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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PRKCE_SNX17

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: PRKCE_SNX17
	KinaseFusionDB ID: KFG4951
	FusionGDB2.0 ID: KFG4951
		Hgene	Tgene
	Gene symbol	PRKCE	SNX17
	Gene ID	5581	9784
	Gene name	protein kinase C epsilon	sorting nexin 17
	Synonyms	PKCE\|nPKC-epsilon	-
	Cytomap	2p21	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	protein kinase C epsilon type	sorting nexin-17
	Modification date	20240403	20240411
	UniProtAcc	Q02156	Q15036
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000306156, ENST00000467135, ENST00000394874,	ENST00000233575, ENST00000543024, ENST00000537606, ENST00000542478,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: PRKCE [Title/Abstract] AND SNX17 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRKCE	GO:0006468	protein phosphorylation	18556656\|34593629
Hgene	PRKCE	GO:0018105	peptidyl-serine phosphorylation	15695813

Kinase Fusion gene breakpoints across PRKCE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across SNX17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
CCLE	Capan-1	PRKCE	chr2	45879587	SNX17	chr2	27594136
CCLE	Capan-1	PRKCE	chr2	45879587	SNX17	chr2	27595490
CCLE	Capan-1	PRKCE	chr2	45928663	SNX17	chr2	27598373

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000306156	ENST00000233575	PRKCE	chr2	45879587	SNX17	chr2	27594136	2434	565
ENST00000306156	ENST00000233575	PRKCE	chr2	45879587	SNX17	chr2	27595490	2359	540

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000306156_ENST00000233575_PRKCE_chr2_45879587_SNX17_chr2_27594136_length(amino acids)=565
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG
YDDFVANCTIQFEELLQNGSRHFEDWAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQA
VRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSF
VRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQT
LRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMS
KDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIG

--------------------------------------------------------------

>ENST00000306156_ENST00000233575_PRKCE_chr2_45879587_SNX17_chr2_27595490_length(amino acids)=540
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG
YDDFVANCTIQFEELLQNGSRHFEDWLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQ
QVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIV
LRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVV
SAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMV
DELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:/chr2:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PRKCE Q02156	SNX17 Q15036
FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). {ECO:0000269\|PubMed:11884385, ECO:0000269\|PubMed:1374067, ECO:0000269\|PubMed:15355962, ECO:0000269\|PubMed:16757566, ECO:0000269\|PubMed:17603037, ECO:0000269\|PubMed:17875639, ECO:0000269\|PubMed:17875724, ECO:0000269\|PubMed:19542546}.	FUNCTION: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269\|PubMed:15121882, ECO:0000269\|PubMed:15769472, ECO:0000269\|PubMed:16712798, ECO:0000269\|PubMed:19005208, ECO:0000269\|PubMed:21512128, ECO:0000269\|PubMed:22492727, ECO:0000269\|PubMed:28892079}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

116116

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Hgene

PRKCE

45879587

SNX17

27594136

ENST00000306156

1_117

738

Domain

Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041

Hgene

PRKCE

45879587

SNX17

27595490

ENST00000306156

1_117

738

Domain

Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>201_PRKCE_SNX17	ENST00000306156	ENST00000233575	PRKCE	chr2	45879587	SNX17	chr2	27595490	MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG YDDFVANCTIQFEELLQNGSRHFEDWLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQ QVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIV LRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVV SAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMV DELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL	540
3D view using mol* of 201_PRKCE_SNX17

PDB file >>>HKFP_289_PRKCE_SNX17	ENST00000306156	ENST00000233575	PRKCE	chr2	45879587	SNX17	chr2	27594136	MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG YDDFVANCTIQFEELLQNGSRHFEDWAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQA VRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSF VRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQT LRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMS KDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIG	565_PRKCE_SNX17
PDB file >>>HKFP_290_PRKCE_SNX17	ENST00000306156	ENST00000233575	PRKCE	chr2	45879587	SNX17	chr2	27595490	MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIG YDDFVANCTIQFEELLQNGSRHFEDWLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQ QVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIV LRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVV SAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMV DELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL	540_PRKCE_SNX17
3D view using mol* of HKFP_290_PRKCE_SNX17

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_289_PRKCE_SNX17_vs_HKFP_290_PRKCE_SNX17_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/HKFP_289_PRKCE_SNX17_vs_HKFP_290_PRKCE_SNX17.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

PRKCE_SNX17 does not have any known PDB structures.

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pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

201_PRKCE_SNX17.png

HKFP_290_PRKCE_SNX17.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
HKFP_290_PRKCE_SNX17	1.054	365	1.1	1701.966	0.654	0.718	0.839	0.928	0.83	1.118	0.791	Chain A: 2,3,4,5,8,9,10,79,102,105,106,107,108,109 ,110,112,113,116,129,132,145,146,149,150,152,153,1 66,167,170,171,172,173,174,175,177,178,180,181,182 ,183,184,206,207,208,211,234,236,244,246,247,254,2 58,261,262,263,345,395,413,414,415,416,435,437,438 ,440,477,479,480,481,483,485,486,488,496,497,498,5 00,501,502,503,504,505

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

201_PRKCE_SNX17_ramachandran.png

HKFP_290_PRKCE_SNX17_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Encorafenib	-6.45091	-6.884710000000001	-48.6591
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Encorafenib	-6.45091	-6.884710000000001	-48.6591
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Lenvatinib	-6.40695	-6.40695	-52.788
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Neratinib	-5.91187	-6.09777	-55.7999
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Afatinib	-5.572030000000002	-5.75433	-49.9137
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Afatinib	-5.572030000000002	-5.75433	-49.9137
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Afatinib	-5.57063	-5.75433	-49.9137
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Cobimetinib	-5.55808	-5.56088	-41.1163
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Pacritinib	-5.50583	-5.51093	-35.4235
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Larotrectinib	-5.41413	-5.41413	-36.5394
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Encorafenib	-5.40902	-5.84282	-48.0211
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Encorafenib	-5.40902	-5.84282	-48.0211
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Zanubrutinib	-5.38285	-5.38285	-42.0712
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Crizotinib	-5.36837	-5.70457	-42.6725
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Crizotinib	-5.36837	-5.70457	-42.6725
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Upadacitinib	-5.32334	-5.32434	-31.3896
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Netarsudil	-5.3121	-5.3232	-46.1072
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Netarsudil	-5.3121	-5.3232	-46.1072
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Capmatinib	-5.2950800000000005	-5.300680000000002	-39.5677
HKFP_290_PRKCE_SNX17_vsw_10-DOCK_HTVS_1-001	Larotrectinib	-5.19557	-5.19557	-46.7222
201_PRKCE_SNX17-DOCK_HTVS_1-001	Lapatinib	-7.58767	-7.67647	-63.5649
201_PRKCE_SNX17-DOCK_HTVS_1-001	Temsirolimus	-7.10527	-7.106669999999999	-61.0307
201_PRKCE_SNX17-DOCK_HTVS_1-001	Temsirolimus	-6.98728	-6.9886800000000004	-63.3752
201_PRKCE_SNX17-DOCK_HTVS_1-001	Larotrectinib	-6.624860000000001	-6.624860000000001	-40.3367
201_PRKCE_SNX17-DOCK_HTVS_1-001	Selpercatinib	-6.2916300000000005	-6.3221300000000005	-49.9729
201_PRKCE_SNX17-DOCK_HTVS_1-001	Selpercatinib	-6.2916300000000005	-6.3221300000000005	-49.9729
201_PRKCE_SNX17-DOCK_HTVS_1-001	Gilteritinib	-6.27445	-6.30085	-50.2262
201_PRKCE_SNX17-DOCK_HTVS_1-001	Gilteritinib	-6.27445	-6.30085	-50.2262
201_PRKCE_SNX17-DOCK_HTVS_1-001	Pralsetinib	-6.15561	-6.24711	-45.7595
201_PRKCE_SNX17-DOCK_HTVS_1-001	Pralsetinib	-6.14079	-6.23229	-45.8777
201_PRKCE_SNX17-DOCK_HTVS_1-001	Selpercatinib	-6.10848	-6.13898	-52.1676
201_PRKCE_SNX17-DOCK_HTVS_1-001	Selpercatinib	-6.10848	-6.13898	-52.1676
201_PRKCE_SNX17-DOCK_HTVS_1-001	Neratinib	-6.08814	-6.27044	-49.5695
201_PRKCE_SNX17-DOCK_HTVS_1-001	Neratinib	-6.08814	-6.27044	-49.5695
201_PRKCE_SNX17-DOCK_HTVS_1-001	Avapritinib	-6.082269999999999	-6.87977	-54.8045
201_PRKCE_SNX17-DOCK_HTVS_1-001	Avapritinib	-6.082269999999999	-6.87977	-54.8045
201_PRKCE_SNX17-DOCK_HTVS_1-001	Avapritinib	-6.082269999999999	-6.87977	-54.8045
201_PRKCE_SNX17-DOCK_HTVS_1-001	Avapritinib	-6.082269999999999	-6.87977	-54.8045
201_PRKCE_SNX17-DOCK_HTVS_1-001	Neratinib	-6.03656	-6.22246	-59.4159
201_PRKCE_SNX17-DOCK_HTVS_1-001	Gilteritinib	-6.028569999999999	-6.05497	-43.3041

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Kinase-Substrate Information of PRKCE_SNX17

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
PRKCE	Q02156	human	UGT1A7	Q9HAW7	S432	KAVINDKsYkENIMR	UDPGT
PRKCE	Q02156	human	MAPT	P10636-8	S352	DFKDrVQskIGsLDN	Tubulin-binding
PRKCE	Q02156	human	ADAP1	O75689	T276	GFRkRWFtMDDRRLM	PH
PRKCE	Q02156	human	KEAP1	Q14145	S602	TRMTsGRsGVGVAVT
PRKCE	Q02156	human	ADAM17	P78536	T735	kPFPAPQtPGRLQPA
PRKCE	Q02156	human	PKM	P14618	Y105	FAsDPILyRPVAVAL	PK
PRKCE	Q02156	human	GNAI2	P04899	S144	VQACFGRsREyQLND	G-alpha
PRKCE	Q02156	human	NANOG	Q9H9S0	T200	LPMWSNQtWNNSTWS
PRKCE	Q02156	human	NANOG	Q9H9S0	S135	LSNILNLsYKQVKTW	Homeodomain
PRKCE	Q02156	human	PRKCE	Q02156	S316	tPDKITNsGQRRkKL
PRKCE	Q02156	human	NANOG	Q9H9S0	S79	PKGKQPtsAEKSVAK
PRKCE	Q02156	human	GNAI2	P04899	S302	NkYDEAAsyIQSkFE	G-alpha
PRKCE	Q02156	human	PPP1R14A	Q96A00	T38	QkRHARVtVkYDRRE	PP1_inhibitor
PRKCE	Q02156	human	MCU	Q8NE86	S92	VISVRLPsRRERCQF
PRKCE	Q02156	human	EGFR	P00533	T678	RHIVRKRtLRRLLQE
PRKCE	Q02156	human	SLC6A2	P23975	S259	LWKGVKtsGKVVWIT	SNF
PRKCE	Q02156	human	MIIP	Q5JXC2	S303	YHIHRRKsFDASDTL	MIIP
PRKCE	Q02156	human	KEAP1	Q14145	S599	SEVTRMTsGRsGVGV
PRKCE	Q02156	human	ADAP1	O75689	S87	AARARFEsKVPSFYY	ArfGap
PRKCE	Q02156	human	MAPT	P10636-8	S324	kVTskCGsLGNIHHk	Tubulin-binding
PRKCE	Q02156	human	AURKB	Q96GD4	S227	GWSVHAPsLRRktMC	Pkinase
PRKCE	Q02156	human	PRKCE	Q02156	S234	EtPDQVGsQRFSVNM
PRKCE	Q02156	human	CHAT	P28329-3	S440	VPTYESAsIRRFQEG	Carn_acyltransf
PRKCE	Q02156	human	ITGB1	P05556	T789	IyksAVttVVNPkyE	Integrin_b_cyt
PRKCE	Q02156	human	STAT3	P40763	S727	NtIDLPMsPrTLDSL
PRKCE	Q02156	human	TNNI3	P19429	S44	KKskIsAsRKLQLKt
PRKCE	Q02156	human	NREP	Q16612	S59	LGSSELRsPRISYLH	Alveol-reg_P311
PRKCE	Q02156	human	PRKCE	Q02156	K534	GVIYRDLkLDNILLD	Pkinase
PRKCE	Q02156	human	MAPT	P10636-8	S293	NVQskCGsKDNIkHV	Tubulin-binding
PRKCE	Q02156	human	BAD	Q92934	S99	PFrGrsRsAPPNLWA	Bcl-2_BAD
PRKCE	Q02156	human	ALDH2	P05091	T429	MQILkFKtIEEVVGR	Aldedh
PRKCE	Q02156	human	PRKD2	Q9BZL6	S706	ARIIGEksFRRsVVG	Pkinase
PRKCE	Q02156	human	PRKD2	Q9BZL6	S710	GEksFRRsVVGtPAy	Pkinase
PRKCE	Q02156	human	OCLN	Q16625	T404	HyEtDyttGGEsCDE
PRKCE	Q02156	human	KCNK3	O14649	T383	TGLHSLStFRGLMKR
PRKCE	Q02156	human	FGFR1	P11362	S779	PLDQysPsFPDTRSS
PRKCE	Q02156	human	TRPV1	Q8NER1	S801	VPLLREAsARDRQsA
PRKCE	Q02156	human	TICAM2	Q86XR7	S16	NSCPLsLsWGKRHsV
PRKCE	Q02156	human	NANOG	Q9H9S0	T78	sPKGKQPtsAEKSVA
PRKCE	Q02156	human	BAD	Q92934	S75	EIRsRHssyPAGtED	Bcl-2_BAD
PRKCE	Q02156	human	MAPT	P10636-8	S258	PDLkNVKskIGstEN	Tubulin-binding
PRKCE	Q02156	human	CREB1	P16220	S119	EILsRRPsyRkILND	pKID
PRKCE	Q02156	human	KIR3DL1	P43629	S415	QRKITRPsQRPKtPP
PRKCE	Q02156	human	XIAP	P98170	S87	VGRHRKVsPNCRFIN	BIR
PRKCE	Q02156	human	RPS6KB2	Q9UBS0	S473	PPSGTKKsKRGRGRP
PRKCE	Q02156	human	KRT18	P05783	S53	IsVsrstsFrGGMGs
PRKCE	Q02156	human	GNAI2	P04899	S44	LLLGAGEsGkSTIVk	G-alpha
PRKCE	Q02156	human	PRKCE	Q02156	S729	QEEFKGFsYFGEDLM	Pkinase_C
PRKCE	Q02156	human	BAD	Q92934	S118	GRELRRMsDEFVDsF	Bcl-2_BAD
PRKCE	Q02156	human	GLS	O94925-3	S314	RYVGKEPsGLRFNKL	Glutaminase
PRKCE	Q02156	human	IQGAP1	P46940	S1443	DKMKKsksVkEDsNL
PRKCE	Q02156	human	ALDH2	P05091	T202	KLGPALAtGNVVVMK	Aldedh
PRKCE	Q02156	human	PRKD1	Q15139	S738	ARIIGEksFRRsVVG	Pkinase
PRKCE	Q02156	human	CORO1B	Q9BR76	S2	______MsFRKVVRQ
PRKCE	Q02156	human	RAB11A	P62491	S177	TEIYRIVsQkQMSDR
PRKCE	Q02156	human	RAB5A	P20339	T7	_MAsrGAtRPNGPNT
PRKCE	Q02156	human	NANOG	Q9H9S0	T280	GLNVIQQtTRYFStP
PRKCE	Q02156	human	ITGB1	P05556	T788	PIyksAVttVVNPky	Integrin_b_cyt
PRKCE	Q02156	human	CHAT	P28329-3	S476	HKAAVPAsEKLLLLK	Carn_acyltransf
PRKCE	Q02156	human	GJA1	P17302	S368	QRPssRAssRAssRP
PRKCE	Q02156	human	PRKD2	Q9BZL6	S876	QGLAERIsVL_____
PRKCE	Q02156	human	IKBKB	O14920	S177	AkELDQGsLCtsFVG	Pkinase
PRKCE	Q02156	human	ALDH2	P05091	S296	KSPNIIMsDADMDWA	Aldedh
PRKCE	Q02156	human	OCLN	Q16625	T403	DHyEtDyttGGEsCD
PRKCE	Q02156	human	PRKCE	Q02156	S368	NNIRKALsFDNRGEE
PRKCE	Q02156	human	ATF2	P15336	T52	HkHKHEMtLKFGPAR
PRKCE	Q02156	human	PRKD1	Q15139	S742	GEksFRRsVVGtPAy	Pkinase
PRKCE	Q02156	human	CTNND1	O60716	S268	PQVRVGGssVDLHRF
PRKCE	Q02156	human	MET	P08581	S985	PHLDRLVsARsVsPt

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
PRKCE	ID	Description	0.00e+00
PRKCE	GO:0035767	endothelial cell chemotaxis	1.33e-05
PRKCE	GO:0001667	ameboidal-type cell migration	1.33e-05
PRKCE	GO:2001028	positive regulation of endothelial cell chemotaxis	2.30e-05
PRKCE	GO:0010634	positive regulation of epithelial cell migration	5.39e-05
PRKCE	GO:0010631	epithelial cell migration	5.39e-05
PRKCE	GO:0090132	epithelium migration	5.39e-05
PRKCE	GO:0090130	tissue migration	5.39e-05
PRKCE	GO:2001026	regulation of endothelial cell chemotaxis	6.60e-05
PRKCE	GO:0051347	positive regulation of transferase activity	8.62e-05
PRKCE	GO:0050679	positive regulation of epithelial cell proliferation	1.33e-04
PRKCE	GO:0033674	positive regulation of kinase activity	1.59e-04
PRKCE	GO:0050920	regulation of chemotaxis	1.59e-04
PRKCE	GO:0050921	positive regulation of chemotaxis	1.59e-04
PRKCE	GO:0043542	endothelial cell migration	5.52e-04
PRKCE	GO:0010632	regulation of epithelial cell migration	6.62e-04
PRKCE	GO:0001938	positive regulation of endothelial cell proliferation	6.96e-04
PRKCE	GO:0043123	positive regulation of canonical NF-kappaB signal transduction	6.96e-04
PRKCE	GO:0002756	MyD88-independent toll-like receptor signaling pathway	7.21e-04
PRKCE	GO:0062197	cellular response to chemical stress	8.37e-04
PRKCE	GO:0060326	cell chemotaxis	9.35e-04
PRKCE	GO:0010595	positive regulation of endothelial cell migration	1.20e-03
PRKCE	GO:0042886	amide transport	1.48e-03
PRKCE	GO:0046887	positive regulation of hormone secretion	1.62e-03
PRKCE	GO:0051091	positive regulation of DNA-binding transcription factor activity	1.71e-03
PRKCE	GO:0046883	regulation of hormone secretion	1.93e-03
PRKCE	GO:0051092	positive regulation of NF-kappaB transcription factor activity	1.93e-03
PRKCE	GO:0034599	cellular response to oxidative stress	1.95e-03
PRKCE	GO:0043536	positive regulation of blood vessel endothelial cell migration	2.09e-03
PRKCE	GO:0043122	regulation of canonical NF-kappaB signal transduction	2.22e-03
PRKCE	GO:1905564	positive regulation of vascular endothelial cell proliferation	2.22e-03
PRKCE	GO:0051090	regulation of DNA-binding transcription factor activity	2.48e-03
PRKCE	GO:0050678	regulation of epithelial cell proliferation	2.48e-03
PRKCE	GO:1903532	positive regulation of secretion by cell	3.08e-03
PRKCE	GO:1902905	positive regulation of supramolecular fiber organization	3.08e-03
PRKCE	GO:0072659	protein localization to plasma membrane	3.08e-03
PRKCE	GO:0031116	positive regulation of microtubule polymerization	3.08e-03
PRKCE	GO:0032273	positive regulation of protein polymerization	3.08e-03
PRKCE	GO:0018105	peptidyl-serine phosphorylation	3.08e-03
PRKCE	GO:0001936	regulation of endothelial cell proliferation	3.08e-03
PRKCE	GO:0043534	blood vessel endothelial cell migration	3.08e-03
PRKCE	GO:0007249	canonical NF-kappaB signal transduction	3.11e-03
PRKCE	GO:0051495	positive regulation of cytoskeleton organization	3.11e-03
PRKCE	GO:0045766	positive regulation of angiogenesis	3.11e-03
PRKCE	GO:1904018	positive regulation of vasculature development	3.11e-03
PRKCE	GO:0018209	peptidyl-serine modification	3.26e-03
PRKCE	GO:0046879	hormone secretion	3.26e-03
PRKCE	GO:0019932	second-messenger-mediated signaling	3.26e-03
PRKCE	GO:0051047	positive regulation of secretion	3.26e-03
PRKCE	GO:0031112	positive regulation of microtubule polymerization or depolymerization	3.27e-03

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Related Drugs to PRKCE_SNX17

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning PRKCE-SNX17 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to PRKCE_SNX17

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PRKCE	C0020429	Hyperalgesia	3	CTD_human
Hgene	PRKCE	C0458247	Allodynia	3	CTD_human
Hgene	PRKCE	C0751211	Hyperalgesia, Primary	3	CTD_human
Hgene	PRKCE	C0751212	Hyperalgesia, Secondary	3	CTD_human
Hgene	PRKCE	C0751213	Tactile Allodynia	3	CTD_human
Hgene	PRKCE	C0751214	Hyperalgesia, Thermal	3	CTD_human
Hgene	PRKCE	C2936719	Mechanical Allodynia	3	CTD_human

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date