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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PRKCZ_KRAS

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PRKCZ_KRAS
KinaseFusionDB ID: KFG4987
FusionGDB2.0 ID: KFG4987
HgeneTgene
Gene symbol

PRKCZ

KRAS

Gene ID

5590

4893

Gene nameprotein kinase C zeta
SynonymsPKC-ZETA|PKC2
Cytomap

1p36.33

Type of geneprotein-coding
Descriptionprotein kinase C zeta typenPKC-zeta
Modification date20240403
UniProtAcc

Q05513

P01116

Ensembl transtripts involved in fusion geneENST idsENST00000400920, ENST00000400921, 
ENST00000479263, 		ENST00000256078, 
ENST00000311936, ENST00000556131, 
ENST00000557334, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PRKCZ [Title/Abstract] AND KRAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRKCZ(1982140)-KRAS(25398329), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCZ

GO:0006468

protein phosphorylation

10770950|17313651

HgenePRKCZ

GO:0018105

peptidyl-serine phosphorylation

15069075


check buttonKinase Fusion gene breakpoints across PRKCZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across KRAS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-IG-A4QSPRKCZchr1

1982140

KRASchr12

25398329



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1982140/:25398329)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKCZ

Q05513

KRAS

P01116

FUNCTION: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (PubMed:17313651). {ECO:0000269|PubMed:11035106, ECO:0000269|PubMed:12162751, ECO:0000269|PubMed:15084291, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:9447975}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000250|UniProtKB:Q02956}.FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269|PubMed:20949621, ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24623306, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PRKCZ_KRAS


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKCZQ05513humanPTENP60484S380EPDHyRYsDttDsDP
PRKCZQ05513humanMARK2Q7KZI7T596rGVssRstFHAGQLR
PRKCZQ05513humanMAPTP10636-8S352DFKDrVQskIGsLDNTubulin-binding
PRKCZQ05513humanRND3P61587S210KNVKRNKsQRATKRI
PRKCZQ05513humanBLVRAP53004S230LKRNRyLsFHFksGsBiliv-reduc_cat
PRKCZQ05513humanGSK3BP49841S147YRVARHYsRAKQTLPPkinase
PRKCZQ05513humanNUMBP49757-3S7_MNKLRQsFRRKKDV
PRKCZQ05513humanSTK11Q15831-2S399DLSGEEAsRPAPQ__
PRKCZQ05513humanAQP9O43315S222MNPARDLsPRLFTALMIP
PRKCZQ05513humanNCOA3Q9Y6Q9S1042DDLVGPPsNLEGQsD
PRKCZQ05513humanOCLNQ16625T438LYKRNFDtGLQEyKsOccludin_ELL
PRKCZQ05513humanMARK3P27448T564RGTASRStFHGQPRE
PRKCZQ05513humanPLA2G4AP47712T376GskFFMGtVVKKYEEPLA2_B
PRKCZQ05513humanPAK4O96013S99MsVTRsNsLRRDsPP
PRKCZQ05513humanPPP1R14AQ96A00T38QkRHARVtVkYDRREPP1_inhibitor
PRKCZQ05513humanNCF1P14598S320QRsRKRLsQDAYRRNNECFESHC
PRKCZQ05513humanEPHA2P29317S892ADFDPRVsIRLPsts
PRKCZQ05513humanPHGDHO43175T57GLIVRsAtkVtADVI2-Hacid_dh
PRKCZQ05513humanPIAS4Q8N2W9S18MVMSFRVsDLQMLLG
PRKCZQ05513humanNUMBP49757-3S284sPFKRQLsLRINELPNumbF
PRKCZQ05513humanCTNNB1P35222S45GATtTAPsLsGkGNP
PRKCZQ05513humanPHGDHO43175T78QVVGrAGtGVDNVDL2-Hacid_dh
PRKCZQ05513humanNCOA3Q9Y6Q9T1064LHtLLsNtDAtGLEENuc_rec_co-act
PRKCZQ05513humanMYH10P35580S1935LRrGGPIsFsssrSG
PRKCZQ05513humanCASP9P55211S144GDVGALEsLRGNADL
PRKCZQ05513humanHMGB1P09429S39PDAsVNFsEFskkCsHMG_box_2
PRKCZQ05513humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
PRKCZQ05513humanSNAI1O95863S249ARTFsRMsLLHKHQE
PRKCZQ05513humanCHATP28329-3S440VPTYESAsIRRFQEGCarn_acyltransf
PRKCZQ05513humanYAP1P46937S109ksHsRQAstDAGtAG
PRKCZQ05513humanNREPQ16612S59LGSSELRsPRISYLHAlveol-reg_P311
PRKCZQ05513humanMAPTP10636-8S293NVQskCGsKDNIkHVTubulin-binding
PRKCZQ05513humanGEMP55040S261AyQKRKEsMPRKARR
PRKCZQ05513humanAGERQ15109S391ERAELNQsEEPEAGE
PRKCZQ05513humanNCF1P14598S304GAPPRRssIRNAHsINECFESHC
PRKCZQ05513humanRELAQ04206S311RtyEtFksIMkksPF
PRKCZQ05513humanPARD6AQ9NPB6S345RGDGSGFsL______
PRKCZQ05513humanNCOA3Q9Y6Q9S1062DQLHtLLsNtDAtGLNuc_rec_co-act
PRKCZQ05513humanNCOA3Q9Y6Q9T1059ALLDQLHtLLsNtDANuc_rec_co-act
PRKCZQ05513humanMYH10P35580S1956EGAsLELsDDDtEsK
PRKCZQ05513humanOCLNQ16625T404HyEtDyttGGEsCDE
PRKCZQ05513humanNCOA3Q9Y6Q9S1033NRPLLRNsLDDLVGP
PRKCZQ05513humanPHGDHO43175S55CEGLIVRsAtkVtAD2-Hacid_dh
PRKCZQ05513humanVIMP08670S34srsyVttstrtysLGFilament_head
PRKCZQ05513humanKLF10Q13118S384GkTYFKssHLkAHTR
PRKCZQ05513humanMAPTP10636-8S258PDLkNVKskIGstENTubulin-binding
PRKCZQ05513humanPAK5Q9P286S99ISVTRSNsLRKESPP
PRKCZQ05513humanGSK3BP49841S9SGRPRttsFAEsCkP
PRKCZQ05513humanMYH10P35580S1937rGGPIsFsssrSGRR
PRKCZQ05513humanRPS6KB2Q9UBS0S473PPSGTKKsKRGRGRP
PRKCZQ05513humanAQP9O43315S11EGAEKGKsFKQRLVL
PRKCZQ05513humanSP1P08047T668SYCGKRFtRsDELQRzf-C2H2
PRKCZQ05513humanBAXQ07812S184VAGVLTAsLtIWKKMTM
PRKCZQ05513humanSMARCD3Q6STE5S247VKRPGDLsVRCTLLL
PRKCZQ05513humanSTK11Q15831S428SSkIRRLsACkQQ__
PRKCZQ05513humanMAP1LC3BQ9GZQ8T50QLPVLDktkFLVPDHATG8
PRKCZQ05513humanNR1H4Q96RI1-2T442GRLTELRtFNHHHAEHormone_recep
PRKCZQ05513humanOCLNQ16625T424IREYPPItSDQQRQLOccludin_ELL
PRKCZQ05513humanIRS1P35568S323MVGGKPGsFRVRAss
PRKCZQ05513humanSP1P08047T681QRHKRtHtGEkkFAC
PRKCZQ05513humanHMGB1P09429S53sERWktMsAkEKGkFHMG_box_2
PRKCZQ05513humanNCF1P14598S315AHsIHQRsRKRLsQDNECFESHC
PRKCZQ05513humanADD2P35612S713KKKFRtPsFLKKsKK
PRKCZQ05513humanADD1P35611S726KKKFRtPsFLKKsKK
PRKCZQ05513humanSTOML2Q9UJZ1S17GALLLRGsLLASGRA
PRKCZQ05513humanVIMP08670S39ttstrtysLGsALrPFilament_head
PRKCZQ05513humanNCOA3Q9Y6Q9T1114KAGLYGQtYPAQGPP
PRKCZQ05513humanNCF1P14598S328QDAYRRNsVRFLQQRNECFESHC
PRKCZQ05513humanADARB1P78563S211GDLSLSAsPVPAsLA
PRKCZQ05513humanNR0B2Q15466T55QLCAPHRtCrEALDVHormone_recep
PRKCZQ05513humanCHATP28329-3S476HKAAVPAsEKLLLLKCarn_acyltransf
PRKCZQ05513humanYAP1P46937T110sHsRQAstDAGtAGA
PRKCZQ05513humanHMGB1P09429S181GVVkAEKsKKKKEEE
PRKCZQ05513humanHABP4Q5JVS0T375GRGARGGtRGGRGRIIHABP4_N
PRKCZQ05513humanIKBKBO14920S177AkELDQGsLCtsFVGPkinase
PRKCZQ05513humanBLVRAP53004S149GkDLLkGsLLFTAGPBiliv-reduc_cat
PRKCZQ05513humanIRS1P35568S441SPCDFRSsFRsVtPD
PRKCZQ05513humanWWC1Q8IX03S978KRPSsVKsLRSERLI
PRKCZQ05513humanNCOA3Q9Y6Q9T1067LLsNtDAtGLEEIDRNuc_rec_co-act
PRKCZQ05513humanNCOA3Q9Y6Q9S1048PsNLEGQsDERALLDNuc_rec_co-act
PRKCZQ05513humanPTENP60484T383HyRYsDttDsDPENE
PRKCZQ05513humanOCLNQ16625T403DHyEtDyttGGEsCD
PRKCZQ05513humanSP1P08047S670CGKRFtRsDELQRHKzf-C2H2
PRKCZQ05513humanIKBKBO14920S181DQGsLCtsFVGTLQyPkinase
PRKCZQ05513humanWWC1Q8IX03S975VRMKRPSsVKsLRSE
PRKCZQ05513humanKLF10Q13118T445FMRSDHLtkHARRHLzf-C2H2
PRKCZQ05513humanSP1P08047S641GKVYGKtsHLRAHLRzf-C2H2
PRKCZQ05513humanHABP4Q5JVS0T354RKPANDItSQLEINFIHABP4_N
PRKCZQ05513humanSTK11Q15831S307IRQIRQHsWFRkKHPPkinase
PRKCZQ05513humanPTENP60484T382DHyRYsDttDsDPEN
PRKCZQ05513humanTRAF2Q12933S55QCGHRYCsFCLASILzf-C3HC4
PRKCZQ05513humanNFE2L2Q16236S40SREVFDFsQRRkEYE
PRKCZQ05513humanNUMBP49757-3S265EQLARQGsFRGFPALNumbF
PRKCZQ05513humanADARB1P78563S216SAsPVPAsLAQPPLP
PRKCZQ05513humanSP1P08047S702FMRsDHLskHIKtHQzf-C2H2
PRKCZQ05513humanVIMP08670S56srsLyAssPGGVyAtFilament_head


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKCZIDDescription0.00e+00
PRKCZGO:0045216cell-cell junction organization8.51e-06
PRKCZGO:2001233regulation of apoptotic signaling pathway8.51e-06
PRKCZGO:0097193intrinsic apoptotic signaling pathway1.06e-04
PRKCZGO:0031400negative regulation of protein modification process1.06e-04
PRKCZGO:0010720positive regulation of cell development1.06e-04
PRKCZGO:2001234negative regulation of apoptotic signaling pathway1.06e-04
PRKCZGO:0034250positive regulation of amide metabolic process1.15e-04
PRKCZGO:0051098regulation of binding1.40e-04
PRKCZGO:0051347positive regulation of transferase activity3.84e-04
PRKCZGO:0043393regulation of protein binding5.16e-04
PRKCZGO:1904019epithelial cell apoptotic process5.16e-04
PRKCZGO:0097191extrinsic apoptotic signaling pathway5.16e-04
PRKCZGO:0007043cell-cell junction assembly6.56e-04
PRKCZGO:0045862positive regulation of proteolysis6.56e-04
PRKCZGO:2001236regulation of extrinsic apoptotic signaling pathway6.56e-04
PRKCZGO:1903829positive regulation of protein localization6.77e-04
PRKCZGO:0010001glial cell differentiation6.84e-04
PRKCZGO:1901653cellular response to peptide8.43e-04
PRKCZGO:0045936negative regulation of phosphate metabolic process8.43e-04
PRKCZGO:0010563negative regulation of phosphorus metabolic process8.43e-04
PRKCZGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage9.13e-04
PRKCZGO:0050767regulation of neurogenesis9.81e-04
PRKCZGO:0033209tumor necrosis factor-mediated signaling pathway1.26e-03
PRKCZGO:1904035regulation of epithelial cell apoptotic process1.30e-03
PRKCZGO:0018105peptidyl-serine phosphorylation1.30e-03
PRKCZGO:0043254regulation of protein-containing complex assembly1.40e-03
PRKCZGO:0018209peptidyl-serine modification1.59e-03
PRKCZGO:0021782glial cell development1.64e-03
PRKCZGO:0010803regulation of tumor necrosis factor-mediated signaling pathway1.67e-03
PRKCZGO:0043588skin development1.67e-03
PRKCZGO:0032092positive regulation of protein binding1.67e-03
PRKCZGO:0002064epithelial cell development1.67e-03
PRKCZGO:0051099positive regulation of binding1.67e-03
PRKCZGO:0034329cell junction assembly1.67e-03
PRKCZGO:1903828negative regulation of protein localization1.76e-03
PRKCZGO:2000810regulation of bicellular tight junction assembly1.83e-03
PRKCZGO:0033674positive regulation of kinase activity2.00e-03
PRKCZGO:0051960regulation of nervous system development2.00e-03
PRKCZGO:0042063gliogenesis2.00e-03
PRKCZGO:0070830bicellular tight junction assembly2.10e-03
PRKCZGO:0033233regulation of protein sumoylation2.10e-03
PRKCZGO:1902993positive regulation of amyloid precursor protein catabolic process2.32e-03
PRKCZGO:0071356cellular response to tumor necrosis factor2.34e-03
PRKCZGO:2000737negative regulation of stem cell differentiation2.46e-03
PRKCZGO:0050769positive regulation of neurogenesis2.46e-03
PRKCZGO:0051091positive regulation of DNA-binding transcription factor activity2.52e-03
PRKCZGO:0120192tight junction assembly2.53e-03
PRKCZGO:0043297apical junction assembly2.74e-03
PRKCZGO:0010950positive regulation of endopeptidase activity3.04e-03

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Related Drugs to PRKCZ_KRAS


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PRKCZ-KRAS and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PRKCZ_KRAS


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate