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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PRKCB_BCL11A

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PRKCB_BCL11A
KinaseFusionDB ID: KFG4927
FusionGDB2.0 ID: KFG4927
HgeneTgene
Gene symbol

PRKCB

BCL11A

Gene ID

5579

53335

Gene nameprotein kinase C betaBCL11 transcription factor A
SynonymsPKC-beta|PKCB|PKCI(2)|PKCbeta|PRKCB1|PRKCB2CTIP1|DILOS|EVI9|HBFQTL5|SMARCM1|ZNF856
Cytomap

16p12.2-p12.1

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptideB-cell lymphoma/leukemia 11AB cell CLL/lymphoma 11AB-cell CLL/lymphoma 11A (zinc finger protein)BAF chromatin remodeling complex subunit BCL11ABCL11A B-cell CLL/lymphoma 11A (zinc finger protein)BCL11A, BAF complex componentC2H2-type zinc finger pro
Modification date2024040720240403
UniProtAcc

P05771

Q9H165

Ensembl transtripts involved in fusion geneENST idsENST00000303531, ENST00000321728, 
ENST00000482000, ENST00000498058, 
ENST00000356842, ENST00000359629, 
ENST00000335712, ENST00000358510, 
ENST00000477659, ENST00000537768, 
ENST00000538214, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PRKCB [Title/Abstract] AND BCL11A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRKCB(23895679)-BCL11A(60679529), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCB

GO:0010827

regulation of glucose transmembrane transport

25982116

HgenePRKCB

GO:0043687

post-translational protein modification

20228790

TgeneBCL11A

GO:0000122

negative regulation of transcription by RNA polymerase II

19153051


check buttonKinase Fusion gene breakpoints across PRKCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across BCL11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0BI030492PRKCBchr16

23895679

BCL11Achr2

60679529



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:23895679/:60679529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKCB

P05771

BCL11A

Q9H165

FUNCTION: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity (PubMed:11598012). Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A (PubMed:20228790). In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1 (PubMed:25982116). Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (PubMed:19176525). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (PubMed:25313067). {ECO:0000250|UniProtKB:P68404, ECO:0000269|PubMed:11598012, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:20228790, ECO:0000269|PubMed:25313067, ECO:0000269|PubMed:25982116}.FUNCTION: Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491). Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene (PubMed:29606353). Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level (PubMed:29606353, PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000269|PubMed:16704730, ECO:0000269|PubMed:23644491, ECO:0000269|PubMed:29606353, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PRKCB_BCL11A


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKCBP05771-2humanMAPTP10636-8S352DFKDrVQskIGsLDNTubulin-binding
PRKCBP05771-2humanITGB2P05107S745FEkEKLksQWNNDNPIntegrin_b_cyt
PRKCBP05771-2humanTRPV1Q8NER1T705WKLQRAItILDTEKS
PRKCBP05771-2humanDAB2P98082S24QAAPKAPsKKEKKKG
PRKCBP05771-2humanPRKCBP05771-2S660QsEFEGFsFVNsEFLPkinase_C
PRKCBP05771-2humanMAPTP10636-8S258PDLkNVKskIGstENTubulin-binding
PRKCBP05771-2humanPPARAQ07869S230VKARVILsGKASNNP
PRKCBP05771-2humanATF2P15336S121LAtPIIRsKIEEPSV
PRKCBP05771-2humanKIR3DL1P43629S415QRKITRPsQRPKtPP
PRKCBP05771-2humanEIF6P56537S235QPstIAtsMRDsLID
PRKCBP05771-2humanPTPN11Q06124S591GLMQQQksFR_____
PRKCBP05771-2humanGSK3BP49841S9SGRPRttsFAEsCkP
PRKCBP05771-2humanMYH9P35579S1916AMNREVssLkNkLRrMyosin_tail_1
PRKCBP05771-2humanRPS6KB2Q9UBS0S473PPSGTKKsKRGRGRP
PRKCBP05771-2humanITGB2P05107T758NPLFksAtttVMNPkIntegrin_b_cyt
PRKCBP05771-2humanTRPV6Q9H1D0S184LARRAsVsARAtGTAAnk_2
PRKCBP05771-2humanC5AR1P21730S334sVVREsKsFTRsTVD
PRKCBP05771-2humanNCF1P14598S320QRsRKRLsQDAYRRNNECFESHC
PRKCBP05771-2humanMFN1Q8IWA4S284QNRIFFVsAkEVLsA
PRKCBP05771-2humanEIF3AQ14152S1364RAEKDREsLRRtKNE
PRKCBP05771-2humanLMNB1P20700S405VtVsRAsssRsVRtt
PRKCBP05771-2humanSYT6Q5T7P8T418RLKKKKttIKKNTLNC2
PRKCBP05771-2humanMCUQ8NE86S92VISVRLPsRRERCQF
PRKCBP05771-2humanEIF4G1Q04637-8S1093FAPGGRLsWGKGSSG
PRKCBP05771-2humanMFN1Q8IWA4S290VsAkEVLsARKQKAQ
PRKCBP05771-2humanPTPN11Q06124S576CAEMREDsARVyENV
PRKCBP05771-2humanNCF1P14598S315AHsIHQRsRKRLsQDNECFESHC
PRKCBP05771-2humanTRPV6Q9H1D0T728MPSVSRstSRssANW
PRKCBP05771-2humanRAB11AP62491S177TEIYRIVsQkQMSDR
PRKCBP05771-2humanPPARAQ07869S179RFGRMPRsEKAKLkA
PRKCBP05771-2humanNCF1P14598S328QDAYRRNsVRFLQQRNECFESHC
PRKCBP05771-2humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
PRKCBP05771-2humanTP73O15350S388VPQPLVDsYRQQQQL
PRKCBP05771-2humanCHATP28329-3S476HKAAVPAsEKLLLLKCarn_acyltransf
PRKCBP05771-2humanLMNB1P20700S395LkLsPsPssRVtVsR
PRKCBP05771-2humanCHATP28329-3S346LLKHVTQssRKLIRACarn_acyltransf
PRKCBP05771-2humanCHATP28329-3S440VPTYESAsIRRFQEGCarn_acyltransf
PRKCBP05771-2humanFUSP35637S257GrGGMGGsDrGGFNk
PRKCBP05771-2humanSYT6Q5T7P8T417RRLKKKKttIKKNTLC2
PRKCBP05771-2humanCHATP28329-3S347LKHVTQssRKLIRADCarn_acyltransf
PRKCBP05771-2humanCHATP28329-3T255TVLVKDStNRDSLDMCarn_acyltransf
PRKCBP05771-2humanNCF1P14598S370PAVPPRPsADLILNRp47_phox_C
PRKCBP05771-2humanNCF1P14598S303RGAPPRRssIRNAHsNECFESHC
PRKCBP05771-2humanGHRLQ9UBU3S41RVQQRKEsKKPPAKLMotilin_ghrelin
PRKCBP05771-2humanMAPTP10636-8S293NVQskCGsKDNIkHVTubulin-binding
PRKCBP05771-2humanKCNE1P15382S102VQARVLEsYRSCYVVISK_Channel
PRKCBP05771-2humanNCF1P14598S359EERQtQRsKPQPAVPp47_phox_C
PRKCBP05771-2humanNCF1P14598S304GAPPRRssIRNAHsINECFESHC
PRKCBP05771-2humanMFN1Q8IWA4S86AFFGRTSsGKSSVINDynamin_N
PRKCBP05771-2humanGSK3AP49840S21sGrARtssFAEPGGG
PRKCBP05771-2humanNCF1P14598S379DLILNRCsEstKRKLp47_phox_C
PRKCBP05771-2humanSYT6Q5T7P8T283DRKCKLQtRVHRKTLC2
PRKCBP05771humanANXA1P04083S28yVQtVksskGGPGsA
PRKCBP05771humanMAPTP10636-8S352DFKDrVQskIGsLDNTubulin-binding
PRKCBP05771humanITGB2P05107S745FEkEKLksQWNNDNPIntegrin_b_cyt
PRKCBP05771humanPRKCBP05771-2S660QsEFEGFsFVNsEFLPkinase_C
PRKCBP05771humanPTPN11Q06124S591GLMQQQksFR_____
PRKCBP05771humanMYH9P35579S1916AMNREVssLkNkLRrMyosin_tail_1
PRKCBP05771humanANXA2P07355S26tPPsAyGsVkAytNF
PRKCBP05771humanLIN28BQ6ZN17S243EQSKkGPsVQKRKKT
PRKCBP05771humanORAI1Q96D31S27GGSTTsGsRRsRRRs
PRKCBP05771humanKCNC4Q03721S9ISSVCVssYRGRKsGPotassium_chann
PRKCBP05771humanITGB2P05107T758NPLFksAtttVMNPkIntegrin_b_cyt
PRKCBP05771humanPIK3CGP48736S582LWHFRYEsLKHPKAYPI3Ka
PRKCBP05771humanAKT1P31749S473RPHFPQFsysAsGtAPkinase_C
PRKCBP05771humanNCF1P14598S320QRsRKRLsQDAYRRNNECFESHC
PRKCBP05771humanIBTKQ9P2D0S1200ASSLHsVsSksFRDF
PRKCBP05771humanEPHA2P29317S892ADFDPRVsIRLPsts
PRKCBP05771humanKCNC4Q03721S21KsGNKPPsKTCLKEEPotassium_chann
PRKCBP05771humanPRKAA1Q13131S496AtPQRsGsVsNyRSCAdenylateSensor
PRKCBP05771humanPTPN11Q06124S576CAEMREDsARVyENV
PRKCBP05771humanNOX5Q96PH1-4T494KRLsRSVtMRKsQRSFAD_binding_8
PRKCBP05771humanEPB41P11171-4S312QAQTRQAsALIDRPAFA
PRKCBP05771humanSTMN1P16949S25QAFELILsPrskEsVStathmin
PRKCBP05771humanTYRP14679S527DYHsLYQsHL_____
PRKCBP05771humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
PRKCBP05771humanMARCKSP29966S163KRFsFkKsFkLsGFsMARCKS
PRKCBP05771humanCHATP28329-3S440VPTYESAsIRRFQEGCarn_acyltransf
PRKCBP05771humanSTMN1P16949S38sVPEFPLsPPkKkDLStathmin
PRKCBP05771humanMSX2P35548T135HMsPTTCtLRKHKtN
PRKCBP05771humanCHATP28329-3S347LKHVTQssRKLIRADCarn_acyltransf
PRKCBP05771humanCHATP28329-3T255TVLVKDStNRDSLDMCarn_acyltransf
PRKCBP05771humanTYRP14679S523MEKEDYHsLYQsHL_
PRKCBP05771humanMAPTP10636-8S293NVQskCGsKDNIkHVTubulin-binding
PRKCBP05771humanNCF1P14598S304GAPPRRssIRNAHsINECFESHC
PRKCBP05771humanSHC1P29353T206VPGAkGAtRRRKPCsPID
PRKCBP05771humanGSK3AP49840S21sGrARtssFAEPGGG
PRKCBP05771humanIBTKQ9P2D0S1203LHsVsSksFRDFLLE
PRKCBP05771humanTRPM8Q7Z2W7S1040CKEKNMEssVCCFKN
PRKCBP05771humanMARCKSP29966S159kkKKKRFsFkKsFkLMARCKS
PRKCBP05771humanNOX5Q96PH1-4S498RSVtMRKsQRSsKGSFAD_binding_8
PRKCBP05771humanGRNP28799S81IFTVSGTsSCCPFPEGranulin
PRKCBP05771humanSHC1P29353S213tRRRKPCsRPLSSILPID
PRKCBP05771humanMAPTP10636-8S258PDLkNVKskIGstENTubulin-binding
PRKCBP05771humanKCNC4Q03721S8MISSVCVssYRGRKsPotassium_chann
PRKCBP05771humanATF2P15336S121LAtPIIRsKIEEPSV
PRKCBP05771humanGSK3BP49841S9SGRPRttsFAEsCkP
PRKCBP05771humanOCLNQ16625S490RLKQVkGsADYKSKKOccludin_ELL
PRKCBP05771humanRPS6KB2Q9UBS0S473PPSGTKKsKRGRGRP
PRKCBP05771humanORAI1Q96D31S30TTsGsRRsRRRsGDG
PRKCBP05771humanMSX2P35548T141CtLRKHKtNRKPRTP
PRKCBP05771humanCFLARO15519-2S193LQAAIQKsLKDPSNN
PRKCBP05771humanC5AR1P21730S334sVVREsKsFTRsTVD
PRKCBP05771humanKCNC4Q03721S15ssYRGRKsGNKPPsKPotassium_chann
PRKCBP05771humanCLDN1O95832T191CSCPRkTtsYPtPRP
PRKCBP05771humanKLHL3Q9UH77S433PMNTRRSsVGVGVVEKelch_1
PRKCBP05771humanIRS1P35568S323MVGGKPGsFRVRAss
PRKCBP05771humanSHC1P29353S139EEWTRHGsFVNkPtR
PRKCBP05771humanNCF1P14598S315AHsIHQRsRKRLsQDNECFESHC
PRKCBP05771humanCFLARO15519S193LQAAIQksLkDPSNN
PRKCBP05771humanTRPM8Q7Z2W7S1041KEKNMEssVCCFKNE
PRKCBP05771humanNCF1P14598S328QDAYRRNsVRFLQQRNECFESHC
PRKCBP05771humanCHATP28329-3S476HKAAVPAsEKLLLLKCarn_acyltransf
PRKCBP05771humanCHATP28329-3S346LLKHVTQssRKLIRACarn_acyltransf
PRKCBP05771humanILF3Q12906S647rGrGRGGsIRGRGRG
PRKCBP05771humanH3C1P68431T6__ArtkQtArkstGGHistone
PRKCBP05771humanFCER1GP30273S69DGVytGLstRNQEtyITAM
PRKCBP05771humanIRS1P35568S441SPCDFRSsFRsVtPD
PRKCBP05771humanACSL4O60488T328LAHVLELtAEISCFTAMP-binding
PRKCBP05771humanAKT1P31749T308kDGAtMKtFCGtPEyPkinase


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKCBIDDescription0.00e+00
PRKCBGO:0043434response to peptide hormone6.72e-08
PRKCBGO:1903829positive regulation of protein localization1.29e-07
PRKCBGO:0032868response to insulin3.59e-07
PRKCBGO:0008286insulin receptor signaling pathway2.13e-06
PRKCBGO:0097284hepatocyte apoptotic process2.13e-06
PRKCBGO:0032869cellular response to insulin stimulus4.55e-06
PRKCBGO:0046879hormone secretion8.73e-06
PRKCBGO:0071375cellular response to peptide hormone stimulus8.73e-06
PRKCBGO:0009914hormone transport1.02e-05
PRKCBGO:0002790peptide secretion1.27e-05
PRKCBGO:0046883regulation of hormone secretion1.37e-05
PRKCBGO:0015833peptide transport1.81e-05
PRKCBGO:0010827regulation of glucose transmembrane transport2.50e-05
PRKCBGO:0030073insulin secretion2.60e-05
PRKCBGO:1901653cellular response to peptide2.70e-05
PRKCBGO:0023061signal release2.82e-05
PRKCBGO:1903532positive regulation of secretion by cell2.82e-05
PRKCBGO:0043467regulation of generation of precursor metabolites and energy2.82e-05
PRKCBGO:0046887positive regulation of hormone secretion2.95e-05
PRKCBGO:0045834positive regulation of lipid metabolic process3.39e-05
PRKCBGO:1903828negative regulation of protein localization3.49e-05
PRKCBGO:0051222positive regulation of protein transport3.89e-05
PRKCBGO:0051047positive regulation of secretion3.90e-05
PRKCBGO:0001774microglial cell activation3.90e-05
PRKCBGO:0042060wound healing4.85e-05
PRKCBGO:0002269leukocyte activation involved in inflammatory response4.85e-05
PRKCBGO:1904951positive regulation of establishment of protein localization4.85e-05
PRKCBGO:0002274myeloid leukocyte activation5.41e-05
PRKCBGO:0030072peptide hormone secretion5.41e-05
PRKCBGO:0050796regulation of insulin secretion5.43e-05
PRKCBGO:0032386regulation of intracellular transport5.72e-05
PRKCBGO:0006816calcium ion transport6.04e-05
PRKCBGO:0061900glial cell activation6.04e-05
PRKCBGO:0019216regulation of lipid metabolic process6.04e-05
PRKCBGO:0006887exocytosis6.94e-05
PRKCBGO:0035265organ growth7.07e-05
PRKCBGO:0046324regulation of glucose import7.07e-05
PRKCBGO:0042886amide transport7.20e-05
PRKCBGO:0050994regulation of lipid catabolic process7.28e-05
PRKCBGO:0051098regulation of binding7.36e-05
PRKCBGO:1904659glucose transmembrane transport8.83e-05
PRKCBGO:0006109regulation of carbohydrate metabolic process9.31e-05
PRKCBGO:0008645hexose transmembrane transport9.76e-05
PRKCBGO:0015749monosaccharide transmembrane transport1.10e-04
PRKCBGO:0090276regulation of peptide hormone secretion1.11e-04
PRKCBGO:0046626regulation of insulin receptor signaling pathway1.15e-04
PRKCBGO:0002791regulation of peptide secretion1.17e-04
PRKCBGO:0005979regulation of glycogen biosynthetic process1.17e-04
PRKCBGO:0010962regulation of glucan biosynthetic process1.17e-04

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Related Drugs to PRKCB_BCL11A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PRKCB-BCL11A and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PRKCB_BCL11A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate