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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:AURKA_PCK1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: AURKA_PCK1
KinaseFusionDB ID: KFG519
FusionGDB2.0 ID: KFG519
HgeneTgene
Gene symbol

AURKA

PCK1

Gene ID

6790

5105

Gene nameaurora kinase Aphosphoenolpyruvate carboxykinase 1
SynonymsAIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7PCKDC|PEPCK-C|PEPCK1|PEPCKC
Cytomap

20q13.2

20q13.31

Type of geneprotein-codingprotein-coding
Descriptionaurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase aphosphoenolpyruvate carboxykinase, cytosolic [GTP]PEP carboxykinasephosphoenolpyruvate carboxykinase 1 (soluble)phosphoenolpyruvate carboxykinase, cytosolicphosphoenolpyruvate carboxylasephosphopyruvate carboxylaseserine-protein kinase PCK1
Modification date2024040720240305
UniProtAcc

O14965

P35558

Ensembl transtripts involved in fusion geneENST idsENST00000312783, ENST00000347343, 
ENST00000371356, ENST00000395907, 
ENST00000395909, ENST00000395911, 
ENST00000395913, ENST00000395914, 
ENST00000395915, 		ENST00000319441, 
ENST00000543666, ENST00000535860, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: AURKA [Title/Abstract] AND PCK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AURKA(54963212)-PCK1(56136428), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAURKA

GO:0006468

protein phosphorylation

21600873

HgeneAURKA

GO:0006468

protein phosphorylation

21820309

HgeneAURKA

GO:0009611

response to wounding

19435814

HgeneAURKA

GO:0032091

negative regulation of protein binding

21820309

HgeneAURKA

GO:0097421

liver regeneration

19435814

TgenePCK1

GO:0006094

gluconeogenesis

30193097

TgenePCK1

GO:0006107

oxaloacetate metabolic process

30193097

TgenePCK1

GO:0018105

peptidyl-serine phosphorylation

32322062

TgenePCK1

GO:0032868

response to insulin

14764811

TgenePCK1

GO:0032869

cellular response to insulin stimulus

32322062

TgenePCK1

GO:0046889

positive regulation of lipid biosynthetic process

32322062

TgenePCK1

GO:0046890

regulation of lipid biosynthetic process

32322062

TgenePCK1

GO:0071333

cellular response to glucose stimulus

30193097

TgenePCK1

GO:0072350

tricarboxylic acid metabolic process

30193097


check buttonKinase Fusion gene breakpoints across AURKA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across PCK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-AR-A24R-01AAURKAchr20

54963212

PCK1chr20

56136428

ChimerDB4TCGA-AR-A24RAURKAchr20

54963211

PCK1chr20

56136427



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:54963212/:56136428)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AURKA

O14965

PCK1

P35558

FUNCTION: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000250|UniProtKB:A0A8I3S724, ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.FUNCTION: Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:30193097, PubMed:24863970, PubMed:26971250, PubMed:28216384). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097, PubMed:24863970, PubMed:26971250, PubMed:28216384). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (By similarity). The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (PubMed:32322062). The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (PubMed:32322062). {ECO:0000250|UniProtKB:Q9Z2V4, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26971250, ECO:0000269|PubMed:28216384, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:32322062}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of AURKA_PCK1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
AURKAO14965humanSDCBPO00560T200RPFERTItMHKDSTGPDZ; Peptidase_M50
AURKAO14965humanCRMP1Q14194T101RAALVGGttMIIDHVAmidohydro_1
AURKAO14965humanWDR62O43379S49LRRRtRLstAsEEtV
AURKAO14965humanFAF1Q9UNN5S291DVHMVsDsDGDDFED
AURKAO14965humanWDR62O43379T50RRRtRLstAsEEtVQ
AURKAO14965humanAURKAO14965S67QAQkLVssHkPVQNQ
AURKAO14965humanSECISBP2LQ93073T573IAKLKRPtALKKVIL
AURKAO14965humanAURKAO14965T287HAPSsRRttLCGtLDPkinase
AURKAO14965humanARPC1BO15143T21HAWNkDRtQIAICPN
AURKAO14965humanNUMA1Q14980S1887tRssARRsQAGVsSG
AURKAO14965humanMCRS1Q96EZ8S36AGQkRAssQALGTIP
AURKAO14965humanSPAG5Q96R06S115IsStPkTsEEAVDPL
AURKAO14965humanDCTN1Q14203S19TPSGSrMsAEAsArP
AURKAO14965humanRUNX3Q13761T14PSTSRRFtPPsPAFP
AURKAO14965humanALDH1A1P00352T493yTEVkTVtVkISQKN
AURKAO14965humanYAP1P46937S397tyHSRDEstDsGLsM
AURKAO14965humanAURKAO14965Y148kGkFGNVyLAREKQSPkinase
AURKAO14965humanAURKAO14965S266PENLLLGsAGELKIAPkinase
AURKAO14965humanARHGEF2Q92974S886PVDPRRRsLPAGDAL
AURKAO14965humanFAF1Q9UNN5S289ITDVHMVsDsDGDDF
AURKAO14965humanAURKAO14965S278KIADFGWsVHAPSsRPkinase
AURKAO14965humanSPIN1Q9Y657S124RVAtSRIsDAHLADt
AURKAO14965humanWDR62O43379S33PARRGQssPPPAPPI
AURKAO14965humanBRCA1P38398S308KAEFCNKskQPGLAR
AURKAO14965humanSKIP12755S383LsAFRPWsPAVSASE
AURKAO14965humanCRMP1Q14194T102AALVGGttMIIDHVVAmidohydro_1
AURKAO14965humanLDHBP07195S162PkHrVIGsGCNLDsA
AURKAO14965humanPAX8Q06710S209DQDSCRLsIDSQSSS
AURKAO14965humanMYBBP1AQ9BQG0S1303ARKKARLsLVIRsPs
AURKAO14965humanGSK3BP49841S9SGRPRttsFAEsCkP
AURKAO14965humanPHLDA1Q8WV24S95PLCLLRVsLLCALRA
AURKAO14965humanCENPJQ9HC77S467LKCSNRksLsPsGLK
AURKAO14965humanCETN2P41208S170LRIMkKTsLY_____
AURKAO14965humanKIF4AO95239T799PPKLRRRtFsLTEVR
AURKAO14965humanHAUS8Q9BT25S20ATGPTNsssAKKKDK
AURKAO14965humanPAX8Q06710T277TLDDGkAtLTPSNTP
AURKAO14965humanNUMA1Q14980T1811tRsARRRttQIINIt
AURKAO14965humanVHLP40337S72SVNsREPsQVIFCNrVHL
AURKAO14965humanLIMK2P53671T494kATTKKRtLRKNDRKPK_Tyr_Ser-Thr
AURKAO14965humanPARD3Q8TEW0S962SSRsGREsVSTAsDQ
AURKAO14965humanNEDD1Q8NHV4S405FDDtGKssLGDMFsP
AURKAO14965humanAURKAO14965S226YRELQKLskFDEQRTPkinase
AURKAO14965humanPLK1P53350T210YDGERKktLCGtPNyPkinase
AURKAO14965humanESR1P03372S167GGRERLAsTNDkGSMOest_recep
AURKAO14965humanNPM1P06748S125AVEEDAEsEDEEEED
AURKAO14965humanDLGAP5Q15398S627VKLFsGLsVssEGPs
AURKAO14965humanAURKAO14965T16IsGPVkAtAPVGGPk
AURKAO14965humanFADDQ13158S203MsWNsDAsTSEAS__
AURKAO14965humanLATS2Q9NRM7S83ALREIRysLLPFANE
AURKAO14965humanSKIP12755S326RRVPRVssEPPASIR
AURKAO14965humanTP73O15350S235DPVTGRQsVVVPYEPP53
AURKAO14965humanAURKAO14965S10RsKENCIsGPVkAtA
AURKAO14965humanNDC80O14777S44kPtFGkLsINkPtsE
AURKAO14965humanMCRS1Q96EZ8S35LAGQkRAssQALGTI
AURKAO14965humanNUMA1Q14980S2047kQADRRQsMAFsILN
AURKAO14965humanMBD3O95983S85RQRVRyDssNQVKGkMBDa
AURKAO14965humanRBBP8Q99708S593IPLRPREsLETENVL
AURKAO14965humanH3C1P68431S10tkQtArkstGGkAPrHistone
AURKAO14965humanRBBP8Q99708S327ELPtRVssPVFGATS
AURKAO14965humanMAP9Q49MG5S625RKQKKRHsFLESEAL
AURKAO14965humanSIRT1Q96EB6T344GkLLRNYtQNIDTLESIR2
AURKAO14965humanSPIN1Q9Y657S109LNkDERVsALEVLPD
AURKAO14965humanPSEN2P49810S19EVCDERTsLMsAEsP
AURKAO14965humanKCTD12Q96CX2S243ITVCGKTsLAkEVFG
AURKAO14965humanNUMA1Q14980S1883YrPttRssARRsQAG
AURKAO14965humanALDH1A1P00352T442kDIDKAItISSALQAAldedh
AURKAO14965humanAURKAO14965S41QNPLPVNsGQAQRVL
AURKAO14965humanBCL2L11O43521S98RSssGyFsFDTDRsP
AURKAO14965humanSDCBPO00560S131kIGLRLKsIDNGIFVPDZ; Peptidase_M50
AURKAO14965humanNFKBIAP25963S63PQEVPRGsEPWkQQL
AURKAO14965humanPKD2Q13563S829HSSRRRGsISSGVSY
AURKAO14965humanNEDD9Q14511S296PVARRHQsLsPNHPP
AURKAO14965humanMAP9Q49MG5S305AVEKSKEsQVTADDL
AURKAO14965humanNSD2O96028S56SkAQLSSsLQEGVMQ
AURKAO14965humanLATS2Q9NRM7S380ATLARRDsLQKPGLE
AURKAO14965humanDLGAP5Q15398S725CLssERMsLPLLAGG
AURKAO14965humanNFKBIAP25963S262QLTWGRPsTRIQQQL
AURKAO14965humanLIMK2P53671T505NDRKKRYtVVGNPYWPK_Tyr_Ser-Thr
AURKAO14965humanRUNX3Q13761T173YHRAIkVtVDGPREPRunt
AURKAO14965humanDLGAP5Q15398S830QEHARHIsFGGNLIt
AURKAO14965humanNDC80O14777S55PtsERkVsLFGkRtsNdc80_HEC
AURKAO14965humanTPX2Q9ULW0S121PAQPQRRsLRLsAQk
AURKAO14965humanAURKAO14965S98PLNNTQKskQPLPsA
AURKAO14965humanHAUS8Q9BT25S19PATGPTNsssAKKKD
AURKAO14965humanMAPRE3Q9UPY8S176MQTSGRLsNVAPPCI
AURKAO14965humanNUMA1Q14980T2084sPNtRSGtRRsPRIA
AURKAO14965humanTP53P04637S106sQkTYQGsYGFrLGFP53
AURKAO14965humanPOU6F1Q14863S197kLDITPKsAQKLKPVPou
AURKAO14965humanNUMA1Q14980T1812RsARRRttQIINItM
AURKAO14965humanBCL2L11O43521S93SsLLSRSssGyFsFD
AURKAO14965humanPHB2Q99623S39VAyGVREsVFTVEGG
AURKAO14965humanPIN1Q13526S16PGWEkRMsRSSGRVyWW
AURKAO14965humanAURKAIP1Q9NWT8S70MLVPRKMsVSPLESW
AURKAO14965humanAURKAO14965S342QETYKRIsRVEFTFPPkinase
AURKAO14965humanBCL2L11O43521S94sLLSRSssGyFsFDT
AURKAO14965humanAURKAO14965S104KskQPLPsAPENNPE
AURKAO14965humanNUMA1Q14980S1969QEtLRRAsMQPIQIA
AURKAO14965humanNUMA1Q14980T1804FLDsGrKtRsARRRt
AURKAO14965humanSOX8P57073S327SAPSASAsPTETGPP
AURKAO14965humanWDR62O43379S32VPARRGQssPPPAPP
AURKAO14965humanWWC1Q8IX03S539tsLsPRSsLSsPSPP
AURKAO14965humanARP10275T282VPPAVRPtPCAPLAEAndrogen_recep
AURKAO14965humanDLGAP5Q15398S757EGMELNSsItSQDVL
AURKAO14965humanMBD3O95983S24REEVPRRsGLSAGHRMBD
AURKAO14965humanTIFAQ96CG3T9tSFEDADtEEtVTCL
AURKAO14965humanFANCAO15360S165HSMFSRLsFCQELWK
AURKAO14965humanTP53P04637S215DrNtFrHsVVVPyEPP53
AURKAO14965humanNDC80O14777S69sGHGsRNsQLGIFssNdc80_HEC
AURKAO14965humanTPX2Q9ULW0S125QRRsLRLsAQkDLEQ
AURKAO14965humanLIMK1P53667T508PDRKKRYtVVGNPYWPK_Tyr_Ser-Thr
AURKAO14965humanNUMA1Q14980S2087tRSGtRRsPRIATTT
AURKAO14965humanAURKAO14965S83QKQLQATsVPHPVsR
AURKAO14965humanNUSAP1Q9BXS6S240VPPRGRLsVAstPIsNUSAP
AURKAO14965humanAURKAO14965S391TANSSKPsNCQNKES
AURKAO14965humanHNRNPKP61978S379syAGGrGsyGDLGGP
AURKAO14965humanAURKAO14965T288APSsRRttLCGtLDyPkinase
AURKAO14965humanLIMK1P53667S307DRsPGAGsLGsPAsQ
AURKAO14965humanCENPAP49450S7_MGPRRRsRKPEAPRHistone
AURKAO14965humanRASSF1Q9NS23-2S203TsVRRRtsFYLPKDARA
AURKAO14965humanESR1P03372S305IkRSkkNsLALSLtA
AURKAO14965humanLIMK2P53671S283EGtLRRRsLRRsNsI
AURKAO14965humanMCM2P49736S220NVFkERIsDMCkENRMCM_N
AURKAO14965humanNFKBIAP25963S32LLDDRHDsGLDsMkD
AURKAO14965humanARP10275S293PLAECKGsLLDDsAGAndrogen_recep
AURKAO14965humanPKMP14618T45PPItARNtGIICtIGPK
AURKAO14965humanALDH1A1P00352T267KSNLKRVtLELGGKSAldedh
AURKAO14965humanTP53P04637S315LPNNtsssPQPkkkP
AURKAO14965humanGMNNO75496T25NSSVPRRtLkMIQPSGeminin
AURKAO14965humanKCTD12Q96CX2S200PLLtPsQsLDGsRRs
AURKAO14965humanRALAP11233S194NGKKKRKsLAKRIRE
AURKAO14965humanRASSF1Q9NS23-2T202GTsVRRRtsFYLPKDRA
AURKAO14965humanTACC3Q9Y6A5S558ESALRKQsLyLkFDP
AURKAO14965humanNUMA1Q14980S1991RQQRkRVsLEPHQGP
AURKAO14965humanYY1P25490S365EGCGkRFsLDFNLRTzf-C2H2
AURKAO14965humanCDC25BP30305S353VQNkRRRsVtPPEEQM-inducer_phosp
PCK1P35558humanINSIG2Q9Y5U4S151LWWTFDRsRSGFGLGINSIG
PCK1P35558humanINSIG1O15503S207LWWTFDRsRsGLGLGINSIG


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
AURKAIDDescription0.00e+00
AURKAGO:0007051spindle organization1.89e-13
AURKAGO:0032886regulation of microtubule-based process2.07e-13
AURKAGO:1902850microtubule cytoskeleton organization involved in mitosis2.04e-12
AURKAGO:0007098centrosome cycle4.87e-12
AURKAGO:0031023microtubule organizing center organization1.64e-11
AURKAGO:0007052mitotic spindle organization4.84e-11
AURKAGO:0140694non-membrane-bounded organelle assembly1.12e-10
AURKAGO:0070507regulation of microtubule cytoskeleton organization4.76e-10
AURKAGO:0051225spindle assembly1.22e-09
AURKAGO:0048285organelle fission1.38e-09
AURKAGO:0090224regulation of spindle organization2.10e-09
AURKAGO:0000280nuclear division2.87e-09
AURKAGO:0140014mitotic nuclear division9.87e-09
AURKAGO:0007059chromosome segregation1.65e-08
AURKAGO:0060236regulation of mitotic spindle organization4.46e-08
AURKAGO:0051298centrosome duplication8.51e-08
AURKAGO:0045787positive regulation of cell cycle8.67e-08
AURKAGO:0051293establishment of spindle localization3.47e-07
AURKAGO:0051653spindle localization6.02e-07
AURKAGO:0040001establishment of mitotic spindle localization1.26e-06
AURKAGO:0030010establishment of cell polarity1.26e-06
AURKAGO:1902115regulation of organelle assembly1.54e-06
AURKAGO:0051294establishment of spindle orientation1.54e-06
AURKAGO:0000819sister chromatid segregation1.97e-06
AURKAGO:0035265organ growth3.19e-06
AURKAGO:0044772mitotic cell cycle phase transition3.30e-06
AURKAGO:0034504protein localization to nucleus3.30e-06
AURKAGO:0098813nuclear chromosome segregation3.40e-06
AURKAGO:0000070mitotic sister chromatid segregation3.84e-06
AURKAGO:2001233regulation of apoptotic signaling pathway4.07e-06
AURKAGO:0000910cytokinesis4.32e-06
AURKAGO:0031109microtubule polymerization or depolymerization4.36e-06
AURKAGO:0045786negative regulation of cell cycle4.72e-06
AURKAGO:0046605regulation of centrosome cycle4.94e-06
AURKAGO:0090068positive regulation of cell cycle process5.66e-06
AURKAGO:0046785microtubule polymerization5.98e-06
AURKAGO:1900180regulation of protein localization to nucleus6.25e-06
AURKAGO:1901990regulation of mitotic cell cycle phase transition9.27e-06
AURKAGO:0044839cell cycle G2/M phase transition1.10e-05
AURKAGO:1901875positive regulation of post-translational protein modification1.30e-05
AURKAGO:1901987regulation of cell cycle phase transition1.30e-05
AURKAGO:0000132establishment of mitotic spindle orientation1.44e-05
AURKAGO:0007163establishment or maintenance of cell polarity1.61e-05
AURKAGO:1902749regulation of cell cycle G2/M phase transition2.08e-05
AURKAGO:0007088regulation of mitotic nuclear division2.28e-05
AURKAGO:0007099centriole replication3.79e-05
AURKAGO:0007020microtubule nucleation4.68e-05
AURKAGO:0098534centriole assembly6.37e-05
AURKAGO:0072234metanephric nephron tubule development7.66e-05

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Related Drugs to AURKA_PCK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning AURKA-PCK1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to AURKA_PCK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate