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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:RAB11A_DYRK1A

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: RAB11A_DYRK1A
KinaseFusionDB ID: KFG5219
FusionGDB2.0 ID: KFG5219
HgeneTgene
Gene symbol

RAB11A

DYRK1A

Gene ID

8766

1859

Gene nameRAB11A, member RAS oncogene familydual specificity tyrosine phosphorylation regulated kinase 1A
SynonymsYL8DYRK|DYRK1|HP86|MNB|MNBH|MRD7
Cytomap

15q22.31

21q22.13

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-11ARAB 11A, member oncogene familyrab-11dual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologs
Modification date2024041120240411
UniProtAcc

P62491

Q13627

Ensembl transtripts involved in fusion geneENST idsENST00000261890, ENST00000564910, 
ENST00000569896, ENST00000435304, 
ENST00000563580, ENST00000565075, 
ENST00000321219, ENST00000338785, 
ENST00000339659, ENST00000398956, 
ENST00000398960, ENST00000451934, 
ENST00000455387, ENST00000462274, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: RAB11A [Title/Abstract] AND DYRK1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAB11A(66180422)-DYRK1A(38825088), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB11A

GO:0016192

vesicle-mediated transport

17462998|19542231

HgeneRAB11A

GO:0060627

regulation of vesicle-mediated transport

20026645|25673879

HgeneRAB11A

GO:0061512

protein localization to cilium

25673879

HgeneRAB11A

GO:0072659

protein localization to plasma membrane

17082457

HgeneRAB11A

GO:1902017

regulation of cilium assembly

31204173

HgeneRAB11A

GO:1902954

regulation of early endosome to recycling endosome transport

20026645

HgeneRAB11A

GO:1903438

positive regulation of mitotic cytokinetic process

15601896

HgeneRAB11A

GO:1904779

regulation of protein localization to centrosome

20026645

HgeneRAB11A

GO:2001135

regulation of endocytic recycling

20026645

TgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

TgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

TgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345

TgeneDYRK1A

GO:0090310

negative regulation of DNA methylation-dependent heterochromatin formation

24820035


check buttonKinase Fusion gene breakpoints across RAB11A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across DYRK1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0AW022642RAB11Achr15

66180422

DYRK1Achr21

38825088



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:66180422/:38825088)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB11A

P62491

DYRK1A

Q13627

FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (PubMed:20026645). Forms a functional Rab11/FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:15601896). Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation (PubMed:25673879, PubMed:31204173). On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth (PubMed:31204173). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (PubMed:32344433). {ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:15689490, ECO:0000269|PubMed:17462998, ECO:0000269|PubMed:19542231, ECO:0000269|PubMed:20026645, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21282656, ECO:0000269|PubMed:25673879, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:32344433}.FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:21127067, PubMed:8769099, PubMed:30773093, PubMed:20981014, PubMed:23665168). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (PubMed:23665168). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (PubMed:31024071). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (PubMed:30773093). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:25620562, PubMed:29849146). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (PubMed:14500717). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro-survival function and negatively regulates the apoptotic process (By similarity). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (By similarity). This in turn inhibits p53/TP53 activity and apoptosis (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q63470, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:25620562, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30773093, ECO:0000269|PubMed:31024071, ECO:0000269|PubMed:8769099}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of RAB11A_DYRK1A


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
DYRK1AQ13627humanMAPTP10636-8S199GDRsGyssPGsPGtP
DYRK1AQ13627humanMAPTP10636-8S396GAEIVyKsPVVsGDt
DYRK1AQ13627humanMAPTP10636-8S404PVVsGDtsPRHLsNV
DYRK1AQ13627humanTRAF3Q13114S75CGHRFCEsCMAALLS
DYRK1AQ13627humanMEF2DQ14814S251NkVIPAksPPPPtHS
DYRK1AQ13627humanCCNL2Q96S94S369AKkAkADsPVNGLPK
DYRK1AQ13627humanCCND1P24385T286EEVDLACtPtDVRDV
DYRK1AQ13627humanAMPHP49418S295PARPRsPsQTRKGPP
DYRK1AQ13627humanFOXO1Q12778S329stIsGRLsPIMtEQD
DYRK1AQ13627humanPLK2Q9NYY3S358VPDFHLSsPAKNFFK
DYRK1AQ13627humanCDKL5O76039S308RLLDRsPsRSAKRkP
DYRK1AQ13627humanCCNL2Q96S94S330LDGtsGFsPAPKLVE
DYRK1AQ13627humanSNCAP37840S87ktVEGAGsIAAATGFSynuclein
DYRK1AQ13627humanDNM1Q05193S857AsPSRPEsPRPPFDL
DYRK1AQ13627humanRCAN1P53805S167FLIsPPAsPPVGWKQCalcipressin
DYRK1AQ13627humanMAPTP10636-8S202sGyssPGsPGtPGsR
DYRK1AQ13627humanTRAF3Q13114T29HTDRSAGtPVFVPEQ
DYRK1AQ13627humanAMPHP49418T310VPPLPKVtPtKELQQ
DYRK1AQ13627humanMAPTP10636-8T217sRtPsLPtPPtREPK
DYRK1AQ13627humanRCAN1P53805T247QtRRPEYtPIHLS__
DYRK1AQ13627humanPOLR2AP24928S1616TPQSPSysPtsPsYSRNA_pol_Rpb1_R
DYRK1AQ13627humanGLI1P08151S408GPLPRAPsISTVEPk
DYRK1AQ13627humanDYRK1AQ13627S529SNSGRARsDPtHQHR
DYRK1AQ13627humanNFATC1O95644S261ARssRPAsPCNKRKY
DYRK1AQ13627humanAMPHP49418S293PAPARPRsPsQTRKG
DYRK1AQ13627humanSF3B1O75533T273AtPGRGDtPGHAtPG
DYRK1AQ13627humanNFATC1O95644S409LsPTSYMsPTLPALD
DYRK1AQ13627humanMAPTP10636-8T212tPGsRsRtPsLPtPP
DYRK1AQ13627humanCCNL2Q96S94S338PAPKLVEsPKEGKGs
DYRK1AQ13627humanLIN52Q52LA3S28FEKLDRAsPDLWPEQLIN52
DYRK1AQ13627humanPOLR2AP24928S1619SPSysPtsPsYSPTSRNA_pol_Rpb1_R
DYRK1AQ13627humanSPRY2O43597T75KPAPRPStQHkHERL
DYRK1AQ13627humanNFATC1O95644S403WAkPKPLsPTSYMsP
DYRK1AQ13627humanTP53P04637S15PsVEPPLsQEtFsDLP53_TAD
DYRK1AQ13627humanMAPTP10636-8T205ssPGsPGtPGsRsRt
DYRK1AQ13627humanSF3B1O75533T434PARkLtAtPtPLGGMSF3b1
DYRK1AQ13627humanMAPTP10636-8S422GsIDMVDsPQLAtLA
DYRK1AQ13627humanTRAF3Q13114S9ESSKKMDsPGALQTN
DYRK1AQ13627humanNFATC1O95644S278NGRQPPYsPHHsPTP
DYRK1AQ13627humanAMPHP49418T312PLPKVtPtKELQQEN


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
DYRK1AIDDescription0.00e+00
DYRK1AGO:0031571mitotic G1 DNA damage checkpoint signaling2.28e-03
DYRK1AGO:0044819mitotic G1/S transition checkpoint signaling2.28e-03
DYRK1AGO:0032886regulation of microtubule-based process2.51e-03
DYRK1AGO:2000377regulation of reactive oxygen species metabolic process4.85e-03
DYRK1AGO:0010506regulation of autophagy5.92e-03
DYRK1AGO:0031113regulation of microtubule polymerization5.92e-03
DYRK1AGO:0042770signal transduction in response to DNA damage5.92e-03
DYRK1AGO:2000379positive regulation of reactive oxygen species metabolic process5.92e-03
DYRK1AGO:0006979response to oxidative stress5.92e-03
DYRK1AGO:0048488synaptic vesicle endocytosis5.92e-03
DYRK1AGO:0140238presynaptic endocytosis5.92e-03
DYRK1AGO:0030330DNA damage respons6.04e-05
DYRK1AGO:0051348negative regulation of transferase activity6.36e-03
DYRK1AGO:0031115negative regulation of microtubule polymerization6.36e-03
DYRK1AGO:0036465synaptic vesicle recycling6.36e-03
DYRK1AGO:0044773mitotic DNA damage checkpoint signaling6.36e-03
DYRK1AGO:0072593reactive oxygen species metabolic process6.36e-03
DYRK1AGO:2000134negative regulation of G1/S transition of mitotic cell cycle6.36e-03
DYRK1AGO:0044774mitotic DNA integrity checkpoint signaling6.36e-03
DYRK1AGO:0046785microtubule polymerization6.39e-03
DYRK1AGO:0050804modulation of chemical synaptic transmission6.39e-03
DYRK1AGO:0099177regulation of trans-synaptic signaling6.39e-03
DYRK1AGO:0031110regulation of microtubule polymerization or depolymerization6.39e-03
DYRK1AGO:1902807negative regulation of cell cycle G1/S phase transition6.39e-03
DYRK1AGO:0034599cellular response to oxidative stress6.39e-03
DYRK1AGO:2000177regulation of neural precursor cell proliferation7.13e-03
DYRK1AGO:0006977DNA damage respons1.62e-04
DYRK1AGO:0044843cell cycle G1/S phase transition7.82e-03
DYRK1AGO:0018105peptidyl-serine phosphorylation9.37e-03
DYRK1AGO:0018209peptidyl-serine modification1.07e-02
DYRK1AGO:0007613memory1.07e-02
DYRK1AGO:0000077DNA damage checkpoint signaling1.09e-02
DYRK1AGO:0062197cellular response to chemical stress1.09e-02
DYRK1AGO:0031109microtubule polymerization or depolymerization1.26e-02
DYRK1AGO:0031570DNA integrity checkpoint signaling1.26e-02
DYRK1AGO:0097421liver regeneration1.39e-02
DYRK1AGO:0007093mitotic cell cycle checkpoint signaling1.39e-02
DYRK1AGO:0043543protein acylation1.49e-02
DYRK1AGO:0010639negative regulation of organelle organization1.54e-02
DYRK1AGO:0060292long-term synaptic depression1.54e-02
DYRK1AGO:0045936negative regulation of phosphate metabolic process1.67e-02
DYRK1AGO:0010563negative regulation of phosphorus metabolic process1.67e-02
DYRK1AGO:0090311regulation of protein deacetylation1.69e-02
DYRK1AGO:0070507regulation of microtubule cytoskeleton organization1.69e-02
DYRK1AGO:0061351neural precursor cell proliferation1.77e-02
DYRK1AGO:0048639positive regulation of developmental growth1.77e-02
DYRK1AGO:0045773positive regulation of axon extension1.77e-02
DYRK1AGO:0031111negative regulation of microtubule polymerization or depolymerization1.79e-02
DYRK1AGO:0043516regulation of DNA damage respons7.33e-04

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Related Drugs to RAB11A_DYRK1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning RAB11A-DYRK1A and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to RAB11A_DYRK1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate