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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:PRKD1_APOBR

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: PRKD1_APOBR
KinaseFusionDB ID: KFG4992
FusionGDB2.0 ID: KFG4992
HgeneTgene
Gene symbol

PRKD1

APOBR

Gene ID

5587

55911

Gene nameprotein kinase D1apolipoprotein B receptor
SynonymsCHDED|PKC-MU|PKCM|PKD|PRKCMAPOB100R|APOB48R
Cytomap

14q12

16p12.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase D1nPKC-D1nPKC-muprotein kinase C mu typeprotein kinase C, muprotein kinase Dapolipoprotein B receptorapoB-48Rapolipoprotein B-100 receptorapolipoprotein B-48 receptorapolipoprotein B100 receptorapolipoprotein B48 receptor
Modification date2024041120240411
UniProtAcc

Q15139

Q0VD83

Ensembl transtripts involved in fusion geneENST idsENST00000331968, ENST00000415220, 
ENST00000551644, 		ENST00000564831, 
ENST00000431282, ENST00000328423, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: PRKD1 [Title/Abstract] AND APOBR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKD1

GO:0034599

cellular response to oxidative stress

12505989

HgenePRKD1

GO:0046777

protein autophosphorylation

24623306

HgenePRKD1

GO:0051897

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

22095288


check buttonKinase Fusion gene breakpoints across PRKD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across APOBR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLEPSS008PRKD1chr14

30396455

APOBRchr16

28506420



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:/chr16:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKD1

Q15139

APOBR

Q0VD83

FUNCTION: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}.FUNCTION: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. {ECO:0000269|PubMed:10852956, ECO:0000269|PubMed:15591219, ECO:0000269|PubMed:9633939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of PRKD1_APOBR


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKD1Q15139humanHDAC7Q8WUI4S486RPLsRAQssPAAPAs
PRKD1Q15139humanATP7BP35670S1453DDDGDKWsLLLNGRD
PRKD1Q15139humanCERT1Q9Y5P4S132ssLRRHGsMVsLVsG
PRKD1Q15139humanCTNNB1P35222T120QFdAAHPtNVQRLAE
PRKD1Q15139humanDLC1Q96QB1S1244NtLKRENsSPRVMQR
PRKD1Q15139humanDNM1LO00429S637VPVARKLsAREQRDC
PRKD1Q15139humanCTNNB1P35222T112EGMQIPstQFdAAHP
PRKD1Q15139humanTLR5O60602S805yQLMKHQsIRGFVQKTIR
PRKD1Q15139humanREM1O75628S18TPLHRRAstPLPLsP
PRKD1Q15139humanSPHK2Q9NRA0S421sPLHRsVsDLPLPLP
PRKD1Q15139humanMAP3K5Q99683T838GINPCTEtFTGtLQYPkinase
PRKD1Q15139humanATP7BP35670S1121AHSERPLsAPASHLNHydrolase
PRKD1Q15139humanPAK4O96013S99MsVTRsNsLRRDsPP
PRKD1Q15139humanPIK3R1P27986S154stLYRtQsSSNLAELRhoGAP
PRKD1Q15139humanAKT1P31749S473RPHFPQFsysAsGtAPkinase_C
PRKD1Q15139humanPPP1R14AQ96A00T38QkRHARVtVkYDRREPP1_inhibitor
PRKD1Q15139humanKAT7O95251T97kKYPLRQtRssGsEt
PRKD1Q15139humanMYBPC3Q14896S304SLLKKRDsFRtPRDs
PRKD1Q15139humanPIP5K1CO60331S448NTVFRKNsSLKSsPS
PRKD1Q15139humanPI4KBQ9UBF8-2S294SNLKRtAsNPKVENE
PRKD1Q15139humanPTRH2Q9Y3E5S5___MPSKsLVMEYLA
PRKD1Q15139humanRTKNQ9BST9-2S435QALAKQGsLYHEMAI
PRKD1Q15139humanCTTNQ14247S298EKLAkHEsQQDyskGHS1_rep
PRKD1Q15139humanATP7BP35670S481ILAKsPQsTRAVAPQ
PRKD1Q15139humanTFAP2AP05549S258GVLRRAKsKNGGRSLTF_AP-2
PRKD1Q15139humanPRKD1Q15139S910KALGERVsIL_____
PRKD1Q15139humanRIN1Q13671S351RPLLRsMsAAFCSLL
PRKD1Q15139humanITGB4P16144-2T1736EFVSRTLttSGTLST
PRKD1Q15139humanPI4KBQ9UBF8S294SNLkRTAsNPKVENE
PRKD1Q15139humanAP2B1P63010Y277LPkDsDyyNMLLkKLAdaptin_N
PRKD1Q15139humanOXTRP30559S261RVALARVsSVKLISK7tm_1
PRKD1Q15139humanAP2B1P63010S258ANSAVVLsAVKVLMkAdaptin_N
PRKD1Q15139humanBADQ92934S99PFrGrsRsAPPNLWABcl-2_BAD
PRKD1Q15139humanATP7BP35670S478APDILAKsPQsTRAV
PRKD1Q15139humanMFFQ9GZY8S172GQLVRNDsLWHRsDsMiff
PRKD1Q15139humanTFAP2AP05549S326EFLNRQHsDPNEQVTTF_AP-2
PRKD1Q15139humanMAP4K1Q92918S171AtLARRLsFIGtPyWPkinase
PRKD1Q15139humanTLR4O00206S790VELYRLLsRNTYLEWTIR
PRKD1Q15139humanHSPB1P04792S82RALsRQLssGVsEIr
PRKD1Q15139humanTCAPO15273S157GALRRsLsRSMsQEATelethonin
PRKD1Q15139humanHDAC7Q8WUI4S155FPLRKtVsEPNLkLR
PRKD1Q15139humanSSH1Q8WYL5S978sPLKRSHsLAKLGSL
PRKD1Q15139humanBADQ92934S75EIRsRHssyPAGtEDBcl-2_BAD
PRKD1Q15139humanHDAC5Q9UQL6S498RPLSRtQsSPLPQsP
PRKD1Q15139humanPAK5Q9P286S99ISVTRSNsLRKESPP
PRKD1Q15139humanCREB1P16220S119EILsRRPsyRkILNDpKID
PRKD1Q15139humanMFFQ9GZY8S275DNVRYGIsNIDTTIEMiff
PRKD1Q15139humanPAK4O96013S474kEVPRRksLVGtPyWPkinase
PRKD1Q15139humanMARK2Q7KZI7S400HkVQRsVsANPKQRR
PRKD1Q15139humanRABEP1Q15276S407DGLRRAQstDsLGtsRabaptin
PRKD1Q15139humanCREB1P16220-1S98KDLKRLFsGtQISTI
PRKD1Q15139humanKAT7O95251T331LRLQGQItEGsNMIk
PRKD1Q15139humanBADQ92934S118GRELRRMsDEFVDsFBcl-2_BAD
PRKD1Q15139humanSPHK2Q9NRA0S419AHsPLHRsVsDLPLP
PRKD1Q15139humanPRKD1Q15139S738ARIIGEksFRRsVVGPkinase
PRKD1Q15139humanHDAC7Q8WUI4S358WPLsRtRsEPLPPsA
PRKD1Q15139humanCACNA1CQ13936S1981ASLGRRAsFHLECLK
PRKD1Q15139humanCTTNQ14247S348EAVTskTsNIRANFE
PRKD1Q15139humanJUNP05412S63kNsDLLtsPDVGLLkJun
PRKD1Q15139humanPIP4K2AP48426T376KAAHAAktVKHGAGAPIP5K
PRKD1Q15139humanKCNH2Q12809S284ASVRRAssADDIEAM
PRKD1Q15139humanSPRY2O43597S112APLSRSIsTVssGsR
PRKD1Q15139humanARFIP1P53367S132LELVRKWsLNtyKCTArfaptin
PRKD1Q15139humanPTRH2Q9Y3E5S87GkVAAQCsHAAVSAyPTH2
PRKD1Q15139humanFAM83GA6ND36S356YALVKAKsVDEIAKI
PRKD1Q15139humanSSH1Q8WYL5S402MGVSRsAstVIAyAMDSPc
PRKD1Q15139humanPAK4O96013S181SRDKRPLsGPDVGtP
PRKD1Q15139humanMBPP02686-5S162FKLGGRDsRSGSPMAMyelin_MBP
PRKD1Q15139humanCFL1P23528S3_____MAsGVAVsDG
PRKD1Q15139humanHDAC5Q9UQL6S259FPLRkTAsEPNLKVR
PRKD1Q15139humanRIN1Q13671S292QLLRREssVGyRVPA
PRKD1Q15139humanSSH1Q8WYL5S937SNLtRssssDsIHsV
PRKD1Q15139humanMFFQ9GZY8S155GRLkRERsMsENAVRMiff
PRKD1Q15139humanPRKD1Q15139S742GEksFRRsVVGtPAyPkinase
PRKD1Q15139humanSNAI1O95863S11SFLVRKPsDPNRKPN
PRKD1Q15139humanOSBPP22059S240tALQRsLsELESLkL
PRKD1Q15139humanVASPP50552S157EHIERRVsNAGGPPA
PRKD1Q15139humanHSPB6O14558S16PSWLRRAsAPLPGLSCrystallin
PRKD1Q15139humanVASPP50552S322TtLPRMkssssVttS
PRKD1Q15139humanAKT1P31749T308kDGAtMKtFCGtPEyPkinase
PRKD1Q15139humanTCAPO15273S161RsLsRSMsQEAQRG_Telethonin


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKD1IDDescription0.00e+00
PRKD1GO:0097306cellular response to alcohol4.24e-04
PRKD1GO:0006936muscle contraction4.24e-04
PRKD1GO:1903829positive regulation of protein localization4.24e-04
PRKD1GO:0032970regulation of actin filament-based process4.55e-04
PRKD1GO:1903532positive regulation of secretion by cell4.55e-04
PRKD1GO:2001233regulation of apoptotic signaling pathway4.55e-04
PRKD1GO:0051047positive regulation of secretion5.28e-04
PRKD1GO:1904627response to phorbol 13-acetate 12-myristate5.28e-04
PRKD1GO:1904628cellular response to phorbol 13-acetate 12-myristate5.28e-04
PRKD1GO:0097193intrinsic apoptotic signaling pathway5.28e-04
PRKD1GO:0003012muscle system process7.04e-04
PRKD1GO:0090199regulation of release of cytochrome c from mitochondria1.19e-03
PRKD1GO:0006937regulation of muscle contraction1.19e-03
PRKD1GO:1901655cellular response to ketone1.46e-03
PRKD1GO:0006941striated muscle contraction1.73e-03
PRKD1GO:2001242regulation of intrinsic apoptotic signaling pathway1.83e-03
PRKD1GO:0001836release of cytochrome c from mitochondria2.18e-03
PRKD1GO:0051222positive regulation of protein transport2.50e-03
PRKD1GO:1901654response to ketone2.57e-03
PRKD1GO:0070584mitochondrion morphogenesis2.71e-03
PRKD1GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress2.71e-03
PRKD1GO:0034329cell junction assembly2.71e-03
PRKD1GO:1904951positive regulation of establishment of protein localization2.71e-03
PRKD1GO:0046854phosphatidylinositol phosphate biosynthetic process2.97e-03
PRKD1GO:0032956regulation of actin cytoskeleton organization3.04e-03
PRKD1GO:0007015actin filament organization3.04e-03
PRKD1GO:0097191extrinsic apoptotic signaling pathway3.04e-03
PRKD1GO:0045670regulation of osteoclast differentiation3.04e-03
PRKD1GO:0090200positive regulation of release of cytochrome c from mitochondria3.29e-03
PRKD1GO:0010506regulation of autophagy3.69e-03
PRKD1GO:2001234negative regulation of apoptotic signaling pathway3.69e-03
PRKD1GO:0035924cellular response to vascular endothelial growth factor stimulus3.69e-03
PRKD1GO:0043536positive regulation of blood vessel endothelial cell migration3.75e-03
PRKD1GO:0090257regulation of muscle system process3.75e-03
PRKD1GO:0010821regulation of mitochondrion organization3.81e-03
PRKD1GO:0043535regulation of blood vessel endothelial cell migration3.82e-03
PRKD1GO:0008654phospholipid biosynthetic process3.92e-03
PRKD1GO:0097305response to alcohol3.92e-03
PRKD1GO:0003007heart morphogenesis4.72e-03
PRKD1GO:1902903regulation of supramolecular fiber organization4.94e-03
PRKD1GO:0110053regulation of actin filament organization5.17e-03
PRKD1GO:0035115embryonic forelimb morphogenesis5.17e-03
PRKD1GO:0045671negative regulation of osteoclast differentiation5.17e-03
PRKD1GO:0010959regulation of metal ion transport5.17e-03
PRKD1GO:0048660regulation of smooth muscle cell proliferation5.17e-03
PRKD1GO:1902176negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway5.30e-03
PRKD1GO:0048659smooth muscle cell proliferation5.52e-03
PRKD1GO:1900182positive regulation of protein localization to nucleus5.70e-03
PRKD1GO:0051347positive regulation of transferase activity5.94e-03

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Related Drugs to PRKD1_APOBR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning PRKD1-APOBR and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to PRKD1_APOBR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate