| Kinase Fusion partner gene information | Kinase Fusion gene name: PRPF4B_SEC63 |
KinaseFusionDB ID: KFG5068 | FusionGDB2.0 ID: KFG5068 | | Hgene | Tgene | Gene symbol | PRPF4B | SEC63 | Gene ID | 8899 | 11231 | | Gene name | pre-mRNA processing factor kinase PRP4K | SEC63 homolog, protein translocation regulator |
| Synonyms | PR4H|PRP4|PRP4H|PRPF4B|Prp4B|dJ1013A10.1 | DNAJC23|ERdj2|PCLD2|PRO2507|SEC63L |
| Cytomap | 6p25.2 | 6q21 |
| Type of gene | protein-coding | protein-coding |
| Description | serine/threonine-protein kinase PRP4 homologPRP4 kinasePRP4 pre-mRNA processing factor 4 homolog BPRP4 pre-mRNA-processing factor 4 homologdJ1013A10.1 (PRP4 protein kinase homolog)pre-mRNA processing factor 4Bprotein-serine/threonine kinase | translocation protein SEC63 homologSEC63 protein translocation regulatorSEC63-like protein |
| Modification date | 20240413 | 20240411 |
| UniProtAcc | Q13523 | Q9UGP8 |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000337659, ENST00000494674,
ENST00000538861, | ENST00000369002,
ENST00000460009, |
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: PRPF4B [Title/Abstract] AND SEC63 [Title/Abstract] AND fusion [Title/Abstract] |
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRPF4B(4062947)-SEC63(108192901), # samples:1
|
 Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Kinase Fusion gene breakpoints across PRPF4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across SEC63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BQ332983 | PRPF4B | chr6 | 4062947 | SEC63 | chr6 | 108192901 |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length
(transcript) | Seq length
(amino acids) |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq
|
Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4062947/:108192901)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
PRPF4B
Q13523 | SEC63
Q9UGP8 |
| FUNCTION: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. | FUNCTION: Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). {ECO:0000250|UniProtKB:Q8VHE0, ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Phosphorylation target of the kinase
(phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PRPF4B | Q13523 | human | ELK1 | P19419 | T417 | ISVDGLstPVVLsPG | |
Biological Network Integration of This Kinase and Substrates
(GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PRPF4B | ID | Description | 0.00e+00 |
| PRPF4B | GO:0071394 | cellular response to testosterone stimulus | 1.34e-02 |
| PRPF4B | GO:0071480 | cellular response to gamma radiation | 1.42e-02 |
| PRPF4B | GO:0033574 | response to testosterone | 1.42e-02 |
| PRPF4B | GO:0010332 | response to gamma radiation | 1.42e-02 |
| PRPF4B | GO:0071479 | cellular response to ionizing radiation | 1.56e-02 |
| PRPF4B | GO:1901655 | cellular response to ketone | 1.59e-02 |
| PRPF4B | GO:0071774 | response to fibroblast growth factor | 1.59e-02 |
| PRPF4B | GO:0010212 | response to ionizing radiation | 1.59e-02 |
| PRPF4B | GO:0001889 | liver development | 1.59e-02 |
| PRPF4B | GO:0061008 | hepaticobiliary system development | 1.59e-02 |
| PRPF4B | GO:0071478 | cellular response to radiation | 1.59e-02 |
| PRPF4B | GO:0030324 | lung development | 1.59e-02 |
| PRPF4B | GO:0030323 | respiratory tube development | 1.59e-02 |
| PRPF4B | GO:1901654 | response to ketone | 1.59e-02 |
| PRPF4B | GO:0060541 | respiratory system development | 1.59e-02 |
| PRPF4B | GO:0051402 | neuron apoptotic process | 1.93e-02 |
| PRPF4B | GO:0009416 | response to light stimulus | 1.96e-02 |
| PRPF4B | GO:0071214 | cellular response to abiotic stimulus | 1.96e-02 |
| PRPF4B | GO:0104004 | cellular response to environmental stimulus | 1.96e-02 |
| PRPF4B | GO:0009314 | response to radiation | 2.35e-02 |
| PRPF4B | GO:0048732 | gland development | 2.35e-02 |
Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Distribution of the number of studies mentioning PRPF4B-SEC63 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024) |
Diseases associated with fusion partners.
(DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston