UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Kinase Fusion Gene Summary

leaf

Kinase Fusion Gene Sample Information

leaf

Kinase Fusion ORF Analysis

leaf

Kinase Fusion Amino Acid Sequences

leaf

Multiple Sequence Alignment of All Fusion Protein Isoforms

leaf

Kinase Fusion Protein Functional Features

leaf

Kinase Fusion Protein Structures

leaf

Comparison of Fusion Protein Isoforms

leaf

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

leaf

pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

leaf

Ramachandran Plot of Kinase Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Virtual Screening Results

leaf

Kinase-Substrate Information

leaf

Related Drugs with This Kinase Fusion Protein

leaf

Related Disease with This Kinase Fusion Protein

leaf

Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:AURKB_ZNF277

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: AURKB_ZNF277
KinaseFusionDB ID: KFG522
FusionGDB2.0 ID: KFG522
HgeneTgene
Gene symbol

AURKB

ZNF277

Gene ID

9212

11179

Gene nameaurora kinase Bzinc finger protein 277
SynonymsAIK2|AIM-1|AIM1|ARK-2|ARK2|AurB|IPL1|PPP1R48|STK-1|STK12|STK5|aurkb-sv1|aurkb-sv2NRIF4|ZNF277P
Cytomap

17p13.1

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionaurora kinase Baurora kinase B-Sv1aurora kinase B-Sv2aurora- and Ipl1-like midbody-associated protein 1aurora- and Ipl1-like midbody-associated protein 1 homologaurora-1aurora-Baurora-related kinase 2aurora/IPL1-related kinase 2protein phosphataszinc finger protein 277nuclear receptor-interacting factor 4zinc finger protein (C2H2 type) 277zinc finger protein 277 pseudogene
Modification date2024041620240403
UniProtAcc

Q96GD4

Q9NRM2

Ensembl transtripts involved in fusion geneENST idsENST00000316199, ENST00000535053, 
ENST00000578549, ENST00000585124, 
ENST00000534871, 		ENST00000361822, 
ENST00000421043, ENST00000450657, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: AURKB [Title/Abstract] AND ZNF277 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AURKB(8113494)-ZNF277(111926927), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAURKB

GO:0000122

negative regulation of transcription by RNA polymerase II

20959462

HgeneAURKB

GO:0002903

negative regulation of B cell apoptotic process

20959462

HgeneAURKB

GO:0006468

protein phosphorylation

21820309|22724069

HgeneAURKB

GO:0032091

negative regulation of protein binding

21820309

HgeneAURKB

GO:0034644

cellular response to UV

20959462

HgeneAURKB

GO:0036089

cleavage furrow formation

16103226

HgeneAURKB

GO:0044839

cell cycle G2/M phase transition

33542149

HgeneAURKB

GO:0045824

negative regulation of innate immune response

33542149

HgeneAURKB

GO:0062033

positive regulation of mitotic sister chromatid segregation

26829474|30409912

HgeneAURKB

GO:0160049

negative regulation of cGAS/STING signaling pathway

33542149

HgeneAURKB

GO:1905116

positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore

28751710


check buttonKinase Fusion gene breakpoints across AURKB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across ZNF277 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


Top

Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-EO-A2CGAURKBchr17

8113494

ZNF277chr7

111926927



Top

Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

Top

Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



Top

Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:8113494/:111926927)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AURKB

Q96GD4

ZNF277

Q9NRM2

FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:26829474). Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis (PubMed:15249581). Required for central/midzone spindle assembly and cleavage furrow formation (PubMed:12458200, PubMed:12686604). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP (PubMed:11516652, PubMed:12925766, PubMed:14610074). Phosphorylation of INCENP leads to increased AURKB activity (PubMed:11516652, PubMed:12925766, PubMed:14610074). Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3 (PubMed:11784863, PubMed:12689593, PubMed:14602875, PubMed:11856369, PubMed:16103226, PubMed:21658950, PubMed:11756469). A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres (PubMed:21658950). Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively) (PubMed:11784863, PubMed:11856369). AURKB is also required for kinetochore localization of BUB1 and SGO1 (PubMed:15020684, PubMed:17617734). Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (PubMed:20959462). Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). Acts as an inhibitor of CGAS during mitosis: catalyzes phosphorylation of the N-terminus of CGAS during the G2-M transition, blocking CGAS liquid phase separation and activation, and thereby preventing CGAS-induced autoimmunity (PubMed:33542149). Phosphorylates KRT5 during anaphase and telophase (By similarity). {ECO:0000250|UniProtKB:O70126, ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515, ECO:0000269|PubMed:26829474, ECO:0000269|PubMed:29449677, ECO:0000269|PubMed:33542149}.FUNCTION: Probable transcription factor. Involved in modulation of cellular senescence; represses transcription of the tumor suppressor gene INK4A/ARF, perhaps acting via the Polycomb group (PcG) complex PRC1. {ECO:0000250|UniProtKB:E9Q6D6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


Top

Kinase-Substrate Information of AURKB_ZNF277


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
AURKBQ96GD4humanNUMA1Q14980T2055MAFsILNtPkkLGNs
AURKBQ96GD4humanRACGAP1Q9H0H5S387ETGLYRIsGCDRTVKRhoGAP
AURKBQ96GD4humanNDC80O14777T49kLsINkPtsERkVsL
AURKBQ96GD4humanSHCBP1Q8NEM2S634QIKKKRLsELGITQA
AURKBQ96GD4humanRB1P06400S780strPPtLsPIPHIPrRb_C
AURKBQ96GD4humanZWINTO95229S262MGRDPGVsFkAVGLQZwint
AURKBQ96GD4humanPRKDCP78527S511EsEDHRAsGEVRtGkDNA-PKcs_N
AURKBQ96GD4humanH2BC14Q99879Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanRUNX3Q13761T14PSTSRRFtPPsPAFP
AURKBQ96GD4humanH2BC9Q93079Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanCDCA8Q53HL2T278QICssIRtHK_____
AURKBQ96GD4humanH2BC5P58876Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanINCENPQ9NQS7S72RRKKRRIsyVQDENR
AURKBQ96GD4humanGFAPP14136S38LGPGTRLsLARMPPPFilament_head
AURKBQ96GD4humanH2BC20PQ6DN03S78ERIAGEAsrLAHyNkHistone
AURKBQ96GD4humanDESP17661T17RVssYRRtFGGAPGFFilament_head
AURKBQ96GD4humanDEKP35659T67KKKVERLtMQVssLQ
AURKBQ96GD4humanKRT8P05787T6__MsIRVtQksykVsKeratin_2_head
AURKBQ96GD4humanCDCA5Q96FF9S126NPEAEsssKEGELDASororin
AURKBQ96GD4humanDIAPH2Q17R91S820HINNIKPsIIAVTLAFH2
AURKBQ96GD4humanMYBBP1AQ9BQG0S1303ARKKARLsLVIRsPs
AURKBQ96GD4humanCDCA5Q96FF9T111ktHsVPAtPtStPVPSororin
AURKBQ96GD4humanHASPINQ8TF76S93RVPKDRPsLTVtPkR
AURKBQ96GD4humanATXN10Q9UBB4S12rPPPArLsGVMVPAP
AURKBQ96GD4humanH2BC4P62807S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanDSN1Q9H410S109KETNRRksLHPIHQGMIS13
AURKBQ96GD4humanKIF4AO95239T799PPKLRRRtFsLTEVR
AURKBQ96GD4humanCOBLL1Q53SF7S876LQMQKRVsGHyVTSA
AURKBQ96GD4humanPPHLN1Q8NEY8S110RDGFRRksFyssHyA
AURKBQ96GD4humanRIF1Q5UIP0S2205VNkVRRVsFADPIyQ
AURKBQ96GD4humanPLEKHG6Q3KR16T544SPStRPstPsLEGSQ
AURKBQ96GD4humanNUMA1Q14980T1811tRsARRRttQIINIt
AURKBQ96GD4humanNSUN2Q08J23S139SRKILRksPHLEkFH
AURKBQ96GD4humanKIF20AO95235S878RILRsRRsPLLKsGP
AURKBQ96GD4humanNINLQ9Y2I6S585RLPKNRHsPSWsPDG
AURKBQ96GD4humanCKAP2Q8WWK9S628FLtPVRRsRRLQEKTCKAP2_C
AURKBQ96GD4humanKIF2CQ99661S95IQkQKRRsVNSkIPA
AURKBQ96GD4humanDESP17661S60VyQVsRtsGGAGGLGFilament_head
AURKBQ96GD4humanNDC80O14777S15SGGAGRLsMQELrSQ
AURKBQ96GD4humanNPM1P06748S125AVEEDAEsEDEEEED
AURKBQ96GD4humanH3C1P68431T3_____ArtkQtArksHistone
AURKBQ96GD4humanATMQ13315S1403CHkTKLKsILEILSk
AURKBQ96GD4humanAURKBQ96GD4T16PWPyGRQtAPsGLST
AURKBQ96GD4humanRPL21P46778S104kHSKsRDsFLkRVKE
AURKBQ96GD4humanNINLQ9Y2I6S448QGYRERLsLLRSEVE
AURKBQ96GD4humanNDC80O14777S44kPtFGkLsINkPtsE
AURKBQ96GD4humanH3C1P68431S10tkQtArkstGGkAPrHistone
AURKBQ96GD4humanZWINTO95229T251TRPQEQstGDTMGRDZwint
AURKBQ96GD4humanSH2D4AQ9H788S261REDYKRLsLGAQKGR
AURKBQ96GD4humanKNL1Q8NG31S24RPVRRRHssILkPPR
AURKBQ96GD4humanHASPINQ8TF76S4____MAAsLPGPGsR
AURKBQ96GD4humanKIF4AO95239S801KLRRRtFsLTEVRGQ
AURKBQ96GD4humanH2BC15Q99877Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanH2BC14Q99879S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanSEPTIN1Q8WYJ6S320RSKLSRQsAtEIPLP
AURKBQ96GD4humanKIF2CQ99661S115RsRstRMstVSELRI
AURKBQ96GD4humanRPS10P46783T118GERPARLtrGEADRD
AURKBQ96GD4humanH3-3AP84243S10tkQTARkstGGkAPRHistone
AURKBQ96GD4humanHMGN2P05204S29QRRsARLsAkPAPPkHMG14_17
AURKBQ96GD4humanDDX52Q9Y2R4S22kFDTRRFsADAArFQ
AURKBQ96GD4humanNFKBIAP25963S262QLTWGRPsTRIQQQL
AURKBQ96GD4humanH2BC11P06899Y83EAsrLAHyNkrstITHistone
AURKBQ96GD4humanNDC80O14777S5___MKRSsVsSGGAG
AURKBQ96GD4humanH2BC19PQ6DRA6Y83EAsrLAHyNkRSTITHistone
AURKBQ96GD4humanARHGAP21Q5T5U3S131IIKVNGEsVIGKTYSPDZ_6
AURKBQ96GD4humanRUNX3Q13761T173YHRAIkVtVDGPREPRunt
AURKBQ96GD4humanCBX5P45973S92SESNKRksNFsNsAD
AURKBQ96GD4humanH2BC9Q93079S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanH2BC18Q5QNW6S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanHSP90AB1P08238S452stNRRRLsELLRyHtHSP90
AURKBQ96GD4humanNDC80O14777S55PtsERkVsLFGkRtsNdc80_HEC
AURKBQ96GD4humanH3-3AP84243S28ATkAARksAPsTGGVHistone
AURKBQ96GD4humanCDT1Q9H211T102GQKIKKStPAAGQPP
AURKBQ96GD4humanTP53P04637S183CPHHERCsDsDGLAPP53
AURKBQ96GD4humanNAGKQ9UJ70S76RsLGLsLsGGDQEDABcrAD_BadFG
AURKBQ96GD4humanPLEKHG6Q3KR16T620LRRDPRLtFSTLELR
AURKBQ96GD4humanLMO7Q8WWI1S300DMsyRRIsAVEPkTADUF4757
AURKBQ96GD4humanH2BC11P06899S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanH3C1P68431S28ATkAArksAPATGGVHistone
AURKBQ96GD4humanLMO7Q8WWI1S751kWKDRRksYtsDLQKDUF4757
AURKBQ96GD4humanHMGN5P82970S20RQEPKRRsARLsAMLHMG14_17
AURKBQ96GD4humanWWC1Q8IX03S539tsLsPRSsLSsPSPP
AURKBQ96GD4humanPLEKHG6Q3KR16S645PQAPQRRsAPELPEG
AURKBQ96GD4humanGFAPP14136S13ItsAArrsyVSsGEMFilament_head
AURKBQ96GD4humanH2BC15Q99877S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanHASPINQ8TF76S143PPFPsRDsGRLsPDL
AURKBQ96GD4humanRPL8P62917S130RGKLARAsGNyATVIRibosomal_L2_C
AURKBQ96GD4humanKIF2CQ99661S109APkEsLRsRstRMst
AURKBQ96GD4humanH2BC20PQ6DN03Y83EAsrLAHyNkRSTITHistone
AURKBQ96GD4humanMIS18AQ9NYP9S36sLLGkrLsEDssRHQ
AURKBQ96GD4humanKNL1Q8NG31S60KKNSRRVsFADTIKV
AURKBQ96GD4humanBIRC5O15392T34FLEGCACtPERMAEABIR
AURKBQ96GD4humanSSU72Q9NP77S3_____MPssPLRVAV
AURKBQ96GD4humanTP53P04637S269GNLLGRNsFEVRVCAP53
AURKBQ96GD4humanKIF2CQ99661S111kEsLRsRstRMstVS
AURKBQ96GD4humanDIAPH2Q17R91T882KSADQKTtLLHFIADFH2
AURKBQ96GD4humanCDT1Q9H211T358PPATEkLtTAQEVLA
AURKBQ96GD4humanSSU72Q9NP77S19CSSNQNRsMEAHNILSsu72
AURKBQ96GD4humanCDCA8Q53HL2S154PSKKRtQsIQGKGKG
AURKBQ96GD4humanH2BC3P33778S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanH2BC4P62807Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanPLEKHG6Q3KR16T540QDRESPStRPstPsL
AURKBQ96GD4humanUTP3Q9NQZ2S462RKEEQRYsGELsGIRSas10
AURKBQ96GD4humanCDCA5Q96FF9S139DARDLEMsKKVRRsySororin
AURKBQ96GD4humanNFKBIAP25963S32LLDDRHDsGLDsMkD
AURKBQ96GD4humanCDT1Q9H211S143RVRALkAsAQDAGES
AURKBQ96GD4humanZWINTO95229S250PTRPQEQstGDTMGRZwint
AURKBQ96GD4humanSSH3Q8TE77S37SRLQRRQsFAVLRGA
AURKBQ96GD4humanAHNAKQ09666T158ItVtRRVtAytVDVT
AURKBQ96GD4humanRSL1D1O76021T312KRQQARktAsVLskD
AURKBQ96GD4humanRBMXP38159S326GyGGsRDsysssRsD
AURKBQ96GD4humanINCENPQ9NQS7T494kVVRPLRtFLHtVQR
AURKBQ96GD4humanCDCA5Q96FF9S33LRRsQRKsGsELPsI
AURKBQ96GD4humanRBM3P98179S147QGGyDrysGGNyRDN
AURKBQ96GD4humanINCENPQ9NQS7S894RYHKRtssAVWNsPP
AURKBQ96GD4humanTP53BP1Q12888S1342GPLrGktsGtEPADF
AURKBQ96GD4humanRPRD1BQ9NQG5S145KATEEKKsLKRTFQQ
AURKBQ96GD4humanZFYVE19Q96K21S22yAGCRRAsGFPALGR
AURKBQ96GD4humanDDX3XO00571S594rSKssrFsGGFGArD
AURKBQ96GD4humanINCENPQ9NQS7S899tssAVWNsPPLQGAR
AURKBQ96GD4humanKIF2CQ99661S192VNsVRRKsCLVkEVE
AURKBQ96GD4humanH2BC17P23527Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanPLEKHG6Q3KR16S546StRPstPsLEGSQSS
AURKBQ96GD4humanHNRNPUQ00839S14NVkKLkVsELkEELkSAP
AURKBQ96GD4humanGFAPP14136T7_MERRRItsAArrsyFilament_head
AURKBQ96GD4humanAURKBQ96GD4S7_MAQkENsyPWPyGR
AURKBQ96GD4humanDIAPH2Q17R91T66ITSFRKStVKKEKPL
AURKBQ96GD4humanTP53P04637T284CPGRDRRtEEENLrkP53
AURKBQ96GD4humanAURKBQ96GD4T232APsLRRktMCGtLDyPkinase
AURKBQ96GD4humanHMGN2P05204S25kDEPQRRsARLsAkPHMG14_17
AURKBQ96GD4humanMYL12BO14950S20KRPQRAtsNVFAMFD
AURKBQ96GD4humanYY1P25490S184GKKsGKksyLsGGAG
AURKBQ96GD4humanPARD3Q8TEW0S962SSRsGREsVSTAsDQ
AURKBQ96GD4humanINCENPQ9NQS7S518APRsVMKsFIKRNtP
AURKBQ96GD4humanPLK1P53350T210YDGERKktLCGtPNyPkinase
AURKBQ96GD4humanNELFEP18615S131SRRPQRksLyEsFVS
AURKBQ96GD4humanCDCA2Q69YH5S977EPGKRRKsFCIsTLA
AURKBQ96GD4humanKIF23Q02241-2S708IRLRHRRsRsAGDRWMKLP1_Arf_bdg
AURKBQ96GD4humanCCDC86Q9H6F5S255DRsKKRFsQMLQDkPCgr1
AURKBQ96GD4humanCDCA8Q53HL2S165KGKGKRssRANtVtPBorealin
AURKBQ96GD4humanH2BC21Q16778Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanVIMP08670S73sAVrLrssVPGVRLLFilament_head
AURKBQ96GD4humanHNRNPUQ00839S26ELkKRRLsDkGLkAESAP
AURKBQ96GD4humanRACGAP1Q9H0H5T249WTRSRRktGtLQPWN
AURKBQ96GD4humanNUMA1Q14980S2047kQADRRQsMAFsILN
AURKBQ96GD4humanH2BC21Q16778S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanMYH10P35580T1847ANKLVRRtEKKLKEIMyosin_tail_1
AURKBQ96GD4humanNINLQ9Y2I6S185WDSEDFGsPQKSCsP
AURKBQ96GD4humanCDCA5Q96FF9S83PRRsPRIsFFLEKEN
AURKBQ96GD4humanCDCA2Q69YH5S893sETKVRRsTRLQKDL
AURKBQ96GD4humanINCENPQ9NQS7T892KPRYHKRtssAVWNs
AURKBQ96GD4humanINCENPQ9NQS7T59EPELMPKtPSQKNRR
AURKBQ96GD4humanCHMP4CQ96CF2S215RRsRAAssQRAEEED
AURKBQ96GD4humanH2BC5P58876S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanH2BC17P23527S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanH2BC12O60814Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanNFKBIAP25963S63PQEVPRGsEPWkQQL
AURKBQ96GD4humanCDCA5Q96FF9T159LGsAStstPGRRsCFSororin
AURKBQ96GD4humanPLEKHG6Q3KR16S697LRGQLPSsPTHADSA
AURKBQ96GD4humanCKAP2Q8WWK9T39EHLLRRktLFAYKQE
AURKBQ96GD4humanH2BC19PQ6DRA6S78ERIAGEAsrLAHyNkHistone
AURKBQ96GD4humanHMGN5P82970S24KRRsARLsAMLVPVtHMG14_17
AURKBQ96GD4humanRBM14Q96PK6S618LsDyrRLsEsQLsFR
AURKBQ96GD4humanMISPQ8IVT2S348RRERGRPsLyVQRDIAKAP2_C
AURKBQ96GD4humanSEPTIN1Q8WYJ6S312PGARDRAsRSKLSRQ
AURKBQ96GD4humanMAPRE3Q9UPY8S176MQTSGRLsNVAPPCI
AURKBQ96GD4humanCDCA5Q96FF9T151RsysRLEtLGsAStsSororin
AURKBQ96GD4humanDIAPH2Q17R91S196CLESLRVsLTSNPVSDrf_GBD
AURKBQ96GD4humanCDCA5Q96FF9S164tstPGRRsCFGFEGLSororin
AURKBQ96GD4humanH2BC12O60814S78ErIAGEAsrLAHyNkHistone
AURKBQ96GD4humanARHGAP23Q9P227S127LVkVNGEsVIGKTYSPDZ_6
AURKBQ96GD4humanMCL1Q07820T301ITDVLVRtkRDWLVkBcl-2
AURKBQ96GD4humanNUMA1Q14980S1969QEtLRRAsMQPIQIA
AURKBQ96GD4humanCAVIN1Q6NZI2S300SRDkLRksFtPDHVVPTRF_SDPR
AURKBQ96GD4humanSUPT16HQ9Y5B9T494EEAkRRLtEQkGEQQ
AURKBQ96GD4humanGBF1Q92538S174ICFEMRLsELLRKSADCB
AURKBQ96GD4humanH2BC3P33778Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanCDCA5Q96FF9T115VPAtPtStPVPNPEASororin
AURKBQ96GD4humanCDCA2Q69YH5S981RRKsFCIsTLANTKA
AURKBQ96GD4humanBIRC5O15392T117kNkIAkEtNNkkkEF
AURKBQ96GD4humanDESP17661S12ysSSQRVssYRRtFGFilament_head
AURKBQ96GD4humanCDT1Q9H211T7_MEQRRVtDFFARRR
AURKBQ96GD4humanTP53P04637S215DrNtFrHsVVVPyEPP53
AURKBQ96GD4humanINCENPQ9NQS7S893PRYHKRtssAVWNsP
AURKBQ96GD4humanNDC80O14777S69sGHGsRNsQLGIFssNdc80_HEC
AURKBQ96GD4humanPLEKHG6Q3KR16S543ESPStRPstPsLEGS
AURKBQ96GD4humanPRRC2CQ9Y520S1013NDRPVRRsGPIKKPV
AURKBQ96GD4humanDSN1Q9H410S100RQsWRRAsMKETNRRMIS13
AURKBQ96GD4humanNUDCQ9Y266T40FSFLRRktDFFIGGENudc_N
AURKBQ96GD4humanCHMP4CQ96CF2S210MSSTARRsRAAssQR
AURKBQ96GD4humanNUSAP1Q9BXS6S240VPPRGRLsVAstPIsNUSAP
AURKBQ96GD4humanRBM14Q96PK6S649HsDyArysGsyNDyL
AURKBQ96GD4humanHSP90AB1P08238S255PKIEDVGsDEEDDsGHSP90
AURKBQ96GD4humanHASPINQ8TF76S108WKLRARPsLtVtPRR
AURKBQ96GD4humanCDCA8Q53HL2S275RLAQICssIRtHK__Borealin
AURKBQ96GD4humanMKI67P46013S374ytTGRREsVNLGkSE
AURKBQ96GD4humanCDCA8Q53HL2S219YNIsGNGsPLADskEBorealin
AURKBQ96GD4humanTP53P04637T211EYLDDrNtFrHsVVVP53
AURKBQ96GD4humanCENPAP49450S7_MGPRRRsRKPEAPRHistone
AURKBQ96GD4humanRASSF1Q9NS23-2S203TsVRRRtsFYLPKDARA
AURKBQ96GD4humanDDA1Q9BW61S33kAsNRRPsVyLPTREDDA1
AURKBQ96GD4humanKIF23Q02241S911NGsRKRRsstVAPAQ
AURKBQ96GD4humanSSU72Q9NP77S4____MPssPLRVAVV
AURKBQ96GD4humanMPHOSPH10O00566T332KESLKRVtFALPDDAMpp10
AURKBQ96GD4humanSEPTIN1Q8WYJ6S253PVRGRRysWGtVEVESeptin
AURKBQ96GD4humanMKI67P46013S538EAPTKRksLVMHtPPPP1_bind
AURKBQ96GD4humanPKMP14618T45PPItARNtGIICtIGPK
AURKBQ96GD4humanCDCA5Q96FF9S79AVQsPRRsPRIsFFL
AURKBQ96GD4humanCHMP4CQ96CF2S214ARRsRAAssQRAEEE
AURKBQ96GD4humanUSP13Q92995S114ALPkRRNsKIFLDLD
AURKBQ96GD4humanDDX3YO15523S592RSKSNrFsGGFGArD
AURKBQ96GD4humanHDAC5Q9UQL6S278QKVAERRssPLLRRK
AURKBQ96GD4humanH2BC18Q5QNW6Y83EAsrLAHyNkrstItHistone
AURKBQ96GD4humanPLECQ15149T2886PVRNRRLtVNEAVKEPlectin
AURKBQ96GD4humanRBMXL1Q96E39S326GyGGsRDsysSSRsD


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
AURKBIDDescription0.00e+00
AURKBGO:0000070mitotic sister chromatid segregation4.20e-23
AURKBGO:0007059chromosome segregation4.25e-22
AURKBGO:0140014mitotic nuclear division4.25e-22
AURKBGO:0000819sister chromatid segregation1.48e-21
AURKBGO:0098813nuclear chromosome segregation1.54e-19
AURKBGO:0051303establishment of chromosome localization1.93e-19
AURKBGO:0050000chromosome localization6.45e-19
AURKBGO:0051310metaphase chromosome alignment7.19e-19
AURKBGO:0000280nuclear division1.79e-18
AURKBGO:0048285organelle fission2.21e-17
AURKBGO:0051656establishment of organelle localization1.01e-16
AURKBGO:0061640cytoskeleton-dependent cytokinesis5.85e-16
AURKBGO:0051983regulation of chromosome segregation3.49e-15
AURKBGO:0008608attachment of spindle microtubules to kinetochore5.28e-15
AURKBGO:0000281mitotic cytokinesis6.76e-15
AURKBGO:0140694non-membrane-bounded organelle assembly6.76e-15
AURKBGO:0033047regulation of mitotic sister chromatid segregation1.58e-14
AURKBGO:0000022mitotic spindle elongation3.75e-14
AURKBGO:0000910cytokinesis3.92e-14
AURKBGO:0000075cell cycle checkpoint signaling5.32e-14
AURKBGO:1902850microtubule cytoskeleton organization involved in mitosis7.36e-14
AURKBGO:0051225spindle assembly7.36e-14
AURKBGO:0010948negative regulation of cell cycle process8.87e-14
AURKBGO:0051231spindle elongation1.69e-13
AURKBGO:0007088regulation of mitotic nuclear division3.03e-13
AURKBGO:1905818regulation of chromosome separation6.03e-13
AURKBGO:0045786negative regulation of cell cycle6.18e-13
AURKBGO:0007080mitotic metaphase chromosome alignment1.01e-12
AURKBGO:0007052mitotic spindle organization1.04e-12
AURKBGO:1901988negative regulation of cell cycle phase transition1.07e-12
AURKBGO:0033045regulation of sister chromatid segregation1.23e-12
AURKBGO:0010965regulation of mitotic sister chromatid separation1.32e-12
AURKBGO:0065004protein-DNA complex assembly1.34e-12
AURKBGO:0007051spindle organization1.39e-12
AURKBGO:0051304chromosome separation1.40e-12
AURKBGO:0051306mitotic sister chromatid separation2.10e-12
AURKBGO:0051256mitotic spindle midzone assembly2.32e-12
AURKBGO:0007093mitotic cell cycle checkpoint signaling2.75e-12
AURKBGO:0007094mitotic spindle assembly checkpoint signaling3.12e-12
AURKBGO:0071173spindle assembly checkpoint signaling3.12e-12
AURKBGO:0071174mitotic spindle checkpoint signaling3.12e-12
AURKBGO:0051783regulation of nuclear division3.61e-12
AURKBGO:1901987regulation of cell cycle phase transition3.61e-12
AURKBGO:0031577spindle checkpoint signaling3.68e-12
AURKBGO:0033046negative regulation of sister chromatid segregation4.24e-12
AURKBGO:0033048negative regulation of mitotic sister chromatid segregation4.24e-12
AURKBGO:0045841negative regulation of mitotic metaphase/anaphase transition4.24e-12
AURKBGO:2000816negative regulation of mitotic sister chromatid separation4.24e-12
AURKBGO:0051315attachment of mitotic spindle microtubules to kinetochore5.43e-12

Top

Related Drugs to AURKB_ZNF277


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning AURKB-ZNF277 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

Top

Related Diseases to AURKB_ZNF277


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


Top

Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate