49840 | S21 | sGrARtssFAEPGGG | |
PRKCA | P17252 | human | SLC6A3 | Q01959 | S12 | kCsVGLMssVVAPAK | |
PRKCA | P17252 | human | ARX | Q96QS3 | S174 | VSISRSKsYRENGAP | |
PRKCA | P17252 | human | ZFP64 | Q9NTW7 | S226 | NKHLRIHsDERPFKC | zf-H2C2_5 |
PRKCA | P17252 | human | ARHGAP35 | Q9NRY4 | S1221 | RRRNILRsLRRNtKK | RhoGAP_pG1_pG2 |
PRKCA | P17252 | human | ANXA2 | P07355 | S12 | HEILCkLsLEGDHst | |
PRKCA | P17252 | human | ADRA1D | P25100 | S300 | KRERGKAsEVVLRIH | 7tm_1 |
PRKCA | P17252 | human | RAB37 | Q96AX2 | T172 | YGVPFLEtSAKTGMN | Ras |
PRKCA | P17252 | human | NCF1 | P14598 | S379 | DLILNRCsEstKRKL | p47_phox_C |
PRKCA | P17252 | human | FRAT1 | Q92837 | S188 | RLQQRRGsQPETRTG | GSK-3_bind |
PRKCA | P17252 | human | LRRK1 | Q38SD2 | T1075 | NQRNRCstFRVKRNQ | |
PRKCA | P17252 | human | MYL9 | P24844 | S3 | _____MssKRAKAKt | |
PRKCA | P17252 | human | APLP2 | Q06481 | T723 | LRKRQYGtISHGIVE | APP_amyloid |
PRKCA | P17252 | human | GHSR | Q92847 | T261 | RDQNHKQtVKMLAVV | 7tm_1 |
PRKCA | P17252 | human | HRH1 | P35367 | T478 | CNENFKKtFKRILHI | |
PRKCA | P17252 | human | MARCKS | P29966 | S159 | kkKKKRFsFkKsFkL | MARCKS |
PRKCA | P17252 | human | CELF1 | Q92879 | S241 | LLQQTASsGNLNTLS | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S129 | WKDIRRFsLttLRNY | p450 |
PRKCA | P17252 | human | NOX5 | Q96PH1-4 | S498 | RSVtMRKsQRSsKGS | FAD_binding_8 |
PRKCA | P17252 | human | TAGLN2 | P37802 | S185 | MGtNrGAsQAGMtGy | Calponin |
PRKCA | P17252 | human | BEST1 | O76090 | S358 | SAQFRRAsFMGSTFN | |
PRKCA | P17252 | human | ITGB4 | P16144 | S1360 | VLRsPSGsQRPsVSD | |
PRKCA | P17252 | human | TRPV1 | Q8NER1 | S801 | VPLLREAsARDRQsA | |
PRKCA | P17252 | human | CYP3A4 | P08684 | T92 | TDPDMIKtVLVKECY | p450 |
PRKCA | P17252 | human | MYL9 | P24844 | T10 | sKRAKAKttKKRPQR | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T58 | KNIPKsFtRLAQRFG | p450 |
PRKCA | P17252 | human | DTNB | O60941 | T179 | KEVLKLPtAVFEGPS | EF-hand_3 |
PRKCA | P17252 | human | APPL1 | Q9UKG1 | S430 | ARTSssGsLGSESTN | |
PRKCA | P17252 | human | ERBB2 | P04626 | T686 | QQKIRKYtMRRLLQE | |
PRKCA | P17252 | human | CLDN4 | O14493 | S194 | PRTDKPysAKysAAR | |
PRKCA | P17252 | human | MMP2 | P08253 | T378 | GKMWCAttANYDDDR | Peptidase_M10; fn2 |
PRKCA | P17252 | human | LRP1 | Q07954 | S4520 | GGHGsRHsLAsTDEk | |
PRKCA | P17252 | human | TNNI3 | P19429 | S199 | RkNIDALsGMEGRKK | |
PRKCA | P17252 | human | ABCB1 | P08183 | S661 | SSNDSRSsLIRKRsT | |
PRKCA | P17252 | human | NR1H4 | Q96RI1-2 | S135 | VVCGDRAsGYHYNAL | zf-C4 |
PRKCA | P17252 | human | MBD4 | O95243 | S262 | sGFVQSDsKRESVCN | |
PRKCA | P17252 | human | KCNJ1 | P48048 | S201 | FSKNAVIskRGGKLC | IRK_C |
PRKCA | P17252 | human | MAPT | P10636-8 | S258 | PDLkNVKskIGstEN | Tubulin-binding |
PRKCA | P17252 | human | ABCB1 | P08183 | S667 | SsLIRKRsTRRsVRG | |
PRKCA | P17252 | human | CFL1 | P23528 | S24 | DMkVRksstPEEVkk | Cofilin_ADF |
PRKCA | P17252 | human | NHERF1 | O14745 | S162 | CtMKKGPsGyGFNLH | PDZ |
PRKCA | P17252 | human | TP53 | P04637 | T377 | kskkGQstsRHkkLM | |
PRKCA | P17252 | human | PANX1 | Q96RD7 | Y199 | KYPIVEQyLkTkkNS | Innexin |
PRKCA | P17252 | human | SNAP25 | P60880 | S187 | RIMEKADsNKTRIDE | |
PRKCA | P17252 | human | ANXA1 | P04083 | S27 | EyVQtVksskGGPGs | |
PRKCA | P17252 | human | DOCK8 | Q8NF50 | S2087 | RDsFHRSsFRKCETQ | |
PRKCA | P17252 | human | RALBP1 | Q15311 | S353 | LSPTVQIsNRVLYVF | RhoGAP |
PRKCA | P17252 | human | CYP3A4 | P08684 | S139 | LLsPtFTsGKLKEMV | p450 |
PRKCA | P17252 | human | PAK5 | Q9P286 | S99 | ISVTRSNsLRKESPP | |
PRKCA | P17252 | human | CYTH2 | Q99418 | S392 | AARKKRIsVKKKQEQ | |
PRKCA | P17252 | human | ATF2 | P15336 | S121 | LAtPIIRsKIEEPSV | |
PRKCA | P17252 | human | CTNND1 | O60716 | S879 | LIDRNQksDkkPDRE | |
PRKCA | P17252 | human | MBD4 | O95243 | S165 | CSMAALTsHLQNQSN | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S74 | VFtLYVGsQRMVVMH | p450 |
PRKCA | P17252 | human | KIR3DL1 | P43629 | S415 | QRKITRPsQRPKtPP | |
PRKCA | P17252 | human | MARCKS | P29966 | S167 | FkKsFkLsGFsFkKN | MARCKS |
PRKCA | P17252 | human | PDE3A | Q14432 | S292 | VFkRRRRsssVVsAE | |
PRKCA | P17252 | human | CD36 | P16671 | T92 | VKQRGPYtYRVRFLA | CD36 |
PRKCA | P17252 | human | TP53 | P04637 | S371 | AHssHLkskkGQsts | |
PRKCA | P17252 | human | TTN | Q8WZ42 | S12022 | RRKLRPGsGGEKPPD | |
PRKCA | P17252 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
PRKCA | P17252 | human | LRRK1 | Q38SD2 | S1074 | GNQRNRCstFRVKRN | |
PRKCA | P17252 | human | FXYD1 | O00168 | S88 | RssIRRLstRRR___ | |
PRKCA | P17252 | human | FSCN1 | Q16658 | S39 | KVNASAssLkkkQIW | Fascin |
PRKCA | P17252 | human | VTN | P04004 | S386 | YRsQRGHsRGRNQNs | |
PRKCA | P17252 | human | ELAVL1 | Q15717 | S221 | QAQrFrFsPMGVDHM | |
PRKCA | P17252 | human | TACSTD2 | P09758 | S322 | GELRkEPsL______ | |
PRKCA | P17252 | human | RALBP1 | Q15311 | S509 | FLRRQIAsEKEEIER | |
PRKCA | P17252 | human | PA2G4 | Q9UQ80 | S360 | ELkALLQssAsRKtQ | |
PRKCA | P17252 | human | NF1 | P21359-2 | S2808 | QKQRSAGsFKRNsIK | |
PRKCA | P17252 | human | PEBP1 | P30086 | S153 | RGKFkVAsFRKKYEL | PBP |
PRKCA | P17252 | human | DNM1 | Q05193 | S778 | GRRsPtssPtPQRRA | |
PRKCA | P17252 | human | RAF1 | P04049 | S499 | VksRWsGsQQVEQPT | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | C5AR1 | P21730 | S338 | EsKsFTRsTVDTMAQ | |
PRKCA | P17252 | human | PRKD3 | O94806 | S731 | ARIIGEksFRRsVVG | Pkinase |
PRKCA | P17252 | human | AR | P10275 | S579 | YGALTCGsCKVFFKR | zf-C4 |
PRKCA | P17252 | human | PDE3A | Q14432 | S428 | IPKRLRRsLPPGLLR | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T132 | IRRFsLttLRNYGMG | p450 |
PRKCA | P17252 | human | BCL2 | P10415 | S70 | RDPVARtsPLQtPAA | |
PRKCA | P17252 | human | CELF1 | Q92879 | S52 | INVLRDRsQNPPQSk | RRM_1 |
PRKCA | P17252 | human | PACSIN2 | Q9UNF0 | S313 | ADLNRtLsRREKKKA | |
PRKCA | P17252 | human | F11R | Q9Y624 | S284 | kVIysQPsARsEGEF | |
PRKCA | P17252 | human | ABCB1 | P08183 | S671 | RKRsTRRsVRGsQAQ | |
PRKCA | P17252 | human | ADRA1D | P25100 | S323 | DGAHGMRsAKGHtFR | 7tm_1 |
PRKCA | P17252 | human | CYP3A4 | P08684 | T136 | LRsLLsPtFTsGKLK | p450 |
PRKCA | P17252 | human | RPS6KB2 | Q9UBS0 | S473 | PPSGTKKsKRGRGRP | |
PRKCA | P17252 | human | SATB1 | Q01826 | S185 | DLPPEQWsHTtVRNA | CUTL |
PRKCA | P17252 | human | CD4 | P01730 | S433 | RRQAERMsQIkRLLs | Tcell_CD4_C |
PRKCA | P17252 | human | PTPN12 | Q05209 | S39 | FMRLRRLstKYRTEK | |
PRKCA | P17252 | human | ACO1 | P21399 | S711 | REFNSYGsRrGNDAV | Aconitase_C |
PRKCA | P17252 | human | TBXA2R | P21731 | S145 | FSRPAVAsQRRAWAT | 7tm_1 |
PRKCA | P17252 | human | SNAP25 | P60880 | T138 | GGFIRRVtNDARENE | SNAP-25 |
PRKCA | P17252 | human | INSR | P06213 | S1064 | kTVNEsAsLRERIEF | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | RAF1 | P04049 | S43 | FGyQRRAsDDGKLtD | |
PRKCA | P17252 | human | FMNL2 | Q96PY5-3 | S1072 | RADAVRRsVRRRFDD | |
PRKCA | P17252 | human | RORA | P35398 | S35 | ETPLNQEsArKSEPP | |
PRKCA | P17252 | human | SLC18A2 | Q05940 | S18 | WLQEsRRsRKLILFI | |
PRKCA | P17252 | human | MMP2 | P08253 | S365 | NKyEsCtsAGRsDGK | Peptidase_M10; fn2 |
PRKCA | P17252 | human | SH2B1 | Q9NRF2 | S161 | sLRsVGRsVRGsVRG | |
PRKCA | P17252 | human | RIGI | O95786 | S8 | MTTEQRRsLQAFQDY | CARD_2 |
PRKCA | P17252 | human | PA2G4 | Q9UQ80 | T366 | QssAsRKtQKKKKKk | |
PRKCA | P17252 | human | RET | P07949 | T675 | PISSAEMtFRRPAQA | |
PRKCA | P17252 | human | CYSLTR1 | Q9Y271 | S316 | FRKHsLssVTYVPRK | |
PRKCA | P17252 | human | CFLAR | O15519-2 | S193 | LQAAIQKsLKDPSNN | |
PRKCA | P17252 | human | GRK2 | P25098 | S29 | ATPAARAskkILLPE | |
PRKCA | P17252 | human | VIM | P08670 | S10 | trsVssssyrrMFGG | Filament_head |
PRKCA | P17252 | human | PITPNC1 | Q9UKF7 | S299 | KDRPRKKsAPEtLtL | |
PRKCA | P17252 | human | C5AR1 | P21730 | S334 | sVVREsKsFTRsTVD | |
PRKCA | P17252 | human | VIM | P08670 | S5 | ___MStrsVssssyr | |
PRKCA | P17252 | human | EIF4G1 | Q04637 | S1185 | RtPATKRsFskEVEE | |
PRKCA | P17252 | human | TRPC3 | Q13507 | S785 | PPFsLVPsPKsFVyF | |
PRKCA | P17252 | human | NHERF1 | O14745 | S77 | ETHQQVVsRIRAALN | PDZ |
PRKCA | P17252 | human | KCNC4 | Q03721 | S15 | ssYRGRKsGNKPPsK | Potassium_chann |
PRKCA | P17252 | human | CLDN1 | O95832 | T191 | CSCPRkTtsYPtPRP | |
PRKCA | P17252 | human | CTPS1 | P17812 | S462 | tLFQTkNsVMRkLYG | GATase |
PRKCA | P17252 | human | TGFBR1 | P36897 | T200 | LPLLVQRtIARtIVL | TGF_beta_GS |
PRKCA | P17252 | human | IQGAP1 | P46940 | S1443 | DKMKKsksVkEDsNL | |
PRKCA | P17252 | human | NR2F6 | P10588 | S83 | CKSFFKRsIRRNLsY | zf-C4 |
PRKCA | P17252 | human | KLHL3 | Q9UH77 | S433 | PMNTRRSsVGVGVVE | Kelch_1 |
PRKCA | P17252 | human | TBXA2R | P21731-2 | T399 | LLPFEPPtGKALSRK | |
PRKCA | P17252 | human | PPP1R1A | Q13522 | S67 | LKSTLAMsPRQRKKM | DARPP-32 |
PRKCA | P17252 | human | CSNK1D | P48730 | T161 | KKYRDARtHQHIPYR | Pkinase |
PRKCA | P17252 | human | ELAVL1 | Q15717 | S158 | FIRFDKRsEAEEAIT | RRM_1 |
PRKCA | P17252 | human | PRKD1 | Q15139 | S738 | ARIIGEksFRRsVVG | Pkinase |
PRKCA | P17252 | human | GJA1 | P17302 | S372 | sRAssRAssRPRPDD | |
PRKCA | P17252 | human | ARHGAP35 | Q9NRY4 | T1226 | LRsLRRNtKKPKPKP | RhoGAP_pG1_pG2 |
PRKCA | P17252 | human | ELAVL1 | Q15717 | S318 | GDkILQVsFkTNkSH | |
PRKCA | P17252 | human | PDE3A | Q14432 | S312 | SKSHRRTsLPCIPRE | |
PRKCA | P17252 | human | KIT | P10721 | S741 | TkADkRRsVRIGsyI | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | CORO1B | Q9BR76 | S2 | ______MsFRKVVRQ | |
PRKCA | P17252 | human | CFTR | P13569 | S660 | FSAERRNsILTETLH | CFTR_R |
PRKCA | P17252 | human | KCNJ13 | O60928 | S201 | TRPSPLTsVRVSAVL | IRK_C |
PRKCA | P17252 | human | CLDN7 | O95471 | S204 | VPRsYPksNsskEyV | |
PRKCA | P17252 | human | PDE3A | Q14432 | S438 | PGLLRRVsstWtttt | |
PRKCA | P17252 | human | KRAS | P01116-2 | S181 | GKKKKkKskTkCVIM | |
PRKCA | P17252 | human | PDE3A | Q14432 | S492 | MTLTkSRsFtSSyAI | |
PRKCA | P17252 | human | SHOC2 | Q9UQ13 | S297 | GLRYNRLsAIPRSLA | LRR_8 |
PRKCA | P17252 | human | NCF1 | P14598 | S315 | AHsIHQRsRKRLsQD | NECFESHC |
PRKCA | P17252 | human | CFTR | P13569 | S686 | WTEtKKQsFKQTGEF | CFTR_R |
PRKCA | P17252 | human | CYP3A4 | P08684 | S398 | GVVVMIPsYALHRDP | p450 |
PRKCA | P17252 | human | PTPN6 | P29350 | S591 | DKEKsKGsLKRK___ | |
PRKCA | P17252 | human | ADD2 | P35612 | S713 | KKKFRtPsFLKKsKK | |
PRKCA | P17252 | human | GNAZ | P19086 | S27 | DRHLRSEsQRQRREI | G-alpha |
PRKCA | P17252 | human | JAK2 | O60674 | T174 | kVPVTHEtQEECLGM | FERM_F2 |
PRKCA | P17252 | human | SLC6A4 | P31645 | S277 | IWKGVKtsGKVVWVT | SNF |
PRKCA | P17252 | human | NR1I3 | Q14994 | T38 | CKGFFRRtVSKSIGP | zf-C4 |
PRKCA | P17252 | human | AHR | P35869 | S12 | SANITYAsRKRRKPV | |
PRKCA | P17252 | human | KCNJ4 | P48050 | T53 | IFTTCVDtRWRYMLM | IRK |
PRKCA | P17252 | human | SPIC | Q8N5J4 | Y191 | KIRRKLTyQFSEAIL | Ets |
PRKCA | P17252 | human | ADD1 | P35611 | S726 | KKKFRtPsFLKKsKK | |
PRKCA | P17252 | human | CFLAR | O15519 | S193 | LQAAIQksLkDPSNN | |
PRKCA | P17252 | human | RGS7 | P49802 | S434 | YKLMKSDsYPRFIRS | RGS |
PRKCA | P17252 | human | KCNQ2 | O43526 | T217 | RMDRRGGtWKLLGSV | Ion_trans; TM |
PRKCA | P17252 | human | PDE3A | Q14432 | S465 | VRRDRsTsIkLQEAP | |
PRKCA | P17252 | human | PPARG | P37231 | T166 | CKGFFRRtIRLKLIY | |
PRKCA | P17252 | human | NOX5 | Q96PH1-4 | S490 | GRGSKRLsRSVtMRK | FAD_binding_8 |
PRKCA | P17252 | human | CYP3A4 | P08684 | S119 | GFMksAIsIAEDEEW | p450 |
PRKCA | P17252 | human | GPSM2 | P81274 | S408 | PKLGRRHsMENMELM | |
PRKCA | P17252 | human | PIM1 | P11309-2 | S65 | HSHSPRHsLRHSPGS | |
PRKCA | P17252 | human | NCF1 | P14598 | S328 | QDAYRRNsVRFLQQR | NECFESHC |
PRKCA | P17252 | human | RASSF1 | Q9NS23-2 | S197 | RGPGRGTsVRRRtsF | |
PRKCA | P17252 | human | NCF4 | Q15080 | T154 | LRRLRPRtRKVKSVs | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S420 | kFLPERFsKKNKDNI | p450 |
PRKCA | P17252 | human | NKX3-1 | Q99801 | S48 | RQGGRTSsQRQRDPE | |
PRKCA | P17252 | human | TP53 | P04637 | S378 | skkGQstsRHkkLMF | |
PRKCA | P17252 | human | ROBO3 | Q96MS0 | S1330 | WLPYSRPsFLSrGQG | |
PRKCA | P17252 | human | CD5 | P06127 | T434 | MsFHRNHtAtVRsHA | |
PRKCA | P17252 | human | SLC6A3 | Q01959 | S7 | _MsKskCsVGLMssV | |
PRKCA | P17252 | human | TP73 | O15350 | S388 | VPQPLVDsYRQQQQL | |
PRKCA | P17252 | human | GNMT | Q14749 | S10 | DSVYRtRsLGVAAEG | |
PRKCA | P17252 | human | CHAT | P28329-3 | S476 | HKAAVPAsEKLLLLK | Carn_acyltransf |
PRKCA | P17252 | human | AFAP1 | Q8N556 | S277 | AELEKKLssERPssD | |
PRKCA | P17252 | human | PPP1R16B | Q96T49 | S331 | sQLRHKSsLsRRTsS | |
PRKCA | P17252 | human | VDR | P11473 | S51 | CKGFFRRsMKRKALF | zf-C4 |
PRKCA | P17252 | human | MMP2 | P08253 | T250 | EYNsCTDtGRSDGFL | Peptidase_M10; fn2 |
PRKCA | P17252 | human | F3 | P13726 | S290 | GQsWkENsPLNVs__ | |
PRKCA | P17252 | human | MYL9 | P24844 | S2 | ______MssKRAKAK | |
PRKCA | P17252 | human | GJA1 | P17302 | S368 | QRPssRAssRAssRP | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T373 | SNLPHEAtRDtIFrG | p450 |
PRKCA | P17252 | human | ADRA1D | P25100 | S516 | QLRAKVssLsHKIRA | |
PRKCA | P17252 | human | KCNK9 | Q9NPC2 | T341 | IEEISPStLKNSLFP | |
PRKCA | P17252 | human | CELF1 | Q92879 | S178 | AQtMEGCssPMVVkF | RRM_1 |
PRKCA | P17252 | human | CYP3A4 | P08684 | S134 | kRLRsLLsPtFTsGK | p450 |
PRKCA | P17252 | human | CYP2E1 | P05181 | T131 | DIRRFsLttLRNYGM | p450 |
PRKCA | P17252 | human | DLG1 | Q12959 | T657 | KERARLKtVkFNsKT | |
PRKCA | P17252 | human | CHAT | P28329-3 | S346 | LLKHVTQssRKLIRA | Carn_acyltransf |
PRKCA | P17252 | human | CFTR | P13569 | S795 | TAsTRKVsLAPQANL | CFTR_R |
PRKCA | P17252 | human | H3C1 | P68431 | T6 | __ArtkQtArkstGG | Histone |
PRKCA | P17252 | human | CSNK1D | P48730 | S191 | THLGIEQsRRDDLES | Pkinase |
PRKCA | P17252 | human | SCN9A | Q15858-3 | I848 | LNMLIKIiGNSVGAL | Ion_trans |
PRKCA | P17252 | human | EGLN2 | Q96KS0 | S234 | QRAIPPRsIRGDQIA | |
PRKCA | P17252 | human | CD44 | P16070 | S672 | AVCIAVNsRRRCGQK | |
PRKCA | P17252 | human | CYP3A4 | P08684 | T103 | KECYsVFtNRRPFGP | p450 |
PRKCA | P17252 | human | HABP4 | Q5JVS0 | T375 | GRGARGGtRGGRGRI | IHABP4_N |
PRKCA | P17252 | human | PRKD2 | Q9BZL6 | S876 | QGLAERIsVL_____ | |
PRKCA | P17252 | human | TXN | P10599 | T100 | NkEkLEAtINELV__ | Thioredoxin |
PRKCA | P17252 | human | GSTA4 | O15217 | T193 | VKLsNIPtIKRFLEP | GST_C_3 |
PRKCA | P17252 | human | TNNT2 | P45379 | S189 | ARKKKALsNMMHFGG | Troponin |
PRKCA | P17252 | human | PPP1R14B | Q96C90 | T57 | VRRQGKVtVkYDRKE | PP1_inhibitor |
PRKCA | P17252 | human | FERMT3 | Q86UX7 | S484 | LSLQRtGsGGPGNHP | FERM_M |
PRKCA | P17252 | human | TRPV5 | Q9NQA5 | S654 | yVEVFKNsDKEDDQE | |
PRKCA | P17252 | human | VTN | P04004 | S381 | RNRKGYRsQRGHsRG | |
PRKCA | P17252 | human | EP300 | Q09472 | S89 | SELLRSGsSPNLNMG | |
PRKCA | P17252 | human | IKBKB | O14920 | S177 | AkELDQGsLCtsFVG | Pkinase |
PRKCA | P17252 | human | ICOSLG | O75144 | S285 | RDRCLQHsYAGAWAV | |
PRKCA | P17252 | human | TUBA1C | Q9BQE3 | S158 | sLLMERLsVDyGkks | Tubulin |
PRKCA | P17252 | human | C5AR1 | P21730 | S317 | RLRKsLPsLLRNVLt | |
PRKCA | P17252 | human | IL2RA | P01589 | T271 | RQRKsRRtI______ | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T432 | DYFkPFstGkRVCAG | p450 |
PRKCA | P17252 | human | CSNK1D | P48730 | T176 | ENkNLtGtARYAsIN | Pkinase |
PRKCA | P17252 | human | PLEK | P08567 | S113 | GQKFARKstRRsIRL | |
PRKCA | P17252 | human | ADRA1D | P25100 | S518 | RAKVssLsHKIRAGG | |
PRKCA | P17252 | human | DOCK8 | Q8NF50 | S2077 | KPIFRVEsQKRDsFH | |
PRKCA | P17252 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
PRKCA | P17252 | human | FFAR4 | Q5NUL3-1 | T363 | PEKGAILtDtsVKRN | |
PRKCA | P17252 | human | SHOC2 | Q9UQ13 | T71 | VAFSVDNtIKRPNPA | |
PRKCA | P17252 | human | TRPM4 | Q8TD43 | S1145 | RDKRESDsERLKRTs | |
PRKCA | P17252 | human | VIM | P08670 | S7 | _MStrsVssssyrrM | Filament_head |
PRKCA | P17252 | human | XRCC6 | P12956 | S78 | YISKIIssDRDLLAV | Ku_N |
PRKCA | P17252 | human | ACO1 | P21399 | S138 | DFNRRADsLQkNQDL | Aconitase |
PRKCA | P17252 | human | H2BC3 | P33778 | S32 | DGKkRKRsRkEsysI | Histone |
PRKCA | P17252 | human | CYP2E1 | P05181 | S145 | MGKQGNEsRIQREAH | p450 |
PRKCA | P17252 | human | AHR | P35869 | S36 | EGIkSNPsKRHRDRL | HLH |
PRKCA | P17252 | human | PRKCE | Q02156 | S368 | NNIRKALsFDNRGEE | |
PRKCA | P17252 | human | MARCKS | P29966 | S170 | sFkLsGFsFkKNKkE | MARCKS |
PRKCA | P17252 | human | CD3G | P09693 | S148 | GVRQsRAsDkQTLLP | |
PRKCA | P17252 | human | NCF1 | P14598 | S303 | RGAPPRRssIRNAHs | NECFESHC |
PRKCA | P17252 | human | FFAR4 | Q5NUL3-1 | S373 | sVKRNDLsIIsG___ | |
PRKCA | P17252 | human | CD300LF | Q8TDQ1 | T221 | GTsPQKAtTKLSSAQ | SIT |
PRKCA | P17252 | human | IKBKB | O14920 | S181 | DQGsLCtsFVGTLQy | Pkinase |
PRKCA | P17252 | human | ILK | Q13418 | T181 | RTRPRNGtLNkHsGI | |
PRKCA | P17252 | human | THOC5 | Q13769 | S5 | ___MSSEssKKRKPK | |
PRKCA | P17252 | human | F3 | P13726 | S285 | RKAGVGQsWkENsPL | |
PRKCA | P17252 | human | TAGLN2 | P37802 | T180 | VIGLQMGtNrGAsQA | Calponin |
PRKCA | P17252 | human | PTGIR | P43119 | S328 | TPLSQLAsGRRDPRA | |
PRKCA | P17252 | human | TAGLN2 | P37802 | S11 | rGPAyGLsREVQQkI | |
PRKCA | P17252 | human | NOXO1 | Q8NFA2-3 | S154 | SRAAGRLsIHSLEAQ | |
PRKCA | P17252 | human | ILK | Q13418 | T173 | DTFWkGttRTRPRNG | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S259 | SVKRMKEsRLEDtQK | p450 |
PRKCA | P17252 | human | GSTP1 | P09211 | S185 | SAYVGRLsARPkLkA | GST_C_3 |
PRKCA | P17252 | human | PRKD1 | Q15139 | S742 | GEksFRRsVVGtPAy | Pkinase |
PRKCA | P17252 | human | HABP4 | Q5JVS0 | T354 | RKPANDItSQLEINF | IHABP4_N |
PRKCA | P17252 | human | PLCB3 | Q01970 | S1105 | LDRKRHNsIsEAKMR | PLC-beta_C |
PRKCA | P17252 | human | EPB41 | P11171-4 | S331 | RTASKRAsRSLDGAA | FA |
PRKCA | P17252 | human | CD5 | P06127 | T436 | FHRNHtAtVRsHAEN | |
PRKCA | P17252 | human | TAGLN | Q01995 | S181 | VIGLQMGsNrGAsQA | Calponin |
PRKCA | P17252 | human | PLD2 | O14939 | S243 | RWLVVKDsFLLYMCL | |
PRKCA | P17252 | human | CYBA | P13498 | T147 | ERPQIGGtIkQPPsN | Cytochrom_B558a |
PRKCA | P17252 | human | SUN1 | O94901 | S55 | sPRMsRRsLRLATTA | |
PRKCA | P17252 | human | ADD1 | P35611 | S716 | GsPGKsPsKKKKKFR | |
PRKCA | P17252 | human | CFTR | P13569 | S641 | QNLQPDFsSKLMGCD | CFTR_R |
PRKCA | P17252 | human | RASSF1 | Q9NS23-2 | S203 | TsVRRRtsFYLPKDA | RA |
PRKCA | P17252 | human | NCF1 | P14598 | S359 | EERQtQRsKPQPAVP | p47_phox_C |
PRKCA | P17252 | human | VASP | P50552 | S157 | EHIERRVsNAGGPPA | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T376 | PHEAtRDtIFrGYLI | p450 |
PRKCA | P17252 | human | TTN | Q8WZ42 | S11878 | KEEVVLKsVLRKRPE | |
PRKCA | P17252 | human | BDKRB2 | P30411 | S373 | sMGTLRTsIsVERQI | |
PRKCA | P17252 | human | NPHS1 | O60500 | T1120 | EYEESQWtGERDtQS | |
PRKCA | P17252 | human | SCN5A | Q14524 | S1503 | NAMKKLGsKKPQKPI | |
PRKCA | P17252 | human | CFTR | P13569 | S813 | DIYsRRLsQEtGLEI | CFTR_R |
PRKCA | P17252 | human | NMNAT1 | Q9HAN9 | S136 | WTETQDSsQKKSLEP | CTP_transf_like |
PRKCA | P17252 | human | THOC5 | Q13769 | S6 | __MSSEssKKRKPKV | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T121 | IIFNNGPtWKDIRRF | p450 |
PRKCA | P17252 | human | GRIA1 | P42261 | S834 | EFcYKsRsEsKRMKG | |
PRKCA | P17252 | human | DRD2 | P14416 | S229 | RVNtkRssRAFRAHL | 7tm_1 |
PRKCA | P17252 | human | TNNI3 | P19429 | S24 | APIRRRssNyRAyAt | Troponin-I_N |
PRKCA | P17252 | human | RALBP1 | Q15311 | T297 | ACGRTTEtEkVQEFQ | RhoGAP |
PRKCA | P17252 | human | DTNB | O60941 | T69 | FRDNGLNtLDHTTEI | EF-hand_2 |
PRKCA | P17252 | human | IGFBP1 | P08833 | S194 | LAKAQETsGEEIsKF | Thyroglobulin_1 |
PRKCA | P17252 | human | GPR15 | P49685 | S357 | FARRRKRsVsL____ | |
PRKCA | P17252 | human | DRD2 | P14416 | S228 | kRVNtkRssRAFRAH | 7tm_1 |
PRKCA | P17252 | human | MET | P08581 | S985 | PHLDRLVsARsVsPt | |
PRKCA | P17252 | human | GRIA1 | P42261 | S849 | FCLIPQQsINEAIRT | |
PRKCA | P17252 | human | TWIST1 | Q15672 | S144 | tLPSDkLskIQTLkL | HLH |
PRKCA | P17252 | human | MAPT | P10636-8 | S305 | kHVPGGGsVQIVykP | Tubulin-binding |
PRKCA | P17252 | human | KCNA5 | P22460 | T15 | LENGGAMtVRGGDEA | |
PRKCA | P17252 | human | AKT1 | P31749 | T308 | kDGAtMKtFCGtPEy | Pkinase |
PRKCA | P17252 | human | ITGB4 | P16144 | S1494 | tLtRDyNsLtRsEHs |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
PRKCA | ID | Description | 0.00e+00 |
PRKCA | GO:0042060 | wound healing | 2.48e-16 |
PRKCA | GO:0009410 | response to xenobiotic stimulus | 5.28e-12 |
PRKCA | GO:0001667 | ameboidal-type cell migration | 5.28e-12 |
PRKCA | GO:0050878 | regulation of body fluid levels | 5.72e-12 |
PRKCA | GO:0050673 | epithelial cell proliferation | 5.72e-12 |
PRKCA | GO:0036293 | response to decreased oxygen levels | 5.72e-12 |
PRKCA | GO:0070482 | response to oxygen levels | 5.84e-12 |
PRKCA | GO:0034765 | regulation of monoatomic ion transmembrane transport | 3.23e-11 |
PRKCA | GO:0001666 | response to hypoxia | 5.67e-11 |
PRKCA | GO:0003012 | muscle system process | 1.36e-10 |
PRKCA | GO:0050678 | regulation of epithelial cell proliferation | 2.93e-10 |
PRKCA | GO:0006816 | calcium ion transport | 4.36e-10 |
PRKCA | GO:0010038 | response to metal ion | 4.54e-10 |
PRKCA | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 9.65e-10 |
PRKCA | GO:0007015 | actin filament organization | 9.65e-10 |
PRKCA | GO:1901653 | cellular response to peptide | 9.65e-10 |
PRKCA | GO:0018105 | peptidyl-serine phosphorylation | 1.24e-09 |
PRKCA | GO:0030522 | intracellular receptor signaling pathway | 1.38e-09 |
PRKCA | GO:0048732 | gland development | 1.38e-09 |
PRKCA | GO:0097553 | calcium ion transmembrane import into cytosol | 2.51e-09 |
PRKCA | GO:0018209 | peptidyl-serine modification | 2.51e-09 |
PRKCA | GO:1902074 | response to salt | 2.59e-09 |
PRKCA | GO:1903522 | regulation of blood circulation | 2.93e-09 |
PRKCA | GO:0070372 | regulation of ERK1 and ERK2 cascade | 3.08e-09 |
PRKCA | GO:0043410 | positive regulation of MAPK cascade | 5.42e-09 |
PRKCA | GO:0031623 | receptor internalization | 5.56e-09 |
PRKCA | GO:1903829 | positive regulation of protein localization | 5.56e-09 |
PRKCA | GO:0007596 | blood coagulation | 9.11e-09 |
PRKCA | GO:0070371 | ERK1 and ERK2 cascade | 1.12e-08 |
PRKCA | GO:0010959 | regulation of metal ion transport | 1.21e-08 |
PRKCA | GO:0050817 | coagulation | 1.23e-08 |
PRKCA | GO:0036294 | cellular response to decreased oxygen levels | 1.23e-08 |
PRKCA | GO:1904375 | regulation of protein localization to cell periphery | 1.25e-08 |
PRKCA | GO:0007265 | Ras protein signal transduction | 1.27e-08 |
PRKCA | GO:0007599 | hemostasis | 1.27e-08 |
PRKCA | GO:0010631 | epithelial cell migration | 1.31e-08 |
PRKCA | GO:0090132 | epithelium migration | 1.51e-08 |
PRKCA | GO:0071496 | cellular response to external stimulus | 1.56e-08 |
PRKCA | GO:0051098 | regulation of binding | 1.62e-08 |
PRKCA | GO:0090130 | tissue migration | 1.85e-08 |
PRKCA | GO:0048511 | rhythmic process | 2.37e-08 |
PRKCA | GO:0045785 | positive regulation of cell adhesion | 2.38e-08 |
PRKCA | GO:0003018 | vascular process in circulatory system | 2.40e-08 |
PRKCA | GO:0007159 | leukocyte cell-cell adhesion | 2.48e-08 |
PRKCA | GO:0043254 | regulation of protein-containing complex assembly | 2.48e-08 |
PRKCA | GO:0051099 | positive regulation of binding | 2.98e-08 |
PRKCA | GO:0071453 | cellular response to oxygen levels | 3.84e-08 |
PRKCA | GO:0062012 | regulation of small molecule metabolic process | 4.19e-08 |
PRKCA | GO:0046879 | hormone secretion | 4.23e-08 |
Top |
Related Drugs to PRKCA_IGF2BP1 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning PRKCA-IGF2BP1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to PRKCA_IGF2BP1 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |