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Kinase Fusion Gene:PRKD3_HNRNPLL |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: PRKD3_HNRNPLL | KinaseFusionDB ID: KFG5016 | FusionGDB2.0 ID: KFG5016 | Hgene | Tgene | Gene symbol | PRKD3 | HNRNPLL | Gene ID | 23683 | 92906 | |
| Gene name | protein kinase D3 | heterogeneous nuclear ribonucleoprotein L like | ||||||||||
| Synonyms | EPK2|PKC-NU|PKD3|PRKCN|nPKC-NU | HNRPLL|SRRF | ||||||||||
| Cytomap | 2p22.2 | 2p22.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase D3protein kinase C nu typeprotein kinase EPK2 | heterogeneous nuclear ribonucleoprotein L-likestromal RNA regulating factor | ||||||||||
| Modification date | 20240403 | 20240403 | ||||||||||
| UniProtAcc | O94806 | Q8WVV9 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000379066, ENST00000234179, ENST00000477132, | ENST00000449105, ENST00000409636, ENST00000378915, ENST00000608859, ENST00000409328, ENST00000358367, ENST00000410076, ENST00000498516, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRKD3 [Title/Abstract] AND HNRNPLL [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HNRNPLL | GO:0033120 | positive regulation of RNA splicing | 18669861 |
| Kinase Fusion gene breakpoints across PRKD3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across HNRNPLL (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | WM-266-4 | PRKD3 | chr2 | 37520276 | HNRNPLL | chr2 | 38797067 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:/chr2:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRKD3 | HNRNPLL |
| FUNCTION: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}. | FUNCTION: RNA-binding protein that functions as a regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. {ECO:0000269|PubMed:18669861}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PRKD3_HNRNPLL |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PRKD3 | O94806 | human | HDAC5 | Q9UQL6 | S498 | RPLSRtQsSPLPQsP | |
| PRKD3 | O94806 | human | PRKD1 | Q15139 | S738 | ARIIGEksFRRsVVG | Pkinase |
| PRKD3 | O94806 | human | CTTN | Q14247 | S298 | EKLAkHEsQQDyskG | HS1_rep |
| PRKD3 | O94806 | human | GIT1 | Q9Y2X7 | S46 | RSLGRHIsIVkHLRH | ArfGap |
| PRKD3 | O94806 | human | PRKD1 | Q15139 | S742 | GEksFRRsVVGtPAy | Pkinase |
| PRKD3 | O94806 | human | MFF | Q9GZY8 | S172 | GQLVRNDsLWHRsDs | Miff |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PRKD3 | ID | Description | 0.00e+00 |
| PRKD3 | GO:1902905 | positive regulation of supramolecular fiber organization | 1.51e-03 |
| PRKD3 | GO:0051495 | positive regulation of cytoskeleton organization | 1.51e-03 |
| PRKD3 | GO:0031334 | positive regulation of protein-containing complex assembly | 1.51e-03 |
| PRKD3 | GO:1902903 | regulation of supramolecular fiber organization | 8.47e-03 |
| PRKD3 | GO:0043254 | regulation of protein-containing complex assembly | 8.47e-03 |
| PRKD3 | GO:0032273 | positive regulation of protein polymerization | 1.49e-02 |
| PRKD3 | GO:0051153 | regulation of striated muscle cell differentiation | 1.49e-02 |
| PRKD3 | GO:0010821 | regulation of mitochondrion organization | 2.64e-02 |
| PRKD3 | GO:0043535 | regulation of blood vessel endothelial cell migration | 2.64e-02 |
| PRKD3 | GO:0090316 | positive regulation of intracellular protein transport | 2.64e-02 |
| PRKD3 | GO:0051147 | regulation of muscle cell differentiation | 2.64e-02 |
| PRKD3 | GO:0006937 | regulation of muscle contraction | 2.66e-02 |
| PRKD3 | GO:0043534 | blood vessel endothelial cell migration | 2.76e-02 |
| PRKD3 | GO:0008361 | regulation of cell size | 2.76e-02 |
| PRKD3 | GO:0032388 | positive regulation of intracellular transport | 2.87e-02 |
| PRKD3 | GO:0032271 | regulation of protein polymerization | 2.87e-02 |
| PRKD3 | GO:0033157 | regulation of intracellular protein transport | 3.05e-02 |
| PRKD3 | GO:0071222 | cellular response to lipopolysaccharide | 3.05e-02 |
| PRKD3 | GO:0010594 | regulation of endothelial cell migration | 3.05e-02 |
| PRKD3 | GO:0071219 | cellular response to molecule of bacterial origin | 3.05e-02 |
| PRKD3 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 3.05e-02 |
| PRKD3 | GO:0090257 | regulation of muscle system process | 3.05e-02 |
| PRKD3 | GO:0071216 | cellular response to biotic stimulus | 3.23e-02 |
| PRKD3 | GO:0043542 | endothelial cell migration | 3.23e-02 |
| PRKD3 | GO:0051258 | protein polymerization | 3.23e-02 |
| PRKD3 | GO:0010632 | regulation of epithelial cell migration | 3.23e-02 |
| PRKD3 | GO:0051146 | striated muscle cell differentiation | 3.23e-02 |
| PRKD3 | GO:0051222 | positive regulation of protein transport | 3.23e-02 |
| PRKD3 | GO:0071375 | cellular response to peptide hormone stimulus | 3.23e-02 |
| PRKD3 | GO:0016559 | peroxisome fission | 3.23e-02 |
| PRKD3 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 3.23e-02 |
| PRKD3 | GO:1904627 | response to phorbol 13-acetate 12-myristate | 3.23e-02 |
| PRKD3 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 3.23e-02 |
| PRKD3 | GO:1904951 | positive regulation of establishment of protein localization | 3.26e-02 |
| PRKD3 | GO:0045793 | positive regulation of cell size | 3.26e-02 |
| PRKD3 | GO:0032386 | regulation of intracellular transport | 3.26e-02 |
| PRKD3 | GO:0032956 | regulation of actin cytoskeleton organization | 3.26e-02 |
| PRKD3 | GO:0106014 | regulation of inflammatory response to wounding | 3.26e-02 |
| PRKD3 | GO:0032496 | response to lipopolysaccharide | 3.26e-02 |
| PRKD3 | GO:0006936 | muscle contraction | 3.26e-02 |
| PRKD3 | GO:0010506 | regulation of autophagy | 3.26e-02 |
| PRKD3 | GO:0002237 | response to molecule of bacterial origin | 3.26e-02 |
| PRKD3 | GO:0032535 | regulation of cellular component size | 3.26e-02 |
| PRKD3 | GO:0010631 | epithelial cell migration | 3.26e-02 |
| PRKD3 | GO:1901653 | cellular response to peptide | 3.26e-02 |
| PRKD3 | GO:0090132 | epithelium migration | 3.26e-02 |
| PRKD3 | GO:0032970 | regulation of actin filament-based process | 3.26e-02 |
| PRKD3 | GO:0090130 | tissue migration | 3.26e-02 |
| PRKD3 | GO:2001028 | positive regulation of endothelial cell chemotaxis | 3.26e-02 |
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Related Drugs to PRKD3_HNRNPLL |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning PRKD3-HNRNPLL and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PRKD3_HNRNPLL |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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