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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PRKCA_OLA1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PRKCA_OLA1
KinaseFusionDB ID: KFG4908
FusionGDB2.0 ID: KFG4908
HgeneTgene
Gene symbol

PRKCA

OLA1

Gene ID

5578

29789

Gene nameprotein kinase C alphaObg like ATPase 1
SynonymsAAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACADOC45|GBP45|GTBP9|GTPBP9|PTD004
Cytomap

17q24.2

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C alpha typePKC-Aaging-associated gene 6obg-like ATPase 1DNA damage-regulated overexpressed in cancer 45 proteinGTP-binding protein 9 (putative)GTP-binding protein PTD004homologous yeast-44.2 protein
Modification date2024040320240413
UniProtAcc

P17252

Q9NTK5

Ensembl transtripts involved in fusion geneENST idsENST00000583361, ENST00000413366, 
ENST00000284719, ENST00000344357, 
ENST00000409546, ENST00000428402, 
ENST00000392560, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PRKCA [Title/Abstract] AND OLA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRKCA(64302245)-OLA1(175006728), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCA

GO:0006468

protein phosphorylation

10770950

HgenePRKCA

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgenePRKCA

GO:0043687

post-translational protein modification

20228790

HgenePRKCA

GO:0090330

regulation of platelet aggregation

12724315

HgenePRKCA

GO:0110063

positive regulation of angiotensin-activated signaling pathway

25313067

TgeneOLA1

GO:0046034

ATP metabolic process

17430889


check buttonKinase Fusion gene breakpoints across PRKCA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across OLA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-CD-A486-01APRKCAchr17

64302245

OLA1chr2

175006728



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:64302245/chr2:175006728)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKCA

P17252

OLA1

Q9NTK5

FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}.FUNCTION: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. {ECO:0000255|HAMAP-Rule:MF_03167}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PRKCA_OLA1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKCAP17252humanNOS3P29474T495TGITRKKtFKEVANA
PRKCAP17252humanTACSTD2P09758S303VITNRRKsGKYKKVE
PRKCAP17252humanJPH2Q9BR39S165PLRTsLssLRsEHsN
PRKCAP17252humanTOP1P11387S21ADFRLNDsHKHKDKH
PRKCAP17252humanCYP2E1P05181S247AEVKEyVsERVkEHHp450
PRKCAP17252humanNCF4Q15080S315RQARGLPsQKRLFPWPB1
PRKCAP17252humanANXA1P04083S28yVQtVksskGGPGsA
PRKCAP17252humanPTPN1P18031S378RSRVVGGsLrGAQAA
PRKCAP17252humanPLCG1P19174S1248HGrAREGsFEsRyQQ
PRKCAP17252humanMAPTP10636-8S352DFKDrVQskIGsLDNTubulin-binding
PRKCAP17252humanADAP1O75689T276GFRkRWFtMDDRRLMPH
PRKCAP17252humanSLC6A4P31645T603RLIITPGtFKERIIK
PRKCAP17252humanITGB2P05107S745FEkEKLksQWNNDNPIntegrin_b_cyt
PRKCAP17252humanGNAZP19086S16EKEAARRsRRIDRHLG-alpha
PRKCAP17252humanC5AR1P21730S314FQGRLRKsLPsLLRN
PRKCAP17252humanCDC42EP4Q9H3Q1S18sVHskRRsRADLtAE
PRKCAP17252humanARHGDIAP52565S34ykPPAQKsIQEIQELRho_GDI
PRKCAP17252humanCSNK1DP48730T174YRENkNLtGtARYAsPkinase
PRKCAP17252humanXRCC6P12956S77VYISKIIssDRDLLAKu_N
PRKCAP17252humanCSNK1DP48730S181tGtARYAsINTHLGIPkinase
PRKCAP17252humanNHERF1O14745S340RAHQKRssKRAPQMDEBP50_C
PRKCAP17252humanADAM17P78536T735kPFPAPQtPGRLQPA
PRKCAP17252humanRRADP55042S257QIRLRRDsKEANARR
PRKCAP17252humanSRFP11831S162LRRYtTFsKRkTGIMSRF-TF
PRKCAP17252humanVTNP04004S393sRGRNQNsRRPsRAT
PRKCAP17252humanATP5F1CP36542S146GILYRtHsDQFLVAFATP-synt
PRKCAP17252humanEGLN2Q96KS0S226LRDGQLVsQRAIPPR
PRKCAP17252humanPPARAQ07869S230VKARVILsGKASNNP
PRKCAP17252humanEZRP15311T567QGRDkyKtLRQIRQGERM_C
PRKCAP17252humanCDKN1AP38936S146GRkRRQtsMTDFyHs
PRKCAP17252humanSRFP11831T159DNkLRRYtTFsKRkTSRF-TF
PRKCAP17252humanCDC42EP4Q9H3Q1S80SskRsLLsRKFRGSKPBD
PRKCAP17252humanGMFBP60983S72QPRFIVYsYkYQHDDCofilin_ADF
PRKCAP17252humanCELF1Q92879S179QtMEGCssPMVVkFA
PRKCAP17252humanKCNH2Q12809S890RQRKRKLsFRRRtDK
PRKCAP17252humanARHGAP35Q9NRY4S1236PKPKPRPsITKATWERhoGAP_pG1_pG2
PRKCAP17252humanSPNP16150S351tFFGRRKsRQGsLAM
PRKCAP17252humanTRPV5Q9NQA5S299FLELVVSsDKREARQ
PRKCAP17252humanFLOT1O75955S315QAEAEAAsVRMRGEA
PRKCAP17252humanIGFBP1P08833S144NFHLMAPsEEDHSIL
PRKCAP17252humanFLNCQ14315S2624sSssRGssyssIPkF
PRKCAP17252humanEIF6P56537S235QPstIAtsMRDsLID
PRKCAP17252humanPTPN11Q06124S591GLMQQQksFR_____
PRKCAP17252humanCELF1Q92879S28GQVPrtWsEkDLRELRRM_1
PRKCAP17252humanMYH9P35579S1916AMNREVssLkNkLRrMyosin_tail_1
PRKCAP17252humanKCNE3Q9Y6H6S82LILGYTRsRKVDKRSISK_Channel
PRKCAP17252humanCTPS1P17812T455MRLGKRRtLFQTkNsGATase
PRKCAP17252humanHRH1P35367S398WKRLRsHsRQyVSGL7tm_1
PRKCAP17252humanCYP2E1P05181T69QRFGPVFtLYVGsQRp450
PRKCAP17252humanANXA2P07355S26tPPsAyGsVkAytNF
PRKCAP17252humanCYP3A4P08684T264KEsRLEDtQKHRVDFp450
PRKCAP17252humanNR1I2O75469T408RSINAQHtQRLLRIQHormone_recep
PRKCAP17252humanSLC6A2P23975T258SLWKGVKtsGKVVWISNF
PRKCAP17252humanCSNK1DP48730S53HPQLHIEskIYkMMQPkinase
PRKCAP17252humanPLAUP00749S158CADGKKPsSPPEELK
PRKCAP17252humanCDKN2AQ8N726T8MVRRFLVtLRIRRACP19Arf_N
PRKCAP17252humanCYSLTR1Q9Y271S315tFRKHsLssVTYVPR
PRKCAP17252humanHDAC4P56524S632RPLSRAQssPAsAtF
PRKCAP17252humanIL2RAP01589S268WQRRQRKsRRtI___
PRKCAP17252humanSLC6A4P31645S149yHRNGCIsIWRKICPSNF
PRKCAP17252humanCFTRP13569S737EPLERRLsLVPDSEQCFTR_R
PRKCAP17252humanPPP2R5AQ15172S41RQKRsQGssQFRsQG
PRKCAP17252humanCFTRP13569T682APVSWTEtKKQsFKQCFTR_R
PRKCAP17252humanRRADP55042S273AGTRRREsLGKKAKR
PRKCAP17252humanITGB4P16144S1356ysDDVLRsPSGsQRP
PRKCAP17252humanKCNAB2Q13303S266IPPYSRAsLkGYQWLAldo_ket_red
PRKCAP17252humanMMP2P08253T377DGKMWCAttANYDDDPeptidase_M10; fn2
PRKCAP17252humanGRIN2AQ12879S929ADFIQRGsLIMDMVSNMDAR2_C
PRKCAP17252humanAQP1P29972T157VLCVLATtDRRRRDLMIP
PRKCAP17252humanITGB2P05107T758NPLFksAtttVMNPkIntegrin_b_cyt
PRKCAP17252humanCYP2E1P05181S56ELKNIPKsFtRLAQRp450
PRKCAP17252humanFLNCQ14315S2623KsSssRGssyssIPk
PRKCAP17252humanPRKCEQ02156S316tPDKITNsGQRRkKL
PRKCAP17252humanPLAUP00749S323TGFGKENsTDYLYPETrypsin
PRKCAP17252humanLRP1Q07954S4523GsRHsLAsTDEkREL
PRKCAP17252humanPDE3AQ14432S293FkRRRRsssVVsAEM
PRKCAP17252humanADD2P35612S726KKKEKVEs_______
PRKCAP17252humanULK1O75385S423GRAGPFSsSRCGAsV
PRKCAP17252humanRRADP55042S214LVRSREVsVDEGRACRas
PRKCAP17252humanTRPV6Q9H1D0T742WERLRQGtLRRDLRG
PRKCAP17252humanKCNJ1P48048T193KKRAKtItFSKNAVIIRK_C
PRKCAP17252humanVTNP04004S397NQNsRRPsRATWLSL
PRKCAP17252humanADRA1DP25100S334HtFRssLsVRLLKFS7tm_1
PRKCAP17252humanITGB1P05556S785GENPIyksAVttVVNIntegrin_b_cyt
PRKCAP17252humanEGLN2Q96KS0S132GGDAPsPsKRPWARQ
PRKCAP17252humanITGB4P16144-2S1424tLTRDyNsLTRSEHS
PRKCAP17252humanCYP3A4P08684S131EEWkRLRsLLsPtFTp450
PRKCAP17252humanMAPKAP1Q9BPZ7S128kSLFEKKsLKEKPPISIN1
PRKCAP17252humanAKT1P31749S473RPHFPQFsysAsGtAPkinase_C
PRKCAP17252humanPPP1R14AQ96A00T38QkRHARVtVkYDRREPP1_inhibitor
PRKCAP17252humanNCF1P14598S320QRsRKRLsQDAYRRNNECFESHC
PRKCAP17252humanTP53P04637S376LkskkGQstsRHkkL
PRKCAP17252humanNOXA1Q86UR1S172DQVQRRGsLPPRQVP
PRKCAP17252humanCD4P01730S440sQIkRLLsEKKTCQCTcell_CD4_C
PRKCAP17252humanRALBP11234S198KSSKNKKsFKERCCL
PRKCAP17252humanRALBP1Q15311S118VFKKPsFsKKKEKDF
PRKCAP17252humanTNNI3P19429S23PAPIRRRssNyRAyATroponin-I_N
PRKCAP17252humanTUBA1CQ9BQE3S165sVDyGkkskLEFSIyTubulin
PRKCAP17252humanEPHA2P29317S892ADFDPRVsIRLPsts
PRKCAP17252humanARHGDIBP52566S31ykPPPQksLkELQEMRho_GDI
PRKCAP17252humanSLC18A2Q05940S15LVRWLQEsRRsRKLI
PRKCAP17252humanAQP4P55087S180TIFASCDsKRTDVTGMIP
PRKCAP17252humanPTPN12Q05209S435KKLERNLsFEIKKVP
PRKCAP17252humanCYP3A4P08684S100VLVKECYsVFtNRRPp450
PRKCAP17252humanEGFRP00533T678RHIVRKRtLRRLLQE
PRKCAP17252humanGRK7Q8WTQ7S36ELQRRRRsLALPGLQ
PRKCAP17252humanTFRCP02786S24PLsytRFsLARQVDG
PRKCAP17252humanINSRP06213S1062AVkTVNEsAsLRERIPK_Tyr_Ser-Thr
PRKCAP17252humanKCNC4Q03721S21KsGNKPPsKTCLKEEPotassium_chann
PRKCAP17252humanAQP2P41181S256REVRRRQsVELHsPQ
PRKCAP17252humanPRKAA1Q13131S496AtPQRsGsVsNyRSCAdenylateSensor
PRKCAP17252humanPTPN11Q06124S576CAEMREDsARVyENV
PRKCAP17252humanPRKG1Q13976T59THIGPRTtRAQGIsA
PRKCAP17252humanSLC6A2P23975S259LWKGVKtsGKVVWITSNF
PRKCAP17252humanNOX5Q96PH1-4T494KRLsRSVtMRKsQRSFAD_binding_8
PRKCAP17252humanCASRP41180S875TIEEVRCsTAAHAFK
PRKCAP17252humanNCOR1O75376S70QQLRRRPsLLsEFHP
PRKCAP17252humanEPB41P11171-4S312QAQTRQAsALIDRPAFA
PRKCAP17252humanADRA1DP25100S332KGHtFRssLsVRLLK7tm_1
PRKCAP17252humanCDKN1AP38936S153sMTDFyHskRrLIFS
PRKCAP17252humanCYP2E1P05181S424ENGkFkYsDYFkPFsp450
PRKCAP17252humanGRIA1P42261S836cYKsRsEsKRMKGFC
PRKCAP17252humanRIGIO95786T170DkENWPktLkLALEkCARD_2
PRKCAP17252humanPPARAQ07869S179RFGRMPRsEKAKLkA
PRKCAP17252humanTNNI3P19429T143RGKFKRPtLRrVrIsTroponin
PRKCAP17252humanRSC1A1Q92681S366LHELLVVsSkPASEN
PRKCAP17252humanADAP1O75689S87AARARFEsKVPSFYYArfGap
PRKCAP17252humanNHERF1O14745S339ERAHQKRssKRAPQMEBP50_C
PRKCAP17252humanLCP1P13796S5___MARGsVsDEEMM
PRKCAP17252humanARHGEF1Q92888S240TkSGDKKsGRNFFRK
PRKCAP17252humanNRGNQ92686S36AAAKIQAsFrGHMARIQ
PRKCAP17252humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
PRKCAP17252humanVIMP08670S8MStrsVssssyrrMFFilament_head
PRKCAP17252humanUGT1A3P35503S43IDGSHWLsMREVLREUDPGT
PRKCAP17252humanGRIN2BQ13224S1323ALAPRSVsLKDKGRFNMDAR2_C
PRKCAP17252humanLCKP06239S42tLLIRNGsEVRDPLV
PRKCAP17252humanVIMP08670S9StrsVssssyrrMFGFilament_head
PRKCAP17252humanL1CAMP32004T1172ARPMkDEtFGEyRSLBravo_FIGEY
PRKCAP17252humanRRADP55042S290GRIVARNsRKMAFRA
PRKCAP17252humanPITPNC1Q9UKF7S274SVRsAPSsAPstPLs
PRKCAP17252humanPGRP06401S400GAEAsARsPRSYLVAProg_receptor
PRKCAP17252humanCYP2E1P05181T387GYLIPKGtVVVPTLDp450
PRKCAP17252humanMARCKSP29966S163KRFsFkKsFkLsGFsMARCKS
PRKCAP17252humanTRPM4Q8TD43S1152sERLKRTsQKVDLAL
PRKCAP17252humanCELF1Q92879T173kAMHQAQtMEGCssPRRM_1
PRKCAP17252humanFBXW7Q969H0S10QELLSVGsKRRRTGG
PRKCAP17252humanJAK2O60674S518VFRTNGVsDVPtsPT
PRKCAP17252humanCFL1P23528S23NDMkVRksstPEEVkCofilin_ADF
PRKCAP17252humanPRKCEQ02156S234EtPDQVGsQRFSVNM
PRKCAP17252humanCYSLTR1Q9Y271S313LstFRKHsLssVTYV
PRKCAP17252humanIGFBP1P08833S126GsPEsPEstEITEEE
PRKCAP17252humanCELF1Q92879S302TSSGSsPsSSSSNSV
PRKCAP17252humanFFAR4Q5NUL3-1S366GAILtDtsVKRNDLs
PRKCAP17252humanKCNJ1P48048S4____MNAsSRNVFDT
PRKCAP17252humanIGFBP1P08833S123AEAGsPEsPEstEIT
PRKCAP17252humanCASRP41180T888FKVAARAtLRRsNVs
PRKCAP17252humanDOCK8Q8NF50S2082VEsQKRDsFHRSsFR
PRKCAP17252humanRELAQ04206S536sGDEDFSsIADMDFS
PRKCAP17252humanNOXO1Q8NFA2-3T341AIQSRCCtVTRRALE
PRKCAP17252humanCHATP28329-3S440VPTYESAsIRRFQEGCarn_acyltransf
PRKCAP17252humanPHB2Q99623S39VAyGVREsVFTVEGG
PRKCAP17252humanFBXW7Q969H0S18KRRRTGGsLRGNPSs
PRKCAP17252humanPLD2O14939T252LLYMCLEtGAISFVQ
PRKCAP17252humanTBXA2RP21731S331sTRPRsLsLQPQLtQ
PRKCAP17252humanGRIN2BQ13224S1415QPtVAGAsKARPDFRNMDAR2_C
PRKCAP17252humanGRIK2Q13002S868MVEELRMsLKcQRRL
PRKCAP17252humanLRP1Q07954T4460GFQHQRMtNGAMNVE
PRKCAP17252humanNR1H4Q96RI1-2S154CKGFFRRsITKNAVYzf-C4
PRKCAP17252humanC5AR1P21730S332EEsVVREsKsFTRsT
PRKCAP17252humanNLGN4XQ8N0W4T707KDKRRHEtHRRPSPQ
PRKCAP17252humanARHGDIAP52565S96DLTGDLEsFKkQsFVRho_GDI
PRKCAP17252humanHSPB1P04792S15FsLLrGPsWDPFrDW
PRKCAP17252humanARRB1P49407S163EkIHKRNsVRLVIRKArrestin_N
PRKCAP17252humanTNNI3P19429S44KKskIsAsRKLQLKt
PRKCAP17252humanLRP1Q07954S4517LyMGGHGsRHsLAsT
PRKCAP17252humanTBXA2RP21731S324RRLQPRLsTRPRsLs
PRKCAP17252humanCHATP28329-3S347LKHVTQssRKLIRADCarn_acyltransf
PRKCAP17252humanCYP3A4P08684S116GPVGFMksAIsIAEDp450
PRKCAP17252humanTBXA2RP21731S329RLsTRPRsLsLQPQL
PRKCAP17252humanDTNBO60941T212MLNMFLDtMMADPPPEF-hand_3
PRKCAP17252humanCSNK1DP48730S298NMLKFGAsRAADDAE
PRKCAP17252humanCORO1AP31146T412RVNRGLDtGRRRAAPTrimer_CC
PRKCAP17252humanCHATP28329-3T255TVLVKDStNRDSLDMCarn_acyltransf
PRKCAP17252humanNCF1P14598S370PAVPPRPsADLILNRp47_phox_C
PRKCAP17252humanNPHS1O60500T1125QWtGERDtQSSTVST
PRKCAP17252humanPFKFB3Q16875S461NPLMRRNsVtPLAsP
PRKCAP17252humanRRADP55042S299KMAFRAKsKsCHDLS
PRKCAP17252humanEIF2S3P41091T66kAISGVHtVRFkNELGTP_EFTU
PRKCAP17252humanCYP3A4P08684T284DSQNSkEtESHKALSp450
PRKCAP17252humanITGB2P05107T760LFksAtttVMNPkFAIntegrin_b_cyt
PRKCAP17252humanKCNMA1Q12791S1200SHSsQSSsKKSSsVH
PRKCAP17252humanITGB4P16144S1364PSGsQRPsVSDDTGC
PRKCAP17252humanTRPV1Q8NER1S502YFLQRRPsMKTLFVDIon_trans
PRKCAP17252humanPTPN22Q9Y2R2S751kSFtRSKsLKILRNM
PRKCAP17252humanMAPTP10636-8S293NVQskCGsKDNIkHVTubulin-binding
PRKCAP17252humanCYP2E1P05181S431sDYFkPFstGkRVCAp450
PRKCAP17252humanTRPM2O94759-3S39NLRRSNSsLFKSWRL
PRKCAP17252humanCELF1Q92879S300VLTSSGSsPsSSSSN
PRKCAP17252humanSH2B1Q9NRF2S165VGRsVRGsVRGILQW
PRKCAP17252humanTBXA2RP21731T337LsLQPQLtQRSGLQ_
PRKCAP17252humanPPP1R1AQ13522T75PRQRKKMtRItPTMKDARPP-32
PRKCAP17252humanTNNI3P19429S42AKKKskIsAsRKLQL
PRKCAP17252humanBCL11BQ9C0K0S2______MsRRKQGNP
PRKCAP17252humanKITP10721S746RRsVRIGsyIERDVTPK_Tyr_Ser-Thr
PRKCAP17252humanNCF1P14598S304GAPPRRssIRNAHsINECFESHC
PRKCAP17252humanAQP1P29972T239APRSsDLtDRVKVWT
PRKCAP17252humanC5AR1P21730S327RNVLtEEsVVREsKs
PRKCAP17252humanBNC1Q01954S541KKksRKSsMPIkIEK
PRKCAP17252humanLRRK1Q38SD2S1064NRKVTIysFTGNQRN
PRKCAP17252humanHRH1P35367S396FTWKRLRsHsRQyVS7tm_1
PRKCAP17252humanMMP2P08253S160DVTPLRFsRIHDGEAPeptidase_M10
PRKCAP17252humanKRT20P35900S13RSFHRsLsSSLQAPV
PRKCAP17252humanTUBA1AQ71U36S165sVDyGkkskLEFSIyTubulin
PRKCAP17252humanRORAP35398S100CKGFFRRsQQSNATYzf-C4
PRKCAP17252humanPRKD2Q9BZL6S706ARIIGEksFRRsVVGPkinase
PRKCAP17252humanPRKD1Q15139S412PLMRVVQsVKHTKRK
PRKCAP17252humanPRKD2Q9BZL6S710GEksFRRsVVGtPAyPkinase
PRKCAP17252humanPLEKP08567S117ARKstRRsIRLPEtI
PRKCAP17252humanEWSR1Q01844S266SSYGQQSsFRQDHPS
PRKCAP17252humanCD226Q15762S329yVNyPTFsRRPKTRV
PRKCAP17252humanGSK3AP49840S21sGrARtssFAEPGGG
PRKCAP17252humanSLC6A3Q01959S12kCsVGLMssVVAPAK
PRKCAP17252humanARXQ96QS3S174VSISRSKsYRENGAP
PRKCAP17252humanZFP64Q9NTW7S226NKHLRIHsDERPFKCzf-H2C2_5
PRKCAP17252humanARHGAP35Q9NRY4S1221RRRNILRsLRRNtKKRhoGAP_pG1_pG2
PRKCAP17252humanANXA2P07355S12HEILCkLsLEGDHst
PRKCAP17252humanADRA1DP25100S300KRERGKAsEVVLRIH7tm_1
PRKCAP17252humanRAB37Q96AX2T172YGVPFLEtSAKTGMNRas
PRKCAP17252humanNCF1P14598S379DLILNRCsEstKRKLp47_phox_C
PRKCAP17252humanFRAT1Q92837S188RLQQRRGsQPETRTGGSK-3_bind
PRKCAP17252humanLRRK1Q38SD2T1075NQRNRCstFRVKRNQ
PRKCAP17252humanMYL9P24844S3_____MssKRAKAKt
PRKCAP17252humanAPLP2Q06481T723LRKRQYGtISHGIVEAPP_amyloid
PRKCAP17252humanGHSRQ92847T261RDQNHKQtVKMLAVV7tm_1
PRKCAP17252humanHRH1P35367T478CNENFKKtFKRILHI
PRKCAP17252humanMARCKSP29966S159kkKKKRFsFkKsFkLMARCKS
PRKCAP17252humanCELF1Q92879S241LLQQTASsGNLNTLS
PRKCAP17252humanCYP2E1P05181S129WKDIRRFsLttLRNYp450
PRKCAP17252humanNOX5Q96PH1-4S498RSVtMRKsQRSsKGSFAD_binding_8
PRKCAP17252humanTAGLN2P37802S185MGtNrGAsQAGMtGyCalponin
PRKCAP17252humanBEST1O76090S358SAQFRRAsFMGSTFN
PRKCAP17252humanITGB4P16144S1360VLRsPSGsQRPsVSD
PRKCAP17252humanTRPV1Q8NER1S801VPLLREAsARDRQsA
PRKCAP17252humanCYP3A4P08684T92TDPDMIKtVLVKECYp450
PRKCAP17252humanMYL9P24844T10sKRAKAKttKKRPQR
PRKCAP17252humanCYP2E1P05181T58KNIPKsFtRLAQRFGp450
PRKCAP17252humanDTNBO60941T179KEVLKLPtAVFEGPSEF-hand_3
PRKCAP17252humanAPPL1Q9UKG1S430ARTSssGsLGSESTN
PRKCAP17252humanERBB2P04626T686QQKIRKYtMRRLLQE
PRKCAP17252humanCLDN4O14493S194PRTDKPysAKysAAR
PRKCAP17252humanMMP2P08253T378GKMWCAttANYDDDRPeptidase_M10; fn2
PRKCAP17252humanLRP1Q07954S4520GGHGsRHsLAsTDEk
PRKCAP17252humanTNNI3P19429S199RkNIDALsGMEGRKK
PRKCAP17252humanABCB1P08183S661SSNDSRSsLIRKRsT
PRKCAP17252humanNR1H4Q96RI1-2S135VVCGDRAsGYHYNALzf-C4
PRKCAP17252humanMBD4O95243S262sGFVQSDsKRESVCN
PRKCAP17252humanKCNJ1P48048S201FSKNAVIskRGGKLCIRK_C
PRKCAP17252humanMAPTP10636-8S258PDLkNVKskIGstENTubulin-binding
PRKCAP17252humanABCB1P08183S667SsLIRKRsTRRsVRG
PRKCAP17252humanCFL1P23528S24DMkVRksstPEEVkkCofilin_ADF
PRKCAP17252humanNHERF1O14745S162CtMKKGPsGyGFNLHPDZ
PRKCAP17252humanTP53P04637T377kskkGQstsRHkkLM
PRKCAP17252humanPANX1Q96RD7Y199KYPIVEQyLkTkkNSInnexin
PRKCAP17252humanSNAP25P60880S187RIMEKADsNKTRIDE
PRKCAP17252humanANXA1P04083S27EyVQtVksskGGPGs
PRKCAP17252humanDOCK8Q8NF50S2087RDsFHRSsFRKCETQ
PRKCAP17252humanRALBP1Q15311S353LSPTVQIsNRVLYVFRhoGAP
PRKCAP17252humanCYP3A4P08684S139LLsPtFTsGKLKEMVp450
PRKCAP17252humanPAK5Q9P286S99ISVTRSNsLRKESPP
PRKCAP17252humanCYTH2Q99418S392AARKKRIsVKKKQEQ
PRKCAP17252humanATF2P15336S121LAtPIIRsKIEEPSV
PRKCAP17252humanCTNND1O60716S879LIDRNQksDkkPDRE
PRKCAP17252humanMBD4O95243S165CSMAALTsHLQNQSN
PRKCAP17252humanCYP2E1P05181S74VFtLYVGsQRMVVMHp450
PRKCAP17252humanKIR3DL1P43629S415QRKITRPsQRPKtPP
PRKCAP17252humanMARCKSP29966S167FkKsFkLsGFsFkKNMARCKS
PRKCAP17252humanPDE3AQ14432S292VFkRRRRsssVVsAE
PRKCAP17252humanCD36P16671T92VKQRGPYtYRVRFLACD36
PRKCAP17252humanTP53P04637S371AHssHLkskkGQsts
PRKCAP17252humanTTNQ8WZ42S12022RRKLRPGsGGEKPPD
PRKCAP17252humanGSK3BP49841S9SGRPRttsFAEsCkP
PRKCAP17252humanLRRK1Q38SD2S1074GNQRNRCstFRVKRN
PRKCAP17252humanFXYD1O00168S88RssIRRLstRRR___
PRKCAP17252humanFSCN1Q16658S39KVNASAssLkkkQIWFascin
PRKCAP17252humanVTNP04004S386YRsQRGHsRGRNQNs
PRKCAP17252humanELAVL1Q15717S221QAQrFrFsPMGVDHM
PRKCAP17252humanTACSTD2P09758S322GELRkEPsL______
PRKCAP17252humanRALBP1Q15311S509FLRRQIAsEKEEIER
PRKCAP17252humanPA2G4Q9UQ80S360ELkALLQssAsRKtQ
PRKCAP17252humanNF1P21359-2S2808QKQRSAGsFKRNsIK
PRKCAP17252humanPEBP1P30086S153RGKFkVAsFRKKYELPBP
PRKCAP17252humanDNM1Q05193S778GRRsPtssPtPQRRA
PRKCAP17252humanRAF1P04049S499VksRWsGsQQVEQPTPK_Tyr_Ser-Thr
PRKCAP17252humanC5AR1P21730S338EsKsFTRsTVDTMAQ
PRKCAP17252humanPRKD3O94806S731ARIIGEksFRRsVVGPkinase
PRKCAP17252humanARP10275S579YGALTCGsCKVFFKRzf-C4
PRKCAP17252humanPDE3AQ14432S428IPKRLRRsLPPGLLR
PRKCAP17252humanCYP2E1P05181T132IRRFsLttLRNYGMGp450
PRKCAP17252humanBCL2P10415S70RDPVARtsPLQtPAA
PRKCAP17252humanCELF1Q92879S52INVLRDRsQNPPQSkRRM_1
PRKCAP17252humanPACSIN2Q9UNF0S313ADLNRtLsRREKKKA
PRKCAP17252humanF11RQ9Y624S284kVIysQPsARsEGEF
PRKCAP17252humanABCB1P08183S671RKRsTRRsVRGsQAQ
PRKCAP17252humanADRA1DP25100S323DGAHGMRsAKGHtFR7tm_1
PRKCAP17252humanCYP3A4P08684T136LRsLLsPtFTsGKLKp450
PRKCAP17252humanRPS6KB2Q9UBS0S473PPSGTKKsKRGRGRP
PRKCAP17252humanSATB1Q01826S185DLPPEQWsHTtVRNACUTL
PRKCAP17252humanCD4P01730S433RRQAERMsQIkRLLsTcell_CD4_C
PRKCAP17252humanPTPN12Q05209S39FMRLRRLstKYRTEK
PRKCAP17252humanACO1P21399S711REFNSYGsRrGNDAVAconitase_C
PRKCAP17252humanTBXA2RP21731S145FSRPAVAsQRRAWAT7tm_1
PRKCAP17252humanSNAP25P60880T138GGFIRRVtNDARENESNAP-25
PRKCAP17252humanINSRP06213S1064kTVNEsAsLRERIEFPK_Tyr_Ser-Thr
PRKCAP17252humanRAF1P04049S43FGyQRRAsDDGKLtD
PRKCAP17252humanFMNL2Q96PY5-3S1072RADAVRRsVRRRFDD
PRKCAP17252humanRORAP35398S35ETPLNQEsArKSEPP
PRKCAP17252humanSLC18A2Q05940S18WLQEsRRsRKLILFI
PRKCAP17252humanMMP2P08253S365NKyEsCtsAGRsDGKPeptidase_M10; fn2
PRKCAP17252humanSH2B1Q9NRF2S161sLRsVGRsVRGsVRG
PRKCAP17252humanRIGIO95786S8MTTEQRRsLQAFQDYCARD_2
PRKCAP17252humanPA2G4Q9UQ80T366QssAsRKtQKKKKKk
PRKCAP17252humanRETP07949T675PISSAEMtFRRPAQA
PRKCAP17252humanCYSLTR1Q9Y271S316FRKHsLssVTYVPRK
PRKCAP17252humanCFLARO15519-2S193LQAAIQKsLKDPSNN
PRKCAP17252humanGRK2P25098S29ATPAARAskkILLPE
PRKCAP17252humanVIMP08670S10trsVssssyrrMFGGFilament_head
PRKCAP17252humanPITPNC1Q9UKF7S299KDRPRKKsAPEtLtL
PRKCAP17252humanC5AR1P21730S334sVVREsKsFTRsTVD
PRKCAP17252humanVIMP08670S5___MStrsVssssyr
PRKCAP17252humanEIF4G1Q04637S1185RtPATKRsFskEVEE
PRKCAP17252humanTRPC3Q13507S785PPFsLVPsPKsFVyF
PRKCAP17252humanNHERF1O14745S77ETHQQVVsRIRAALNPDZ
PRKCAP17252humanKCNC4Q03721S15ssYRGRKsGNKPPsKPotassium_chann
PRKCAP17252humanCLDN1O95832T191CSCPRkTtsYPtPRP
PRKCAP17252humanCTPS1P17812S462tLFQTkNsVMRkLYGGATase
PRKCAP17252humanTGFBR1P36897T200LPLLVQRtIARtIVLTGF_beta_GS
PRKCAP17252humanIQGAP1P46940S1443DKMKKsksVkEDsNL
PRKCAP17252humanNR2F6P10588S83CKSFFKRsIRRNLsYzf-C4
PRKCAP17252humanKLHL3Q9UH77S433PMNTRRSsVGVGVVEKelch_1
PRKCAP17252humanTBXA2RP21731-2T399LLPFEPPtGKALSRK
PRKCAP17252humanPPP1R1AQ13522S67LKSTLAMsPRQRKKMDARPP-32
PRKCAP17252humanCSNK1DP48730T161KKYRDARtHQHIPYRPkinase
PRKCAP17252humanELAVL1Q15717S158FIRFDKRsEAEEAITRRM_1
PRKCAP17252humanPRKD1Q15139S738ARIIGEksFRRsVVGPkinase
PRKCAP17252humanGJA1P17302S372sRAssRAssRPRPDD
PRKCAP17252humanARHGAP35Q9NRY4T1226LRsLRRNtKKPKPKPRhoGAP_pG1_pG2
PRKCAP17252humanELAVL1Q15717S318GDkILQVsFkTNkSH
PRKCAP17252humanPDE3AQ14432S312SKSHRRTsLPCIPRE
PRKCAP17252humanKITP10721S741TkADkRRsVRIGsyIPK_Tyr_Ser-Thr
PRKCAP17252humanCORO1BQ9BR76S2______MsFRKVVRQ
PRKCAP17252humanCFTRP13569S660FSAERRNsILTETLHCFTR_R
PRKCAP17252humanKCNJ13O60928S201TRPSPLTsVRVSAVLIRK_C
PRKCAP17252humanCLDN7O95471S204VPRsYPksNsskEyV
PRKCAP17252humanPDE3AQ14432S438PGLLRRVsstWtttt
PRKCAP17252humanKRASP01116-2S181GKKKKkKskTkCVIM
PRKCAP17252humanPDE3AQ14432S492MTLTkSRsFtSSyAI
PRKCAP17252humanSHOC2Q9UQ13S297GLRYNRLsAIPRSLALRR_8
PRKCAP17252humanNCF1P14598S315AHsIHQRsRKRLsQDNECFESHC
PRKCAP17252humanCFTRP13569S686WTEtKKQsFKQTGEFCFTR_R
PRKCAP17252humanCYP3A4P08684S398GVVVMIPsYALHRDPp450
PRKCAP17252humanPTPN6P29350S591DKEKsKGsLKRK___
PRKCAP17252humanADD2P35612S713KKKFRtPsFLKKsKK
PRKCAP17252humanGNAZP19086S27DRHLRSEsQRQRREIG-alpha
PRKCAP17252humanJAK2O60674T174kVPVTHEtQEECLGMFERM_F2
PRKCAP17252humanSLC6A4P31645S277IWKGVKtsGKVVWVTSNF
PRKCAP17252humanNR1I3Q14994T38CKGFFRRtVSKSIGPzf-C4
PRKCAP17252humanAHRP35869S12SANITYAsRKRRKPV
PRKCAP17252humanKCNJ4P48050T53IFTTCVDtRWRYMLMIRK
PRKCAP17252humanSPICQ8N5J4Y191KIRRKLTyQFSEAILEts
PRKCAP17252humanADD1P35611S726KKKFRtPsFLKKsKK
PRKCAP17252humanCFLARO15519S193LQAAIQksLkDPSNN
PRKCAP17252humanRGS7P49802S434YKLMKSDsYPRFIRSRGS
PRKCAP17252humanKCNQ2O43526T217RMDRRGGtWKLLGSVIon_trans; TM
PRKCAP17252humanPDE3AQ14432S465VRRDRsTsIkLQEAP
PRKCAP17252humanPPARGP37231T166CKGFFRRtIRLKLIY
PRKCAP17252humanNOX5Q96PH1-4S490GRGSKRLsRSVtMRKFAD_binding_8
PRKCAP17252humanCYP3A4P08684S119GFMksAIsIAEDEEWp450
PRKCAP17252humanGPSM2P81274S408PKLGRRHsMENMELM
PRKCAP17252humanPIM1P11309-2S65HSHSPRHsLRHSPGS
PRKCAP17252humanNCF1P14598S328QDAYRRNsVRFLQQRNECFESHC
PRKCAP17252humanRASSF1Q9NS23-2S197RGPGRGTsVRRRtsF
PRKCAP17252humanNCF4Q15080T154LRRLRPRtRKVKSVs
PRKCAP17252humanCYP3A4P08684S420kFLPERFsKKNKDNIp450
PRKCAP17252humanNKX3-1Q99801S48RQGGRTSsQRQRDPE
PRKCAP17252humanTP53P04637S378skkGQstsRHkkLMF
PRKCAP17252humanROBO3Q96MS0S1330WLPYSRPsFLSrGQG
PRKCAP17252humanCD5P06127T434MsFHRNHtAtVRsHA
PRKCAP17252humanSLC6A3Q01959S7_MsKskCsVGLMssV
PRKCAP17252humanTP73O15350S388VPQPLVDsYRQQQQL
PRKCAP17252humanGNMTQ14749S10DSVYRtRsLGVAAEG
PRKCAP17252humanCHATP28329-3S476HKAAVPAsEKLLLLKCarn_acyltransf
PRKCAP17252humanAFAP1Q8N556S277AELEKKLssERPssD
PRKCAP17252humanPPP1R16BQ96T49S331sQLRHKSsLsRRTsS
PRKCAP17252humanVDRP11473S51CKGFFRRsMKRKALFzf-C4
PRKCAP17252humanMMP2P08253T250EYNsCTDtGRSDGFLPeptidase_M10; fn2
PRKCAP17252humanF3P13726S290GQsWkENsPLNVs__
PRKCAP17252humanMYL9P24844S2______MssKRAKAK
PRKCAP17252humanGJA1P17302S368QRPssRAssRAssRP
PRKCAP17252humanCYP2E1P05181T373SNLPHEAtRDtIFrGp450
PRKCAP17252humanADRA1DP25100S516QLRAKVssLsHKIRA
PRKCAP17252humanKCNK9Q9NPC2T341IEEISPStLKNSLFP
PRKCAP17252humanCELF1Q92879S178AQtMEGCssPMVVkFRRM_1
PRKCAP17252humanCYP3A4P08684S134kRLRsLLsPtFTsGKp450
PRKCAP17252humanCYP2E1P05181T131DIRRFsLttLRNYGMp450
PRKCAP17252humanDLG1Q12959T657KERARLKtVkFNsKT
PRKCAP17252humanCHATP28329-3S346LLKHVTQssRKLIRACarn_acyltransf
PRKCAP17252humanCFTRP13569S795TAsTRKVsLAPQANLCFTR_R
PRKCAP17252humanH3C1P68431T6__ArtkQtArkstGGHistone
PRKCAP17252humanCSNK1DP48730S191THLGIEQsRRDDLESPkinase
PRKCAP17252humanSCN9AQ15858-3I848LNMLIKIiGNSVGALIon_trans
PRKCAP17252humanEGLN2Q96KS0S234QRAIPPRsIRGDQIA
PRKCAP17252humanCD44P16070S672AVCIAVNsRRRCGQK
PRKCAP17252humanCYP3A4P08684T103KECYsVFtNRRPFGPp450
PRKCAP17252humanHABP4Q5JVS0T375GRGARGGtRGGRGRIIHABP4_N
PRKCAP17252humanPRKD2Q9BZL6S876QGLAERIsVL_____
PRKCAP17252humanTXNP10599T100NkEkLEAtINELV__Thioredoxin
PRKCAP17252humanGSTA4O15217T193VKLsNIPtIKRFLEPGST_C_3
PRKCAP17252humanTNNT2P45379S189ARKKKALsNMMHFGGTroponin
PRKCAP17252humanPPP1R14BQ96C90T57VRRQGKVtVkYDRKEPP1_inhibitor
PRKCAP17252humanFERMT3Q86UX7S484LSLQRtGsGGPGNHPFERM_M
PRKCAP17252humanTRPV5Q9NQA5S654yVEVFKNsDKEDDQE
PRKCAP17252humanVTNP04004S381RNRKGYRsQRGHsRG
PRKCAP17252humanEP300Q09472S89SELLRSGsSPNLNMG
PRKCAP17252humanIKBKBO14920S177AkELDQGsLCtsFVGPkinase
PRKCAP17252humanICOSLGO75144S285RDRCLQHsYAGAWAV
PRKCAP17252humanTUBA1CQ9BQE3S158sLLMERLsVDyGkksTubulin
PRKCAP17252humanC5AR1P21730S317RLRKsLPsLLRNVLt
PRKCAP17252humanIL2RAP01589T271RQRKsRRtI______
PRKCAP17252humanCYP2E1P05181T432DYFkPFstGkRVCAGp450
PRKCAP17252humanCSNK1DP48730T176ENkNLtGtARYAsINPkinase
PRKCAP17252humanPLEKP08567S113GQKFARKstRRsIRL
PRKCAP17252humanADRA1DP25100S518RAKVssLsHKIRAGG
PRKCAP17252humanDOCK8Q8NF50S2077KPIFRVEsQKRDsFH
PRKCAP17252humanHDAC5Q9UQL6S259FPLRkTAsEPNLKVR
PRKCAP17252humanFFAR4Q5NUL3-1T363PEKGAILtDtsVKRN
PRKCAP17252humanSHOC2Q9UQ13T71VAFSVDNtIKRPNPA
PRKCAP17252humanTRPM4Q8TD43S1145RDKRESDsERLKRTs
PRKCAP17252humanVIMP08670S7_MStrsVssssyrrMFilament_head
PRKCAP17252humanXRCC6P12956S78YISKIIssDRDLLAVKu_N
PRKCAP17252humanACO1P21399S138DFNRRADsLQkNQDLAconitase
PRKCAP17252humanH2BC3P33778S32DGKkRKRsRkEsysIHistone
PRKCAP17252humanCYP2E1P05181S145MGKQGNEsRIQREAHp450
PRKCAP17252humanAHRP35869S36EGIkSNPsKRHRDRLHLH
PRKCAP17252humanPRKCEQ02156S368NNIRKALsFDNRGEE
PRKCAP17252humanMARCKSP29966S170sFkLsGFsFkKNKkEMARCKS
PRKCAP17252humanCD3GP09693S148GVRQsRAsDkQTLLP
PRKCAP17252humanNCF1P14598S303RGAPPRRssIRNAHsNECFESHC
PRKCAP17252humanFFAR4Q5NUL3-1S373sVKRNDLsIIsG___
PRKCAP17252humanCD300LFQ8TDQ1T221GTsPQKAtTKLSSAQSIT
PRKCAP17252humanIKBKBO14920S181DQGsLCtsFVGTLQyPkinase
PRKCAP17252humanILKQ13418T181RTRPRNGtLNkHsGI
PRKCAP17252humanTHOC5Q13769S5___MSSEssKKRKPK
PRKCAP17252humanF3P13726S285RKAGVGQsWkENsPL
PRKCAP17252humanTAGLN2P37802T180VIGLQMGtNrGAsQACalponin
PRKCAP17252humanPTGIRP43119S328TPLSQLAsGRRDPRA
PRKCAP17252humanTAGLN2P37802S11rGPAyGLsREVQQkI
PRKCAP17252humanNOXO1Q8NFA2-3S154SRAAGRLsIHSLEAQ
PRKCAP17252humanILKQ13418T173DTFWkGttRTRPRNG
PRKCAP17252humanCYP3A4P08684S259SVKRMKEsRLEDtQKp450
PRKCAP17252humanGSTP1P09211S185SAYVGRLsARPkLkAGST_C_3
PRKCAP17252humanPRKD1Q15139S742GEksFRRsVVGtPAyPkinase
PRKCAP17252humanHABP4Q5JVS0T354RKPANDItSQLEINFIHABP4_N
PRKCAP17252humanPLCB3Q01970S1105LDRKRHNsIsEAKMRPLC-beta_C
PRKCAP17252humanEPB41P11171-4S331RTASKRAsRSLDGAAFA
PRKCAP17252humanCD5P06127T436FHRNHtAtVRsHAEN
PRKCAP17252humanTAGLNQ01995S181VIGLQMGsNrGAsQACalponin
PRKCAP17252humanPLD2O14939S243RWLVVKDsFLLYMCL
PRKCAP17252humanCYBAP13498T147ERPQIGGtIkQPPsNCytochrom_B558a
PRKCAP17252humanSUN1O94901S55sPRMsRRsLRLATTA
PRKCAP17252humanADD1P35611S716GsPGKsPsKKKKKFR
PRKCAP17252humanCFTRP13569S641QNLQPDFsSKLMGCDCFTR_R
PRKCAP17252humanRASSF1Q9NS23-2S203TsVRRRtsFYLPKDARA
PRKCAP17252humanNCF1P14598S359EERQtQRsKPQPAVPp47_phox_C
PRKCAP17252humanVASPP50552S157EHIERRVsNAGGPPA
PRKCAP17252humanCYP2E1P05181T376PHEAtRDtIFrGYLIp450
PRKCAP17252humanTTNQ8WZ42S11878KEEVVLKsVLRKRPE
PRKCAP17252humanBDKRB2P30411S373sMGTLRTsIsVERQI
PRKCAP17252humanNPHS1O60500T1120EYEESQWtGERDtQS
PRKCAP17252humanSCN5AQ14524S1503NAMKKLGsKKPQKPI
PRKCAP17252humanCFTRP13569S813DIYsRRLsQEtGLEICFTR_R
PRKCAP17252humanNMNAT1Q9HAN9S136WTETQDSsQKKSLEPCTP_transf_like
PRKCAP17252humanTHOC5Q13769S6__MSSEssKKRKPKV
PRKCAP17252humanCYP2E1P05181T121IIFNNGPtWKDIRRFp450
PRKCAP17252humanGRIA1P42261S834EFcYKsRsEsKRMKG
PRKCAP17252humanDRD2P14416S229RVNtkRssRAFRAHL7tm_1
PRKCAP17252humanTNNI3P19429S24APIRRRssNyRAyAtTroponin-I_N
PRKCAP17252humanRALBP1Q15311T297ACGRTTEtEkVQEFQRhoGAP
PRKCAP17252humanDTNBO60941T69FRDNGLNtLDHTTEIEF-hand_2
PRKCAP17252humanIGFBP1P08833S194LAKAQETsGEEIsKFThyroglobulin_1
PRKCAP17252humanGPR15P49685S357FARRRKRsVsL____
PRKCAP17252humanDRD2P14416S228kRVNtkRssRAFRAH7tm_1
PRKCAP17252humanMETP08581S985PHLDRLVsARsVsPt
PRKCAP17252humanGRIA1P42261S849FCLIPQQsINEAIRT
PRKCAP17252humanTWIST1Q15672S144tLPSDkLskIQTLkLHLH
PRKCAP17252humanMAPTP10636-8S305kHVPGGGsVQIVykPTubulin-binding
PRKCAP17252humanKCNA5P22460T15LENGGAMtVRGGDEA
PRKCAP17252humanAKT1P31749T308kDGAtMKtFCGtPEyPkinase
PRKCAP17252humanITGB4P16144S1494tLtRDyNsLtRsEHs


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKCAIDDescription0.00e+00
PRKCAGO:0042060wound healing2.48e-16
PRKCAGO:0009410response to xenobiotic stimulus5.28e-12
PRKCAGO:0001667ameboidal-type cell migration5.28e-12
PRKCAGO:0050878regulation of body fluid levels5.72e-12
PRKCAGO:0050673epithelial cell proliferation5.72e-12
PRKCAGO:0036293response to decreased oxygen levels5.72e-12
PRKCAGO:0070482response to oxygen levels5.84e-12
PRKCAGO:0034765regulation of monoatomic ion transmembrane transport3.23e-11
PRKCAGO:0001666response to hypoxia5.67e-11
PRKCAGO:0003012muscle system process1.36e-10
PRKCAGO:0050678regulation of epithelial cell proliferation2.93e-10
PRKCAGO:0006816calcium ion transport4.36e-10
PRKCAGO:0010038response to metal ion4.54e-10
PRKCAGO:0043491phosphatidylinositol 3-kinase/protein kinase B signal transduction9.65e-10
PRKCAGO:0007015actin filament organization9.65e-10
PRKCAGO:1901653cellular response to peptide9.65e-10
PRKCAGO:0018105peptidyl-serine phosphorylation1.24e-09
PRKCAGO:0030522intracellular receptor signaling pathway1.38e-09
PRKCAGO:0048732gland development1.38e-09
PRKCAGO:0097553calcium ion transmembrane import into cytosol2.51e-09
PRKCAGO:0018209peptidyl-serine modification2.51e-09
PRKCAGO:1902074response to salt2.59e-09
PRKCAGO:1903522regulation of blood circulation2.93e-09
PRKCAGO:0070372regulation of ERK1 and ERK2 cascade3.08e-09
PRKCAGO:0043410positive regulation of MAPK cascade5.42e-09
PRKCAGO:0031623receptor internalization5.56e-09
PRKCAGO:1903829positive regulation of protein localization5.56e-09
PRKCAGO:0007596blood coagulation9.11e-09
PRKCAGO:0070371ERK1 and ERK2 cascade1.12e-08
PRKCAGO:0010959regulation of metal ion transport1.21e-08
PRKCAGO:0050817coagulation1.23e-08
PRKCAGO:0036294cellular response to decreased oxygen levels1.23e-08
PRKCAGO:1904375regulation of protein localization to cell periphery1.25e-08
PRKCAGO:0007265Ras protein signal transduction1.27e-08
PRKCAGO:0007599hemostasis1.27e-08
PRKCAGO:0010631epithelial cell migration1.31e-08
PRKCAGO:0090132epithelium migration1.51e-08
PRKCAGO:0071496cellular response to external stimulus1.56e-08
PRKCAGO:0051098regulation of binding1.62e-08
PRKCAGO:0090130tissue migration1.85e-08
PRKCAGO:0048511rhythmic process2.37e-08
PRKCAGO:0045785positive regulation of cell adhesion2.38e-08
PRKCAGO:0003018vascular process in circulatory system2.40e-08
PRKCAGO:0007159leukocyte cell-cell adhesion2.48e-08
PRKCAGO:0043254regulation of protein-containing complex assembly2.48e-08
PRKCAGO:0051099positive regulation of binding2.98e-08
PRKCAGO:0071453cellular response to oxygen levels3.84e-08
PRKCAGO:0062012regulation of small molecule metabolic process4.19e-08
PRKCAGO:0046879hormone secretion4.23e-08

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Related Drugs to PRKCA_OLA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PRKCA-OLA1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PRKCA_OLA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate