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Kinase Fusion Gene:PRKCD_SLC4A8 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: PRKCD_SLC4A8 | KinaseFusionDB ID: KFG4939 | FusionGDB2.0 ID: KFG4939 | Hgene | Tgene | Gene symbol | PRKCD | SLC4A8 | Gene ID | 5580 | 9498 | |
Gene name | protein kinase C delta | solute carrier family 4 member 8 | ||||||||||
Synonyms | ALPS3|CVID9|MAY1|PKCD|nPKC-delta | NBC3|NDCBE | ||||||||||
Cytomap | 3p21.1 | 12q13.13 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | protein kinase C delta typeprotein kinase C delta VIIItyrosine-protein kinase PRKCD | electroneutral sodium bicarbonate exchanger 1electroneutral Na(+)-driven Cl-HCO3 exchangerk-NBC3solute carrier family 4, sodium bicarbonate cotransporter, member 8 | ||||||||||
Modification date | 20240403 | 20240403 | ||||||||||
UniProtAcc | Q969G5 | Q2Y0W8 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000330452, ENST00000394729, ENST00000477794, | ENST00000358657, ENST00000394856, ENST00000453097, ENST00000514353, ENST00000535225, ENST00000546663, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRKCD [Title/Abstract] AND SLC4A8 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKCD(53224017)-SLC4A8(51883484), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRKCD | GO:0006468 | protein phosphorylation | 10713049|12649167|16611985|34593629 |
Hgene | PRKCD | GO:0006915 | apoptotic process | 10770950|12649167 |
Hgene | PRKCD | GO:0018105 | peptidyl-serine phosphorylation | 18285462 |
Hgene | PRKCD | GO:0018107 | peptidyl-threonine phosphorylation | 10770950 |
Hgene | PRKCD | GO:0032147 | activation of protein kinase activity | 10713049 |
Hgene | PRKCD | GO:0034644 | cellular response to UV | 17303575 |
Hgene | PRKCD | GO:0042119 | neutrophil activation | 10770950 |
Hgene | PRKCD | GO:0043687 | post-translational protein modification | 19059439 |
Hgene | PRKCD | GO:0070301 | cellular response to hydrogen peroxide | 10713049 |
Hgene | PRKCD | GO:0071447 | cellular response to hydroperoxide | 19059439 |
Hgene | PRKCD | GO:1904385 | cellular response to angiotensin | 18285462 |
Hgene | PRKCD | GO:2000303 | regulation of ceramide biosynthetic process | 17303575 |
Tgene | SLC4A8 | GO:0015701 | bicarbonate transport | 11133997 |
Tgene | SLC4A8 | GO:0035725 | sodium ion transmembrane transport | 11133997 |
Tgene | SLC4A8 | GO:0042391 | regulation of membrane potential | 11133997|18577713 |
Tgene | SLC4A8 | GO:0051453 | regulation of intracellular pH | 11133997|18577713 |
Tgene | SLC4A8 | GO:1902476 | chloride transmembrane transport | 11133997 |
Kinase Fusion gene breakpoints across PRKCD (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across SLC4A8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-UF-A7JA-01A | PRKCD | chr3 | 53224017 | SLC4A8 | chr12 | 51883484 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:53224017/:51883484) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PRKCD | SLC4A8 |
FUNCTION: Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). {ECO:0000250|UniProtKB:Q91VJ2, ECO:0000250|UniProtKB:Q9Z1H9, ECO:0000269|PubMed:19262564}. | FUNCTION: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity). {ECO:0000250|UniProtKB:Q8JZR6, ECO:0000269|PubMed:18577713}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PRKCD_SLC4A8 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
PRKCD | Q05655 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
PRKCD | Q05655 | human | PTPRA | P18433-2 | S204 | PLLARSPsTNRKYPP | |
PRKCD | Q05655 | human | BCL2 | P10415 | S70 | RDPVARtsPLQtPAA | |
PRKCD | Q05655 | human | HNRNPK | P61978 | S302 | GrGGrGGsrArNLPL | |
PRKCD | Q05655 | human | SLC9A1 | P19634 | S648 | KTRQRLRsYNRHtLV | NEXCaM_BD |
PRKCD | Q05655 | human | SHOC2 | Q9UQ13 | T71 | VAFSVDNtIKRPNPA | |
PRKCD | Q05655 | human | BLVRA | P53004 | S237 | sFHFksGsLENVPNV | Biliv-reduc_cat |
PRKCD | Q05655 | human | MUC1 | P15941 | T1224 | RyVPPsstDRsPyEK | |
PRKCD | Q05655 | human | ADD1 | P35611 | S726 | KKKFRtPsFLKKsKK | |
PRKCD | Q05655 | human | NCF1 | P14598 | S370 | PAVPPRPsADLILNR | p47_phox_C |
PRKCD | Q05655 | human | FBXO25 | Q8TCJ0 | S178 | DLLQDLSsTLCILIR | |
PRKCD | Q05655 | human | ENOX2 | Q16206 | S504 | ENLKEKEsCASRLCA | |
PRKCD | Q05655 | human | MARK2 | Q7KZI7 | T596 | rGVssRstFHAGQLR | |
PRKCD | Q05655 | human | TNNI3 | P19429 | T143 | RGKFKRPtLRrVrIs | Troponin |
PRKCD | Q05655 | human | FOSL1 | P15407 | T217 | LEPEALHtPTLMTtP | |
PRKCD | Q05655 | human | BEST1 | O76090 | S358 | SAQFRRAsFMGSTFN | |
PRKCD | Q05655 | human | RPS6KB2 | Q9UBS0 | S473 | PPSGTKKsKRGRGRP | |
PRKCD | Q05655 | human | NCF4 | Q15080 | S315 | RQARGLPsQKRLFPW | PB1 |
PRKCD | Q05655 | human | NCF1 | P14598 | S303 | RGAPPRRssIRNAHs | NECFESHC |
PRKCD | Q05655 | human | CARD9 | Q9H257 | T231 | CKVERKHtLKLRHAM | |
PRKCD | Q05655 | human | ITGB2 | P05107 | T758 | NPLFksAtttVMNPk | Integrin_b_cyt |
PRKCD | Q05655 | human | PRKCD | Q05655 | T218 | TAANSRDtIFQkERF | |
PRKCD | Q05655 | human | TRPV4 | Q9HBA0 | S162 | FDIVSRGsTADLDGL | |
PRKCD | Q05655 | human | LCP1 | P13796 | S5 | ___MARGsVsDEEMM | |
PRKCD | Q05655 | human | SQSTM1 | Q13501 | S349 | sskEVDPstGELQsL | |
PRKCD | Q05655 | human | KRT8 | P05787 | S74 | tVNQsLLsPLVLEVD | Keratin_2_head |
PRKCD | Q05655 | human | GAPDH | P04406 | T246 | NVsVVDLtCrLEkPA | Gp_dh_C |
PRKCD | Q05655 | human | GAPDH | P04406 | S241 | rVPtANVsVVDLtCr | Gp_dh_C |
PRKCD | Q05655 | human | NRG1 | Q02297-6 | S286 | LHDRLRQsLRSERNN | Neuregulin |
PRKCD | Q05655 | human | NCF1 | P14598 | S328 | QDAYRRNsVRFLQQR | NECFESHC |
PRKCD | Q05655 | human | DAP3 | P51398 | S31 | MGTQARQsIAAHLDN | |
PRKCD | Q05655 | human | STAT1 | P42224 | S727 | TDNLLPMsPEEFDEV | STAT1_TAZ2bind |
PRKCD | Q05655 | human | NCF4 | Q15080 | T154 | LRRLRPRtRKVKSVs | |
PRKCD | Q05655 | human | PRKCD | Q05655 | S503 | kENIFGEsRAstFCG | Pkinase |
PRKCD | Q05655 | human | RPS6 | P62753 | S235 | IAKRRRLssLRAsts | |
PRKCD | Q05655 | human | ITGB2 | P05107 | S745 | FEkEKLksQWNNDNP | Integrin_b_cyt |
PRKCD | Q05655 | human | PRKCD | Q05655 | S299 | NQVtQRAsRRsDsAs | |
PRKCD | Q05655 | human | SLC29A1 | Q99808 | S281 | QPTNESHsIkAILkN | Nucleoside_tran |
PRKCD | Q05655 | human | TIRAP | P58753 | Y106 | AAQDLVSyLEGSTAS | TIR_2 |
PRKCD | Q05655 | human | DAP3 | P51398 | S280 | tLKREDksPIAPEEL | DAP3 |
PRKCD | Q05655 | human | CTTN | Q14247 | S405 | KtQtPPVsPAPQPtE | |
PRKCD | Q05655 | human | DAB2 | P98082 | S24 | QAAPKAPsKKEKKKG | |
PRKCD | Q05655 | human | PTPN22 | Q9Y2R2 | S35 | FLkLkRQsTKYKADK | |
PRKCD | Q05655 | human | PRKD1 | Q15139 | S742 | GEksFRRsVVGtPAy | Pkinase |
PRKCD | Q05655 | human | PRKCD | Q05655 | S302 | tQRAsRRsDsAssEP | |
PRKCD | Q05655 | human | NCF1 | P14598 | S348 | PGPQsPGsPLEEERQ | |
PRKCD | Q05655 | human | BLVRA | P53004 | S230 | LKRNRyLsFHFksGs | Biliv-reduc_cat |
PRKCD | Q05655 | human | PRKCD | Q05655 | S645 | LNEkARLsysDKNLI | Pkinase_C |
PRKCD | Q05655 | human | DAP3 | P51398 | T237 | ItRVRNAtDAVGIVL | DAP3 |
PRKCD | Q05655 | human | PRKCD | Q05655 | S304 | RAsRRsDsAssEPVG | |
PRKCD | Q05655 | human | FGF1 | P05230 | S131 | VGLKKNGsCKRGPRT | FGF |
PRKCD | Q05655 | human | PRKCD | Q05655 | T295 | AEALNQVtQRAsRRs | |
PRKCD | Q05655 | human | SMPD1 | P17405 | S510 | DGNYSGSsHVVLDHE | ASMase_C |
PRKCD | Q05655 | human | H3C1 | P68431 | T45 | PHryrPGtVALrEIR | Histone |
PRKCD | Q05655 | human | CHAT | P28329-3 | S476 | HKAAVPAsEKLLLLK | Carn_acyltransf |
PRKCD | Q05655 | human | CYBA | P13498 | T147 | ERPQIGGtIkQPPsN | Cytochrom_B558a |
PRKCD | Q05655 | human | PTPRA | P18433-2 | S180 | QAGSHSNsFRLSNGR | |
PRKCD | Q05655 | human | TP53 | P04637 | S46 | AMDDLMLsPDDIEQW | TAD2 |
PRKCD | Q05655 | human | PGR | P06401 | S400 | GAEAsARsPRSYLVA | Prog_receptor |
PRKCD | Q05655 | human | PREX1 | Q8TCU6 | S313 | RVtGsKKsTKRTKsI | |
PRKCD | Q05655 | human | ADAM17 | P78536 | T735 | kPFPAPQtPGRLQPA | |
PRKCD | Q05655 | human | CDH1 | P12830 | T790 | TRNDVAPtLMsVPRy | |
PRKCD | Q05655 | human | C5AR1 | P21730 | S334 | sVVREsKsFTRsTVD | |
PRKCD | Q05655 | human | IRS1 | P35568 | S574 | RLPGHRHsAFVPTRs | |
PRKCD | Q05655 | human | PLSCR3 | Q9NRY6 | T21 | PPPPYPVtPGYPEPA | |
PRKCD | Q05655 | human | NADK | O95544 | S46 | RGRAKsrsLsAsPAL | |
PRKCD | Q05655 | human | TRPV4 | Q9HBA0 | T175 | GLLPFLLtHKKRLTD | |
PRKCD | Q05655 | human | PPP1R14A | Q96A00 | T38 | QkRHARVtVkYDRRE | PP1_inhibitor |
PRKCD | Q05655 | human | NCF1 | P14598 | S320 | QRsRKRLsQDAYRRN | NECFESHC |
PRKCD | Q05655 | human | NCF1 | P14598 | S359 | EERQtQRsKPQPAVP | p47_phox_C |
PRKCD | Q05655 | human | G6PD | P11413-3 | S210 | FGRDLQSsDRLSNHI | G6PD_N |
PRKCD | Q05655 | human | NADK | O95544 | S64 | kEFRRtRsLHGPCPV | |
PRKCD | Q05655 | human | CDK5 | Q00535 | T77 | LHsDkKLtLVFEFCD | Pkinase |
PRKCD | Q05655 | human | LIMK2 | P53671 | S283 | EGtLRRRsLRRsNsI | |
PRKCD | Q05655 | human | DAP3 | P51398 | S185 | FDQPLEAstWLkNFk | DAP3 |
PRKCD | Q05655 | human | NR2F6 | P10588 | S83 | CKSFFKRsIRRNLsY | zf-C4 |
PRKCD | Q05655 | human | NCF1 | P14598 | S304 | GAPPRRssIRNAHsI | NECFESHC |
PRKCD | Q05655 | human | HVCN1 | Q96D96-4 | S77 | GMLRKLFsSHRFQVI | |
PRKCD | Q05655 | human | TNNI3 | P19429 | S23 | PAPIRRRssNyRAyA | Troponin-I_N |
PRKCD | Q05655 | human | IRS1 | P35568 | S323 | MVGGKPGsFRVRAss | |
PRKCD | Q05655 | human | IL6ST | P40189 | T890 | GQVERFEtVGMEAAt | |
PRKCD | Q05655 | human | DAP3 | P51398 | T186 | DQPLEAstWLkNFkT | DAP3 |
PRKCD | Q05655 | human | PRKCD | Q05655 | T141 | EDEAkFPtMNRRGAI | |
PRKCD | Q05655 | human | RPS3 | P23396 | S6 | __MAVQIskkRkFVA | |
PRKCD | Q05655 | human | PRKD1 | Q15139 | S738 | ARIIGEksFRRsVVG | Pkinase |
PRKCD | Q05655 | human | PLD2 | O14939 | T566 | FIQRWNFtKTTKAKy | |
PRKCD | Q05655 | human | BAG3 | O95817 | S187 | sSSSSSAsLPsSGRs | |
PRKCD | Q05655 | human | MCU | Q8NE86 | S92 | VISVRLPsRRERCQF | |
PRKCD | Q05655 | human | CHAT | P28329-3 | S440 | VPTYESAsIRRFQEG | Carn_acyltransf |
PRKCD | Q05655 | human | FOSL1 | P15407 | T227 | LMTtPSLtPFtPSLV | |
PRKCD | Q05655 | human | SHC1 | P29353-2 | S29 | EEWTRHGsFVNKPTR | |
PRKCD | Q05655 | human | EGFR | P00533 | T678 | RHIVRKRtLRRLLQE | |
PRKCD | Q05655 | human | ELAVL1 | Q15717 | S318 | GDkILQVsFkTNkSH | |
PRKCD | Q05655 | human | RPS6 | P62753 | S236 | AKRRRLssLRAstsK | |
PRKCD | Q05655 | human | NFE2L2 | Q16236 | S40 | SREVFDFsQRRkEYE | |
PRKCD | Q05655 | human | HAX1 | O00165 | S210 | QPkSYFksIsVtkIT | |
PRKCD | Q05655 | human | RPS3 | P23396 | T221 | kDEILPttPIsEQkG | |
PRKCD | Q05655 | human | CTNNB1 | P35222 | S715 | GYRQDDPsyRsFHsG | |
PRKCD | Q05655 | human | PRKD1 | Q15139 | S412 | PLMRVVQsVKHTKRK | |
PRKCD | Q05655 | human | IRS1 | P35568 | S307 | TRRsRtEsItAtsPA | |
PRKCD | Q05655 | human | GSK3A | P49840 | S21 | sGrARtssFAEPGGG | |
PRKCD | Q05655 | human | CXCR4 | P61073 | S324 | LtsVsRGssLkILsk | |
PRKCD | Q05655 | human | HVCN1 | Q96D96-4 | T9 | SKFLRHFtVVGDDYH | |
PRKCD | Q05655 | human | TNNI3 | P19429 | S24 | APIRRRssNyRAyAt | Troponin-I_N |
PRKCD | Q05655 | human | PPP1R14B | Q96C90 | T57 | VRRQGKVtVkYDRKE | PP1_inhibitor |
PRKCD | Q05655 | human | TSC2 | P49815 | S939 | sFRARstsLNERPKs | |
PRKCD | Q05655 | human | FCER1G | P30273 | S69 | DGVytGLstRNQEty | ITAM |
PRKCD | Q05655 | human | TBL1XR1 | Q9BZK7 | S123 | AAAsQQGsAKNGENT | |
PRKCD | Q05655 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
PRKCD | Q05655 | human | STAT3 | P40763 | S727 | NtIDLPMsPrTLDSL | |
PRKCD | Q05655 | human | CXCR4 | P61073 | S325 | tsVsRGssLkILskG | |
PRKCD | Q05655 | human | DNM1L | O00429 | S616 | PIPIMPAsPQKGHAV | |
PRKCD | Q05655 | human | TRPV4 | Q9HBA0 | S189 | DEEFREPsTGKTCLP | |
PRKCD | Q05655 | human | EP300 | Q09472 | S89 | SELLRSGsSPNLNMG | |
PRKCD | Q05655 | human | TSC2 | P49815 | S932 | DDtPEkDsFRARsts | |
PRKCD | Q05655 | human | LMNA | P02545 | S22 | QAsstPLsPtRItRL | |
PRKCD | Q05655 | human | FLI1 | Q01543 | T312 | TNGEFKMtDPDEVAR | Ets |
PRKCD | Q05655 | human | MET | P08581 | S985 | PHLDRLVsARsVsPt | |
PRKCD | Q05655 | human | ELAVL1 | Q15717 | S221 | QAQrFrFsPMGVDHM | |
PRKCD | Q05655 | human | IRS1 | P35568 | S441 | SPCDFRSsFRsVtPD | |
PRKCD | Q05655 | human | TACSTD2 | P09758 | S322 | GELRkEPsL______ | |
PRKCD | Q05655 | human | BLVRA | P53004 | S33 | DLRNPHPsSAFLNLI | GFO_IDH_MocA |
PRKCD | Q05655 | human | PA2G4 | Q9UQ80 | S360 | ELkALLQssAsRKtQ | |
PRKCD | Q05655 | human | HVCN1 | Q96D96 | T29 | SKFLRHFtVVGDDyH | |
PRKCD | Q05655 | human | CAT | P04040 | S167 | LFPSFIHsQKRNPQT | Catalase |
PRKCD | Q05655 | human | TP73 | O15350-2 | S289 | GQVLGRRsFEGRICA | P53 |
PRKCD | Q05655 | human | SRC | P12931 | S12 | KSKPKDAsQRRRsLE | |
PRKCD | Q05655 | human | G6PD | P11413-3 | T266 | NIACVILtFKEPFGT | G6PD_C |
PRKCD | Q05655 | human | CHN2 | P52757 | S171 | EKVsRRLsRsKNEPR | |
PRKCD | Q05655 | human | PEBP1 | P30086 | S153 | RGKFkVAsFRKKYEL | PBP |
PRKCD | Q05655 | human | SHOC2 | Q9UQ13 | S297 | GLRYNRLsAIPRSLA | LRR_8 |
PRKCD | Q05655 | human | NCF1 | P14598 | S315 | AHsIHQRsRKRLsQD | NECFESHC |
PRKCD | Q05655 | human | BLVRA | P53004 | S21 | VGVGRAGsVRMRDLR | GFO_IDH_MocA |
PRKCD | Q05655 | human | NCF1 | P14598 | S379 | DLILNRCsEstKRKL | p47_phox_C |
PRKCD | Q05655 | human | RASGRP3 | Q8IV61 | T133 | YDWMRRVtQRKKVSK | |
PRKCD | Q05655 | human | HVCN1 | Q96D96 | S97 | GMLRKLFsSHRFQVI |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
PRKCD | ID | Description | 0.00e+00 |
PRKCD | GO:1901653 | cellular response to peptide | 3.02e-10 |
PRKCD | GO:0010506 | regulation of autophagy | 8.59e-10 |
PRKCD | GO:0010821 | regulation of mitochondrion organization | 5.80e-09 |
PRKCD | GO:0043434 | response to peptide hormone | 6.55e-09 |
PRKCD | GO:0034504 | protein localization to nucleus | 6.55e-09 |
PRKCD | GO:0071375 | cellular response to peptide hormone stimulus | 6.55e-09 |
PRKCD | GO:0006935 | chemotaxis | 1.84e-08 |
PRKCD | GO:0042330 | taxis | 1.84e-08 |
PRKCD | GO:0043254 | regulation of protein-containing complex assembly | 2.92e-08 |
PRKCD | GO:0009410 | response to xenobiotic stimulus | 4.41e-08 |
PRKCD | GO:0000302 | response to reactive oxygen species | 5.28e-08 |
PRKCD | GO:0006606 | protein import into nucleus | 5.58e-08 |
PRKCD | GO:0051170 | import into nucleus | 6.64e-08 |
PRKCD | GO:0060326 | cell chemotaxis | 6.64e-08 |
PRKCD | GO:0032868 | response to insulin | 6.92e-08 |
PRKCD | GO:0006979 | response to oxidative stress | 8.72e-08 |
PRKCD | GO:1903829 | positive regulation of protein localization | 1.00e-07 |
PRKCD | GO:0051347 | positive regulation of transferase activity | 1.25e-07 |
PRKCD | GO:0072593 | reactive oxygen species metabolic process | 1.40e-07 |
PRKCD | GO:0006801 | superoxide metabolic process | 2.26e-07 |
PRKCD | GO:0051222 | positive regulation of protein transport | 2.58e-07 |
PRKCD | GO:0031334 | positive regulation of protein-containing complex assembly | 2.75e-07 |
PRKCD | GO:0034599 | cellular response to oxidative stress | 3.07e-07 |
PRKCD | GO:0062197 | cellular response to chemical stress | 3.20e-07 |
PRKCD | GO:0032869 | cellular response to insulin stimulus | 3.68e-07 |
PRKCD | GO:1904951 | positive regulation of establishment of protein localization | 3.84e-07 |
PRKCD | GO:0006913 | nucleocytoplasmic transport | 4.45e-07 |
PRKCD | GO:0051169 | nuclear transport | 4.45e-07 |
PRKCD | GO:0032386 | regulation of intracellular transport | 5.33e-07 |
PRKCD | GO:0033674 | positive regulation of kinase activity | 5.34e-07 |
PRKCD | GO:0033157 | regulation of intracellular protein transport | 7.81e-07 |
PRKCD | GO:0001666 | response to hypoxia | 1.27e-06 |
PRKCD | GO:0000422 | autophagy of mitochondrion | 1.58e-06 |
PRKCD | GO:0061726 | mitochondrion disassembly | 1.58e-06 |
PRKCD | GO:1900180 | regulation of protein localization to nucleus | 1.87e-06 |
PRKCD | GO:0042542 | response to hydrogen peroxide | 1.90e-06 |
PRKCD | GO:0050921 | positive regulation of chemotaxis | 1.97e-06 |
PRKCD | GO:0036293 | response to decreased oxygen levels | 1.97e-06 |
PRKCD | GO:0097193 | intrinsic apoptotic signaling pathway | 2.18e-06 |
PRKCD | GO:1903146 | regulation of autophagy of mitochondrion | 2.18e-06 |
PRKCD | GO:0032388 | positive regulation of intracellular transport | 2.40e-06 |
PRKCD | GO:0042554 | superoxide anion generation | 2.42e-06 |
PRKCD | GO:2001233 | regulation of apoptotic signaling pathway | 2.62e-06 |
PRKCD | GO:0043410 | positive regulation of MAPK cascade | 2.62e-06 |
PRKCD | GO:0034614 | cellular response to reactive oxygen species | 2.77e-06 |
PRKCD | GO:0031330 | negative regulation of cellular catabolic process | 2.95e-06 |
PRKCD | GO:0090316 | positive regulation of intracellular protein transport | 3.29e-06 |
PRKCD | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 3.29e-06 |
PRKCD | GO:0070482 | response to oxygen levels | 3.89e-06 |
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Related Drugs to PRKCD_SLC4A8 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning PRKCD-SLC4A8 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PRKCD_SLC4A8 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |