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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PRKCQ_TNS1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PRKCQ_TNS1
KinaseFusionDB ID: KFG4980
FusionGDB2.0 ID: KFG4980
HgeneTgene
Gene symbol

PRKCQ

TNS1

Gene ID

5588

7145

Gene nameprotein kinase C thetatensin 1
SynonymsPRKCT|nPKC-thetaMST091|MST122|MST127|MSTP091|MSTP122|MSTP127|MXRA6|PPP1R155|TNS
Cytomap

10p15.1

2q35

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C theta typetensin-1Matrix-remodelling-associated protein 6matrix-remodelling associated 6protein phosphatase 1, regulatory subunit 155
Modification date2024030520240407
UniProtAcc

Q04759

Q9HBL0

Ensembl transtripts involved in fusion geneENST idsENST00000263125, ENST00000397176, 
ENST00000539722, 		ENST00000171887, 
ENST00000310858, ENST00000419504, 
ENST00000430930, ENST00000480665, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PRKCQ [Title/Abstract] AND TNS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRKCQ(6530373)-TNS1(218858491), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCQ

GO:0006468

protein phosphorylation

34593629

HgenePRKCQ

GO:0051092

positive regulation of NF-kappaB transcription factor activity

16356855


check buttonKinase Fusion gene breakpoints across PRKCQ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across TNS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0DL057791PRKCQchr10

6530373

TNS1chr2

218858491



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6530373/:218858491)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKCQ

Q04759

TNS1

Q9HBL0

FUNCTION: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylates CCDC88A/GIV and inhibits its guanine nucleotide exchange factor activity (PubMed:23509302). {ECO:0000269|PubMed:11342610, ECO:0000269|PubMed:14988727, ECO:0000269|PubMed:15364919, ECO:0000269|PubMed:16252004, ECO:0000269|PubMed:16356855, ECO:0000269|PubMed:16709830, ECO:0000269|PubMed:19549985, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:8657160}.FUNCTION: May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (PubMed:21768292, PubMed:28005397). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition (PubMed:28005397). Enhances RHOA activation in the presence of DLC1 (PubMed:26427649). Plays a role in cell polarization and migration (PubMed:19826001). May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton (PubMed:21768292). {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:28005397, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PRKCQ_TNS1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKCQQ04759humanHEXIM1O94992S158KKHRRRPsKKKRHWk
PRKCQQ04759humanRDXP35241T564AGRDKyKtLRQIRQGERM_C
PRKCQQ04759humanLLGL1Q15334S663LkKsLRQsFRRIRKs
PRKCQQ04759humanPDPK1O15530S241skQARANsFVGtAQyPkinase
PRKCQQ04759humanCARD11Q9BXL7S893sPRLSRAsFLFGQLL
PRKCQQ04759humanBADQ92934S75EIRsRHssyPAGtEDBcl-2_BAD
PRKCQQ04759humanLLGL1Q15334S673RIRKsRVsGKKRAAN
PRKCQQ04759humanNKD2Q969F2S31FVASAYAsGRKGAEE
PRKCQQ04759humanEZRP15311T567QGRDkyKtLRQIRQGERM_C
PRKCQQ04759humanPDPK1O15530S64EPRPGAGsLQHAQPP
PRKCQQ04759humanPRKCQQ04759T219SAINSREtMFHkERF
PRKCQQ04759humanIRS1P35568S1101GCRRRHssEtFsStP
PRKCQQ04759humanRANGAP1P46060S504LMQKAFNsssFNSNTRanGAP1_C
PRKCQQ04759humanPTPN7P35236S246QYQEERRsVkHILFSY_phosphatase
PRKCQQ04759humanCCDC88AQ3V6T2S1690LQQFLEEsNKLTSVQ
PRKCQQ04759humanHPCAL1P37235T149EStPEKRtDKIFRQMEF-hand_7
PRKCQQ04759humanRASGRP1O95267T184RDWSRKLtQRIKSNT
PRKCQQ04759humanCARD11Q9BXL7S559QPPRsRssIMsITAE
PRKCQQ04759humanNR2F6P10588S83CKSFFKRsIRRNLsYzf-C4
PRKCQQ04759humanLLGL1Q15334S655GPLSRVKsLkKsLRQ
PRKCQQ04759humanH3C1P68431S10tkQtArkstGGkAPrHistone
PRKCQQ04759humanLLGL1Q15334S659RVKsLkKsLRQsFRR
PRKCQQ04759humanKRASP01116-2S181GKKKKkKskTkCVIM
PRKCQQ04759humanPTPN6P29350S591DKEKsKGsLKRK___
PRKCQQ04759humanLLGL1Q15334S670sFRRIRKsRVsGKKR
PRKCQQ04759humanFOSL1P15407S265PSSDPLGsPtLLAL_
PRKCQQ04759humanMSNP26038T558LGRDKyKtLRQIRQGERM_C
PRKCQQ04759humanWIPF1O43516S488RNESRSGsNRRErGA
PRKCQQ04759humanRAPGEF2Q9Y4G8S960KKRVRRssFLNAKKL
PRKCQQ04759humanCBLBQ13191S282KysTKPGsYIFRLSCCbl_N3
PRKCQQ04759humanHABP4Q5JVS0T375GRGARGGtRGGRGRIIHABP4_N
PRKCQQ04759humanSTK39Q9UEW8S323LCLQkDPskRPTAAEPkinase
PRKCQQ04759humanPTPN7P35236S44RLQERrGsNVALMLD
PRKCQQ04759humanICAM3P32942S518REHQRsGsyHVREEs
PRKCQQ04759humanFOSL1P15407T230tPSLtPFtPSLVFTY
PRKCQQ04759humanFOSL1P15407T223HtPTLMTtPSLtPFt
PRKCQQ04759humanHABP4Q5JVS0T354RKPANDItSQLEINFIHABP4_N
PRKCQQ04759humanBADQ92934S99PFrGrsRsAPPNLWABcl-2_BAD
PRKCQQ04759humanPPP1R12AO14974T853PREKRRstGVsFWtQ
PRKCQQ04759humanRANGAP1P46060S506QKAFNsssFNSNTFLRanGAP1_C
PRKCQQ04759humanARHGEF6Q15052S225KSSERPLsPkAVkGF
PRKCQQ04759humanTBK1Q9UHD2S716HILERFGsLTMDGGL
PRKCQQ04759humanARHGEF6Q15052S488LSASPRMsGFIyQGkPH
PRKCQQ04759humanSTK39Q9UEW8S309MMKKyGKsFRkLLSLPkinase
PRKCQQ04759humanRASGRP3Q8IV61T133YDWMRRVtQRKKVSK


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKCQIDDescription0.00e+00
PRKCQGO:0007159leukocyte cell-cell adhesion1.47e-05
PRKCQGO:0032943mononuclear cell proliferation1.12e-04
PRKCQGO:0022407regulation of cell-cell adhesion1.12e-04
PRKCQGO:0050856regulation of T cell receptor signaling pathway1.12e-04
PRKCQGO:1902946protein localization to early endosome1.12e-04
PRKCQGO:1905668positive regulation of protein localization to endosome1.12e-04
PRKCQGO:0002764immune response-regulating signaling pathway1.12e-04
PRKCQGO:0042098T cell proliferation1.12e-04
PRKCQGO:0002064epithelial cell development1.12e-04
PRKCQGO:0070661leukocyte proliferation1.12e-04
PRKCQGO:1905666regulation of protein localization to endosome1.12e-04
PRKCQGO:0061028establishment of endothelial barrier1.12e-04
PRKCQGO:1903651positive regulation of cytoplasmic transport1.54e-04
PRKCQGO:0050863regulation of T cell activation1.54e-04
PRKCQGO:1903037regulation of leukocyte cell-cell adhesion1.54e-04
PRKCQGO:0050870positive regulation of T cell activation1.91e-04
PRKCQGO:0051347positive regulation of transferase activity2.21e-04
PRKCQGO:0001885endothelial cell development2.21e-04
PRKCQGO:2000641regulation of early endosome to late endosome transport2.25e-04
PRKCQGO:0050854regulation of antigen receptor-mediated signaling pathway2.25e-04
PRKCQGO:1903039positive regulation of leukocyte cell-cell adhesion2.46e-04
PRKCQGO:0072659protein localization to plasma membrane2.93e-04
PRKCQGO:0035739CD4-positiv5.47e-06
PRKCQGO:0046651lymphocyte proliferation3.65e-04
PRKCQGO:1903829positive regulation of protein localization3.65e-04
PRKCQGO:0050860negative regulation of T cell receptor signaling pathway3.74e-04
PRKCQGO:0022409positive regulation of cell-cell adhesion4.40e-04
PRKCQGO:0036010protein localization to endosome4.43e-04
PRKCQGO:0051251positive regulation of lymphocyte activation4.73e-04
PRKCQGO:0033674positive regulation of kinase activity5.16e-04
PRKCQGO:1990778protein localization to cell periphery6.51e-04
PRKCQGO:1903649regulation of cytoplasmic transport6.60e-04
PRKCQGO:0045732positive regulation of protein catabolic process6.66e-04
PRKCQGO:0045577regulation of B cell differentiation6.66e-04
PRKCQGO:0050858negative regulation of antigen receptor-mediated signaling pathway6.66e-04
PRKCQGO:0002696positive regulation of leukocyte activation8.56e-04
PRKCQGO:0050867positive regulation of cell activation1.05e-03
PRKCQGO:0045446endothelial cell differentiation1.37e-03
PRKCQGO:0045022early endosome to late endosome transport1.41e-03
PRKCQGO:0046640regulation of alpha-beta T cell proliferation1.41e-03
PRKCQGO:0045088regulation of innate immune response1.42e-03
PRKCQGO:0046633alpha-beta T cell proliferation1.64e-03
PRKCQGO:0031295T cell costimulation1.71e-03
PRKCQGO:0098927vesicle-mediated transport between endosomal compartments1.78e-03
PRKCQGO:0031294lymphocyte costimulation1.85e-03
PRKCQGO:0003158endothelium development1.99e-03
PRKCQGO:0050852T cell receptor signaling pathway2.01e-03
PRKCQGO:0045785positive regulation of cell adhesion2.40e-03
PRKCQGO:0002279mast cell activation involved in immune response2.40e-03

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Related Drugs to PRKCQ_TNS1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PRKCQ-TNS1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PRKCQ_TNS1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate