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Kinase Fusion Gene:PRKCA_PHB |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: PRKCA_PHB | KinaseFusionDB ID: KFG4912 | FusionGDB2.0 ID: KFG4912 | Hgene | Tgene | Gene symbol | PRKCA | PHB | Gene ID | 5578 | 5245 | |
Gene name | protein kinase C alpha | prohibitin 1 | ||||||||||
Synonyms | AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA | HEL-215|HEL-S-54e|PHB | ||||||||||
Cytomap | 17q24.2 | 17q21.33 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | protein kinase C alpha typePKC-Aaging-associated gene 6 | prohibitin 1epididymis luminal protein 215epididymis secretory sperm binding protein Li 54eprohibitin | ||||||||||
Modification date | 20240403 | 20240407 | ||||||||||
UniProtAcc | P17252 | P35232 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000583361, ENST00000413366, | ENST00000300408, ENST00000511832, ENST00000508009, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRKCA [Title/Abstract] AND PHB [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKCA(64302245)-PHB(47490653), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRKCA | GO:0006468 | protein phosphorylation | 10770950 |
Hgene | PRKCA | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
Hgene | PRKCA | GO:0043687 | post-translational protein modification | 20228790 |
Hgene | PRKCA | GO:0090330 | regulation of platelet aggregation | 12724315 |
Hgene | PRKCA | GO:0110063 | positive regulation of angiotensin-activated signaling pathway | 25313067 |
Tgene | PHB | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16964284 |
Tgene | PHB | GO:0006355 | regulation of DNA-templated transcription | 14500729 |
Tgene | PHB | GO:0010944 | negative regulation of transcription by competitive promoter binding | 18487222 |
Tgene | PHB | GO:0039529 | RIG-I signaling pathway | 31522117 |
Tgene | PHB | GO:0040029 | epigenetic regulation of gene expression | 12466959 |
Tgene | PHB | GO:0045892 | negative regulation of DNA-templated transcription | 12065415|12566959 |
Tgene | PHB | GO:0045893 | positive regulation of DNA-templated transcription | 14500729 |
Tgene | PHB | GO:0045917 | positive regulation of complement activation | 17070910 |
Tgene | PHB | GO:0050821 | protein stabilization | 18339324 |
Tgene | PHB | GO:0050847 | progesterone receptor signaling pathway | 16964284 |
Tgene | PHB | GO:0060766 | negative regulation of androgen receptor signaling pathway | 16964284 |
Tgene | PHB | GO:0071354 | cellular response to interleukin-6 | 17324931 |
Tgene | PHB | GO:0072538 | T-helper 17 type immune response | 31899195 |
Tgene | PHB | GO:0140374 | antiviral innate immune response | 31522117 |
Tgene | PHB | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway | 16964284 |
Kinase Fusion gene breakpoints across PRKCA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across PHB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-A8-A08J-01A | PRKCA | chr17 | 64302245 | PHB | chr17 | 47490653 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:64302245/:47490653) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PRKCA | PHB |
FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteasomal degradation (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}. | FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:P67778, ECO:0000250|UniProtKB:P67779, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; FUNCTION: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:P67778, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305}.; FUNCTION: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (PubMed:14500729). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (PubMed:31899195). {ECO:0000269|PubMed:14500729, ECO:0000269|PubMed:31899195}.; FUNCTION: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:P67778}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PRKCA_PHB |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
PRKCA | P17252 | human | NOS3 | P29474 | T495 | TGITRKKtFKEVANA | |
PRKCA | P17252 | human | TACSTD2 | P09758 | S303 | VITNRRKsGKYKKVE | |
PRKCA | P17252 | human | JPH2 | Q9BR39 | S165 | PLRTsLssLRsEHsN | |
PRKCA | P17252 | human | TOP1 | P11387 | S21 | ADFRLNDsHKHKDKH | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S247 | AEVKEyVsERVkEHH | p450 |
PRKCA | P17252 | human | NCF4 | Q15080 | S315 | RQARGLPsQKRLFPW | PB1 |
PRKCA | P17252 | human | ANXA1 | P04083 | S28 | yVQtVksskGGPGsA | |
PRKCA | P17252 | human | PTPN1 | P18031 | S378 | RSRVVGGsLrGAQAA | |
PRKCA | P17252 | human | PLCG1 | P19174 | S1248 | HGrAREGsFEsRyQQ | |
PRKCA | P17252 | human | MAPT | P10636-8 | S352 | DFKDrVQskIGsLDN | Tubulin-binding |
PRKCA | P17252 | human | ADAP1 | O75689 | T276 | GFRkRWFtMDDRRLM | PH |
PRKCA | P17252 | human | SLC6A4 | P31645 | T603 | RLIITPGtFKERIIK | |
PRKCA | P17252 | human | ITGB2 | P05107 | S745 | FEkEKLksQWNNDNP | Integrin_b_cyt |
PRKCA | P17252 | human | GNAZ | P19086 | S16 | EKEAARRsRRIDRHL | G-alpha |
PRKCA | P17252 | human | C5AR1 | P21730 | S314 | FQGRLRKsLPsLLRN | |
PRKCA | P17252 | human | CDC42EP4 | Q9H3Q1 | S18 | sVHskRRsRADLtAE | |
PRKCA | P17252 | human | ARHGDIA | P52565 | S34 | ykPPAQKsIQEIQEL | Rho_GDI |
PRKCA | P17252 | human | CSNK1D | P48730 | T174 | YRENkNLtGtARYAs | Pkinase |
PRKCA | P17252 | human | XRCC6 | P12956 | S77 | VYISKIIssDRDLLA | Ku_N |
PRKCA | P17252 | human | CSNK1D | P48730 | S181 | tGtARYAsINTHLGI | Pkinase |
PRKCA | P17252 | human | NHERF1 | O14745 | S340 | RAHQKRssKRAPQMD | EBP50_C |
PRKCA | P17252 | human | ADAM17 | P78536 | T735 | kPFPAPQtPGRLQPA | |
PRKCA | P17252 | human | RRAD | P55042 | S257 | QIRLRRDsKEANARR | |
PRKCA | P17252 | human | SRF | P11831 | S162 | LRRYtTFsKRkTGIM | SRF-TF |
PRKCA | P17252 | human | VTN | P04004 | S393 | sRGRNQNsRRPsRAT | |
PRKCA | P17252 | human | ATP5F1C | P36542 | S146 | GILYRtHsDQFLVAF | ATP-synt |
PRKCA | P17252 | human | EGLN2 | Q96KS0 | S226 | LRDGQLVsQRAIPPR | |
PRKCA | P17252 | human | PPARA | Q07869 | S230 | VKARVILsGKASNNP | |
PRKCA | P17252 | human | EZR | P15311 | T567 | QGRDkyKtLRQIRQG | ERM_C |
PRKCA | P17252 | human | CDKN1A | P38936 | S146 | GRkRRQtsMTDFyHs | |
PRKCA | P17252 | human | SRF | P11831 | T159 | DNkLRRYtTFsKRkT | SRF-TF |
PRKCA | P17252 | human | CDC42EP4 | Q9H3Q1 | S80 | SskRsLLsRKFRGSK | PBD |
PRKCA | P17252 | human | GMFB | P60983 | S72 | QPRFIVYsYkYQHDD | Cofilin_ADF |
PRKCA | P17252 | human | CELF1 | Q92879 | S179 | QtMEGCssPMVVkFA | |
PRKCA | P17252 | human | KCNH2 | Q12809 | S890 | RQRKRKLsFRRRtDK | |
PRKCA | P17252 | human | ARHGAP35 | Q9NRY4 | S1236 | PKPKPRPsITKATWE | RhoGAP_pG1_pG2 |
PRKCA | P17252 | human | SPN | P16150 | S351 | tFFGRRKsRQGsLAM | |
PRKCA | P17252 | human | TRPV5 | Q9NQA5 | S299 | FLELVVSsDKREARQ | |
PRKCA | P17252 | human | FLOT1 | O75955 | S315 | QAEAEAAsVRMRGEA | |
PRKCA | P17252 | human | IGFBP1 | P08833 | S144 | NFHLMAPsEEDHSIL | |
PRKCA | P17252 | human | FLNC | Q14315 | S2624 | sSssRGssyssIPkF | |
PRKCA | P17252 | human | EIF6 | P56537 | S235 | QPstIAtsMRDsLID | |
PRKCA | P17252 | human | PTPN11 | Q06124 | S591 | GLMQQQksFR_____ | |
PRKCA | P17252 | human | CELF1 | Q92879 | S28 | GQVPrtWsEkDLREL | RRM_1 |
PRKCA | P17252 | human | MYH9 | P35579 | S1916 | AMNREVssLkNkLRr | Myosin_tail_1 |
PRKCA | P17252 | human | KCNE3 | Q9Y6H6 | S82 | LILGYTRsRKVDKRS | ISK_Channel |
PRKCA | P17252 | human | CTPS1 | P17812 | T455 | MRLGKRRtLFQTkNs | GATase |
PRKCA | P17252 | human | HRH1 | P35367 | S398 | WKRLRsHsRQyVSGL | 7tm_1 |
PRKCA | P17252 | human | CYP2E1 | P05181 | T69 | QRFGPVFtLYVGsQR | p450 |
PRKCA | P17252 | human | ANXA2 | P07355 | S26 | tPPsAyGsVkAytNF | |
PRKCA | P17252 | human | CYP3A4 | P08684 | T264 | KEsRLEDtQKHRVDF | p450 |
PRKCA | P17252 | human | NR1I2 | O75469 | T408 | RSINAQHtQRLLRIQ | Hormone_recep |
PRKCA | P17252 | human | SLC6A2 | P23975 | T258 | SLWKGVKtsGKVVWI | SNF |
PRKCA | P17252 | human | CSNK1D | P48730 | S53 | HPQLHIEskIYkMMQ | Pkinase |
PRKCA | P17252 | human | PLAU | P00749 | S158 | CADGKKPsSPPEELK | |
PRKCA | P17252 | human | CDKN2A | Q8N726 | T8 | MVRRFLVtLRIRRAC | P19Arf_N |
PRKCA | P17252 | human | CYSLTR1 | Q9Y271 | S315 | tFRKHsLssVTYVPR | |
PRKCA | P17252 | human | HDAC4 | P56524 | S632 | RPLSRAQssPAsAtF | |
PRKCA | P17252 | human | IL2RA | P01589 | S268 | WQRRQRKsRRtI___ | |
PRKCA | P17252 | human | SLC6A4 | P31645 | S149 | yHRNGCIsIWRKICP | SNF |
PRKCA | P17252 | human | CFTR | P13569 | S737 | EPLERRLsLVPDSEQ | CFTR_R |
PRKCA | P17252 | human | PPP2R5A | Q15172 | S41 | RQKRsQGssQFRsQG | |
PRKCA | P17252 | human | CFTR | P13569 | T682 | APVSWTEtKKQsFKQ | CFTR_R |
PRKCA | P17252 | human | RRAD | P55042 | S273 | AGTRRREsLGKKAKR | |
PRKCA | P17252 | human | ITGB4 | P16144 | S1356 | ysDDVLRsPSGsQRP | |
PRKCA | P17252 | human | KCNAB2 | Q13303 | S266 | IPPYSRAsLkGYQWL | Aldo_ket_red |
PRKCA | P17252 | human | MMP2 | P08253 | T377 | DGKMWCAttANYDDD | Peptidase_M10; fn2 |
PRKCA | P17252 | human | GRIN2A | Q12879 | S929 | ADFIQRGsLIMDMVS | NMDAR2_C |
PRKCA | P17252 | human | AQP1 | P29972 | T157 | VLCVLATtDRRRRDL | MIP |
PRKCA | P17252 | human | ITGB2 | P05107 | T758 | NPLFksAtttVMNPk | Integrin_b_cyt |
PRKCA | P17252 | human | CYP2E1 | P05181 | S56 | ELKNIPKsFtRLAQR | p450 |
PRKCA | P17252 | human | FLNC | Q14315 | S2623 | KsSssRGssyssIPk | |
PRKCA | P17252 | human | PRKCE | Q02156 | S316 | tPDKITNsGQRRkKL | |
PRKCA | P17252 | human | PLAU | P00749 | S323 | TGFGKENsTDYLYPE | Trypsin |
PRKCA | P17252 | human | LRP1 | Q07954 | S4523 | GsRHsLAsTDEkREL | |
PRKCA | P17252 | human | PDE3A | Q14432 | S293 | FkRRRRsssVVsAEM | |
PRKCA | P17252 | human | ADD2 | P35612 | S726 | KKKEKVEs_______ | |
PRKCA | P17252 | human | ULK1 | O75385 | S423 | GRAGPFSsSRCGAsV | |
PRKCA | P17252 | human | RRAD | P55042 | S214 | LVRSREVsVDEGRAC | Ras |
PRKCA | P17252 | human | TRPV6 | Q9H1D0 | T742 | WERLRQGtLRRDLRG | |
PRKCA | P17252 | human | KCNJ1 | P48048 | T193 | KKRAKtItFSKNAVI | IRK_C |
PRKCA | P17252 | human | VTN | P04004 | S397 | NQNsRRPsRATWLSL | |
PRKCA | P17252 | human | ADRA1D | P25100 | S334 | HtFRssLsVRLLKFS | 7tm_1 |
PRKCA | P17252 | human | ITGB1 | P05556 | S785 | GENPIyksAVttVVN | Integrin_b_cyt |
PRKCA | P17252 | human | EGLN2 | Q96KS0 | S132 | GGDAPsPsKRPWARQ | |
PRKCA | P17252 | human | ITGB4 | P16144-2 | S1424 | tLTRDyNsLTRSEHS | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S131 | EEWkRLRsLLsPtFT | p450 |
PRKCA | P17252 | human | MAPKAP1 | Q9BPZ7 | S128 | kSLFEKKsLKEKPPI | SIN1 |
PRKCA | P17252 | human | AKT1 | P31749 | S473 | RPHFPQFsysAsGtA | Pkinase_C |
PRKCA | P17252 | human | PPP1R14A | Q96A00 | T38 | QkRHARVtVkYDRRE | PP1_inhibitor |
PRKCA | P17252 | human | NCF1 | P14598 | S320 | QRsRKRLsQDAYRRN | NECFESHC |
PRKCA | P17252 | human | TP53 | P04637 | S376 | LkskkGQstsRHkkL | |
PRKCA | P17252 | human | NOXA1 | Q86UR1 | S172 | DQVQRRGsLPPRQVP | |
PRKCA | P17252 | human | CD4 | P01730 | S440 | sQIkRLLsEKKTCQC | Tcell_CD4_C |
PRKCA | P17252 | human | RALB | P11234 | S198 | KSSKNKKsFKERCCL | |
PRKCA | P17252 | human | RALBP1 | Q15311 | S118 | VFKKPsFsKKKEKDF | |
PRKCA | P17252 | human | TNNI3 | P19429 | S23 | PAPIRRRssNyRAyA | Troponin-I_N |
PRKCA | P17252 | human | TUBA1C | Q9BQE3 | S165 | sVDyGkkskLEFSIy | Tubulin |
PRKCA | P17252 | human | EPHA2 | P29317 | S892 | ADFDPRVsIRLPsts | |
PRKCA | P17252 | human | ARHGDIB | P52566 | S31 | ykPPPQksLkELQEM | Rho_GDI |
PRKCA | P17252 | human | SLC18A2 | Q05940 | S15 | LVRWLQEsRRsRKLI | |
PRKCA | P17252 | human | AQP4 | P55087 | S180 | TIFASCDsKRTDVTG | MIP |
PRKCA | P17252 | human | PTPN12 | Q05209 | S435 | KKLERNLsFEIKKVP | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S100 | VLVKECYsVFtNRRP | p450 |
PRKCA | P17252 | human | EGFR | P00533 | T678 | RHIVRKRtLRRLLQE | |
PRKCA | P17252 | human | GRK7 | Q8WTQ7 | S36 | ELQRRRRsLALPGLQ | |
PRKCA | P17252 | human | TFRC | P02786 | S24 | PLsytRFsLARQVDG | |
PRKCA | P17252 | human | INSR | P06213 | S1062 | AVkTVNEsAsLRERI | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | KCNC4 | Q03721 | S21 | KsGNKPPsKTCLKEE | Potassium_chann |
PRKCA | P17252 | human | AQP2 | P41181 | S256 | REVRRRQsVELHsPQ | |
PRKCA | P17252 | human | PRKAA1 | Q13131 | S496 | AtPQRsGsVsNyRSC | AdenylateSensor |
PRKCA | P17252 | human | PTPN11 | Q06124 | S576 | CAEMREDsARVyENV | |
PRKCA | P17252 | human | PRKG1 | Q13976 | T59 | THIGPRTtRAQGIsA | |
PRKCA | P17252 | human | SLC6A2 | P23975 | S259 | LWKGVKtsGKVVWIT | SNF |
PRKCA | P17252 | human | NOX5 | Q96PH1-4 | T494 | KRLsRSVtMRKsQRS | FAD_binding_8 |
PRKCA | P17252 | human | CASR | P41180 | S875 | TIEEVRCsTAAHAFK | |
PRKCA | P17252 | human | NCOR1 | O75376 | S70 | QQLRRRPsLLsEFHP | |
PRKCA | P17252 | human | EPB41 | P11171-4 | S312 | QAQTRQAsALIDRPA | FA |
PRKCA | P17252 | human | ADRA1D | P25100 | S332 | KGHtFRssLsVRLLK | 7tm_1 |
PRKCA | P17252 | human | CDKN1A | P38936 | S153 | sMTDFyHskRrLIFS | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S424 | ENGkFkYsDYFkPFs | p450 |
PRKCA | P17252 | human | GRIA1 | P42261 | S836 | cYKsRsEsKRMKGFC | |
PRKCA | P17252 | human | RIGI | O95786 | T170 | DkENWPktLkLALEk | CARD_2 |
PRKCA | P17252 | human | PPARA | Q07869 | S179 | RFGRMPRsEKAKLkA | |
PRKCA | P17252 | human | TNNI3 | P19429 | T143 | RGKFKRPtLRrVrIs | Troponin |
PRKCA | P17252 | human | RSC1A1 | Q92681 | S366 | LHELLVVsSkPASEN | |
PRKCA | P17252 | human | ADAP1 | O75689 | S87 | AARARFEsKVPSFYY | ArfGap |
PRKCA | P17252 | human | NHERF1 | O14745 | S339 | ERAHQKRssKRAPQM | EBP50_C |
PRKCA | P17252 | human | LCP1 | P13796 | S5 | ___MARGsVsDEEMM | |
PRKCA | P17252 | human | ARHGEF1 | Q92888 | S240 | TkSGDKKsGRNFFRK | |
PRKCA | P17252 | human | NRGN | Q92686 | S36 | AAAKIQAsFrGHMAR | IQ |
PRKCA | P17252 | human | MAPT | P10636-8 | S324 | kVTskCGsLGNIHHk | Tubulin-binding |
PRKCA | P17252 | human | VIM | P08670 | S8 | MStrsVssssyrrMF | Filament_head |
PRKCA | P17252 | human | UGT1A3 | P35503 | S43 | IDGSHWLsMREVLRE | UDPGT |
PRKCA | P17252 | human | GRIN2B | Q13224 | S1323 | ALAPRSVsLKDKGRF | NMDAR2_C |
PRKCA | P17252 | human | LCK | P06239 | S42 | tLLIRNGsEVRDPLV | |
PRKCA | P17252 | human | VIM | P08670 | S9 | StrsVssssyrrMFG | Filament_head |
PRKCA | P17252 | human | L1CAM | P32004 | T1172 | ARPMkDEtFGEyRSL | Bravo_FIGEY |
PRKCA | P17252 | human | RRAD | P55042 | S290 | GRIVARNsRKMAFRA | |
PRKCA | P17252 | human | PITPNC1 | Q9UKF7 | S274 | SVRsAPSsAPstPLs | |
PRKCA | P17252 | human | PGR | P06401 | S400 | GAEAsARsPRSYLVA | Prog_receptor |
PRKCA | P17252 | human | CYP2E1 | P05181 | T387 | GYLIPKGtVVVPTLD | p450 |
PRKCA | P17252 | human | MARCKS | P29966 | S163 | KRFsFkKsFkLsGFs | MARCKS |
PRKCA | P17252 | human | TRPM4 | Q8TD43 | S1152 | sERLKRTsQKVDLAL | |
PRKCA | P17252 | human | CELF1 | Q92879 | T173 | kAMHQAQtMEGCssP | RRM_1 |
PRKCA | P17252 | human | FBXW7 | Q969H0 | S10 | QELLSVGsKRRRTGG | |
PRKCA | P17252 | human | JAK2 | O60674 | S518 | VFRTNGVsDVPtsPT | |
PRKCA | P17252 | human | CFL1 | P23528 | S23 | NDMkVRksstPEEVk | Cofilin_ADF |
PRKCA | P17252 | human | PRKCE | Q02156 | S234 | EtPDQVGsQRFSVNM | |
PRKCA | P17252 | human | CYSLTR1 | Q9Y271 | S313 | LstFRKHsLssVTYV | |
PRKCA | P17252 | human | IGFBP1 | P08833 | S126 | GsPEsPEstEITEEE | |
PRKCA | P17252 | human | CELF1 | Q92879 | S302 | TSSGSsPsSSSSNSV | |
PRKCA | P17252 | human | FFAR4 | Q5NUL3-1 | S366 | GAILtDtsVKRNDLs | |
PRKCA | P17252 | human | KCNJ1 | P48048 | S4 | ____MNAsSRNVFDT | |
PRKCA | P17252 | human | IGFBP1 | P08833 | S123 | AEAGsPEsPEstEIT | |
PRKCA | P17252 | human | CASR | P41180 | T888 | FKVAARAtLRRsNVs | |
PRKCA | P17252 | human | DOCK8 | Q8NF50 | S2082 | VEsQKRDsFHRSsFR | |
PRKCA | P17252 | human | RELA | Q04206 | S536 | sGDEDFSsIADMDFS | |
PRKCA | P17252 | human | NOXO1 | Q8NFA2-3 | T341 | AIQSRCCtVTRRALE | |
PRKCA | P17252 | human | CHAT | P28329-3 | S440 | VPTYESAsIRRFQEG | Carn_acyltransf |
PRKCA | P17252 | human | PHB2 | Q99623 | S39 | VAyGVREsVFTVEGG | |
PRKCA | P17252 | human | FBXW7 | Q969H0 | S18 | KRRRTGGsLRGNPSs | |
PRKCA | P17252 | human | PLD2 | O14939 | T252 | LLYMCLEtGAISFVQ | |
PRKCA | P17252 | human | TBXA2R | P21731 | S331 | sTRPRsLsLQPQLtQ | |
PRKCA | P17252 | human | GRIN2B | Q13224 | S1415 | QPtVAGAsKARPDFR | NMDAR2_C |
PRKCA | P17252 | human | GRIK2 | Q13002 | S868 | MVEELRMsLKcQRRL | |
PRKCA | P17252 | human | LRP1 | Q07954 | T4460 | GFQHQRMtNGAMNVE | |
PRKCA | P17252 | human | NR1H4 | Q96RI1-2 | S154 | CKGFFRRsITKNAVY | zf-C4 |
PRKCA | P17252 | human | C5AR1 | P21730 | S332 | EEsVVREsKsFTRsT | |
PRKCA | P17252 | human | NLGN4X | Q8N0W4 | T707 | KDKRRHEtHRRPSPQ | |
PRKCA | P17252 | human | ARHGDIA | P52565 | S96 | DLTGDLEsFKkQsFV | Rho_GDI |
PRKCA | P17252 | human | HSPB1 | P04792 | S15 | FsLLrGPsWDPFrDW | |
PRKCA | P17252 | human | ARRB1 | P49407 | S163 | EkIHKRNsVRLVIRK | Arrestin_N |
PRKCA | P17252 | human | TNNI3 | P19429 | S44 | KKskIsAsRKLQLKt | |
PRKCA | P17252 | human | LRP1 | Q07954 | S4517 | LyMGGHGsRHsLAsT | |
PRKCA | P17252 | human | TBXA2R | P21731 | S324 | RRLQPRLsTRPRsLs | |
PRKCA | P17252 | human | CHAT | P28329-3 | S347 | LKHVTQssRKLIRAD | Carn_acyltransf |
PRKCA | P17252 | human | CYP3A4 | P08684 | S116 | GPVGFMksAIsIAED | p450 |
PRKCA | P17252 | human | TBXA2R | P21731 | S329 | RLsTRPRsLsLQPQL | |
PRKCA | P17252 | human | DTNB | O60941 | T212 | MLNMFLDtMMADPPP | EF-hand_3 |
PRKCA | P17252 | human | CSNK1D | P48730 | S298 | NMLKFGAsRAADDAE | |
PRKCA | P17252 | human | CORO1A | P31146 | T412 | RVNRGLDtGRRRAAP | Trimer_CC |
PRKCA | P17252 | human | CHAT | P28329-3 | T255 | TVLVKDStNRDSLDM | Carn_acyltransf |
PRKCA | P17252 | human | NCF1 | P14598 | S370 | PAVPPRPsADLILNR | p47_phox_C |
PRKCA | P17252 | human | NPHS1 | O60500 | T1125 | QWtGERDtQSSTVST | |
PRKCA | P17252 | human | PFKFB3 | Q16875 | S461 | NPLMRRNsVtPLAsP | |
PRKCA | P17252 | human | RRAD | P55042 | S299 | KMAFRAKsKsCHDLS | |
PRKCA | P17252 | human | EIF2S3 | P41091 | T66 | kAISGVHtVRFkNEL | GTP_EFTU |
PRKCA | P17252 | human | CYP3A4 | P08684 | T284 | DSQNSkEtESHKALS | p450 |
PRKCA | P17252 | human | ITGB2 | P05107 | T760 | LFksAtttVMNPkFA | Integrin_b_cyt |
PRKCA | P17252 | human | KCNMA1 | Q12791 | S1200 | SHSsQSSsKKSSsVH | |
PRKCA | P17252 | human | ITGB4 | P16144 | S1364 | PSGsQRPsVSDDTGC | |
PRKCA | P17252 | human | TRPV1 | Q8NER1 | S502 | YFLQRRPsMKTLFVD | Ion_trans |
PRKCA | P17252 | human | PTPN22 | Q9Y2R2 | S751 | kSFtRSKsLKILRNM | |
PRKCA | P17252 | human | MAPT | P10636-8 | S293 | NVQskCGsKDNIkHV | Tubulin-binding |
PRKCA | P17252 | human | CYP2E1 | P05181 | S431 | sDYFkPFstGkRVCA | p450 |
PRKCA | P17252 | human | TRPM2 | O94759-3 | S39 | NLRRSNSsLFKSWRL | |
PRKCA | P17252 | human | CELF1 | Q92879 | S300 | VLTSSGSsPsSSSSN | |
PRKCA | P17252 | human | SH2B1 | Q9NRF2 | S165 | VGRsVRGsVRGILQW | |
PRKCA | P17252 | human | TBXA2R | P21731 | T337 | LsLQPQLtQRSGLQ_ | |
PRKCA | P17252 | human | PPP1R1A | Q13522 | T75 | PRQRKKMtRItPTMK | DARPP-32 |
PRKCA | P17252 | human | TNNI3 | P19429 | S42 | AKKKskIsAsRKLQL | |
PRKCA | P17252 | human | BCL11B | Q9C0K0 | S2 | ______MsRRKQGNP | |
PRKCA | P17252 | human | KIT | P10721 | S746 | RRsVRIGsyIERDVT | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | NCF1 | P14598 | S304 | GAPPRRssIRNAHsI | NECFESHC |
PRKCA | P17252 | human | AQP1 | P29972 | T239 | APRSsDLtDRVKVWT | |
PRKCA | P17252 | human | C5AR1 | P21730 | S327 | RNVLtEEsVVREsKs | |
PRKCA | P17252 | human | BNC1 | Q01954 | S541 | KKksRKSsMPIkIEK | |
PRKCA | P17252 | human | LRRK1 | Q38SD2 | S1064 | NRKVTIysFTGNQRN | |
PRKCA | P17252 | human | HRH1 | P35367 | S396 | FTWKRLRsHsRQyVS | 7tm_1 |
PRKCA | P17252 | human | MMP2 | P08253 | S160 | DVTPLRFsRIHDGEA | Peptidase_M10 |
PRKCA | P17252 | human | KRT20 | P35900 | S13 | RSFHRsLsSSLQAPV | |
PRKCA | P17252 | human | TUBA1A | Q71U36 | S165 | sVDyGkkskLEFSIy | Tubulin |
PRKCA | P17252 | human | RORA | P35398 | S100 | CKGFFRRsQQSNATY | zf-C4 |
PRKCA | P17252 | human | PRKD2 | Q9BZL6 | S706 | ARIIGEksFRRsVVG | Pkinase |
PRKCA | P17252 | human | PRKD1 | Q15139 | S412 | PLMRVVQsVKHTKRK | |
PRKCA | P17252 | human | PRKD2 | Q9BZL6 | S710 | GEksFRRsVVGtPAy | Pkinase |
PRKCA | P17252 | human | PLEK | P08567 | S117 | ARKstRRsIRLPEtI | |
PRKCA | P17252 | human | EWSR1 | Q01844 | S266 | SSYGQQSsFRQDHPS | |
PRKCA | P17252 | human | CD226 | Q15762 | S329 | yVNyPTFsRRPKTRV | |
PRKCA | P17252 | human | GSK3A | P49840 | S21 | sGrARtssFAEPGGG | |
PRKCA | P17252 | human | SLC6A3 | Q01959 | S12 | kCsVGLMssVVAPAK | |
PRKCA | P17252 | human | ARX | Q96QS3 | S174 | VSISRSKsYRENGAP | |
PRKCA | P17252 | human | ZFP64 | Q9NTW7 | S226 | NKHLRIHsDERPFKC | zf-H2C2_5 |
PRKCA | P17252 | human | ARHGAP35 | Q9NRY4 | S1221 | RRRNILRsLRRNtKK | RhoGAP_pG1_pG2 |
PRKCA | P17252 | human | ANXA2 | P07355 | S12 | HEILCkLsLEGDHst | |
PRKCA | P17252 | human | ADRA1D | P25100 | S300 | KRERGKAsEVVLRIH | 7tm_1 |
PRKCA | P17252 | human | RAB37 | Q96AX2 | T172 | YGVPFLEtSAKTGMN | Ras |
PRKCA | P17252 | human | NCF1 | P14598 | S379 | DLILNRCsEstKRKL | p47_phox_C |
PRKCA | P17252 | human | FRAT1 | Q92837 | S188 | RLQQRRGsQPETRTG | GSK-3_bind |
PRKCA | P17252 | human | LRRK1 | Q38SD2 | T1075 | NQRNRCstFRVKRNQ | |
PRKCA | P17252 | human | MYL9 | P24844 | S3 | _____MssKRAKAKt | |
PRKCA | P17252 | human | APLP2 | Q06481 | T723 | LRKRQYGtISHGIVE | APP_amyloid |
PRKCA | P17252 | human | GHSR | Q92847 | T261 | RDQNHKQtVKMLAVV | 7tm_1 |
PRKCA | P17252 | human | HRH1 | P35367 | T478 | CNENFKKtFKRILHI | |
PRKCA | P17252 | human | MARCKS | P29966 | S159 | kkKKKRFsFkKsFkL | MARCKS |
PRKCA | P17252 | human | CELF1 | Q92879 | S241 | LLQQTASsGNLNTLS | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S129 | WKDIRRFsLttLRNY | p450 |
PRKCA | P17252 | human | NOX5 | Q96PH1-4 | S498 | RSVtMRKsQRSsKGS | FAD_binding_8 |
PRKCA | P17252 | human | TAGLN2 | P37802 | S185 | MGtNrGAsQAGMtGy | Calponin |
PRKCA | P17252 | human | BEST1 | O76090 | S358 | SAQFRRAsFMGSTFN | |
PRKCA | P17252 | human | ITGB4 | P16144 | S1360 | VLRsPSGsQRPsVSD | |
PRKCA | P17252 | human | TRPV1 | Q8NER1 | S801 | VPLLREAsARDRQsA | |
PRKCA | P17252 | human | CYP3A4 | P08684 | T92 | TDPDMIKtVLVKECY | p450 |
PRKCA | P17252 | human | MYL9 | P24844 | T10 | sKRAKAKttKKRPQR | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T58 | KNIPKsFtRLAQRFG | p450 |
PRKCA | P17252 | human | DTNB | O60941 | T179 | KEVLKLPtAVFEGPS | EF-hand_3 |
PRKCA | P17252 | human | APPL1 | Q9UKG1 | S430 | ARTSssGsLGSESTN | |
PRKCA | P17252 | human | ERBB2 | P04626 | T686 | QQKIRKYtMRRLLQE | |
PRKCA | P17252 | human | CLDN4 | O14493 | S194 | PRTDKPysAKysAAR | |
PRKCA | P17252 | human | MMP2 | P08253 | T378 | GKMWCAttANYDDDR | Peptidase_M10; fn2 |
PRKCA | P17252 | human | LRP1 | Q07954 | S4520 | GGHGsRHsLAsTDEk | |
PRKCA | P17252 | human | TNNI3 | P19429 | S199 | RkNIDALsGMEGRKK | |
PRKCA | P17252 | human | ABCB1 | P08183 | S661 | SSNDSRSsLIRKRsT | |
PRKCA | P17252 | human | NR1H4 | Q96RI1-2 | S135 | VVCGDRAsGYHYNAL | zf-C4 |
PRKCA | P17252 | human | MBD4 | O95243 | S262 | sGFVQSDsKRESVCN | |
PRKCA | P17252 | human | KCNJ1 | P48048 | S201 | FSKNAVIskRGGKLC | IRK_C |
PRKCA | P17252 | human | MAPT | P10636-8 | S258 | PDLkNVKskIGstEN | Tubulin-binding |
PRKCA | P17252 | human | ABCB1 | P08183 | S667 | SsLIRKRsTRRsVRG | |
PRKCA | P17252 | human | CFL1 | P23528 | S24 | DMkVRksstPEEVkk | Cofilin_ADF |
PRKCA | P17252 | human | NHERF1 | O14745 | S162 | CtMKKGPsGyGFNLH | PDZ |
PRKCA | P17252 | human | TP53 | P04637 | T377 | kskkGQstsRHkkLM | |
PRKCA | P17252 | human | PANX1 | Q96RD7 | Y199 | KYPIVEQyLkTkkNS | Innexin |
PRKCA | P17252 | human | SNAP25 | P60880 | S187 | RIMEKADsNKTRIDE | |
PRKCA | P17252 | human | ANXA1 | P04083 | S27 | EyVQtVksskGGPGs | |
PRKCA | P17252 | human | DOCK8 | Q8NF50 | S2087 | RDsFHRSsFRKCETQ | |
PRKCA | P17252 | human | RALBP1 | Q15311 | S353 | LSPTVQIsNRVLYVF | RhoGAP |
PRKCA | P17252 | human | CYP3A4 | P08684 | S139 | LLsPtFTsGKLKEMV | p450 |
PRKCA | P17252 | human | PAK5 | Q9P286 | S99 | ISVTRSNsLRKESPP | |
PRKCA | P17252 | human | CYTH2 | Q99418 | S392 | AARKKRIsVKKKQEQ | |
PRKCA | P17252 | human | ATF2 | P15336 | S121 | LAtPIIRsKIEEPSV | |
PRKCA | P17252 | human | CTNND1 | O60716 | S879 | LIDRNQksDkkPDRE | |
PRKCA | P17252 | human | MBD4 | O95243 | S165 | CSMAALTsHLQNQSN | |
PRKCA | P17252 | human | CYP2E1 | P05181 | S74 | VFtLYVGsQRMVVMH | p450 |
PRKCA | P17252 | human | KIR3DL1 | P43629 | S415 | QRKITRPsQRPKtPP | |
PRKCA | P17252 | human | MARCKS | P29966 | S167 | FkKsFkLsGFsFkKN | MARCKS |
PRKCA | P17252 | human | PDE3A | Q14432 | S292 | VFkRRRRsssVVsAE | |
PRKCA | P17252 | human | CD36 | P16671 | T92 | VKQRGPYtYRVRFLA | CD36 |
PRKCA | P17252 | human | TP53 | P04637 | S371 | AHssHLkskkGQsts | |
PRKCA | P17252 | human | TTN | Q8WZ42 | S12022 | RRKLRPGsGGEKPPD | |
PRKCA | P17252 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
PRKCA | P17252 | human | LRRK1 | Q38SD2 | S1074 | GNQRNRCstFRVKRN | |
PRKCA | P17252 | human | FXYD1 | O00168 | S88 | RssIRRLstRRR___ | |
PRKCA | P17252 | human | FSCN1 | Q16658 | S39 | KVNASAssLkkkQIW | Fascin |
PRKCA | P17252 | human | VTN | P04004 | S386 | YRsQRGHsRGRNQNs | |
PRKCA | P17252 | human | ELAVL1 | Q15717 | S221 | QAQrFrFsPMGVDHM | |
PRKCA | P17252 | human | TACSTD2 | P09758 | S322 | GELRkEPsL______ | |
PRKCA | P17252 | human | RALBP1 | Q15311 | S509 | FLRRQIAsEKEEIER | |
PRKCA | P17252 | human | PA2G4 | Q9UQ80 | S360 | ELkALLQssAsRKtQ | |
PRKCA | P17252 | human | NF1 | P21359-2 | S2808 | QKQRSAGsFKRNsIK | |
PRKCA | P17252 | human | PEBP1 | P30086 | S153 | RGKFkVAsFRKKYEL | PBP |
PRKCA | P17252 | human | DNM1 | Q05193 | S778 | GRRsPtssPtPQRRA | |
PRKCA | P17252 | human | RAF1 | P04049 | S499 | VksRWsGsQQVEQPT | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | C5AR1 | P21730 | S338 | EsKsFTRsTVDTMAQ | |
PRKCA | P17252 | human | PRKD3 | O94806 | S731 | ARIIGEksFRRsVVG | Pkinase |
PRKCA | P17252 | human | AR | P10275 | S579 | YGALTCGsCKVFFKR | zf-C4 |
PRKCA | P17252 | human | PDE3A | Q14432 | S428 | IPKRLRRsLPPGLLR | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T132 | IRRFsLttLRNYGMG | p450 |
PRKCA | P17252 | human | BCL2 | P10415 | S70 | RDPVARtsPLQtPAA | |
PRKCA | P17252 | human | CELF1 | Q92879 | S52 | INVLRDRsQNPPQSk | RRM_1 |
PRKCA | P17252 | human | PACSIN2 | Q9UNF0 | S313 | ADLNRtLsRREKKKA | |
PRKCA | P17252 | human | F11R | Q9Y624 | S284 | kVIysQPsARsEGEF | |
PRKCA | P17252 | human | ABCB1 | P08183 | S671 | RKRsTRRsVRGsQAQ | |
PRKCA | P17252 | human | ADRA1D | P25100 | S323 | DGAHGMRsAKGHtFR | 7tm_1 |
PRKCA | P17252 | human | CYP3A4 | P08684 | T136 | LRsLLsPtFTsGKLK | p450 |
PRKCA | P17252 | human | RPS6KB2 | Q9UBS0 | S473 | PPSGTKKsKRGRGRP | |
PRKCA | P17252 | human | SATB1 | Q01826 | S185 | DLPPEQWsHTtVRNA | CUTL |
PRKCA | P17252 | human | CD4 | P01730 | S433 | RRQAERMsQIkRLLs | Tcell_CD4_C |
PRKCA | P17252 | human | PTPN12 | Q05209 | S39 | FMRLRRLstKYRTEK | |
PRKCA | P17252 | human | ACO1 | P21399 | S711 | REFNSYGsRrGNDAV | Aconitase_C |
PRKCA | P17252 | human | TBXA2R | P21731 | S145 | FSRPAVAsQRRAWAT | 7tm_1 |
PRKCA | P17252 | human | SNAP25 | P60880 | T138 | GGFIRRVtNDARENE | SNAP-25 |
PRKCA | P17252 | human | INSR | P06213 | S1064 | kTVNEsAsLRERIEF | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | RAF1 | P04049 | S43 | FGyQRRAsDDGKLtD | |
PRKCA | P17252 | human | FMNL2 | Q96PY5-3 | S1072 | RADAVRRsVRRRFDD | |
PRKCA | P17252 | human | RORA | P35398 | S35 | ETPLNQEsArKSEPP | |
PRKCA | P17252 | human | SLC18A2 | Q05940 | S18 | WLQEsRRsRKLILFI | |
PRKCA | P17252 | human | MMP2 | P08253 | S365 | NKyEsCtsAGRsDGK | Peptidase_M10; fn2 |
PRKCA | P17252 | human | SH2B1 | Q9NRF2 | S161 | sLRsVGRsVRGsVRG | |
PRKCA | P17252 | human | RIGI | O95786 | S8 | MTTEQRRsLQAFQDY | CARD_2 |
PRKCA | P17252 | human | PA2G4 | Q9UQ80 | T366 | QssAsRKtQKKKKKk | |
PRKCA | P17252 | human | RET | P07949 | T675 | PISSAEMtFRRPAQA | |
PRKCA | P17252 | human | CYSLTR1 | Q9Y271 | S316 | FRKHsLssVTYVPRK | |
PRKCA | P17252 | human | CFLAR | O15519-2 | S193 | LQAAIQKsLKDPSNN | |
PRKCA | P17252 | human | GRK2 | P25098 | S29 | ATPAARAskkILLPE | |
PRKCA | P17252 | human | VIM | P08670 | S10 | trsVssssyrrMFGG | Filament_head |
PRKCA | P17252 | human | PITPNC1 | Q9UKF7 | S299 | KDRPRKKsAPEtLtL | |
PRKCA | P17252 | human | C5AR1 | P21730 | S334 | sVVREsKsFTRsTVD | |
PRKCA | P17252 | human | VIM | P08670 | S5 | ___MStrsVssssyr | |
PRKCA | P17252 | human | EIF4G1 | Q04637 | S1185 | RtPATKRsFskEVEE | |
PRKCA | P17252 | human | TRPC3 | Q13507 | S785 | PPFsLVPsPKsFVyF | |
PRKCA | P17252 | human | NHERF1 | O14745 | S77 | ETHQQVVsRIRAALN | PDZ |
PRKCA | P17252 | human | KCNC4 | Q03721 | S15 | ssYRGRKsGNKPPsK | Potassium_chann |
PRKCA | P17252 | human | CLDN1 | O95832 | T191 | CSCPRkTtsYPtPRP | |
PRKCA | P17252 | human | CTPS1 | P17812 | S462 | tLFQTkNsVMRkLYG | GATase |
PRKCA | P17252 | human | TGFBR1 | P36897 | T200 | LPLLVQRtIARtIVL | TGF_beta_GS |
PRKCA | P17252 | human | IQGAP1 | P46940 | S1443 | DKMKKsksVkEDsNL | |
PRKCA | P17252 | human | NR2F6 | P10588 | S83 | CKSFFKRsIRRNLsY | zf-C4 |
PRKCA | P17252 | human | KLHL3 | Q9UH77 | S433 | PMNTRRSsVGVGVVE | Kelch_1 |
PRKCA | P17252 | human | TBXA2R | P21731-2 | T399 | LLPFEPPtGKALSRK | |
PRKCA | P17252 | human | PPP1R1A | Q13522 | S67 | LKSTLAMsPRQRKKM | DARPP-32 |
PRKCA | P17252 | human | CSNK1D | P48730 | T161 | KKYRDARtHQHIPYR | Pkinase |
PRKCA | P17252 | human | ELAVL1 | Q15717 | S158 | FIRFDKRsEAEEAIT | RRM_1 |
PRKCA | P17252 | human | PRKD1 | Q15139 | S738 | ARIIGEksFRRsVVG | Pkinase |
PRKCA | P17252 | human | GJA1 | P17302 | S372 | sRAssRAssRPRPDD | |
PRKCA | P17252 | human | ARHGAP35 | Q9NRY4 | T1226 | LRsLRRNtKKPKPKP | RhoGAP_pG1_pG2 |
PRKCA | P17252 | human | ELAVL1 | Q15717 | S318 | GDkILQVsFkTNkSH | |
PRKCA | P17252 | human | PDE3A | Q14432 | S312 | SKSHRRTsLPCIPRE | |
PRKCA | P17252 | human | KIT | P10721 | S741 | TkADkRRsVRIGsyI | PK_Tyr_Ser-Thr |
PRKCA | P17252 | human | CORO1B | Q9BR76 | S2 | ______MsFRKVVRQ | |
PRKCA | P17252 | human | CFTR | P13569 | S660 | FSAERRNsILTETLH | CFTR_R |
PRKCA | P17252 | human | KCNJ13 | O60928 | S201 | TRPSPLTsVRVSAVL | IRK_C |
PRKCA | P17252 | human | CLDN7 | O95471 | S204 | VPRsYPksNsskEyV | |
PRKCA | P17252 | human | PDE3A | Q14432 | S438 | PGLLRRVsstWtttt | |
PRKCA | P17252 | human | KRAS | P01116-2 | S181 | GKKKKkKskTkCVIM | |
PRKCA | P17252 | human | PDE3A | Q14432 | S492 | MTLTkSRsFtSSyAI | |
PRKCA | P17252 | human | SHOC2 | Q9UQ13 | S297 | GLRYNRLsAIPRSLA | LRR_8 |
PRKCA | P17252 | human | NCF1 | P14598 | S315 | AHsIHQRsRKRLsQD | NECFESHC |
PRKCA | P17252 | human | CFTR | P13569 | S686 | WTEtKKQsFKQTGEF | CFTR_R |
PRKCA | P17252 | human | CYP3A4 | P08684 | S398 | GVVVMIPsYALHRDP | p450 |
PRKCA | P17252 | human | PTPN6 | P29350 | S591 | DKEKsKGsLKRK___ | |
PRKCA | P17252 | human | ADD2 | P35612 | S713 | KKKFRtPsFLKKsKK | |
PRKCA | P17252 | human | GNAZ | P19086 | S27 | DRHLRSEsQRQRREI | G-alpha |
PRKCA | P17252 | human | JAK2 | O60674 | T174 | kVPVTHEtQEECLGM | FERM_F2 |
PRKCA | P17252 | human | SLC6A4 | P31645 | S277 | IWKGVKtsGKVVWVT | SNF |
PRKCA | P17252 | human | NR1I3 | Q14994 | T38 | CKGFFRRtVSKSIGP | zf-C4 |
PRKCA | P17252 | human | AHR | P35869 | S12 | SANITYAsRKRRKPV | |
PRKCA | P17252 | human | KCNJ4 | P48050 | T53 | IFTTCVDtRWRYMLM | IRK |
PRKCA | P17252 | human | SPIC | Q8N5J4 | Y191 | KIRRKLTyQFSEAIL | Ets |
PRKCA | P17252 | human | ADD1 | P35611 | S726 | KKKFRtPsFLKKsKK | |
PRKCA | P17252 | human | CFLAR | O15519 | S193 | LQAAIQksLkDPSNN | |
PRKCA | P17252 | human | RGS7 | P49802 | S434 | YKLMKSDsYPRFIRS | RGS |
PRKCA | P17252 | human | KCNQ2 | O43526 | T217 | RMDRRGGtWKLLGSV | Ion_trans; TM |
PRKCA | P17252 | human | PDE3A | Q14432 | S465 | VRRDRsTsIkLQEAP | |
PRKCA | P17252 | human | PPARG | P37231 | T166 | CKGFFRRtIRLKLIY | |
PRKCA | P17252 | human | NOX5 | Q96PH1-4 | S490 | GRGSKRLsRSVtMRK | FAD_binding_8 |
PRKCA | P17252 | human | CYP3A4 | P08684 | S119 | GFMksAIsIAEDEEW | p450 |
PRKCA | P17252 | human | GPSM2 | P81274 | S408 | PKLGRRHsMENMELM | |
PRKCA | P17252 | human | PIM1 | P11309-2 | S65 | HSHSPRHsLRHSPGS | |
PRKCA | P17252 | human | NCF1 | P14598 | S328 | QDAYRRNsVRFLQQR | NECFESHC |
PRKCA | P17252 | human | RASSF1 | Q9NS23-2 | S197 | RGPGRGTsVRRRtsF | |
PRKCA | P17252 | human | NCF4 | Q15080 | T154 | LRRLRPRtRKVKSVs | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S420 | kFLPERFsKKNKDNI | p450 |
PRKCA | P17252 | human | NKX3-1 | Q99801 | S48 | RQGGRTSsQRQRDPE | |
PRKCA | P17252 | human | TP53 | P04637 | S378 | skkGQstsRHkkLMF | |
PRKCA | P17252 | human | ROBO3 | Q96MS0 | S1330 | WLPYSRPsFLSrGQG | |
PRKCA | P17252 | human | CD5 | P06127 | T434 | MsFHRNHtAtVRsHA | |
PRKCA | P17252 | human | SLC6A3 | Q01959 | S7 | _MsKskCsVGLMssV | |
PRKCA | P17252 | human | TP73 | O15350 | S388 | VPQPLVDsYRQQQQL | |
PRKCA | P17252 | human | GNMT | Q14749 | S10 | DSVYRtRsLGVAAEG | |
PRKCA | P17252 | human | CHAT | P28329-3 | S476 | HKAAVPAsEKLLLLK | Carn_acyltransf |
PRKCA | P17252 | human | AFAP1 | Q8N556 | S277 | AELEKKLssERPssD | |
PRKCA | P17252 | human | PPP1R16B | Q96T49 | S331 | sQLRHKSsLsRRTsS | |
PRKCA | P17252 | human | VDR | P11473 | S51 | CKGFFRRsMKRKALF | zf-C4 |
PRKCA | P17252 | human | MMP2 | P08253 | T250 | EYNsCTDtGRSDGFL | Peptidase_M10; fn2 |
PRKCA | P17252 | human | F3 | P13726 | S290 | GQsWkENsPLNVs__ | |
PRKCA | P17252 | human | MYL9 | P24844 | S2 | ______MssKRAKAK | |
PRKCA | P17252 | human | GJA1 | P17302 | S368 | QRPssRAssRAssRP | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T373 | SNLPHEAtRDtIFrG | p450 |
PRKCA | P17252 | human | ADRA1D | P25100 | S516 | QLRAKVssLsHKIRA | |
PRKCA | P17252 | human | KCNK9 | Q9NPC2 | T341 | IEEISPStLKNSLFP | |
PRKCA | P17252 | human | CELF1 | Q92879 | S178 | AQtMEGCssPMVVkF | RRM_1 |
PRKCA | P17252 | human | CYP3A4 | P08684 | S134 | kRLRsLLsPtFTsGK | p450 |
PRKCA | P17252 | human | CYP2E1 | P05181 | T131 | DIRRFsLttLRNYGM | p450 |
PRKCA | P17252 | human | DLG1 | Q12959 | T657 | KERARLKtVkFNsKT | |
PRKCA | P17252 | human | CHAT | P28329-3 | S346 | LLKHVTQssRKLIRA | Carn_acyltransf |
PRKCA | P17252 | human | CFTR | P13569 | S795 | TAsTRKVsLAPQANL | CFTR_R |
PRKCA | P17252 | human | H3C1 | P68431 | T6 | __ArtkQtArkstGG | Histone |
PRKCA | P17252 | human | CSNK1D | P48730 | S191 | THLGIEQsRRDDLES | Pkinase |
PRKCA | P17252 | human | SCN9A | Q15858-3 | I848 | LNMLIKIiGNSVGAL | Ion_trans |
PRKCA | P17252 | human | EGLN2 | Q96KS0 | S234 | QRAIPPRsIRGDQIA | |
PRKCA | P17252 | human | CD44 | P16070 | S672 | AVCIAVNsRRRCGQK | |
PRKCA | P17252 | human | CYP3A4 | P08684 | T103 | KECYsVFtNRRPFGP | p450 |
PRKCA | P17252 | human | HABP4 | Q5JVS0 | T375 | GRGARGGtRGGRGRI | IHABP4_N |
PRKCA | P17252 | human | PRKD2 | Q9BZL6 | S876 | QGLAERIsVL_____ | |
PRKCA | P17252 | human | TXN | P10599 | T100 | NkEkLEAtINELV__ | Thioredoxin |
PRKCA | P17252 | human | GSTA4 | O15217 | T193 | VKLsNIPtIKRFLEP | GST_C_3 |
PRKCA | P17252 | human | TNNT2 | P45379 | S189 | ARKKKALsNMMHFGG | Troponin |
PRKCA | P17252 | human | PPP1R14B | Q96C90 | T57 | VRRQGKVtVkYDRKE | PP1_inhibitor |
PRKCA | P17252 | human | FERMT3 | Q86UX7 | S484 | LSLQRtGsGGPGNHP | FERM_M |
PRKCA | P17252 | human | TRPV5 | Q9NQA5 | S654 | yVEVFKNsDKEDDQE | |
PRKCA | P17252 | human | VTN | P04004 | S381 | RNRKGYRsQRGHsRG | |
PRKCA | P17252 | human | EP300 | Q09472 | S89 | SELLRSGsSPNLNMG | |
PRKCA | P17252 | human | IKBKB | O14920 | S177 | AkELDQGsLCtsFVG | Pkinase |
PRKCA | P17252 | human | ICOSLG | O75144 | S285 | RDRCLQHsYAGAWAV | |
PRKCA | P17252 | human | TUBA1C | Q9BQE3 | S158 | sLLMERLsVDyGkks | Tubulin |
PRKCA | P17252 | human | C5AR1 | P21730 | S317 | RLRKsLPsLLRNVLt | |
PRKCA | P17252 | human | IL2RA | P01589 | T271 | RQRKsRRtI______ | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T432 | DYFkPFstGkRVCAG | p450 |
PRKCA | P17252 | human | CSNK1D | P48730 | T176 | ENkNLtGtARYAsIN | Pkinase |
PRKCA | P17252 | human | PLEK | P08567 | S113 | GQKFARKstRRsIRL | |
PRKCA | P17252 | human | ADRA1D | P25100 | S518 | RAKVssLsHKIRAGG | |
PRKCA | P17252 | human | DOCK8 | Q8NF50 | S2077 | KPIFRVEsQKRDsFH | |
PRKCA | P17252 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
PRKCA | P17252 | human | FFAR4 | Q5NUL3-1 | T363 | PEKGAILtDtsVKRN | |
PRKCA | P17252 | human | SHOC2 | Q9UQ13 | T71 | VAFSVDNtIKRPNPA | |
PRKCA | P17252 | human | TRPM4 | Q8TD43 | S1145 | RDKRESDsERLKRTs | |
PRKCA | P17252 | human | VIM | P08670 | S7 | _MStrsVssssyrrM | Filament_head |
PRKCA | P17252 | human | XRCC6 | P12956 | S78 | YISKIIssDRDLLAV | Ku_N |
PRKCA | P17252 | human | ACO1 | P21399 | S138 | DFNRRADsLQkNQDL | Aconitase |
PRKCA | P17252 | human | H2BC3 | P33778 | S32 | DGKkRKRsRkEsysI | Histone |
PRKCA | P17252 | human | CYP2E1 | P05181 | S145 | MGKQGNEsRIQREAH | p450 |
PRKCA | P17252 | human | AHR | P35869 | S36 | EGIkSNPsKRHRDRL | HLH |
PRKCA | P17252 | human | PRKCE | Q02156 | S368 | NNIRKALsFDNRGEE | |
PRKCA | P17252 | human | MARCKS | P29966 | S170 | sFkLsGFsFkKNKkE | MARCKS |
PRKCA | P17252 | human | CD3G | P09693 | S148 | GVRQsRAsDkQTLLP | |
PRKCA | P17252 | human | NCF1 | P14598 | S303 | RGAPPRRssIRNAHs | NECFESHC |
PRKCA | P17252 | human | FFAR4 | Q5NUL3-1 | S373 | sVKRNDLsIIsG___ | |
PRKCA | P17252 | human | CD300LF | Q8TDQ1 | T221 | GTsPQKAtTKLSSAQ | SIT |
PRKCA | P17252 | human | IKBKB | O14920 | S181 | DQGsLCtsFVGTLQy | Pkinase |
PRKCA | P17252 | human | ILK | Q13418 | T181 | RTRPRNGtLNkHsGI | |
PRKCA | P17252 | human | THOC5 | Q13769 | S5 | ___MSSEssKKRKPK | |
PRKCA | P17252 | human | F3 | P13726 | S285 | RKAGVGQsWkENsPL | |
PRKCA | P17252 | human | TAGLN2 | P37802 | T180 | VIGLQMGtNrGAsQA | Calponin |
PRKCA | P17252 | human | PTGIR | P43119 | S328 | TPLSQLAsGRRDPRA | |
PRKCA | P17252 | human | TAGLN2 | P37802 | S11 | rGPAyGLsREVQQkI | |
PRKCA | P17252 | human | NOXO1 | Q8NFA2-3 | S154 | SRAAGRLsIHSLEAQ | |
PRKCA | P17252 | human | ILK | Q13418 | T173 | DTFWkGttRTRPRNG | |
PRKCA | P17252 | human | CYP3A4 | P08684 | S259 | SVKRMKEsRLEDtQK | p450 |
PRKCA | P17252 | human | GSTP1 | P09211 | S185 | SAYVGRLsARPkLkA | GST_C_3 |
PRKCA | P17252 | human | PRKD1 | Q15139 | S742 | GEksFRRsVVGtPAy | Pkinase |
PRKCA | P17252 | human | HABP4 | Q5JVS0 | T354 | RKPANDItSQLEINF | IHABP4_N |
PRKCA | P17252 | human | PLCB3 | Q01970 | S1105 | LDRKRHNsIsEAKMR | PLC-beta_C |
PRKCA | P17252 | human | EPB41 | P11171-4 | S331 | RTASKRAsRSLDGAA | FA |
PRKCA | P17252 | human | CD5 | P06127 | T436 | FHRNHtAtVRsHAEN | |
PRKCA | P17252 | human | TAGLN | Q01995 | S181 | VIGLQMGsNrGAsQA | Calponin |
PRKCA | P17252 | human | PLD2 | O14939 | S243 | RWLVVKDsFLLYMCL | |
PRKCA | P17252 | human | CYBA | P13498 | T147 | ERPQIGGtIkQPPsN | Cytochrom_B558a |
PRKCA | P17252 | human | SUN1 | O94901 | S55 | sPRMsRRsLRLATTA | |
PRKCA | P17252 | human | ADD1 | P35611 | S716 | GsPGKsPsKKKKKFR | |
PRKCA | P17252 | human | CFTR | P13569 | S641 | QNLQPDFsSKLMGCD | CFTR_R |
PRKCA | P17252 | human | RASSF1 | Q9NS23-2 | S203 | TsVRRRtsFYLPKDA | RA |
PRKCA | P17252 | human | NCF1 | P14598 | S359 | EERQtQRsKPQPAVP | p47_phox_C |
PRKCA | P17252 | human | VASP | P50552 | S157 | EHIERRVsNAGGPPA | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T376 | PHEAtRDtIFrGYLI | p450 |
PRKCA | P17252 | human | TTN | Q8WZ42 | S11878 | KEEVVLKsVLRKRPE | |
PRKCA | P17252 | human | BDKRB2 | P30411 | S373 | sMGTLRTsIsVERQI | |
PRKCA | P17252 | human | NPHS1 | O60500 | T1120 | EYEESQWtGERDtQS | |
PRKCA | P17252 | human | SCN5A | Q14524 | S1503 | NAMKKLGsKKPQKPI | |
PRKCA | P17252 | human | CFTR | P13569 | S813 | DIYsRRLsQEtGLEI | CFTR_R |
PRKCA | P17252 | human | NMNAT1 | Q9HAN9 | S136 | WTETQDSsQKKSLEP | CTP_transf_like |
PRKCA | P17252 | human | THOC5 | Q13769 | S6 | __MSSEssKKRKPKV | |
PRKCA | P17252 | human | CYP2E1 | P05181 | T121 | IIFNNGPtWKDIRRF | p450 |
PRKCA | P17252 | human | GRIA1 | P42261 | S834 | EFcYKsRsEsKRMKG | |
PRKCA | P17252 | human | DRD2 | P14416 | S229 | RVNtkRssRAFRAHL | 7tm_1 |
PRKCA | P17252 | human | TNNI3 | P19429 | S24 | APIRRRssNyRAyAt | Troponin-I_N |
PRKCA | P17252 | human | RALBP1 | Q15311 | T297 | ACGRTTEtEkVQEFQ | RhoGAP |
PRKCA | P17252 | human | DTNB | O60941 | T69 | FRDNGLNtLDHTTEI | EF-hand_2 |
PRKCA | P17252 | human | IGFBP1 | P08833 | S194 | LAKAQETsGEEIsKF | Thyroglobulin_1 |
PRKCA | P17252 | human | GPR15 | P49685 | S357 | FARRRKRsVsL____ | |
PRKCA | P17252 | human | DRD2 | P14416 | S228 | kRVNtkRssRAFRAH | 7tm_1 |
PRKCA | P17252 | human | MET | P08581 | S985 | PHLDRLVsARsVsPt | |
PRKCA | P17252 | human | GRIA1 | P42261 | S849 | FCLIPQQsINEAIRT | |
PRKCA | P17252 | human | TWIST1 | Q15672 | S144 | tLPSDkLskIQTLkL | HLH |
PRKCA | P17252 | human | MAPT | P10636-8 | S305 | kHVPGGGsVQIVykP | Tubulin-binding |
PRKCA | P17252 | human | KCNA5 | P22460 | T15 | LENGGAMtVRGGDEA | |
PRKCA | P17252 | human | AKT1 | P31749 | T308 | kDGAtMKtFCGtPEy | Pkinase |
PRKCA | P17252 | human | ITGB4 | P16144 | S1494 | tLtRDyNsLtRsEHs |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
PRKCA | ID | Description | 0.00e+00 |
PRKCA | GO:0042060 | wound healing | 2.48e-16 |
PRKCA | GO:0009410 | response to xenobiotic stimulus | 5.28e-12 |
PRKCA | GO:0001667 | ameboidal-type cell migration | 5.28e-12 |
PRKCA | GO:0050878 | regulation of body fluid levels | 5.72e-12 |
PRKCA | GO:0050673 | epithelial cell proliferation | 5.72e-12 |
PRKCA | GO:0036293 | response to decreased oxygen levels | 5.72e-12 |
PRKCA | GO:0070482 | response to oxygen levels | 5.84e-12 |
PRKCA | GO:0034765 | regulation of monoatomic ion transmembrane transport | 3.23e-11 |
PRKCA | GO:0001666 | response to hypoxia | 5.67e-11 |
PRKCA | GO:0003012 | muscle system process | 1.36e-10 |
PRKCA | GO:0050678 | regulation of epithelial cell proliferation | 2.93e-10 |
PRKCA | GO:0006816 | calcium ion transport | 4.36e-10 |
PRKCA | GO:0010038 | response to metal ion | 4.54e-10 |
PRKCA | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 9.65e-10 |
PRKCA | GO:0007015 | actin filament organization | 9.65e-10 |
PRKCA | GO:1901653 | cellular response to peptide | 9.65e-10 |
PRKCA | GO:0018105 | peptidyl-serine phosphorylation | 1.24e-09 |
PRKCA | GO:0030522 | intracellular receptor signaling pathway | 1.38e-09 |
PRKCA | GO:0048732 | gland development | 1.38e-09 |
PRKCA | GO:0097553 | calcium ion transmembrane import into cytosol | 2.51e-09 |
PRKCA | GO:0018209 | peptidyl-serine modification | 2.51e-09 |
PRKCA | GO:1902074 | response to salt | 2.59e-09 |
PRKCA | GO:1903522 | regulation of blood circulation | 2.93e-09 |
PRKCA | GO:0070372 | regulation of ERK1 and ERK2 cascade | 3.08e-09 |
PRKCA | GO:0043410 | positive regulation of MAPK cascade | 5.42e-09 |
PRKCA | GO:0031623 | receptor internalization | 5.56e-09 |
PRKCA | GO:1903829 | positive regulation of protein localization | 5.56e-09 |
PRKCA | GO:0007596 | blood coagulation | 9.11e-09 |
PRKCA | GO:0070371 | ERK1 and ERK2 cascade | 1.12e-08 |
PRKCA | GO:0010959 | regulation of metal ion transport | 1.21e-08 |
PRKCA | GO:0050817 | coagulation | 1.23e-08 |
PRKCA | GO:0036294 | cellular response to decreased oxygen levels | 1.23e-08 |
PRKCA | GO:1904375 | regulation of protein localization to cell periphery | 1.25e-08 |
PRKCA | GO:0007265 | Ras protein signal transduction | 1.27e-08 |
PRKCA | GO:0007599 | hemostasis | 1.27e-08 |
PRKCA | GO:0010631 | epithelial cell migration | 1.31e-08 |
PRKCA | GO:0090132 | epithelium migration | 1.51e-08 |
PRKCA | GO:0071496 | cellular response to external stimulus | 1.56e-08 |
PRKCA | GO:0051098 | regulation of binding | 1.62e-08 |
PRKCA | GO:0090130 | tissue migration | 1.85e-08 |
PRKCA | GO:0048511 | rhythmic process | 2.37e-08 |
PRKCA | GO:0045785 | positive regulation of cell adhesion | 2.38e-08 |
PRKCA | GO:0003018 | vascular process in circulatory system | 2.40e-08 |
PRKCA | GO:0007159 | leukocyte cell-cell adhesion | 2.48e-08 |
PRKCA | GO:0043254 | regulation of protein-containing complex assembly | 2.48e-08 |
PRKCA | GO:0051099 | positive regulation of binding | 2.98e-08 |
PRKCA | GO:0071453 | cellular response to oxygen levels | 3.84e-08 |
PRKCA | GO:0062012 | regulation of small molecule metabolic process | 4.19e-08 |
PRKCA | GO:0046879 | hormone secretion | 4.23e-08 |
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Related Drugs to PRKCA_PHB |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning PRKCA-PHB and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PRKCA_PHB |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |