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Kinase Fusion Gene:PRKG2_GRTP1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: PRKG2_GRTP1 | KinaseFusionDB ID: KFG5056 | FusionGDB2.0 ID: KFG5056 | Hgene | Tgene | Gene symbol | PRKG2 | GRTP1 | Gene ID | 5593 | 79774 | |
| Gene name | protein kinase cGMP-dependent 2 | growth hormone regulated TBC protein 1 | ||||||||||
| Synonyms | AMD4|PKG2|PRKGR2|SMDP|cGK2|cGKII | TBC1D6 | ||||||||||
| Cytomap | 4q21.21 | 13q34 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | cGMP-dependent protein kinase 2cGMP-dependent protein kinase IIprotein kinase, cGMP-dependent, type IItesticular tissue protein Li 99 | growth hormone-regulated TBC protein 1TBC1 domain family member 6 | ||||||||||
| Modification date | 20240411 | 20240305 | ||||||||||
| UniProtAcc | Q13237 | Q5TC63 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000264399, ENST00000395578, ENST00000418486, ENST00000509169, ENST00000545647, | ENST00000326039, ENST00000375430, ENST00000375431, ENST00000476439, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRKG2 [Title/Abstract] AND GRTP1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKG2(82035463)-GRTP1(113978505), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Kinase Fusion gene breakpoints across PRKG2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across GRTP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | CA432798 | PRKG2 | chr4 | 82035463 | GRTP1 | chr13 | 113978505 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:82035463/:113978505) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRKG2 | GRTP1 |
| FUNCTION: Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). {ECO:0000250|UniProtKB:Q61410, ECO:0000250|UniProtKB:Q64595, ECO:0000269|PubMed:33106379}. | FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of PRKG2_GRTP1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PRKG2 | Q13237 | human | NOS3 | P29474 | T495 | TGITRKKtFKEVANA | |
| PRKG2 | Q13237 | human | PTPN6 | P29350 | S557 | AKAsRtssKHkEDVy | |
| PRKG2 | Q13237 | human | PDGFRB | P09619 | S712 | sDkRRPPsAELysNA | PK_Tyr_Ser-Thr |
| PRKG2 | Q13237 | human | EGFR | P00533 | T430 | LEIIRGRtKQHGQFS | Recep_L_domain |
| PRKG2 | Q13237 | human | PDGFRB | P09619 | S254 | WTYPRKEsGRLVEPV | Ig_3 |
| PRKG2 | Q13237 | human | CTH | P32929 | S377 | SDTLIRLsVGLEDEE | Cys_Met_Meta_PP |
| PRKG2 | Q13237 | human | ERBB2 | P04626 | T686 | QQKIRKYtMRRLLQE | |
| PRKG2 | Q13237 | human | PTPN6 | P29350 | S556 | HAKAsRtssKHkEDV | |
| PRKG2 | Q13237 | human | NOS3 | P29474 | S1177 | TSRIRtQsFsLQERQ | |
| PRKG2 | Q13237 | human | NOS3 | P29474 | S633 | WRRKRKEssNtDsAG | Flavodoxin_1 |
| PRKG2 | Q13237 | human | LASP1 | Q14847 | S146 | MEPERRDsQDGssyR | |
| PRKG2 | Q13237 | human | EGFR | P00533 | T693 | RELVEPLtPsGEAPN | |
| PRKG2 | Q13237 | human | PTPN6 | P29350 | S553 | kNAHAKAsRtssKHk | |
| PRKG2 | Q13237 | human | PTS | Q03393 | S19 | AQVSRRIsFSASHRL | PTPS |
| PRKG2 | Q13237 | human | MET | P08581 | S985 | PHLDRLVsARsVsPt |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PRKG2 | ID | Description | 0.00e+00 |
| PRKG2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 1.32e-03 |
| PRKG2 | GO:0018212 | peptidyl-tyrosine modification | 1.32e-03 |
| PRKG2 | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 1.32e-03 |
| PRKG2 | GO:0043406 | positive regulation of MAP kinase activity | 1.32e-03 |
| PRKG2 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 1.32e-03 |
| PRKG2 | GO:0070371 | ERK1 and ERK2 cascade | 1.32e-03 |
| PRKG2 | GO:0033674 | positive regulation of kinase activity | 1.32e-03 |
| PRKG2 | GO:0051347 | positive regulation of transferase activity | 2.42e-03 |
| PRKG2 | GO:0038128 | ERBB2 signaling pathway | 2.42e-03 |
| PRKG2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 2.42e-03 |
| PRKG2 | GO:0043405 | regulation of MAP kinase activity | 2.42e-03 |
| PRKG2 | GO:0034614 | cellular response to reactive oxygen species | 2.83e-03 |
| PRKG2 | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 3.56e-03 |
| PRKG2 | GO:0007263 | nitric oxide mediated signal transduction | 4.85e-03 |
| PRKG2 | GO:0046777 | protein autophosphorylation | 4.85e-03 |
| PRKG2 | GO:0000302 | response to reactive oxygen species | 4.96e-03 |
| PRKG2 | GO:0050866 | negative regulation of cell activation | 5.82e-03 |
| PRKG2 | GO:0010863 | positive regulation of phospholipase C activity | 5.82e-03 |
| PRKG2 | GO:1900274 | regulation of phospholipase C activity | 6.13e-03 |
| PRKG2 | GO:0071364 | cellular response to epidermal growth factor stimulus | 6.57e-03 |
| PRKG2 | GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 6.57e-03 |
| PRKG2 | GO:0051924 | regulation of calcium ion transport | 6.57e-03 |
| PRKG2 | GO:0034599 | cellular response to oxidative stress | 6.58e-03 |
| PRKG2 | GO:0070849 | response to epidermal growth factor | 6.77e-03 |
| PRKG2 | GO:0010518 | positive regulation of phospholipase activity | 7.38e-03 |
| PRKG2 | GO:0045860 | positive regulation of protein kinase activity | 7.78e-03 |
| PRKG2 | GO:0071900 | regulation of protein serine/threonine kinase activity | 7.78e-03 |
| PRKG2 | GO:0006520 | amino acid metabolic process | 7.98e-03 |
| PRKG2 | GO:0010517 | regulation of phospholipase activity | 8.93e-03 |
| PRKG2 | GO:0019932 | second-messenger-mediated signaling | 8.93e-03 |
| PRKG2 | GO:0060193 | positive regulation of lipase activity | 8.93e-03 |
| PRKG2 | GO:0062197 | cellular response to chemical stress | 8.98e-03 |
| PRKG2 | GO:0042130 | negative regulation of T cell proliferation | 1.21e-02 |
| PRKG2 | GO:0060191 | regulation of lipase activity | 1.38e-02 |
| PRKG2 | GO:0010959 | regulation of metal ion transport | 1.57e-02 |
| PRKG2 | GO:0006979 | response to oxidative stress | 1.57e-02 |
| PRKG2 | GO:0050672 | negative regulation of lymphocyte proliferation | 1.60e-02 |
| PRKG2 | GO:0032945 | negative regulation of mononuclear cell proliferation | 1.60e-02 |
| PRKG2 | GO:0042060 | wound healing | 1.71e-02 |
| PRKG2 | GO:0070664 | negative regulation of leukocyte proliferation | 1.76e-02 |
| PRKG2 | GO:1903035 | negative regulation of response to wounding | 1.76e-02 |
| PRKG2 | GO:0006816 | calcium ion transport | 1.84e-02 |
| PRKG2 | GO:1905477 | positive regulation of protein localization to membrane | 1.93e-02 |
| PRKG2 | GO:0007173 | epidermal growth factor receptor signaling pathway | 1.99e-02 |
| PRKG2 | GO:0043410 | positive regulation of MAPK cascade | 2.06e-02 |
| PRKG2 | GO:0038127 | ERBB signaling pathway | 2.55e-02 |
| PRKG2 | GO:0098773 | skin epidermis development | 2.66e-02 |
| PRKG2 | GO:0010595 | positive regulation of endothelial cell migration | 2.69e-02 |
| PRKG2 | GO:0030168 | platelet activation | 2.70e-02 |
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Related Drugs to PRKG2_GRTP1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning PRKG2-GRTP1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to PRKG2_GRTP1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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