Ensembl transtripts involved in fusion gene | ENST ids | ENST00000332981, ENST00000555082, ENST00000556245, | ENST00000322030, ENST00000372688, ENST00000372692, ENST00000409104, ENST00000477806,
|
Hgene | Tgene |
PRKCH
P24723 | SET
Q7Z333 |
FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization. {ECO:0000269|PubMed:10806212, ECO:0000269|PubMed:11112424, ECO:0000269|PubMed:11772428, ECO:0000269|PubMed:15489897, ECO:0000269|PubMed:17146445, ECO:0000269|PubMed:18780722, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:20558593, ECO:0000269|PubMed:21820409, ECO:0000269|PubMed:22304920}. | FUNCTION: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). {ECO:0000250|UniProtKB:A2AKX3, ECO:0000269|PubMed:17562789, ECO:0000269|PubMed:19515850, ECO:0000269|PubMed:21112256, ECO:0000269|PubMed:21576111, ECO:0000269|PubMed:21700224, ECO:0000269|PubMed:24105744, ECO:0000269|PubMed:26700805}. |
Kinase | GOID | GO term | P.adjust |
PRKCH | ID | Description | 0.00e+00 |
PRKCH | GO:0033157 | regulation of intracellular protein transport | 1.26e-05 |
PRKCH | GO:0018105 | peptidyl-serine phosphorylation | 1.47e-05 |
PRKCH | GO:0018107 | peptidyl-threonine phosphorylation | 1.47e-05 |
PRKCH | GO:0018209 | peptidyl-serine modification | 1.47e-05 |
PRKCH | GO:0018210 | peptidyl-threonine modification | 1.47e-05 |
PRKCH | GO:0032386 | regulation of intracellular transport | 1.52e-05 |
PRKCH | GO:0046825 | regulation of protein export from nucleus | 3.95e-05 |
PRKCH | GO:0090316 | positive regulation of intracellular protein transport | 3.95e-05 |
PRKCH | GO:1903829 | positive regulation of protein localization | 5.73e-05 |
PRKCH | GO:0032388 | positive regulation of intracellular transport | 8.29e-05 |
PRKCH | GO:0006611 | protein export from nucleus | 1.59e-04 |
PRKCH | GO:0051222 | positive regulation of protein transport | 3.14e-04 |
PRKCH | GO:0071375 | cellular response to peptide hormone stimulus | 3.14e-04 |
PRKCH | GO:0071868 | cellular response to monoamine stimulus | 3.14e-04 |
PRKCH | GO:0071870 | cellular response to catecholamine stimulus | 3.14e-04 |
PRKCH | GO:1904951 | positive regulation of establishment of protein localization | 3.14e-04 |
PRKCH | GO:0071867 | response to monoamine | 3.14e-04 |
PRKCH | GO:0071869 | response to catecholamine | 3.14e-04 |
PRKCH | GO:0070874 | negative regulation of glycogen metabolic process | 3.64e-04 |
PRKCH | GO:1901653 | cellular response to peptide | 4.61e-04 |
PRKCH | GO:0046822 | regulation of nucleocytoplasmic transport | 4.61e-04 |
PRKCH | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 4.61e-04 |
PRKCH | GO:0007229 | integrin-mediated signaling pathway | 4.63e-04 |
PRKCH | GO:0008286 | insulin receptor signaling pathway | 6.33e-04 |
PRKCH | GO:2001028 | positive regulation of endothelial cell chemotaxis | 6.46e-04 |
PRKCH | GO:0043434 | response to peptide hormone | 6.52e-04 |
PRKCH | GO:0032930 | positive regulation of superoxide anion generation | 6.83e-04 |
PRKCH | GO:0010508 | positive regulation of autophagy | 8.31e-04 |
PRKCH | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 8.31e-04 |
PRKCH | GO:0032928 | regulation of superoxide anion generation | 8.31e-04 |
PRKCH | GO:0046827 | positive regulation of protein export from nucleus | 8.31e-04 |
PRKCH | GO:0045785 | positive regulation of cell adhesion | 8.31e-04 |
PRKCH | GO:0051168 | nuclear export | 1.12e-03 |
PRKCH | GO:0003323 | type B pancreatic cell development | 1.21e-03 |
PRKCH | GO:2001026 | regulation of endothelial cell chemotaxis | 1.21e-03 |
PRKCH | GO:1901028 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 1.38e-03 |
PRKCH | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 1.45e-03 |
PRKCH | GO:0046777 | protein autophosphorylation | 1.60e-03 |
PRKCH | GO:0003309 | type B pancreatic cell differentiation | 1.62e-03 |
PRKCH | GO:0032869 | cellular response to insulin stimulus | 1.62e-03 |
PRKCH | GO:0005979 | regulation of glycogen biosynthetic process | 1.62e-03 |
PRKCH | GO:0010962 | regulation of glucan biosynthetic process | 1.62e-03 |
PRKCH | GO:0035767 | endothelial cell chemotaxis | 1.62e-03 |
PRKCH | GO:0090322 | regulation of superoxide metabolic process | 1.62e-03 |
PRKCH | GO:0019082 | viral protein processing | 1.69e-03 |
PRKCH | GO:0051348 | negative regulation of transferase activity | 1.91e-03 |
PRKCH | GO:0097191 | extrinsic apoptotic signaling pathway | 1.97e-03 |
PRKCH | GO:0002068 | glandular epithelial cell development | 2.01e-03 |
PRKCH | GO:0035883 | enteroendocrine cell differentiation | 2.04e-03 |