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Kinase Fusion Gene:PRKD1_EFHD2 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: PRKD1_EFHD2 | KinaseFusionDB ID: KFG4995 | FusionGDB2.0 ID: KFG4995 | Hgene | Tgene | Gene symbol | PRKD1 | EFHD2 | Gene ID | 5587 | 79180 | |
Gene name | protein kinase D1 | EF-hand domain family member D2 | ||||||||||
Synonyms | CHDED|PKC-MU|PKCM|PKD|PRKCM | SWS1 | ||||||||||
Cytomap | 14q12 | 1p36.21 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | serine/threonine-protein kinase D1nPKC-D1nPKC-muprotein kinase C mu typeprotein kinase C, muprotein kinase D | EF-hand domain-containing protein D2EF hand domain containing 2swiprosin 1testicular tissue protein Li 62 | ||||||||||
Modification date | 20240411 | 20240407 | ||||||||||
UniProtAcc | Q15139 | Q96C19 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000331968, ENST00000415220, ENST00000551644, | ENST00000375980, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRKD1 [Title/Abstract] AND EFHD2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKD1(30579639)-EFHD2(15756703), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PRKD1 | GO:0034599 | cellular response to oxidative stress | 12505989 |
Hgene | PRKD1 | GO:0046777 | protein autophosphorylation | 24623306 |
Hgene | PRKD1 | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 22095288 |
Kinase Fusion gene breakpoints across PRKD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across EFHD2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | AA531025 | PRKD1 | chr14 | 30579639 | EFHD2 | chr1 | 15756703 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30579639/:15756703) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PRKD1 | EFHD2 |
FUNCTION: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. | FUNCTION: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PRKD1_EFHD2 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
PRKD1 | Q15139 | human | HDAC7 | Q8WUI4 | S486 | RPLsRAQssPAAPAs | |
PRKD1 | Q15139 | human | ATP7B | P35670 | S1453 | DDDGDKWsLLLNGRD | |
PRKD1 | Q15139 | human | CERT1 | Q9Y5P4 | S132 | ssLRRHGsMVsLVsG | |
PRKD1 | Q15139 | human | CTNNB1 | P35222 | T120 | QFdAAHPtNVQRLAE | |
PRKD1 | Q15139 | human | DLC1 | Q96QB1 | S1244 | NtLKRENsSPRVMQR | |
PRKD1 | Q15139 | human | DNM1L | O00429 | S637 | VPVARKLsAREQRDC | |
PRKD1 | Q15139 | human | CTNNB1 | P35222 | T112 | EGMQIPstQFdAAHP | |
PRKD1 | Q15139 | human | TLR5 | O60602 | S805 | yQLMKHQsIRGFVQK | TIR |
PRKD1 | Q15139 | human | REM1 | O75628 | S18 | TPLHRRAstPLPLsP | |
PRKD1 | Q15139 | human | SPHK2 | Q9NRA0 | S421 | sPLHRsVsDLPLPLP | |
PRKD1 | Q15139 | human | MAP3K5 | Q99683 | T838 | GINPCTEtFTGtLQY | Pkinase |
PRKD1 | Q15139 | human | ATP7B | P35670 | S1121 | AHSERPLsAPASHLN | Hydrolase |
PRKD1 | Q15139 | human | PAK4 | O96013 | S99 | MsVTRsNsLRRDsPP | |
PRKD1 | Q15139 | human | PIK3R1 | P27986 | S154 | stLYRtQsSSNLAEL | RhoGAP |
PRKD1 | Q15139 | human | AKT1 | P31749 | S473 | RPHFPQFsysAsGtA | Pkinase_C |
PRKD1 | Q15139 | human | PPP1R14A | Q96A00 | T38 | QkRHARVtVkYDRRE | PP1_inhibitor |
PRKD1 | Q15139 | human | KAT7 | O95251 | T97 | kKYPLRQtRssGsEt | |
PRKD1 | Q15139 | human | MYBPC3 | Q14896 | S304 | SLLKKRDsFRtPRDs | |
PRKD1 | Q15139 | human | PIP5K1C | O60331 | S448 | NTVFRKNsSLKSsPS | |
PRKD1 | Q15139 | human | PI4KB | Q9UBF8-2 | S294 | SNLKRtAsNPKVENE | |
PRKD1 | Q15139 | human | PTRH2 | Q9Y3E5 | S5 | ___MPSKsLVMEYLA | |
PRKD1 | Q15139 | human | RTKN | Q9BST9-2 | S435 | QALAKQGsLYHEMAI | |
PRKD1 | Q15139 | human | CTTN | Q14247 | S298 | EKLAkHEsQQDyskG | HS1_rep |
PRKD1 | Q15139 | human | ATP7B | P35670 | S481 | ILAKsPQsTRAVAPQ | |
PRKD1 | Q15139 | human | TFAP2A | P05549 | S258 | GVLRRAKsKNGGRSL | TF_AP-2 |
PRKD1 | Q15139 | human | PRKD1 | Q15139 | S910 | KALGERVsIL_____ | |
PRKD1 | Q15139 | human | RIN1 | Q13671 | S351 | RPLLRsMsAAFCSLL | |
PRKD1 | Q15139 | human | ITGB4 | P16144-2 | T1736 | EFVSRTLttSGTLST | |
PRKD1 | Q15139 | human | PI4KB | Q9UBF8 | S294 | SNLkRTAsNPKVENE | |
PRKD1 | Q15139 | human | AP2B1 | P63010 | Y277 | LPkDsDyyNMLLkKL | Adaptin_N |
PRKD1 | Q15139 | human | OXTR | P30559 | S261 | RVALARVsSVKLISK | 7tm_1 |
PRKD1 | Q15139 | human | AP2B1 | P63010 | S258 | ANSAVVLsAVKVLMk | Adaptin_N |
PRKD1 | Q15139 | human | BAD | Q92934 | S99 | PFrGrsRsAPPNLWA | Bcl-2_BAD |
PRKD1 | Q15139 | human | ATP7B | P35670 | S478 | APDILAKsPQsTRAV | |
PRKD1 | Q15139 | human | MFF | Q9GZY8 | S172 | GQLVRNDsLWHRsDs | Miff |
PRKD1 | Q15139 | human | TFAP2A | P05549 | S326 | EFLNRQHsDPNEQVT | TF_AP-2 |
PRKD1 | Q15139 | human | MAP4K1 | Q92918 | S171 | AtLARRLsFIGtPyW | Pkinase |
PRKD1 | Q15139 | human | TLR4 | O00206 | S790 | VELYRLLsRNTYLEW | TIR |
PRKD1 | Q15139 | human | HSPB1 | P04792 | S82 | RALsRQLssGVsEIr | |
PRKD1 | Q15139 | human | TCAP | O15273 | S157 | GALRRsLsRSMsQEA | Telethonin |
PRKD1 | Q15139 | human | HDAC7 | Q8WUI4 | S155 | FPLRKtVsEPNLkLR | |
PRKD1 | Q15139 | human | SSH1 | Q8WYL5 | S978 | sPLKRSHsLAKLGSL | |
PRKD1 | Q15139 | human | BAD | Q92934 | S75 | EIRsRHssyPAGtED | Bcl-2_BAD |
PRKD1 | Q15139 | human | HDAC5 | Q9UQL6 | S498 | RPLSRtQsSPLPQsP | |
PRKD1 | Q15139 | human | PAK5 | Q9P286 | S99 | ISVTRSNsLRKESPP | |
PRKD1 | Q15139 | human | CREB1 | P16220 | S119 | EILsRRPsyRkILND | pKID |
PRKD1 | Q15139 | human | MFF | Q9GZY8 | S275 | DNVRYGIsNIDTTIE | Miff |
PRKD1 | Q15139 | human | PAK4 | O96013 | S474 | kEVPRRksLVGtPyW | Pkinase |
PRKD1 | Q15139 | human | MARK2 | Q7KZI7 | S400 | HkVQRsVsANPKQRR | |
PRKD1 | Q15139 | human | RABEP1 | Q15276 | S407 | DGLRRAQstDsLGts | Rabaptin |
PRKD1 | Q15139 | human | CREB1 | P16220-1 | S98 | KDLKRLFsGtQISTI | |
PRKD1 | Q15139 | human | KAT7 | O95251 | T331 | LRLQGQItEGsNMIk | |
PRKD1 | Q15139 | human | BAD | Q92934 | S118 | GRELRRMsDEFVDsF | Bcl-2_BAD |
PRKD1 | Q15139 | human | SPHK2 | Q9NRA0 | S419 | AHsPLHRsVsDLPLP | |
PRKD1 | Q15139 | human | PRKD1 | Q15139 | S738 | ARIIGEksFRRsVVG | Pkinase |
PRKD1 | Q15139 | human | HDAC7 | Q8WUI4 | S358 | WPLsRtRsEPLPPsA | |
PRKD1 | Q15139 | human | CACNA1C | Q13936 | S1981 | ASLGRRAsFHLECLK | |
PRKD1 | Q15139 | human | CTTN | Q14247 | S348 | EAVTskTsNIRANFE | |
PRKD1 | Q15139 | human | JUN | P05412 | S63 | kNsDLLtsPDVGLLk | Jun |
PRKD1 | Q15139 | human | PIP4K2A | P48426 | T376 | KAAHAAktVKHGAGA | PIP5K |
PRKD1 | Q15139 | human | KCNH2 | Q12809 | S284 | ASVRRAssADDIEAM | |
PRKD1 | Q15139 | human | SPRY2 | O43597 | S112 | APLSRSIsTVssGsR | |
PRKD1 | Q15139 | human | ARFIP1 | P53367 | S132 | LELVRKWsLNtyKCT | Arfaptin |
PRKD1 | Q15139 | human | PTRH2 | Q9Y3E5 | S87 | GkVAAQCsHAAVSAy | PTH2 |
PRKD1 | Q15139 | human | FAM83G | A6ND36 | S356 | YALVKAKsVDEIAKI | |
PRKD1 | Q15139 | human | SSH1 | Q8WYL5 | S402 | MGVSRsAstVIAyAM | DSPc |
PRKD1 | Q15139 | human | PAK4 | O96013 | S181 | SRDKRPLsGPDVGtP | |
PRKD1 | Q15139 | human | MBP | P02686-5 | S162 | FKLGGRDsRSGSPMA | Myelin_MBP |
PRKD1 | Q15139 | human | CFL1 | P23528 | S3 | _____MAsGVAVsDG | |
PRKD1 | Q15139 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
PRKD1 | Q15139 | human | RIN1 | Q13671 | S292 | QLLRREssVGyRVPA | |
PRKD1 | Q15139 | human | SSH1 | Q8WYL5 | S937 | SNLtRssssDsIHsV | |
PRKD1 | Q15139 | human | MFF | Q9GZY8 | S155 | GRLkRERsMsENAVR | Miff |
PRKD1 | Q15139 | human | PRKD1 | Q15139 | S742 | GEksFRRsVVGtPAy | Pkinase |
PRKD1 | Q15139 | human | SNAI1 | O95863 | S11 | SFLVRKPsDPNRKPN | |
PRKD1 | Q15139 | human | OSBP | P22059 | S240 | tALQRsLsELESLkL | |
PRKD1 | Q15139 | human | VASP | P50552 | S157 | EHIERRVsNAGGPPA | |
PRKD1 | Q15139 | human | HSPB6 | O14558 | S16 | PSWLRRAsAPLPGLS | Crystallin |
PRKD1 | Q15139 | human | VASP | P50552 | S322 | TtLPRMkssssVttS | |
PRKD1 | Q15139 | human | AKT1 | P31749 | T308 | kDGAtMKtFCGtPEy | Pkinase |
PRKD1 | Q15139 | human | TCAP | O15273 | S161 | RsLsRSMsQEAQRG_ | Telethonin |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
PRKD1 | ID | Description | 0.00e+00 |
PRKD1 | GO:0097306 | cellular response to alcohol | 4.24e-04 |
PRKD1 | GO:0006936 | muscle contraction | 4.24e-04 |
PRKD1 | GO:1903829 | positive regulation of protein localization | 4.24e-04 |
PRKD1 | GO:0032970 | regulation of actin filament-based process | 4.55e-04 |
PRKD1 | GO:1903532 | positive regulation of secretion by cell | 4.55e-04 |
PRKD1 | GO:2001233 | regulation of apoptotic signaling pathway | 4.55e-04 |
PRKD1 | GO:0051047 | positive regulation of secretion | 5.28e-04 |
PRKD1 | GO:1904627 | response to phorbol 13-acetate 12-myristate | 5.28e-04 |
PRKD1 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 5.28e-04 |
PRKD1 | GO:0097193 | intrinsic apoptotic signaling pathway | 5.28e-04 |
PRKD1 | GO:0003012 | muscle system process | 7.04e-04 |
PRKD1 | GO:0090199 | regulation of release of cytochrome c from mitochondria | 1.19e-03 |
PRKD1 | GO:0006937 | regulation of muscle contraction | 1.19e-03 |
PRKD1 | GO:1901655 | cellular response to ketone | 1.46e-03 |
PRKD1 | GO:0006941 | striated muscle contraction | 1.73e-03 |
PRKD1 | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 1.83e-03 |
PRKD1 | GO:0001836 | release of cytochrome c from mitochondria | 2.18e-03 |
PRKD1 | GO:0051222 | positive regulation of protein transport | 2.50e-03 |
PRKD1 | GO:1901654 | response to ketone | 2.57e-03 |
PRKD1 | GO:0070584 | mitochondrion morphogenesis | 2.71e-03 |
PRKD1 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 2.71e-03 |
PRKD1 | GO:0034329 | cell junction assembly | 2.71e-03 |
PRKD1 | GO:1904951 | positive regulation of establishment of protein localization | 2.71e-03 |
PRKD1 | GO:0046854 | phosphatidylinositol phosphate biosynthetic process | 2.97e-03 |
PRKD1 | GO:0032956 | regulation of actin cytoskeleton organization | 3.04e-03 |
PRKD1 | GO:0007015 | actin filament organization | 3.04e-03 |
PRKD1 | GO:0097191 | extrinsic apoptotic signaling pathway | 3.04e-03 |
PRKD1 | GO:0045670 | regulation of osteoclast differentiation | 3.04e-03 |
PRKD1 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 3.29e-03 |
PRKD1 | GO:0010506 | regulation of autophagy | 3.69e-03 |
PRKD1 | GO:2001234 | negative regulation of apoptotic signaling pathway | 3.69e-03 |
PRKD1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 3.69e-03 |
PRKD1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 3.75e-03 |
PRKD1 | GO:0090257 | regulation of muscle system process | 3.75e-03 |
PRKD1 | GO:0010821 | regulation of mitochondrion organization | 3.81e-03 |
PRKD1 | GO:0043535 | regulation of blood vessel endothelial cell migration | 3.82e-03 |
PRKD1 | GO:0008654 | phospholipid biosynthetic process | 3.92e-03 |
PRKD1 | GO:0097305 | response to alcohol | 3.92e-03 |
PRKD1 | GO:0003007 | heart morphogenesis | 4.72e-03 |
PRKD1 | GO:1902903 | regulation of supramolecular fiber organization | 4.94e-03 |
PRKD1 | GO:0110053 | regulation of actin filament organization | 5.17e-03 |
PRKD1 | GO:0035115 | embryonic forelimb morphogenesis | 5.17e-03 |
PRKD1 | GO:0045671 | negative regulation of osteoclast differentiation | 5.17e-03 |
PRKD1 | GO:0010959 | regulation of metal ion transport | 5.17e-03 |
PRKD1 | GO:0048660 | regulation of smooth muscle cell proliferation | 5.17e-03 |
PRKD1 | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 5.30e-03 |
PRKD1 | GO:0048659 | smooth muscle cell proliferation | 5.52e-03 |
PRKD1 | GO:1900182 | positive regulation of protein localization to nucleus | 5.70e-03 |
PRKD1 | GO:0051347 | positive regulation of transferase activity | 5.94e-03 |
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Related Drugs to PRKD1_EFHD2 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning PRKD1-EFHD2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PRKD1_EFHD2 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |